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Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study

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Journal of Pharmaceutical Analysis 2021年第4期11卷 444-457页

作者： Seung-Hyun Jeong ji-Hun jang Guk-Yeo Lee Seung-Jung Yang Hea-Young Cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea National Development Institute of Korean Medicine 288 Udeuraendeu-gilAnyang-myeonJangheung-gunJeollanam-do59338Republic of Korea Department of Oriental Rehabilitation Medicine Dongshin University Gwangju Korean Medicine Hospital141 Wolsan-roNam-guGwangju61619Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-do13488Republic of Korea

Gumiganghwal-tang is a traditional herbal medicine widely used for its anti-inflammatory,analgesic,and antipyretic ***,the safety and efficacy of its active ingredients based on an in vivo pharmacokinetic(PK)study have yet been *** have established a sensitive and accurate UPLC-ESI-MS/MS method and conducted a PK study on 14 constituents of Gumiganghwal-tang through human plasma *** conditions were optimized according to the physicochemical properties of the 14 compounds to facilitate efficient separation and eliminate overlap or interference between ***-C18 and Inertsil-C8 columns were used as UPLC stationary phases,and acetonitrile and aqueous formic acid were used as mobile *** the analytes were quantified with a triple quadrupole mass spectrometer using electrospray ionization in multiple reaction monitoring *** chromatograms of 14 bioactive compounds showed excellent elution and sensitivity,and each peak was selectively separated and quantified without interference with each other or *** established analytical method was based on international guidelines and was successfully used to perform PK studies of 14 herbal ingredients in humans after oral administration with Gumiganghwal-tang *** oral absorption of most active components of Gumiganghwal-tang was relatively rapid and remained considerably long in the body to be quantified in plasma up to 48 h after administration.

关键词： Gumiganghwal-tang Fourteen bioactive ingredients Simultaneous analysis UPLC-ESI-MS/MS Pharmacokinetics Clinical study

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Bilateral musculocutaneous neuropathy:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1237-1246页

作者： ji Won Jung Yu Chan Park Jae Young Lee Jae hyeon Park Seong Ho jang Department of Rehabilitation Medicine Hanyang University HospitalSeoul 04763South Korea Department of Rehabilitation Medicine Hanyang University Guri HospitalGuri 11923South Korea

BACKGROUND Isolated musculocutaneous nerve injury is a rare ***,we report the first case of bilateral musculocutaneous neuropathy after vigorous stretching of both upper extremities with normal results of sensory nerve action *** should be aware of this rare condition that can appear *** addition,the interpretation of the aberrant electrodiagnostic study results of this case was *** SUMMARY A 29-year-old male complaining of bilateral forearm tingling and upper extremity weakness visited the outpatient *** symptoms began 6 mo prior,and he visited another hospital before visiting our *** diagnosis was not made even after cervical spine magnetic resonance imaging,electrodiagnostic study,brain magnetic resonance imaging,and arteriography were *** patient performed unique exercises that stretched the pectoralis minor and coracobrachialis *** the follow-up electrodiagnostic study,abnormal spontaneous activities in the bilateral biceps and brachialis muscles were *** patient was diagnosed with bilateral musculocutaneous *** pulse therapy was administered for approximately 6 *** treatment,his muscle strength returned to the predisease *** Clinicians should be aware of this condition,have adequate understanding of anatomy,and advise to correct inappropriate exercises.

关键词： Musculocutaneous nerve Peripheral neuropathy Electrodiagnosis Exercise Diagnosis Case report

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Optimal Operation of Turbo Blowers Serially Connected Using Inlet Vanes

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Journal of Thermal Science 2011年第1期20卷 26-31页

作者： Choon-Man jang Plant Research Division Korea Institute of Construction Technology1190 IIsanseo-GuGoyang-Si411-712Korea

Optimal operation of the turbo blowers having an inlet vane has been studied to understand the blowers' operating *** analyze three-dimensional flow field in the turbo blowers serially connected,general analysis code,CFX,is introduced in the present *** turbulence model is employed to estimate the eddy *** the numerical analysis,it is found that the flow rates of the turbo blowers can be controlled at the vane angle between 90 (full open condition) degrees and 60 degrees effectively,because pressure loss rapidly increases below 60 degree of a vane *** also has almost the same values from 90 degrees to 60 degrees of a vane *** is noted that the distorted inlet velocity generated in the small vane angle makes performance deterioration of the turbo blowers due to the local leading edge separation and the following non-uniform blade loading.

关键词： Turbo Blower Inlet Vane Refuse Collection System Efficiency Numerical Simulation

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Fluorescent nanoswitch for monitoring specific pluripotency-related microRNAs of induced pluripotent stem cells： Development of polyethyleneimine- oligonucleotide hybridization probes

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Nano Research 2017年第8期10卷 2545-2559页

作者： Seungmin Han hye Young Son Byunghoon Kang Eunji jang jisun Ki Na Geum Lee Jongjin Park Moo-Kwang Shin Byeonggeol Mun Jeong-Ki Min Seungjoo Haam Department of Chemical and Biomolecular Engineering College of Engineering Yonsei University Seou1120-749 Republic of Korea Department of Radiology College of Medicine Yonsei University Seou1120-752 Republic of Korea Severance Biomedical Science Institute College of Medicine Yonsei University Seou1120-752 Republic of Korea Biotherapeutics Translational Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 Republic of Korea Department of Biomolecular Science University of Science & Technology Daejeon 34113 Republic of Korea

The isolation of high-grade （i.e. high-pluripotency） human induced pluripotent stem cells （hiPSCs） is a decisive factor for enhancing the purity of hiPSC populations or differentiation efficiency. A non-invasive imaging system that can monitor microRNA （miRNA） expression provides a useful tool to identify and analyze specific cell populations. However, previous studies on the monitoring/isolation of hiPSCs by miRNA expression have limited hiPSCs＇ differentiation system owing to long-term incubation with miRNA imaging probe-nanocarriers. Therefore, we focused on monitoring high-grade hiPSCs without influencing the pluripotency of hiPSCs. We reduced nanoparticle transfection time, because hiPSCs are prone to spontaneous differentiation under external factors during incubation. The fluorescent nanoswitch （＂ON＂ with target miRNA）, which can be applied for either imaging or sorting specific cells by fluorescence signals, contains an miRNA imaging probe （miP） and a PEI-PEG nanoparticle （miP-P）. Consequently, this nanoswitch can sense various endogenous target miRNAs within 30 min in vitro, and demonstrates strong potential for not only imaging but also sorting pluripotent hiPSCs without affecting pluripotency. Moreover, miP-P-treated hiPSCs differentiate well into endothelial cells, indicating that miP-P does not alter the pluripotency of hiPSCs. We envisage that this miRNA imaging system could be valuable for identifying and sorting high-grade hiPSCs for improved practical applications.

关键词： induced pluripotent stem cells (iPSCs) pluripotency microRNA (miRNA) fluorescence imaging nanoparticle

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Magnifying endoscopy for the diagnosis of specialized intestinal metaplasia in short-segment Barrett's esophagus

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World Journal of Gastroenterology 2013年第41期19卷 7089-7096页

作者： Nam Seok Ham Jae Young jang Sung Woo Ryu ji hye Kim Eui Ju Park Woong Cheul Lee Kwang Yeun Shim Soung Won Jeong Hyun Gun Kim Tae Hee Lee Sung Ran Jeon Jun Hyung Cho Joo Young Cho So Young jin ji Sung Lee Institution for Digestive Research Digestive Disease CenterDepartment of Internal MedicineSoonchunhyang University HospitalSeoul 140-743South Korea Department of Pathology Soonchunhyang University HospitalSeoul 140-743South Korea Biostatistical Consulting Unit Soonchunhyang University HospitalSeoul 140-743South Korea

AIM:To determine whether magnified observation of short-segment Barrett’s esophagus(BE)is useful for the detection of specialized intestinal metaplasia(SIM).METHODS:Thirty patients with suspected short-segment BE underwent magnifying endoscopy up to×*** magnified images were analyzed with respect to their pit-patterns,which were simultaneously classified into five epithelial types[Ⅰ(small round),Ⅱ(straight),Ⅲ(long oval),Ⅳ(tubular),Ⅴ(villous)]by Endo’s ***,a 0.5%solution of methylene blue(MB)was sprayed over columnar *** patterns of the magnified image and MB staining were *** were obtained from the regions previously observed by magnifying endoscopy and MB ***:Three of five patients with a typeⅤ(villous)epithelial pattern had SIM,whereas 21 patients with a non-typeⅤepithelial patterns did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of pit-patterns in detecting SIM were 100%,91.3%,92.3%,60%and100%,respectively(P=0.004).Three of the 12 patients with positive MB staining had SIM,whereas 14patients with negative MB staining did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of MB staining in detecting SIM were 100%,60.9%,65.4%,25%and100%,respectively(P=0.085).The specificity and accuracy of pit-pattern evaluation were significantly superior compared with MB staining for detecting SIM by comparison with the exact McNemar’s test(P=0.0391).CONCLUSION:The magnified observation of a shortsegment BE according to the mucosal pattern and its classification can be predictive of SIM.

关键词： Short-segment Barrett’s esophagus Magnifying endoscopy Methylene blue chromoendoscopy Specialized intestinal metaplasia Dysplasia Esophageal adenocarcinoma Diagnosis

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High Resolution Regional and Coastal Operational Storm Surges/Tide Forecasting System in Korea

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Journal of Environmental Science and Engineering(B) 2012年第3期1卷 324-335页

作者： Sung Hyup You Woo Jeong Lee ji hye Kwun jang-Won Seo and Sang Boom Ryoo Marine Meteorology Division Observation Infrastructure Bureau KMA Seoul 156720 Korea Global Environment System Research Laboratory National Institute of Meteorological Research KMA Seoul 156720 Korea

This study was performed to compare storm surges/tide simulated by the regional and coastal storm surges/tide forecast system （RTSM （regional tide/storm surges model）, CTSM （coastal tide/storm surges model）） using two different inputs from weather models （RDAPS （Regional Data Assimilation and Prediction System） and KWRF （Korea Weather and Research Forecasting）） during two typhoons that occurred between 2007 and 2008. Both the RDAPS and KWRF are the operational weather forecasting system in KMA （Korea Meteorological Administration）. The horizontal resolutions of RDAPS and KWRF are 30 and 10 km, respectively. The storm surges/tide was hind casted using sea wind and pressure fields of two Typhoons which was approaching Korean Peninsula. The CTSM using input from KWRF simulate very well the storm surges/tide pattern in the complex coastal areas. The result showed that the storm surges by the coastal storm surges/tide model with high resolution input was in well agreement with the observed sea level occurred by high tide and storm surges in the coastal areas.

关键词： Storm surges/tide RTSM CTSM RDAPS KWRF KMA.

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Safety assessment of condensed phosphate intake from fishery and processed marine food products in Korea with respect to gender,age,and region

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Food Quality and Safety 2021年第2期5卷 161-169页

作者： Hyung Soo Kim Dae Yong jang Ye ji Koo Eun Chul Pack Seung Ha Lee Dal Woong Choi Health Science Research Center Korea UniversitySeoulRepublic of Korea department of Public Health Sciences Graduate SchoolKorea UniversitySeoulRepublic of Korea School of Health and Environmental Sciences Korea UniversitySeoulRepublic of Korea and department of Health and Safety Convergence Science Graduate SchoolKorea UniversitySeoulRepublic of Korea.

Condensed phosphates are used as food additives,especially in marine products and meat,to improve food *** import and consumption of fishery and processed marine food products in Republic of Korea have reportedly increased by~5 per cent ***,processed marine food products are often intentionally adulterated with excessive amounts of condensed phosphates to increase their *** intake of condensed phosphates via consuming processed marine food products can lead to various adverse effects on human health due to anionic ***,we conducted a safety assessment of condensed phosphates in 14 types of fishery and processed marine food products in Korea for the first *** analysis of various factors including gender,age,and region was also performed,and the risk level of exposure for each group was *** assessments by age and gender indicated that infants were at the highest *** the regional safety assessment,Chungnam,the most inland region,showed the lowest *** both the general and the high-intake groups(95th percentile)in all classifications,the risk was lower(<20 per cent)than the international standard,and the phosphorus content of the 14 types of processed marine products in Korea was confirmed to be safe for human consumption.

关键词： Condensed phosphates safety assessment ion chromatography fishery and processed marine food products

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Optimization of rotor shape for constant torque improvement and radial magnetic force minimization

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Journal of Central South University 2012年第2期19卷 357-364页

作者： CHO Gyu-won WOO Seok-hyun ji Seung-hun PARK Kyoung-won jang Ki-bong KIM Gyu-tak School of Mechatronics Changwon National University

The design of notch and barrier was optimized in order to improve the characteristics of constant torque while minimizing the cogging torque that occurs as a result of teeth and slot structure. The barrier was installed in order to minimize the cogging torque and torque ripple by finite element method (FEM) with a reduced barrier width toward the center of magnetic pole. The position and width of notch, which can offset cogging torque, can be calculated with energy distribution of air-gap using Fourier series. The optimized model demonstrates a 60% decrease in the cogging torque, a 75.3% decrease in the torque ripple and a 3% increase in the operating torque when compared with the basic model.

关键词： permanent magnet synchronous motor barrier notch radial magnetic force cogging torque

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Iridium oxide fabrication and application: A review

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Journal of Energy Chemistry 2020年第7期29卷 152-172,I0005页

作者： Hansaem jang Jaeyoung Lee Electrochemical Reaction&Technology Laboratory(ERTL) School of Earth Sciences and Environmental EngineeringGwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Ertl Center for Electrochemistry and Catalysis GRIGISTGwangju 61005Republic of Korea

Despite the scarcity and cost of iridium oxide,it is still the material of choice in numerous fields of science and applications,including capacitors,electrochromism,sensors,and various oxidation electrocatalysis(e.g.,chlorine evolution reaction,detoxification,and oxygen evolution reaction).Such versatility is attributed to the distinct features of iridium oxides,such as their activity,biocompatibility,conductivity,and *** features and properties of iridium oxides are strongly dependent on the fabrication *** this review,methodologies relating to the synthesis and fabrication of solid-state iridium oxides have been thoroughly collected and *** and crystallization techniques for iridium oxides are also *** the end of the review,the effects of utilizing a certain fabrication method on the characteristics of the iridium oxide product are recapitulated,together with the recommended application of the product in various fields.

关键词： Iridium oxide Iridium dioxide Electrode Electrocatalyst Electrochromism pH sensor Oxygen evolution reaction

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Cavity-Suppressing Electrode Integrated with Multi-Quantum Well Emitter:A Universal Approach Toward High-Performance Blue TADF Top Emission OLED

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Nano-Micro Letters 2022年第4期14卷 75-89页

作者： Il Gyu jang Vignesh Murugadoss Tae Hoon Park Kyung Rock Son Ho jin Lee WanQi Ren Min ji Yu Tae Geun Kim School of Electrical Engineering Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841Republic of Korea

A novel device structure for thermally activated delayed fluorescence(TADF)top emission organic light-emitting diodes(TEOLEDs)that improves the viewing angle characteristics and reduces the efficiency roll-off is ***,we describe the design and fabrication of a cavity-suppressing electrode(CSE),Ag(12 nm)/WO_(3)(65 nm)/Ag(12 nm)that can be used as a transparent *** the TADF-TEOLED fabricated using the CSE exhibits higher external quantum efficiency(EQE)and improved angular dependency than the device fabricated using the microcavity-based Ag electrode,it suffers from low color purity and severe efficiency *** drawbacks can be reduced by using an optimized multi-quantum well emissive layer(MQW EML).The CSE-based TADF-TEOLED with an MQW EML fabricated herein exhibits a high EQE(18.05%),high color purity(full width at half maximum~59 nm),reduced efficiency roll-off(~46%at 1000 cd m^(−2)),and low angular *** improvements can be attributed to the synergistic effect of the CSE and MQW *** optimized transparent CSE improves charge injection and light outcoupling with low angular dependence,and the MQW EML effectively confines charges and excitons,thereby improving the color purity and EQE *** proposed approach facilitates the optimization of multiple output characteristics of TEOLEDs for future display applications.

关键词： Cavity suppression Multi-quantum well Viewing angle Efficiency roll-off Top emission OLED

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