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Multiplexed Profiling of extracellular Vesicles for Biomarker Development

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Nano-Micro Letters 2022年第1期14卷 59-94页

作者： Cheng Jiang Ying Fu Guozhen Liu Bowen Shu jason davis George K.Tofaris Nuffield Department of Clinical Neurosciences New Biochemistry BuildingUniversity of OxfordOxford OX13QUUK Department of Chemistry University of OxfordOxford OX13QZUK School of Life and Health Sciences The Chinese University of Hong KongShenzhen 518172People’s Republic of China Dermatology Hospital Southern Medical UniversityGuangzhou 510091People’s Republic of China Kavli Institute for Nanoscience Discovery New Biochemistry BuildingUniversity of OxfordOxfordUK

extracellular vesicles(eVs)are cell-derived membranous particles that play a crucial role in molecular trafficking,intercellular transport and the egress of unwanted *** have been implicated in many diseases including cancer and *** are detected in all bodily fluids,and their protein and nucleic acid content offers a means of assessing the status of the cells from which they *** such,they provide opportunities in biomarker discovery for diagnosis,prognosis or the stratification of diseases as well as an objective monitoring of *** simultaneous assaying of multiple eV-derived markers will be required for an impactful practical application,and multiplexing platforms have evolved with the potential to achieve ***,we provide a comprehensive overview of the currently available multiplexing platforms for eV analysis,with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power,throughput and consistency.

关键词： Multiplexed profiling extracellular vesicles exosomes Liquid biopsy Point-of-care Biomarker

Prostate-specific antigen （PSA） screening： has the pendulum swung too far？

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Asian Journal of Andrology 2011年第5期13卷 655-656页

作者： jason M Phillips e David Crawford Department of Urology University of Colorado HealthSciences Center Aurora CO 80045 USA

Prostate-specific antigen （PSA） along with digital rectal exam has been the standard for prostate cancer screening in the United States for the past 20 years.1 During this time period, the improved detection of prostate cancer decreased related mortality more than 30%.2 In fact, metastases and their comorbidities have decreased more than 75% since the early 1990s, resulting in a higher incidence of early organ-confined disease. While it is clear that prostate cancer mortality statistics have improved, it is unclear whether men are overscreened.

关键词： overscreened Prostate-specific

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全球背景中的城市:学术史概要

国外城市规划 2006年第6期21卷 112-120页

作者： Diane e.davis 张艳美国麻省理工学院建筑与规划学院同济大学建筑与城市规划学院城市规划系

学者们研究全球背景中的城市几乎与研究城市的时间一样长（Weber．1927：Pirenne．1936）。在早期有关城市的作品中．”全球城市”的概念未必使用过．但是国际金融市场联系与贸易关系却是存在的。在许多早期作品中．城市的物质、社会和... 详细信息

学者们研究全球背景中的城市几乎与研究城市的时间一样长（Weber．1927：Pirenne．1936）。在早期有关城市的作品中．”全球城市”的概念未必使用过．但是国际金融市场联系与贸易关系却是存在的。在许多早期作品中．城市的物质、社会和经济变迁与国家和国际的政治环境——从封建专制主义秩序的灭亡（weber．1958）到现代民族国家的兴起（Tilly．1975；1990）——以及现代性的社会关系（Durkheim．1993：Simmel,1950）的出现紧密相连．

关键词：全球城市学术史社会关系金融市场民族国家政治环境国际作品

Renewable biomass reinvigorates sustainable water-energy nexus

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Science Bulletin 2024年第16期69卷 2543-2554页

作者： Hongxu Chen Jiatao Xu Zhiyong jason Ren Hailong Lin Leli Zhang eReaihan Yanhao Yuan Zihan Wang Zhidan Liu Laboratory of environment-enhancing energy(e2e) College of Water Resources and Civil EngineeringChina Agricultural UniversityBeijing 100083China Key Laboratory of Agricultural engineering in Structure and environment Ministry of Agriculture and Rural AffairsBeijing 100083China Department of Civil and environmental engineering Princeton UniversityPrinceton NJ 08544USA Andlinger Center for energy and the environment Princeton UniversityPrinceton NJ 08544USA Department of earth and environmental engineering Columbia UniversityNew York NY 10027USA State Key Laboratory of efficient Utilization of Agricultural Water Resources Beijing 100083China

The water-energy nexus has garnered worldwide *** dual-functional research aimed at coproducing freshwater and electricity faces significant challenges,including sub-optimal capacities("1+1er-functional coordination,high carbon footprints,and large *** water-toelectricity conversions are often compromised owing to functionality separation and erratic ***,we present a sustainable strategy based on renewable biomass that addresses these issues by jointly achieving competitive solar-evaporative desalination and robust clean electricity *** hydrothermally activated basswood,our solar desalination exceeded the 100% efficiency bottleneck even under reduced solar *** simple size-tuning,we achieved a high evaporation rate of 3.56 kg h^(-1)m^(-2)and an efficiency of 149.1%,representing 128%-251% of recent values without sophisticated surface *** incorporating an electron-ion nexus with interfacial Faradaic electron circulation and co-ion-predominated micro-tunnel hydrodynamic flow,we leveraged free energy from evaporation to generate long-term electricity(0.38 W m^(-3)for over 14 d),approximately 322% of peer performance *** inter-functional nexus strengthened dual functionalities and validated general engineering *** presented strategy holds significant promise for global human–society–environment sustainability.

关键词： Biomass Water-energy nexus Solar desalination Clean energy Hydrothermal carbonization Sustainable development

Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation:a multi-institutional,retrospective study

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Stroke & Vascular Neurology 2024年第3期9卷 221-229,I0130,I0131页

作者： Chloe Dumot Georgios Mantziaris Sam Dayawansa Zhiyuan Xu Stylianos Pikis Selcuk Peker Yavuz Samanci Gokce D Ardor Ahmed M Nabeel Wael A Reda Sameh R Tawadros Khaled Abdelkarim Amr M N el-Shehaby Reem M emad eldin Ahmed H elazzazi Nuria Martínez Moreno Roberto MartínezÁlvarez Roman Liscak Jaromir May David Mathieu Jean-Nicolas Tourigny Manjul Tripathi Akshay Rajput Narendra Kumar Rupinder Kaur Piero Picozzi Andrea Franzini Herwin Speckter Wenceslao Hernandez Anderson Brito Ronald e Warnick Juan Alzate Douglas Kondziolka Greg N Bowden Samir Patel jason Sheehan Department of Neurological Surgery Hospices Civils de LyonLyonFrance Department of Neurological Surgery University of VirginiaCharlottesvilleVirginiaUSA Department of Neurosurgery Koc University School of MedicineIstanbulTurkey Gamma-knife Center Nasser institute HospitalCairoEgypt Neurosurgery Department Benha UniversityBenhaEgypt Departments of Neurosurgery Ain Shams UniversityCairoEgypt Department of Clinical Oncology Ain Shams UniversityCairoEgypt Department of Radiation Oncology National Cancer InstituteCairo UniversityGizaEgypt Faculty of Medicine Extended Modular ProgramAin Shams UniversityCairoEgypt Department of Radiosurgery Rúber Internacional HospitalMadridSpain Department of Stereotactic and Radiation Neurosurgery Na Homolce HospitalPragueCzech Republic Neurosurgery Centre de recherche du CHUSUniversitéde SherbrookeSherbrookeQuebecCanada Neurosurgery PGIMERChandigarhChandigarhIndia Radiation Therapy PGIMERChandigarhChandigarhIndia Neurosurgery IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Dominican Gamma Knife Center and Radiology Department CEDIMATSanto DomingoDominican Republic Gamma Knife Center Mayfield ClinicThe Jewish Hospital-Mercy HealthCincinnatiOhioUSA Neurosurgery NYU Langone HealthNew YorkNew YorkUSA Neurosurgery University of AlbertaEdmontonAlbertaCanada Division of Radiation Oncology Department of OncologyUniversity of AlbertaEdmontonAlbertaCanada

Background Cerebral cavernous malformations(CCMs)frequently manifest with *** radiosurgery(SRS)has been employed for CCM not suitable for *** effect on reducing haemorrhage risk is still *** aim of this study was to expand on the safety and efficacy of SRS for haemorrhagic *** This retrospective multicentric study included CCM with at least one haemorrhage treated with single-session *** annual haemorrhagic rate(AHR)was calculated before and after *** event analysis and Cox regression were used to evaluate factors associated with *** radiation effects(ARes)and occurrence of new neurological deficits were *** The study included 381 patients (median age:37.5 years(Q1–Q3:25.8–51.9))with 414 *** AHR from diagnosis to SRS excluding the first haemorrhage was 11.08 per 100 CCM-years and was reduced to 2.7 per 100 CCM-years after *** recurrent event analysis,SRS,HR 0.27(95%CI 0.17 to 0.44),ped with a decreased risk of haemorrhage,and the presence of developmental venous anomaly(DVA)with an increased risk,HR 1.60(95%CI 1.07 to 2.40),p=*** cumulative risk of first haemorrhage after SRS was 9.4%(95%CI 6%to 12.6%)at 5 years and 15.6%(95%CI%9 to 21.8%)at 10 *** doses>13 Gy,HR 2.27(95%CI 1.20 to 4.32),p=0.012 and the presence of DVA,HR 2.08(95%CI 1.00 to 4.31),p=0.049 were factors associated with higher probability of post-SRS ***-SRS haemorrhage was symptomatic in 22 out of 381(5.8%)patients,presenting with transient(15/381)or permanent(7/381)neurological *** occurred in 11.1%(46/414)CCM and was responsible for transient neurological deficit in 3.9%(15/381)of the patients and permanent deficit in 1.1%(4/381)of the *** doses>13 Gy and CCM volume>0.7 cc were associated with increased risk of ARe.

关键词： doses haemorrhagic diagnosis

Crustacean parasites associated with hermit crabs from the western Mediterranean Sea,with first documentation of egg predation by the burrowing barnacle Trypetesa lampas(Cirripedia:Acrothoracica:Trypetesidae)

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Integrative Zoology 2011年第1期6卷 13-27页

作者： jason D.WILLIAMS Alejandra GALLARDO Angela e.MURPHY Department of Biology Hofstra UniversityHempsteadNYUSA

Parasitic isopods(family Bopyridae)and burrowing barnacles(family Trypetesidae)infesting hermit crabs were investigated from shallow subtidal collections made along the southeastern coast of Spain in 2009.A total of 713 specimens of Clibanarius erythropus(Latreille,1818)and 82 Calcinus tubularis(L.,1767)were *** shells and worm tubes inhabited by hermit crabs were collected by hand while snorkeling and were cracked to determine host species,size,sex and presence of *** species of bopyrid isopods were found on ***:the branchial parasite Bopyrissa fraiseii(Carayon,1943)and the abdominal parasite Parathelges cardonae Codreanu and Codreanu in Codreanu,*** all *** examined,Bopyrissa fraiseii was found on 0.6%of hermit crabs and *** was found on 0.3%.A redescription of *** is provided and the species is documented with light and scanning electron microscopy for the first *** Calcinus tubularis harbored parasitic isopods,but one specimen was parasitized by an unidentified rhizocephalan barnacle of the genus Septosaccus(1.2%).The burrowing barnacle Trypetesa lampas(Hancock,1849)was found associated with both hermit crab species and evidence of predation on host eggs by this barnacle is shown for the first *** lampas was found in 4.2%of the shells *** present study expands our knowledge of the parasite fauna of hermit crabs from the Mediterranean Sea and indicates that additional research is needed to determine the impact of trypetesid egg predators on hermit crab populations.

关键词： Bopyridae egg predator Isopoda parasitism Rhizocephala

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水杨酸类的临床药理学

动物医学进展 1982年第5期 53-54页

作者： Lloyd e.davis 王建元

水杨酸类已在医学上用了几个世纪。自1900年以来阿斯匹林已成为我们医疗设施的一个组成部分。水杨酸类在兽医上的许多应用可能是很优越的。在人上仔细设计的一些研究未能显示一些新的解热镇痛药比阿斯匹林有任何优越性。如果给有关动物... 详细信息

水杨酸类已在医学上用了几个世纪。自1900年以来阿斯匹林已成为我们医疗设施的一个组成部分。水杨酸类在兽医上的许多应用可能是很优越的。在人上仔细设计的一些研究未能显示一些新的解热镇痛药比阿斯匹林有任何优越性。如果给有关动物给予相应的剂量,很可能对病畜同样有效。

关键词：水杨酸钠兽医水杨酸类解热镇痛药阿斯匹林血浆浓度大剂量

Utility of positron emission tomography-computed tomography scan in detecting residual hepatocellular carcinoma post treatment:Series of case reports

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 358-364页

作者： jason T Cheng Nelly e Tan Michael L Volk Transplantation Institute Loma Linda University Medical CenterSan BernardinoCA 92408United States Department of Radiology Loma Linda University Medical CenterLoma LindaCA 92354United States

BACKGROUND Multi-phase computed tomography(CT)or magnetic resonance imaging(MRI)has been the standard of care for hepatocellular carcinoma(HCC)diagnosis for *** SUMMARY We report a case series of four patients in whom positron emission tomographycomputed tomography(PeT-CT)scan complemented the conventional CT/MRI scans in evaluating treatment *** these four cases the conventional multi-phase CT and MRI failed to identify residual HCC disease post-treatment,while PeT-CT complemented and aided in treatment response *** each case,the addition of PeT-CT identified and located residual HCC disease,allowed retreatment,and altered medical *** This case series suggests that PeT-CT should perhaps play a role in the HCC management algorithm,in addition to the conventional contrast-enhanced multiphase scans.

关键词： Hepatocellular carcinoma Positron emission tomography Contrast-enhanced multiphase scan Cirrhosis Residual cancer Treatment response evaluation Case series

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易拉罐美容记

小哥白尼（趣味科学） 2009年第8期 24-25页

作者： Jan McHarry e.davis P.Sanford

一.惊魂记：首先它和其他易拉罐兄弟们一起，被像压面包一样地压成一个个大大的金属面包!二.粉身记：金属面包被喂进切割机切成零零碎碎的小铁片。看着支离破碎的身躯，那个惨啊!据操作师说“这样是为了对每个铁片的每个部位都进行充分... 详细信息

一.惊魂记：首先它和其他易拉罐兄弟们一起，被像压面包一样地压成一个个大大的金属面包!二.粉身记：金属面包被喂进切割机切成零零碎碎的小铁片。看着支离破碎的身躯，那个惨啊!据操作师说“这样是为了对每个铁片的每个部位都进行充分挺作……”

关键词：易拉罐美容面包切割机金属铁片