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Metabotropic glutamate receptor 1 alpha:a unique receptor variant with variable implications for Alzheimer’s disease pathogenesis

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Neural Regeneration Research 2023年第10期18卷 2196-2197页

作者： jason HY Yeung Andrea Kwakowsky Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreOllscoil na Gaillimhe-University of GalwayGalwayIreland

Alzheimer’s disease (AD) is the leading neurodegenerative disorder *** this,there is minimal effective therapeutics proven to reduce or prevent the progression of this *** is the main excitatory neurotransmitter with... 详细信息

关键词： Alzheimer Metab pathogenesis

Effect of Artificial Intelligence on Social Trust in American Institutions

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Journal of Social Computing 2023年第3期4卷 221-231页

作者： Andrew Collins jason Jeffrey Jones the Department of Sociology Stony Brook UniversityStony BrookNY 11790USA

In recent decades,social scientists have debated declining levels of trust in American *** the same time,many American institutions are coming under scrutiny for their use of artificial intelligence(AI)*** paper analyzes the results of a survey experiment over a nationally representative sample to gauge the effect that the use of AI has on the American public’s trust in their social institutions,including government,private corporations,police precincts,and *** find that artificial intelligence systems were associated with significant trust penalties when used by American police precincts,companies,and *** penalties were especially strong for American police precincts and,in most cases,were notably stronger than the trust penalties associated with the use of smartphone apps,implicit bias training,machine learning,and mindfulness ***’trust in institutions tends to be negatively impacted by the use of new *** there are significant variations in trust between different pairings of institutions and tools,generally speaking,institutions which use AI suffer the most significant loss of *** government agencies are a notable exception here,receiving a small but puzzling boost in trust when associated with the use of AI systems.

关键词： social trust artificial intelligence(AI) algorithm aversion

Prostate-specific antigen （PSA） screening： has the pendulum swung too far？

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Asian Journal of Andrology 2011年第5期13卷 655-656页

作者： jason M Phillips E David Crawford Department of Urology University of Colorado HealthSciences Center Aurora CO 80045 USA

Prostate-specific antigen （PSA） along with digital rectal exam has been the standard for prostate cancer screening in the United States for the past 20 years.1 During this time period, the improved detection of prostate cancer decreased related mortality more than 30%.2 In fact, metastases and their comorbidities have decreased more than 75% since the early 1990s, resulting in a higher incidence of early organ-confined disease. While it is clear that prostate cancer mortality statistics have improved, it is unclear whether men are overscreened.

关键词： overscreened Prostate-specific

The Impact of Agricultural Practices in China on Land-Atmosphere Interactions

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Advances in Atmospheric Sciences 2011年第4期28卷 821-831页

作者：徐兴奎 jason K.LEVY State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University Institute of Atmospheric Physics Chinese Academy of Science L.Douglas Wilder School of Government and Public Affairs Virginia Commonwealth University Richmond

Human-induced land use changes and the resulting alterations in vegetation features are major but poorly recognized drivers of regional climatic *** order to investigate the impacts of anthropogenically-induced seasonal vegetation cover changes on regional climate in China,harmonic analysis is applied to 1982-2000 National Oceanic and Atmospheric Administration（NOAA） Advanced Very High Resolution Radiometer（AVVHRR）-derived normalized difference vegetation index（NDVI） time series（ten day interval data）.For two climatic divisions of South China,it is shown that the first harmonic term is in phase with air temperature,while the second and third harmonics are in phase with agricultural *** Penman-Monteith Equation and the Complementary Relationship Areal Evapotranspiration（CRAE） model suggest that monthly mean evapotranspiration is out of phase with temperature and precipitation in regions with signiffcant second or third ***,seasonal vegetation cover changes associated with agricultural cultivation are identiffed：for cropped areas,the temperature and precipitation time series have a single maximum value,while the monthly evapotranspiration time series has a bimodal *** is hypothesized that multi-cropping causes the land surface albedo to sharply increase during harvesting,thereby altering the energy distribution ratio and contributing to observed seasonal vegetation cover changes.

关键词： NDVI land surface cover phenologies multi-crop latent heat discrete Fourier transform

Molecular phylogeny, morphology and life-history comparisons within Circus cyaneus reveal the presence of two distinct evolutionary lineages

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Chinese Birds 2016年第4期7卷 187-198页

作者： Graham J.Etherington jason A.Mobley Museum of Vertebrate Zoology 3101 Valley Life Science Building University of California Organisms and Ecosystems The Earlham Institute Norwich Research Park Aquasis Caucaia

Background: Circus cyaneus is a medium-sized bird of prey that is widely distributed across the Northern Hemisphere. There are two currently recognized forms, the Palearctic form C. c. cyaneus(Hen Harrier), and the Nearctic form C. c. hudsonius(Northern Harrier). The forms have recently been split by the British Ornithologists' Union but the American Ornithologists' Union and some other taxonomic committees have not yet made any change. Here we examine the phylogenetic relationship between the two forms using sequence data from multiple nuclear and mitochondrial genes and examine breeding biology, body size, morphology, dispersal and other ***: In order to fully compare cyaneus and hudsonius, we carried out a full literature review, measured museum skins and carried out phylogenetic analysis using a number of different mitochondrial genes and compare our findings to other recent ***: We find that these two allopatric taxa form reciprocally monophyletic groups, show substantial mt DNA sequence divergence, and further differ significantly with respect to body size, plumage characters, breeding biology, dispersal and other behavioral ***: Based on an array of consistently divergent characteristics, it is suggested that the two forms are best regarded as separate species, Hen Harrier(Circus cyaneus) and Northern Harrier(Circus hudsonius).

关键词： Circus cyaneus Circus hudsonius Hen Harrier Northern Harrier Phylogenetics Speciation Evolution

From Reads to Insights: Integrative Pipelines for Biological Interpretation of ATAC-seq Data

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Genomics, Proteomics & Bioinformatics 2021年第4期19卷 519-521页

作者： Ya Cui jason Sheng Li Wei Li Division of Computational Biomedicine Department of Biological ChemistrySchool of MedicineUniversity of CaliforniaIrvineIrvineCA 92697USA

Underlying the regulation of mammalian gene expression at the level of transcription is the structure and modifications of chromatin. Understanding the twisting structures of DNA wrapped around histones and their high... 详细信息

关键词： closer lying modification

Naval derusting wastewater containing high concentration of iron, treated in UV photo-Fenton-like oxidation

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Journal of Environmental Sciences 2010年第7期22卷 991-997页

作者： Daeik Kim jason Kou-Chaw Chen Teh Fu Yen Sonny Astani Department of Civil and Environmental Engineering Viterbi School of Engineering University of Southern California BooKang Tech. Inc. Korea Building

The UV photooxidation with Fe（Ⅲ） and H2O2 was employed to treat a naval derusting wastewater, which contains the high COD （chemical oxygen demand） and various metal concentrations exceptionally with high concentrations of citric acid and iron. Because of its iron containment, the Fenton-like reaction automatically took place with the added amount of H2O2. The decomposition rate was found in a sequence of： UV/HEOE/Fe（Ⅲ）〉 UV/H2O2 〉 Fe（Ⅱ）/H2O2. Two H2O2 injection methods, single and multiple points, were evaluated. The multiple-point H2O2 injection was more efficient to decompose the citric acid. The decomposition of the synthetic citric acid and the real derusting citric acid wastewater was also compared. The 93% COD reduction of the derusting wastewater was achieved using the UV/HEOE/Fe（Ⅲ） treatment.

关键词： naval derusting wastewater citric acid UV photooxidation Fenton-like

A review of methods,applications and limitations for incorporating fluid flow in the discrete element method

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第3期14卷 1005-1024页

作者： Tuo Wang Fengshou Zhang jason Furtney Branko Damjanac Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai200092China Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai200092China Itasca Consulting Group Inc.MinneapolisMN55041USA

The past decade has witnessed the substantial growth in research interests and progress on the subject of coupled hydro-mechanical processes in rocks and soils,driven mainly by the surge of research in unconventional hydrocarbon reservoirs and associated *** coupling techniques have been developed to include the effects of fluid flow in the discrete element method(DEM),and the techniques have been applied to a variety of geomechanical *** these coupling methods have been successfully applied in various engineering fields,no single fluid/DEM coupling method is universal due to the complexity of engineering problems and the limitations of the numerical *** researchers and engineers,the key to solve a specific problem is to select the most appropriate fluid/DEM coupling method among these modeling *** purpose of this paper is to give a comprehensive review of fluid flow/DEM coupling methods and relevant *** their importance,the availability or unavailability of best practice guidelines is *** theoretical background and current status of DEM are introduced first,and the principles,applications,and advantages and disadvantages of different fluid flow/DEM coupling methods are ***,a summary with speculation on future development trends is given.

关键词： Hydro-mechanical process Fluid/discrete element method(DEM) coupling Geomechanics Numerical modeling

Tumor organoids to study gastroesophageal cancer: a primer

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Journal of Molecular Cell Biology 2020年第8期12卷 593-606页

作者： Ramon U.Jin jason C.Mills Division of Oncology Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63130USA Division of Gastroenterology Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63130USA Department of Developmental Biology Washington University School of MedicineSt.LouisMO 63130USA Department of Pathology and Immunology Washington University School of MedicineSt.LouisMO 63130USA

Gastroesophageal cancers are leading causes of cancer *** attempts at adopting molecularly based treatment approaches have been slow and ineffective even though we begin to identify specific targetable gene mutations and *** is dear that we should no longer treat all gastroesophageal cancers as a homogeneous disease,which is what we do when we use nonspecific ***,we currently cannot monitor successful gene/pathway targeting,nor understand how/when tumors develop resistance,nor predict which patients will derive maximal *** improve outcomes,we must precisely detail the heterogeneity of these tumors to then individualize cancer therapy as well as develop novel avenues to study and predict treatment effects in individual *** this end,patient-derived organoids,in which tumor cells from individual patients are grown in a Petri dish,are a new versatile system that allows for timely expandability,detailed molecular characterization,and genetic manipulation with the promise of enabling predictive assessment of treatment *** this review,we will explore the development and basic techniques for organoid generation,and discuss the current and potential future applications of this exciting technology to study the basic science of carcinogenesis and to predict/guide cancer patient care in the clinics.

关键词： targeted therapy precision oncology cancer model tumor heterogeneity cancer evolution personalized medicine