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Metal and Composite Intermodal Containers in Comparative Cold Tests with Wood Chips

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Journal of Sustainable Bioenergy Systems 2015年第1期5卷 32-39页

作者： jarno fohr Kalle Karttunen Johanna Enstrom Tomas Johannesson Tapio Ranta Bioenergy Technology Lappeenranta University of TechnologyMikkeliFinland Department of Forest Sciences University of HelsinkiHelsinkiFinland Forest Energy Forestry Research Institute of SwedenUppsalaSweden

Intermodal containers have many advantages in the bulk supply chain, but idle times may cause freezing problems for containers in terminals and long-lasting deliveries, especially during the winter time in Nordic conditions. The aim of the cold tests was to study metal and composite containers’ ability to tolerate wood chips freezing into the inner surface of the container. Two of the containers were normal metal containers and one was a composite container. The loaded containers were put inside the laboratory hall, the temperature of which was -30°C, and kept there for variable times: less than 24 hours. The inner surface of one of metal containers was treated with a special coolant, EC1. After the test, the chips were unloaded, and the container walls were checked to determine whether there was any material left on them. The test results indicated the advantages of composite containers having a thermally insulated structure without freezing problems. At the same time, chips were freezing badly onto the floor of both metal containers. A frozen chip layer with a thickness of approximately 50 cm - 60 cm was stuck to the floors. As such, EC1 did not seem to prevent the freezing of the chips onto the inner surfaces. The results proved that intermodal logistics of truck and train transportation would be more suitable for composite containers than for metal containers in the winter time in Nordic conditions.

关键词： Metal Composite Container Cold Test Wood Chips

Hydrothermal Carbonization of Deciduous Biomass(Alnus incana)and Pelletization Prospects

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Journal of Sustainable Bioenergy Systems 2017年第3期7卷 138-148页

作者： Raghu Kc Indu Babu Sara Alatalo jarno fohr Tapio Ranta Ismo Tiihonen Laboratory of Bioenergy Lappeenranta University of TechnologyMikkeliFinland Laboratory of Green Chemistry LappeenrantaUniversity of TechnologyMikkeliFinland Riihikatu 3 11100RiihimakiFinland Tiihonen Ismo Olavi Saahkarintie 176 77700 Rautalampi Finland

Thermal treatment of biomass has been attracting attention for a decade or so, especially torrefaction. However, for the past few years, wet pyrolysis, also known as hydrothermal carbonization (HTC), has been getting some attention. Hydrothermal carbonization is a thermal treatment of biomass in the presence of water in a temperature range of 180°C - 260°C. This method of treating biomass has some benefits which others do not, such as it can handle extremely wet biomass. However, treating biomass may not be enough for practical use. It may need to be transported and stored. Thus, this study explored the idea of pelletizing the HTC biomass. The mechanical strength of the HTC pellets was found to be 93%, whereas, higher heating value (HHV) (dry basis) was found to be 4% higher than the corresponding white pellets. The initial results with some limited parameters indicated that it would be possible to pelletize without binder. However, extensive research on energy balance and economic assessment would be necessary to achieve economic feasibility.

关键词： Sustainable Bioenergy Hydrothermal Carbonization Hydrochar Pelletization

High-performance portable grating-based surface plasmon resonance sensor using a tunable laser at normal incidence

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Photonics Research 2024年第5期12卷 947-958页

作者： DUC LE ANNI RANTA-LASSILA TEEMU SIPOLA MIKKO KARPPINEN jarno PETAJA MINNA KEHUSMAA SANNA AIKIO TIAN-LONG GUO MATTHIEU ROUSSEY JUSSI HILTUNEN ALEXEY POPOV VTT Technical Research Centre of Finland 90570 OuluFinland Department of Physics and Mathematics University of Eastern FinlandFI-80101 JoensuuFinland

Surface plasmon resonance(SPR)sensors are among the most sensitive *** such devices,a grating is a compelling alternative to a prism for the excitation of a surface plasmon,especially in the development of sensors for point-of-care applications due to their compactness and ***,we demonstrate the use of a tunable laser in a grating-based SPR system for further miniaturization and *** tunable laser working at normal incidence replaces spectral and moving components,while also simplifying the optical *** incidence is conventionally avoided due to the complexity of the control of degenerated SPR *** investigate,both computationally and experimentally,the splitting of the SPR modes at small nonzero incidences,which is lacking in previously reported *** optimizing the grating configuration,we were able to diminish the SPR mode splitting phenomenon when the excitation was feasible with the normal incidence *** fabricated sensor showed a high sensitivity of 1101.6 nm/***,the figure of merit of the sensor,defined as the ratio between the sensitivity and bandwidth of the SPR dip,was *** experimental results were consistent with the simulation *** also demonstrate its capability for detecting low concentrations of glucose and creatinine with the limit of detection of 14.2 and 19.1 mmol/L,respectively.

关键词： tunable splitting excitation

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An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha Jeong jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos Santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

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Distributed power allocation over indoor multi-pico stations

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Journal of Beijing Institute of Technology 2015年第2期24卷 227-232页

作者：费泽松高强傅友 Tero Isotalo jarno Niemela School of Information and Electronics Beijing Institute of Technology Department of Communication Engineering Tampere University of Technology

A low-complexity distributed power allocation algorithm is proposed to reduce the interference and improve the transmitting rate of edge users. Different scenarios are considered and user experience of indoor communication is promoted. The simulation results prove the effectiveness of our algorithm. The proposed power control scheme ensures that more users can achieve their required rate and the fairness of different users is improved. Besides, more than 5096 energy can be saved without loss in outage ability, and energy efficiency is also promoted. In addition, the proposed algorithm can be extended to scenarios that the required rates of pico stations can be changed periodically.

关键词： distributed power allocation indoor communication multi-pico stations

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Optimal power allocation for homogeneous and heterogeneous CA-MIMO systems

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Science China(Information Sciences) 2013年第2期56卷 177-190页

作者： CUI QiMei KANG PeiChuan HUANG XueQing VALKAMA Mikko NIEMELA jarno Key Laboratory of Universal Wireless Communications Beijing University of Posts and Telecommunications Department of Communications Engineering Tampere University of Technology

Carrier aggregation (CA) technique has been adopted by 3GPP LTE-Advanced due to its ability of enhancing the spectrum efficiency and peak data rates through aggregating multiple component carriers (CCs). Two main factors make power control optimization very essential for CA-MIMO radio link: the different channel characteristics in multiple CCs, and multiple power constraint conditions (per-CC, per-antenna and pertransmitter power constraints) in the actual CA system deployment. This paper firstly derives the degenerate conditions of optimal power allocation for a single-transmitter CA-MIMO system. Stemming from the derived degenerate conditions, we propose a modified hybrid gradient optimal power allocation(MHGOPA) algorithm to maximize the system performance. Simulation results verify the validity of the proposed resource allocation approach by comparing with baseline average power allocation algorithm. Finally, we extend the MHGOPA algorithm into a heterogeneous CA network with multiple transmitters working simultaneously.

关键词： LTE-advanced carrier aggregation CA-MIMO heterogenous network modified hybrid gradient optimal power allocation

Structured PDMS Chambers for Enhanced Human Neuronal Cell Activity on MEA Platforms

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Journal of Bionic Engineering 2012年第1期9卷 1-10页

作者： Joose Kreutzer Laura Yla-Outinen Paula Karna Tiina Kaarela jarno Mikkonen Heli Skottman Susanna Narkilahti Pasi KaUio Department of Automation Science and Engineering Tampere University of Technology Korkeakoulunkatu 3 33720 Tampere Finland BioMediTech Biokatu 10 33520 Tampere Finland NeuroGroup Institute of Biomedical Technology University of Tampere Biokatu 12 33520 Tampere Finland The Science Center of Pirkanmaa Hospital District Biokatu 12 33521 Tampere Finland Department of Psychology University of Jyvdskyld Ylistonmgientie 33 40500 Jyvdskyla Finland

Structured poly（dimethylsiloxane）（PDMS） chambers were designed and fabricated to enhance the signaling of human Embryonic Stem Cell （hESC） - derived neuronal networks on Microelectrode Array （MEA） platforms. The structured PDMS chambers enable cell seeding on restricted areas and thus, reduce the amount of needed coating materials and cells. In addition, the neuronal cells formed spontaneously active networks faster in the structured PDMS chambers than that in control chambers. In the PDMS chambers, the neuronal networks were more active and able to develop their signaling into organized signal trains faster than control cultures. The PDMS chamber design enables much more repeatable analysis and rapid growth of functional neuronal network in vitro. Moreover, due to its easy and cheap fabrication process, new configurations can be easily fabricated based on investigator requirements.

关键词： cell culturing electrical activity human embryonic stem cells microelectrode array poly(dimethylsiloxane)

Oligonucleotide delivery by chitosan-functionalized porous silicon nanoparticles

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Nano Research 2015年第6期8卷 2033-2046页

作者： Morteza Hasanzadeh Kafshgari Bahman Delalat Wing Yin Tong Frances J. Harding Martti Kaasalainen jarno Salonen Nicolas H. Voelcker ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Mawson Institute University of South Australia GPO Box 247 Adelaide SA 500 1 Australia Department of Physics and Astronomy University of Turku FI-20014 Turku Finland

Porous silicon nanoparficles （pSiNPs） are a promising nanocarrier system for drug delivery owing to their biocompatibility, biodegradability, and non-inflammatory nature. Here, we investigate the fabrication and characterization of thermally hydrocarbonized pSiNPs （THCpSiNPs） and chitosan-coated THCpSiNPs for therapeutic oligonucleotide delivery. Chitosan coating after oligonucleotide loading significantly improves sustained oligonucleotide release and suppresses burst release effects. Moreover, cellular uptake, endocytosis, and cytotoxicity of oligonucleotide-loaded THCpSiNPs have been evaluated in vitro. Standard cell viability assays demonstrate that cells incubated with the NPs at a concentration of 0.1 mg/mL are 95% viable. In addition, chitosan coating significantly enhances the uptake of oligonucleotide-loaded THCpSiNPs across the cell membrane. Moreover, histopathological analysis of liver, kidney, spleen, and skin tissue collected from mice receiving NPs further demonstrates the biocompatible and non-inflammatory properties of the NPs as a gene delivery vehicle for intravenous and subcutaneous administration in vivo. Taken together, these results suggest that THCpSiNPs provide a versatile platform that could be used as efficient vehicles for the intracellular delivery of oligonucleotides for gene therapy.

关键词： nanoparticles porous silicon chitosan gene delivery

A prospective cancer chemo-immunotherapy approach mediated by synergistic CD326 targeted porous silicon nanovectors

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Nano Research 2015年第5期8卷 1505-1521页

作者： Mohammad-Ali Shahbazi Neha Shrestha Ermei Makila Francisca Araujo Alexandra Correia Tomas Ramos Bruno Sarmento jarno Salonen Jouni Hirvonen Helder A. Santos Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University ofHelsinki FI-00014 Helsinki Finland Laboratory of Industrial Physics Departmen t of Physics and Astronomy University of Turku FI-20014 Turku Finland INEB - Instituto de Engenharia Biomedica NewTherapies Group Universidade do Porto Rua do Campo Alegre 823 4150-180 Porto Portuga ICBAS - Instituto Ciencias Biomedicas Abel Salazar University of Porto Rua de Jorge Viterbo Ferreira 4050-313 Porto Portugal Faculty of Pharmacy University of Coimbra 3000-548 Coimbra Portugal IINFACTS - Instituto de Investigacao e Formacao Avancada em Ciencias e Tecnologias da Saude Instituto Superior de Ciencias da Saude-Norte Department of Pharmaceutical Sciences CESPU Rua Central de Gandra 4585-116 Gandra Portugal

Combination therapy via nanoparticulate systems has already been proposed as a synergistic approach for cancer treatment. Herein, undecylenic acid modified thermally hydrocarbonized porous silicon nanoparticles （UnTHCPSi NPs） loaded with sorafenib and surface-biofunctionalized with anti-CD326 antibody （Ab） were developed for cancer chemo-immunotherapy in MCF-7 and MDA-MB-231 breast cancer cells. The cytocompatibility study showed no significant toxicity for the bare and antibody-conjugated UnTHCPSi （Un-Ab） NPs at concentrations lower than 200 μg·mL^-1. Compared to the bare UnTHCPSi, Un-Ab NPs loaded with sorafenib reduced the premature drug release in plasma, increasing the probability of proper drug targeting. In addition, high cellular interaction and subsequent internalization of the Un-Ab NPs into the cells expressing CD326 antigen demonstrated the possibility of improving antigen-mediated endocytosis via CD326 targeting. While an in vitro antitumor study revealed a higher inhibitory effect of the sorafenib-loaded Un-Ab NPs compared to the drug-loaded UnTHCPSi NPs in the CD326 positive MCF-7 cells, there was no difference in the anti-proliferation impact of both the abovementioned NPs in the CD326 negative MDA-MB-231 cells, suggesting CD326 as an appropriate receptor for Ab-mediated drug delivery. It was also shown that the anti-CD326 Ab can act as an immunotherapeutic agent by inducing antibody dependent cellular cytotoxicity and enhancing the interaction of effector immune and cancer cells for subsequent phagocytosis and cytokine secretion. Hence, the developed nanovectors can be applied for simultaneous tumor-selective drug targeting and immunotherapy.

关键词： CD326 antibody porous silicon nanopartides chemo-immunotherapy breast cancer drug targeting