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Crohn’s disease-Defect in innate defence

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World Journal of Gastroenterology 2008年第36期14卷 5499-5503页

作者： Michael Gersemann jan wehkamp Klaus Fellermann Eduard Friedrich Stange Robert Bosch Hospital and Dr. Margarete Fischer Bosch Institute of Clinical Pharmacology and University of Tübingen Stuttgart Germany

Crohn’s disease may prinicipally involve the whole gastrointestinal tract. Most commonly, the inflammation occurs in the small intestine and/or in the colon with stable disease location over the years. The pathogenesis of both disease phenotypes is complex, the likely primary defect lies in the innate rather than adaptive immunity, particularly in the chemical antimicrobial barrier of the mucosa. Crohn’s ileitis is associated with a reduced expression of the Wnt signalling pathway transcription factor T-cell factor 4 (TCF4), which is regulating Paneth cell differentiation. As a result, the alpha-defensins and principal Paneth cell products HD5 and HD6 are deficiently expressed in ileal disease, independent of current inflammation. In contrast, Crohn’s colitis is typically associated with an impaired induction of the beta-defensins HBD2 and HBD3 caused by fewer gene copy numbers in the gene locus of the beta-defensins on chromosome 8. This ileal and colonic defect in innate defence mediated by a deficiency of the protective alpha- and beta- defensins may enable the luminal microbes to invade the mucosa and trigger the inflammation. A better understanding of the exact molecular mechanisms behind ileal and colonic Crohn’s disease may give rise to new therapeutic strategies based on a stimulation of the protective innate immune system.

关键词： Crohn's disease Intestinal stem cell Differentiation Defensins Transcription factor T-cell factor 4

Intestinal barrier in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第5期20卷 1165-1179页

作者： Lena Antoni Sabine Nuding jan wehkamp Eduard F Stange Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart University of Tübingen Eduard F Stange Department of Internal Medicine I Robert-Bosch-Hospital

A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms. In this review, we provide an overview about the major components of this protective system as for example an intact epithelium, the synthesis of various antimicrobial peptides (AMPs) and the formation of the mucus layer. We highlight the crucial importance of their correct functioning for the maintenance of a proper intestinal function and the prevention of dysbiosis and disease. Barrier disturbances including a defective production of AMPs, alterations in thickness or composition of the intestinal mucus layer, alterations of pattern-recognition receptors, defects in the process of autophagy as well as unresolved endoplasmic reticulum stress result in an inadequate host protection and are thought to play a crucial role in the pathogenesis of the inflammatory bowel diseases Crohn’s disease and ulcerative colitis.

关键词： Intestinal barrier, Antimicrobial peptide, Mucus layer, Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Goblet cell, Paneth cell

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

The role of zonal flows in reactive fluid closures

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Plasma Science and Technology 2018年第7期20卷 41-49页

作者： jan weiland Chalmers University of Technology and EURATOM-VR Association SE-41296 GothenburgSweden

We will give an overview of results obtained by our reactive fluid model. It is characterised as a fluid model where all moments with sources in the experiment are kept. Furthermore, full account is taken for the highest moments appearing in unexpanded denominators also including full toroidicity. It has been demonstrated that the strength of zonal flows is dramatically larger in reactive fluid closures than in those which involve dissipation. This gives a direct connection between the fluid closure and the level of excitation of turbulence. This is because zonal flows are needed to absorb the inverse cascade in quasi 2D turbulence. This also explains the similarity in structure of the transport coefficients in our model with a reactive closure in the energy equation and models which have a reactive closure because of zero ion temperature such as the Hasegawa-Wakatani model. Our exact reactive closure unifies several well-known features of tokamak experiments such as the L-H transition, internal transport barriers and the nonlinear Dimits upshift of the critical gradient for onset of transport. It also gives transport of the same level as that in nonlinear gyrokinetic codes. Since these include the kinetic resonance this confirms the validity of the thermodynamic properties of our model. Furthermore, we can show that while a strongly nonlinear model is needed in kinetic theory a quasilinear model is sufficient in the fluid description. Thus our quasilinear fluid model will be adequate for treating all relevant problems in bulk transport. This is finally confirmed by the reproduction by the model of the experimental power scaling of the confinement time Te ~ P-2/3. This confirms the validity of our reactive fluid model. This also gives credibility to our ITER simulations including the H-mode barrier. A new result is here, that alpha heating strongly reduces the slope of the H-mode barrier. This should significantly reduce the effects of ELM＇s.

关键词： turbulent transport improved mixing length estimates zonal flows toroidicity

Comparative study of electrostatic sensors with circular and probe electrodes for velocity measurement of pulverised coal

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仪器仪表学报 2007年第11期28卷 1921-1926页

作者： Krabicka jan Department of Electronics University of Kent

This paper presents recent progress on the velocity measurement of pulverised coal in pneumatic pipelines using electrostatic sensors in combination with correlation signal processing techniques.A comparative study of electrostatic sensors with circular and probe electrodes was conducted on a 94 mm bore horizontal pipeline in a 4 MW *** advantages and limitations of both sensors are *** results demonstrate that both sensors are capable of providing pulverised coal velocity measurement with excellent repeatability and dynamic response.

关键词：电话无线电电子仪器技术性能

Grain Size Distribution of Soils within the Cordillera Blanca, Peru: An Indicator of Basic Mechanical Properties for Slope Stability Evaluation

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Journal of Mountain Science 2014年第3期11卷 563-577页

作者： jan NOVOTNY jan KLIME ARCADIS CZ a.s. Institute of Hydrogeology Engineering Geology and Applied Geophysics Charles University in Prague Albertov Department of Engineering Geology Institute of Rock Structure and Mechanics Academy of Sciences of the Czech Republic v.v.i

This paper presents results of a study on the mechanical properties of sandy and gravely soils within the Cordillera Blanca, Peru. The soils were divided into groups according to their origin(glacial, fluvial, or debris flow). The grain size distribution of forty three soil samples was used to classify the soils according to the scheme of the Unified Soil Classification System(USCS). These distributions have then been used to estimate shear strength and hydraulic properties of the soils. There are clear differences between the soils which reflect their divergent origins. The glacial soils normally fit within one of two distinctive groups according to the proportion of fines(Group A, 7%-21.5%; Group B, 21%-65%). The estimation of shear strength at constant volume friction angle and peak shear strength of the glacial sediments with low content of fines was made using published data relating to the measured shear strength characteristics of soils with similar origins and grain size distributions. The estimated values were supported by measurements of the angle of repose taken from fourteen samples from two moraines and by shear tests on samples from one locality. The results of the grain size distribution werealso used to estimate the average hydraulic conductivity using the empirical Hazen formula which results were verified by field infiltration tests at two localities.

关键词： Moraines Grain size distribution Shearstrength Hydraulic conductivity Cordillera Blanca Peru

A new GIS-compatible methodology for visibility analysis in digital surface models of earth sites

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Geoscience Frontiers 2021年第4期12卷 21-33页

作者： Katerina Ruzickova jan Ruzicka jan Bitta VSB–Technical University of Ostrava Czech Republic

As a GIS tool,visibility analysis is used in many areas to evaluate both visible and non-visible *** analysis builds on a digital surface model describing the terrain morphology,including the position and shapes of all objects that can sometimes act as visibility ***,some barriers,for example vegetation,may be permeable to a certain *** extensive research and use of visibility analysis in different areas,standard GIS tools do not take permeability into *** article presents a new method to calculate visibility through partly permeable *** method is based on a quasi-Monte Carlo simulation with 100 iterations of visibility *** iteration result represents 1%of vegetation permeability,which can thus range from 1%to 100%visibility behind vegetation *** main advantage of the method is greater accuracy of visibility results and easy implementation on any GIS *** incorporation of the proposed method in GIS software would facilitate work in many fields,such as architecture,archaeology,radio communication,and the military.

关键词： Digital surface model Visibility analysis Topographic data processing Obstacle object Permeability

The effect of Tyrophagus putrescentiae on Fusarium poae transmission and fungal community in stored barley in a laboratory experiment

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Insect Science 2014年第1期21卷 65-73页

作者： jan Hubert Marta Nesvorna jan Kopecky Crop Research Institute Praha 6 Czech Repubfic

The effect of Tyrophagus putrescentiae on Fusarium poae transmission and fungal community composition was studied in nonsterile barley grain. The experiments included following treatments： control barley without mites; barley containing l0 or 50 mites without preincubation on E poae （Tpl0 and TpS0）; barley containing 10 or 50 mites after preincubation on E poae （FTp 10 and FTp50）. The number of mites, suc cessful transfer of E poae, and changes in the fungal communities were examined after 21 d of experiment. Increase of deoxynivalenol （DON） content in the barley was chosen as a criterion of successful Epoae transfer. The preincubation of T. putrescentiae on Epoae increased DON level approximately to 800 and 300μg/kg of grain for FTpl0 and FTpS0, respectively. T. putrescentiae population growth in FTpl0 was lower than in Tpl0, while no difference was found between FTp50 and Tp50. Fungal communities were compared by amplification, cloning and sequencing of ITS fragments, and operational taxonomic units （OTU） analysis. The OTU analysis did not support the transfer ofF. poae via mites. From the analyzed clones, only 13 cloned sequences clustered with E poae in an OTU defined at distance level 0.07. The related clones originated from FTpl0, Tpl 0, Tp50 and control treatments, but not from FTp50. However, the presence of E poae in FTp50 was confirmed by PCR amplification with specific primers. The observation may be explained by different effect of mite population density, that is, in the high density, （FTp50 treatment） the fungus was overgrazed, while the lower population density （FTp 10） supported E poae transfer.

关键词： barley deoxinivalenol (DON) Fusariumpoae mites mycotoxin storage

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Hepatorenal syndrome

World Journal of Gastroenterology 2012年第36期18卷 4978-4984页

作者： jan Lata Department of Internal Medicine University Hospital and Faculty of MedicineOstrava University70103 OstravaCzech Republic

Hepatorenal syndrome(HRS) is defined as a functional renal failure in patients with liver disease with portal hypertension and it constitutes the climax of systemic circulatory changes associated with portal *** term refers to a precisely specified syndrome featuring in particular morphologically intact kidneys,where regulatory mechanisms have minimised glomerular filtration and maximised tubular resorption and urine concentration,which ultimately results in *** syndrome occurs almost exclusively in patients with *** 1 HRS develops as a consequence of a severe reduction of effective circulating volume due to both an extreme splanchnic arterial vasodilatation and a reduction of cardiac *** 2 HRS is characterised by a stable or slowly progressive renal failure so that its main clinical consequence is not acute renal failure,but refractory ascites,and its impact on prognosis is less *** transplantation is the most appropriate therapeutic method,nevertheless,only a few patients can receive *** most suitable "bridge treatments" or treatment for patients ineligible for a liver transplant include terlipressin plus *** is at an initial dose of 0.5-1 mg every 4 h by intravenous bolus to 3 mg every 4 h in cases when there is no *** function recovery can be achieved in less than 50% of patients and a considerable decrease in renal function may reoccur even in patients who have been responding to therapy over the short *** intrahepatic portosystemic shunt plays only a marginal role in the treatment of HRS.

关键词： Liver cirrhosis Hepatorenal syndrome As-cites Vasoconstrictors Terlipressin