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T-regulatory lymphocytes in peripheral blood of gastric and colorectal cancer patients

World Journal of Gastroenterology 2011年第3期17卷 343-348页

作者： Antoni M Szczepanik Maciej Siedlar Marek Sierzega Dominika Goroszeniuk Karolina Bukowska-Strakova Antoni Czupryna jan kulig 1st Department of General and Gastrointestinal Surgery Jagiellonian University Medical College Department of Clinical Immunology Polish-American Institute of Pediatrics Jagiellonian University Medical College SHO Orthopaedics Derriford HospitalPlymouth NHS Trust erriford Road

AIM: To assess the absolute number of T-regulatory cells (Tregs; CD4+CD25+Foxp3+) in the peripheral blood of gastric and colorectal cancer patients. METHODS: We enrolled 70 cancer patients (33 gastric cancer, 37 colorectal cancer) and 17 healthy volunteers. The CD3+CD4+ lymphocytes and CD4+CD25+Foxp3+ Tregs in the peripheral blood were analyzed with flow cytometry. The absolute numbers of Tregs were calculated based on the CD4+CD25+Foxp3+ cells percent-age of CD3+CD4+ cells and the absolute numbers of CD3+CD4+ cells per microliter. RESULTS: The mean number of CD4+CD25+Foxp3+ cells per microliter in colorectal cancer patients was 15.7 (SD: 21.8), for gastric cancer patients 12.2 (SD: 14.3), and for controls 17.5 (SD: 11.4). The absolute number of Tregs was significantly lower in gastric cancer patients than in controls (P = 0.026). There was no statistically significant difference for gastric vs colorectal cancer or colorectal cancer vs controls. The absolute number of Tregs was also significantly depressed in N+ vs Ncancer patients [22.0 (27.7) vs 10.1 (9.0), P = 0.013], and in the subgroup of gastric cancer patients [30.3 (27.6) vs 9.6 (8.0), P = 0.003]. No statistical difference was observed in the proportion of Tregs in the CD4+ population between the groups. CONCLUSION: The absolute number of Tregs in peripheral blood of gastric cancer but not colorectal cancer patients was significantly decreased in comparison with that in healthy controls.

关键词： CD4+CD25+Foxp3+ cells T regulatory cells Peripheral blood Gastric cancer Colorectal cancer

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Liver transplantation and liver resection as alternative treatments for primary hepatobiliary and secondary liver tumors: Competitors or allies?

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 111-116页

作者： jan Lerut Institute for Experimental and Clinical Research(IREC) Universitécatholique Louvain(UCL)Avenue Hippocrate 561200 Woluwe Saint PierreBrusselsBelgium

Although Starzl designed in the 1960’s liver transplantation(LT)to treat unresectable primary and also secondary liver tumors,transplantation still occupies a(too)small place in the respective therapeutic algorithms[1].Due to the lack of(any)selection criteria,the concept of transplantation became rapidly challenged because of the prohibitively high incidence of tumor recurrence[1–3].

关键词： liver tumors Liver

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Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation

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World Journal of Gastroenterology 2013年第27期19卷 4363-4373页

作者： Piotr M Wierzbicki Krystian Adrych Dorota Kartanowicz Marcin Stanislawowski Anna Kowalczyk janusz Godlewski Iwona Skwierz-Bogdanska Krzysztof Celinski Tomasz Gach jan kulig Bartlomiej Korybalski Zbigniew Kmiec Department of Histology Faculty of MedicineMedical University of Gdansk Department of Hepatology and Gastroenterology Faculty of MedicineMedical University of Gdansk Department of Human Histology and Embryology Faculty of Medical SciencesUniversity of Varmia and Masuria Department of General Surgery Hospital Ministry Internal Affairs Department of Gastroenterology Medical University of Lublin 1st Department of General Surgery Jagiellonian University Endoscopy Unit St. Adalbert Hospital

AIM:To investigate large tumor suppressor 1 (LATS1 ) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC).METHODS:RNA was isolated from tumor tissue of 142 CRC patients and 40 colon mucosal biopsies of healthy controls. After reverse transcription, quantitative polymerase chain reaction (PCR) was performed, and LATS1 expression was normalized to expression of the ACTB and RPL32 housekeeping genes. To analyze hypermethylation, genomic DNA was isolated from 44 tumor CRC biopsies, and methylation-specific PCR was performed. Microsatellite instability (MSI) status was checked with PCR using BAT26, BAT25, and BAT40 markers in the genomic DNA of 84 CRC patients, followed by denaturing gel electrophoresis. RESULTS:Decreased LATS1 expression was found in 127/142 (89.4%) CRC cases with the average ratio of the LATS1 level 10.33 ± 32.64 in CRC patients vs 32.85 ± 33.56 in healthy controls. The lowest expression was found in Dukes' B stage tumors and G1 (welldifferentiated) cells. Hypermethylation of the LATS1 promoter was present in 25/44 (57%) CRC cases analyzed. LATS1 promoter hypermethylation was strongly associated with decreased gene expression; methylated cases showed 162× lower expression of LATS1 than unmethylated cases. Although high-grade MSI (mutation in all three markers) was found in 14/84 (17%) cases and low-grade MSI (mutation in 1-2 markers) was found in 30/84 (36%) cases, we found no association with LATS1 expression. CONCLUSION:Decreased expression of LATS1 in CRC was associated with promoter hypermethylation, but not MSI status. Such reduced expression may promote progression of CRC.

关键词： Large tumor suppressor 1 Colorectal cancer Quantitative polymerase chain reaction Reduced expression Promoter hypermethylation Microsatellite instability Salvador-Warts-Hippo pathway

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Potential of molecular chaperones for treating Alzheimer’s disease

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Neural Regeneration Research 2024年第11期19卷 2343-2344页

作者： Gefei Chen jan Johansson Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Department of Cell and Molecular Biology Uppsala UniversityUppsalaSweden

Alzheimer’s disease(AD)is the most prevalent form of dementia,i.e.,progressive memory loss and profound cognitive dysfunction,resulting in a considerable societal *** the neuropathological level,the brains of AD patients exhibit amyloid-β(Aβ)plaques,neurofibrillary tangles,and neuroinflammation(Sala Frigerio and De Strooper,2016).

关键词： Alzheimer inflammation Aβ

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A fiducial approach to the nonparametric deconvolution problem:The discrete case

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Science China Mathematics 2024年第11期67卷 2653-2670页

作者： Yifan Cui jan Hannig Center for Data Science Zhejiang University Department of Statistics and Operations Research University of North Carolina at Chapel Hill

Fiducial inference is applied to nonparametric g-modeling in the discrete *** propose a computationally efficient algorithm to sample from the fiducial distribution and use the generated samples to construct point estimates and confidence *** study the theoretical properties of the fiducial distribution and perform extensive simulations in various *** proposed approach gives rise to good statistical performance in terms of the mean squared error of point estimators and coverage of confidence ***,we apply the proposed fiducial method to estimate the probability of each satellite site being malignant using gastric adenocarcinoma data with 844 patients.

关键词： confidence intervals empirical Bayes fiducial inference nonparametric deconvolution

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Solid Bi_(2)O_(3)-derived nanostructured metallic bismuth with high formate selectivity for the electrocatalytic reduction of CO_(2)

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 803-811页

作者： Xiaoyan Wang Safeer jan Zhiyong Wang Xianbo Jin College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power SourcesWuhan UniversityWuhan 430072China Engineering Research Center of Organosilicon Compounds&Materials Ministry of EducationWuhan 430072China

CO_(2) electrochemical reduction(CO_(2)ER)is an important research area for carbon ***,available catalysts for CO_(2) reduction are still characterized by limited stability and ***,metallic bismuth(Bi)has emerged as a promising catalyst for CO_(2) ***,we report the solid cathode electroreduction of commercial micronized Bi2O3as a straightforward approach for the preparation of nanostructured ***-1.1 V versus reversible hydrogen electrode in a KHCO3aqueous electrolyte,the resulting nanostructure Bi delivers a formate current density of~40 mA·cm^(-2) with a current efficiency of~86%,and the formate selectivity reaches97.6% at-0.78 *** nanosized Bi2O3as the precursor can further reduce the primary particle sizes of the resulting Bi,leading to a significantly increased formate selectivity at relatively low *** high catalytic activity of nanostructured Bi is attributable to the ultrafine and interconnected Bi nanoparticles in the nanoporous structure,which exposes abundant active sites for CO_(2) electrocatalytic reduction.

关键词： bismuth carbon dioxide electrocatalysis formate solid electroreduction

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Effects of acid deposition control in China:a review based on responses of subtropical forests

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 115-126页

作者： Danni Xie Xiaodong Ge Lei Duan jan Mulder School of Land Engineering Chang’an UniversityXi’an 710064China State Key Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing 100084China Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesBox 5003NO-1432ÅsNorway

For many decades,acid deposition used to pose a significant regional air pollution challenge in *** substantial emission control of anthropogenically derived sulfur and nitrogen containing gasses,both sulfur and nitrogen deposition,as well as the acid rain-affected area,have significantly decreased compared to their peak ***,particularly in the humid subtropics,are sensitive to acid deposition,as evidenced by soil acidification,sulfate and nitrate leaching in stream water,and elevated soil nitrous oxide *** in the total deposition of sulfur and nitrogen,caused a significant decline in sulfate and nitrate leaching from subtropical forest and subsequently in sulfate and nitrate concentrations in stream water,although there was about a 5-year *** delay may be attributed to the desorption of accumulated sulfate and continued elevated mineralization of accumulated nitrogen *** of nitrous oxide,a potent greenhouse gas,also declined in nitrogen-saturated subtropical forest soils,as soil water nitrate concentration ***,subtropical forests in China suffering from elevated acid deposition have begun to ***,the current levels of sulfur and nitrogen deposition continue to exceed the critical loads,i.e.,the assigned threshold levels in accordance with emission control policies,in more than 10%of the country’s land area,respectively,indicating remaining risks of acidification and ***,further emission reductions are urgently needed,also because they will help achieving goals related to air quality and nitrous oxide emissions.

关键词： Acidification Critical load Nitrous oxide Surface water chemistry Recovery

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Weak influence of natural vegetation in urban green spaces compared to agricultural ecosystems on House Martin populations:Insights from nationwide citizen science data in the Czech Republic

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Avian Research 2024年第2期15卷 139-146页

作者： Denisa Dvorakova jan Sipos Josef Suchomel Department of Zoology FisheriesHydrobiology and ApicultureMendel University in BrnoZemedelska 161300BrnoCzech Republic

The House Martin(Delichon urbicum)is a common farmland bird species in the European landscape,yet its population numbers are currently in ***,it is not yet sufficiently explained why this long-term decline *** fill this gap in our knowledge,we investigated how land cover composition affects the abundance of House Martins on the landscape scale by using nationwide citizen science *** a generalised linear mixed-effect model(GLMM),we evaluated 12,094 records from the Czech Republic spanning *** analysis underscores the significance of land cover type in shaping House Martin *** specifically,our results indicate that within agricultural land covers“naturally managed arable lands”exhibited significant positive effect,while forests,orchards,and vineyards were deemed less favourable for House Martin *** urban land covers,we found a clear distinction in the impact on House Martin populations,with a positive effect observed in urban infrastructure,development areas,and post-industrial sites(i.e.,UrbanAreas),while an indifferent impact was noted within urban green spaces and landscaped areas(i.e.,GreenUrban).Notably,our findings suggest that the simple spatial,age,and species structure typical of forests in Europe,and similarly,the uniform structure of parks and gardens,may be responsible for the decline in the abundance of the House *** advocate for the preservation or enhancement of urban greenery,expansion of natural vegetation in rural areas and adoption of ecological management practices in orchards and vineyards to mitigate further declines in House Martin populations.

关键词： Citizen science Habitat preferences House Martin Species distribution Urban and suburban landscape

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Cut stumps vs broken stumps:Does it make any difference in the maintenance of plant and lichen biodiversity in Central European mountain forests?

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Forest Ecosystems 2024年第4期11卷 457-468页

作者： Monika Staniaszek-Kik jan Zarnowiec Damian Chmura Department of Geobotany and Plant Ecology University of Lodz90-237LodzPoland Institute of Nature Protection and Engineering University of Bielsko-BialaWillowa Str 243-309Bielsko-BiałaPoland

Fxcessive forest exploitation significantly contributes to land degradation and the creation of human-made *** are sometimes ignored in studies on the biodiversity of coarse woody *** investigated whether the type of stump,*** stumps(naturally created)and cut stumps(formed during forestry operations)had an impact on the species composition and species diversity as well as due to this fact they can be characterized by plant *** research covered 728 spruce stumps(287 broken and 441 cut stumps)that were inhabited by lichens,liverworts,mosses and vascular plants in mountain forest belt(Karkonosze Mts.,Poland).The following types of microhabitats were included in the research:the upper surface and the lateral surface of a stump with both bark and *** are statistically significant compositional differences between the two types of stumps,which was demonstrated by ordination analyses and indicator species *** to the generalized linear models,the probability of occurrence increases in cut stumps in case of liverworts and vascular plants and also along the decomposition *** generalized linear mixed-effects model showed that there was a higher species richness of liverworts,mosses and vascular plants on the cut stumps and less drier but the reverse situation was in *** generalized additive models for their cover showed similar *** all of the taxonomic groups were affected by altitude both in terms of species composition and total cover on the *** concluded that cut stumps are an important type of deadwood for biodiversity and provide a convenient habitat,especially for many lichens and bryophytes.

关键词： Coarse woody debris Spruce stumps Epixylic flora Plant indicators

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Dieback of managed spruce stands in western Germany promotes beetle diversity

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Journal of Forestry Research 2024年第3期35卷 55-71页

作者： Eva Plath Chantal Trauth jan Gerhards Laura Griebel Klaus Fischer Department Biology Institute of Integrated Natural SciencesKoblenz-Landau University56070 KoblenzGermany

Biodiversity loss is a significant problem at a global scale and may be amplified by climate *** recent years,coniferous forests have had substantial die-back across Europe due to drought and subsequent bark-beetle *** many studies on the consequences of disturbance and subsequent management have focused on natural stands,management implications for managed spruce stands are not well understood,even though such stands are widespread throughout *** this study,beetle taxonomy,conservation value,and community com-position are compared among spruce plantations and four post-disturbance management approaches:standing dead-wood,lying deadwood,clear cuts,and long-term *** and community composition differed significantly among management categories,while different beetle fami-lies responded *** spruce stands harbored the lowest beetle diversity while the highest taxonomic diver-sity and conservation value was on clear cuts and stands with lying or standing *** proportion of forest specialists was highest in successional *** summary,different forest management categories harbored distinct beetle communities at the family-,species-,and ecological guild ***,post-disturbance management should consider the landscape scale and include different management *** enhances landscape heterogeneity and thus overall biodiversity but could also mitigate negative impacts of natural disturbances on ecosystem services.

关键词： Bark-beetle outbreak Forest dieback Spruce Deadwood Nature conservation Beetle biodiversity-Coleoptera Coniferous forests

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