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Applying heteroatom co-doped carbon nanotube for manifesting high performance in the electrochemical reduction of aqueous nitrogen oxide by gold nanoparticles

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Nano Research 2024年第3期17卷 1151-1164页

作者： jane Chung Haibo Yin Rong Wang Yunlong Wang Junyang Zhang Yue Peng Joung Woo Han Seongyun Ryu Junhua Li State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China EHS Research Center Samsung Electronics Co.Ltd.Gyeonggi-do 18448Republic of Korea

Electrochemical NO-to-NH_(3) under ambient conditions could be a viable alternative having advantages in terms of energy consumption and exhaust gas recycling of NO,replacing a traditional ammonia synthesis method of the Haber–Bosch *** synthesizing boron(B-)and nitrogen(N-)co-doped carbon nanotube(CNT)based gold(Au)catalysts,B-dopants elevate the conductivity of carbon nanotube by sp2 hybridization on graphene and implant B–N domains within the graphene layer,and result in facilitating the embedding amount of Au accompanied by high dispersibility with low particle *** density functional theory(DFT)calculations elucidate that the electron cloud transmitted from B-dopant to the active site of Au induces the Lewis acidic site,and the O-distal pathway occurs following a spontaneous *** of the electron-deficient B-doping area accompanied by N-defects and B–O edges retains the major valence state of Au as Au^(δ+),and suppresses hydrogen evolution reaction(HER)by repulsing the hindrance of H*.This record exhibits the highest faradaic efficiency(FE)of 94.7%,and NH_(3) yield rate of 1877.4μg·h^(-1)·mg_(cat)^(-1),which is the optimal yield over energy consumption in the field of the ambient reduction of aqueous NO.

关键词： boron heteroatom nitrogen defect gold nanoparticles valence states of gold electrochemical NO-to-NH3

Did pediatric drug development advance epilepsy treatment in young patients?It is time for new research goals

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World Journal of methodology 2024年第2期14卷 65-74页

作者： Earl B Ettienne Emilio Russo Pasquale Striano jane m Grant-Kels Klaus Rose College of Pharmacy Howard University College of PharmacyWashingtonDC 20059United States Department of Health Sciences School of MedicineRussoUniversity"Magna Graecia"of CatanzaroCatanzaro 88100Italy IRCCS Istituto Giannina Gaslini Genova 16148Italy Department of Dermatology University of Connecticut Health CenterFarmingtonCT 06032United States klausrose Consulting Pediatric Drug Development and moreMedical ScienceCH-4125 RiehenSwitzerland

modern drugs have changed epilepsy,which affects people of all ***,for young people with epilepsy,the framework of drug development has *** the wake of the thalidomide catastrophe,the misconception emerged that for peoplemedications(ASms),need separate proof of efficacy and safety,overall called"pediatric drug development".For ASms,this has changed to some *** now accept that ASms are effective inminors were another *** a result,some of the pediatric clinical epilepsy research over the past decades was *** more importantly,this has hampered research on meaningful research *** do not need to confirm that ASms work before as they do after the 18th ***,we need to learn how to prevent brain damage in young patients by preventing seizures and optimize ASms’*** we discuss how to proceed in this endeavor.

关键词： Epilepsy Pediatric drug development Therapeutic orphans Antiseizure medications Pediatric investigation plan Clinical pharmacology

Concurrence of high dust aerosol and stratosphere-intruded ozone pollution in super sandstorms

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Science Bulletin 2024年第16期69卷 2509-2513页

作者： Zhixiong Chen jane Liu Xiushu Qie Xugeng Cheng mengmiao Yang Lei Shu Jing m.Chen Key Laboratory for Humid Subtropical Eco-Geographical Processes of the ministry of Education School of Geographical SciencesFujian Normal UniversityFuzhou 350117China Key Laboratory of Atmospheric Environment and Extreme meteorology Chinese Academy of SciencesBeijing 100029China Department of Geography and Planning University of TorontoToronto M5S 3G3Canada Key Laboratory of middle Atmosphere and Global Environment Observation(LAGEO) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Science University of Chinese Academy of SciencesBeijing 100049China

The air quality in China has substantially improved in recent years,as indicated by the declining trends in SO_(2),NO_(2),Pm_(2.5)and Pm_(10)*** the reduced anthropogenic pollutant emissions;however,sustained increases in surface ozone(O_(3))that may impair the effectiveness of clean air actions have been ***,complex heavy pollution episodes can still occur,and some of these episodes are closely linked with *** example,two severe sandstorms occurred successively in the early spring of 2021 in North China,despite the sandstorm frequency in China having significantly decreased in recent years[1-3].

关键词： ozone sands aerosol

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Impower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 103-113页

作者： Yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang Amy Cai Lilian Bu jane Shi Jinjing Xia Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Respiration Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Department of Thoracic Oncology and Surgery the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Department of Pulmonary medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Department of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Product Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: Impower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab *** as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian ***: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT ***: median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82;95% CI, 0.66-1.03]. median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel ***: Impower210 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.

关键词： Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody

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肝细胞癌患者的症状和症状群及常用工具的整合性综述（英文）

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International Journal of Nursing Sciences 2024年第1期 66-75+159页

作者： Thitiporn Pathomjaruwat Yaowarat matchim jane m.Armer Research Unit in Palliative Care for Adults and Older Adults Faculty of Nursing Thammasat University mU Sinclair School of Nursing University of Missouri

目的综合现有知识,识别肝细胞癌(hepatocellular carcinoma, HCC)患者的症状和症状群,以及相关评估工具,以最大限度地改善症状管理。方法采用Whittemore和Knafl提出的整合性综述方法框架,在Pubmed、ScienceDirect、Scopus、CINAHL和Th... 详细信息

目的综合现有知识,识别肝细胞癌(hepatocellular carcinoma, HCC)患者的症状和症状群,以及相关评估工具,以最大限度地改善症状管理。方法采用Whittemore和Knafl提出的整合性综述方法框架,在Pubmed、ScienceDirect、Scopus、CINAHL和ThaiJO等数据库中对文献进行系统检索。检索文献发表时间限定为2005年—2022年,仅纳入经过同行评审及有英文摘要的文献。由2名研究员独立进行文献的筛选、提取和分析。结果共纳入14篇文献。分为3个主题:HCC患者的症状、症状评估和症状群。疲劳、乏力、胃痛或腹痛/腹胀、食欲不振、味觉改变、睡眠障碍、苦恼和悲伤是HCC患者最常见的症状。患者症状与肿瘤分期和治疗方法有关。常用的症状评估工具包括5种类型:HCC特异性症状评估、癌症一般症状评估、非症状构念测量、特定症状(如疲劳、睡眠障碍、焦虑和抑郁)测量及结合临床检查的症状评估等5种。HCC患者的症状群分为5类:疼痛相关症状、胃肠道症状、神经心理症状和感觉症状、肝功能异常相关症状及其他。结论该综述对HCC患者症状、症状评估和症状群相关知识进行了综合。尽管目前有多种评估工具,但没有一种能涵盖HCC患者的所有症状。建议今后的研究纳入更大的同质化的样本,以便更准确地评估测量工具的效能,避免在将症状分类为症状群时出现歧义,提高症状管理的有效性。

关键词：肝细胞癌肝癌综述症状评估症状群

Storylines of family medicine Ⅴ:ways of thinking—honing the therapeutic self

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Family medicine and Community Health 2024年第S3期12卷 43-51页

作者： William B Ventres Leslie A Stone Johanna F Shapiro Cynthia Haq Jéssica R B Leao Donald E Nease Jr Liz Grant Stewart W mercer John C m Gillies Pablo González Blasco maria Auxiliadora C De Benedetto Graziela moreto marcelo R Levites Jennifer E DeVoe William R Phillips jane m Uygur Thomas R Egnew Colette S Stanley Family and Preventive medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family medicine University of California Irvine School of MedicineIrvineCaliforniaUSA Faculty of medicine University of Sao PauloSao PauloBrazil Family medicine University of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK SOBRAmFA-medical Education and Humanism Sao PauloBrazil Family medicine Oregon Health&Science University School of MedicinePortlandOregonUSA Family medicine University of Washington School of MedicineSeattleWashingtonUSA General Practice Royal College of Surgeons in IrelandDublinIreland General Internal medicine Geriatrics&Palliative MedicineTulane University School of MedicineNew OrleansLouisianaUSA

Storylines of Family medicine is a 12-part series of thematically linked essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅴ:ways of thinking—honing the therapeutic self’,authors present the following sections:‘Reflective practice in action’,‘The doctor as drug—Balint groups’,‘Cultivating compassion’,‘Towards a humanistic approach to doctoring’,‘Intimacy in family medicine’,‘The many faces of suffering’,‘Transcending suffering’and‘The power of listening to stories.’may readers feel a deeper sense of their own therapeutic agency by reflecting on these essays.

关键词： illustration dimensions suffering

Satisfaction with patient-doctor relationships in inflammatory bowel diseases:Examining patient-initiated change of specialist

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World Journal of Gastroenterology 2012年第18期18卷 2212-2218页

作者： Daniel R van Langenberg jane m Andrews Department of Gastroenterology and Hepatology Royal Adelaide HospitalSchool of MedicineUniversity of AdelaideSouth Australia 5000Australia Department of Gastroenterology and Hepatology Eastern Health Clinical SchoolMonash UniversityVictoria 3128Australia

AIm:To assess the reasons for,and factors associated with,patient-initiated changes in treating specialist in inflammatory bowel diseases(IBD).mETHODS:Prospectively identified IBD patients(n = 256) with ≥ 1 encounter at a metropolitan hospital were surveyed,including whether they had changed treating specialist and *** reasons included loss of confidence,disagreement,and/or personality clash with the ***:Of 162 respondents,70(43%) had ever changed specialists;30/70(43%) for negative reasons,52/70(74%) in the preceding *** with negative reasons for changing(n = 30) were younger(median,35.2 years vs 45.3 years),had higher IBD knowledge(median,5.0 years vs 4.0 years),yet had lower medication adherence and satisfaction scores(median,19.0 years vs 22.0 years,14.0 years vs 16.0 years respectively,mann-Whitney tests,all P mpared to all other responders(n = 132).Patients with a recent change(for any reason) were more likely to have Crohn's disease,currently active disease,previous bowel resection and recent hospitalization [OR 2.6,95% CI(1.3-5.4),2.2(1.0-4.7),5.56(1.92-16.67),2.0(1.3-3.0),eachP mporaneous disease-related factors(recent relapse) which,where modifiable,may enhance patient-doctor relationships and therefore quality of care.

关键词： Inflammatory bowel disease Patient-doctor relationship Quality of care Disease outcomes Quality of life

Defining Soil and Water Assessment Tool(SWAT)hydrologic responseunits(HRUs)by field boundaries

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International Journal of Agricultural and Biological Engineering 2015年第3期8卷 69-80页

作者： margaret m.Kalcic Indrajeet Chaubey jane Frankenberger Graham Sustainability Institute University of MichiganAnn ArborMI 48104USA Department of Earth Atmosphericand Planetary SciencesPurdue UniversityWest LafayetteIN 47907USA Department of Agricultural and Biological Engineeri ng Purdue UniversityWest LafayetteIN 47907USA

The Soil and Water Assessment Tool(SWAT)is widely used to relate farm management practices to their impacts on surface waters at the watershed scale,yet its smallest spatial unit is not generally defined by physically meaningful *** hydrologic response unit(HRU)is the smallest spatial unit of the model,and the standard HRU definition approach lumps all similar land uses,soils,and slopes within a subbasin based upon user-defined *** standard method provides an efficient way to discretize large watersheds where simulation at the field scale may not be computationally *** relatively smaller watersheds,however,defining HRUs to specific spatial locations bounded by property lines or field borders would often be advantageous,yet this is not currently possible within the ArcSWAT *** this study,a simple approach is demonstrated that defines HRUs by field boundaries through addition of uniquely named soils to the SWAT user soil database and creation of a field boundary layer with majority land use and soil *** of nitrogen,phosphorus,and sediment losses were compared in a case study watershed where SWAT was set up using both the standard HRU definition and field boundary ***-scale results were reasonable and similar for both methods,but aggregating fields by majority soil type masked extremely high soil erosion predicted for a few *** from field-based HRU delineation may be quite different from the standard approach due to choosing a majority soil type in each farm *** approach is flexible such that any land use and soil data prepared for SWAT can be used and any shapefile boundary can divide HRUs.

关键词： watershed modeling Soil and Water Assessment Tool(SWAT) hydrologic response units field boundaries common land units landuse management

Sedimentary diatom and pigment-inferred recent anthropogenic accelerated eutrophication of a mediterranean lake(Lake Dojran,Republic of North macedonia/Greece)

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Journal of Oceanology and Limnology 2020年第6期38卷 1787-1798页

作者： ZHANG Xiaosen XU Xinyu jane mREED Institute of Loess Plateau Shanxi UniversityTaiyuan 030006China Department of Geography Geology and EnvironmentUniversity of HullHull HU67RXUK

Lake eutrophication is recognised as a serious global challenge,and many regional legislative programmes are being made to attempt to relieve nutrient pollution and restore deteriorated lake ecological ***,it is of primary importance to understand the degradation processes and reference *** palaeolimnological approach allows us to use ecological evidences preserved in lake sediments to track the changes of lake trophic status under human ***,a proxy for ecological and limnological change,and pigments,a proxy for algal production and composition,were analysed on a short sediment sequence from Lake Dojran(Republic of North macedonia and Greece),and their preservation qualities were evaluated before environmental *** diatom preservation is inferred mainly from the consistent co-occurrence of robust,highly-silicified taxa and small taxa throughout the *** evaluation of the comparison between wet sediment samples in dark and cold storage and their corresponding dry sediment samples lyophilized immediately after the recovery reveals that sediment restoration conditions are critical for the accuracy of *** show that the increased chlorophyll and xanthophyll pigment concentrations,particularly the siliceous-algae pigment fucoxanthin and diatoxanthin,together with the distinct increase in diatom concentration,indicate accelerated lake eutrophication and a major ecological shift linked to intensified water abstraction practice and agricultural expansion in the late 18th to early 19th *** of diatom assemblage composition is muted probably by the dominance of widely-tolerant small fragilaroid species in diatom composition and the better competitive ability of cyanobacteria and chlorophytes than diatoms for low light under eutrophic and turbid *** study improves our understanding of recent human-induced environmental change and current ecological restoration target in this lake.

关键词： diatom,pigment Lake Dojran mediterranean lake eutrophication palaeolimnology

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