检索结果-南通市图书馆

岭南现代临床外科 2014年第6期14卷 722-722页

作者： Roshan M.Kumar Patrick Cahan Alex K.Shalek Rahul Satija A.Jay Daley Keyser Hu Li Jin Zhang Keith Pardee David Gennert John J.Trombetta Thomas C.Ferrante Aviv Regev George q.Daley james J. Collins

论文作者George Daley教授说：＂这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。＂研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们... 详细信息

论文作者George Daley教授说：＂这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。＂研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们的发育景观。随后,他们分析了每个细胞的遗传组成,观察了每个细胞多能状态的微小波动。他们发现内部、化学和环境信号影响干细胞方式的许多细微差异,揭示出了复杂的发育调控因子＂决策＂回路。

关键词：环境信号 Nature 多能性异质性发育调控化学物质细胞类型 pluripotent 博士后研究人员 heterogeneity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rotational assisted endoscopic retrograde cholangiopancreatography in patients with reconstructive gastrointestinal surgical anatomy

引用

World Journal of Gastrointestinal Endoscopy 2015年第3期7卷 278-282页

作者： Majed El Zouhairi james B Watson Svetang V Desai David K Swartz Alejandra Castillo-Roth Mahfuzul Haq.e Paul S Jowell Malcolm S Branch Rebecca A Burbridge Division of Gastroenterology Duke University Medical Center Northern New Mexico Gastroenterology Associates

AIM: To evaluate the success rates of performing therapy utilizing a rotational assisted enteroscopy device in endoscopic retrograde cholangiopancreatography(ERCP) in surgically altered anatomy patients. METHODS: Between June 1, 2009 and November 8, 2012, we performed 42 ERCPs with the use of rotational enteroscopy for patients with altered anatomy(39 with gastric bypass Roux-en-Y, 2 with Billroth Ⅱ gastrectomy, and 1 with hepaticojejunostomy associated with liver transplant). The indications for ERCP were: choledocholithiasis: 13 of 42(30.9%), biliary obstruction suggested on imaging: 20 of 42(47.6%), suspected sphincter of Oddi dysfunction: 4 of 42(9.5%), abnormal liver enzymes: 1 of 42(2.4%), ascending cholangitis: 2 of 42(4.8%), and bile leak: 2 of 42(4.8%). All procedures were completed with the Olympus SIF-q.80 enteroscope and the Endo-Ease Discovery SB overtube produced by Spirus Medical. RESULTS: Successful visualization of the major ampulla was accomplished in 32 of 42 procedures(76.2%). Cannulation of the bile duct was successful in 26 of 32 procedures reaching the major ampulla(81.3%). Successful therapeutic intervention was completed in 24 of 26 procedures in which the bileduct was cannulated(92.3%). The overall intention to treat success rate was 64.3%. In terms of cannulation success, the intention to treat success rate was 61.5%. Ten out of forty two patients(23.8%) req.ired admission to the hospital after procedure for abdominal pain and nausea, and 3 of those 10 patients(7.1%) had a diagnosis of post-ERCP pancreatitis. The average hospital stay was 3 ***: It is reasonable to consider an attempt at rotational assisted ERCP prior to a surgical intervention to alleviate biliary complications in patients with altered surgical anatomy.

关键词： Gastric bypass Gastrostomy Cholangiopancreatography Endoscopic retrograde Double-Balloon enteroscopy Ampulla of vater Sphincterotomy Endoscopic Pancreatitis Retrospective studies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

染色体7p14．1和染色体14q.1．2上DNA复制数量的变异与掌腱膜挛缩症有关：MMP及Wnt信号通路的潜在作用

引用

中国美容整形外科杂志 2013年第1期24卷 I0017-I0017页

作者： Barbara Shih May Tassabehji james Stewart Watson Ardeshir Bayat 石金鹭(译) 郭澍(译) 孙强(译) 魏峰(译) 高景恒英国曼彻斯特曼彻斯特大学曼彻斯特跨学科生物中心整形再造外科研究中心曼彻斯特大学圣玛利亚医院遗传学中心南曼彻斯特基金会大学医院 Wythenshawe医院整形再造外科及曼彻斯特健康科学学术研究中心中国医科大学附属第一医院整形外科《中国美容整形外科杂志》编辑部

背景掌腱膜挛缩症（Dupuytren’s disease）是一个常见的由不知名致病源引起的纤维增生障碍。新的证据表明，遗传因素与疾病相关紧密。这项研究的目的在于评估DNA复制数量的变异对于掌腱膜挛缩症发病机制的潜在影响。方法利用微阵列比... 详细信息

背景掌腱膜挛缩症（Dupuytren’s disease）是一个常见的由不知名致病源引起的纤维增生障碍。新的证据表明，遗传因素与疾病相关紧密。这项研究的目的在于评估DNA复制数量的变异对于掌腱膜挛缩症发病机制的潜在影响。方法利用微阵列比较基因组杂交（NimbleGenHumanCGH2．1M）来比较：①来自疾病结节的DNA（n=4）与内对照组的DNA（患者的血液；n=4）；②外对照组的DNA（购买的10个来自捐赠者的基因，n=4）。应用Nexus5．1（BioDiscovery美国加利福尼亚州埃尔塞贡多）对包括已发表的微阵列比较基因组杂交的结果和本研究的数据，进行统计学分析。复制数量变异在掌腱膜挛缩症中很常见，并存在于大多数掌腱膜挛缩症结节中（与对照组相比，占75％～87．5％）。发生基因复制变异的位置也和近期发表的全基因组关联研究进行了对比。用定量聚合酶链反应对常见的基因复制数量变异进行进一步地验证，选取了25个掌腱膜挛缩症病例和30个外对照组。此外，还在掌腱膜挛缩症结节和内对照组（掌腱膜，n=7）进行了基因表达的对比。结果通过微阵列比较基因组杂交发现，基因复制数量变异常发生在染色体17q.2、1p31．1、20p13、7p14．1和14q.1．2上。定量聚合酶链反应证实，掌腱膜挛缩症的染色体7p14．1和14q.1．2在复制基因数量变异尤为显著。基质金属蛋白酶-14和分泌型卷曲相关蛋白4在疾病结节中的数量显著上升。结论这项研究表明掌腱膜挛缩症与染色体7p14．1和14q.1．2的基因复制数量变异相关。

关键词：掌腱膜挛缩症 DNA复制基因数量 Wnt信号通路染色体变异潜在作用比较基因组杂交

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

R&D of back-end electronics for improved resistive plate chambers for the phase 2 upgrade of the CMS end-capmuon system

引用

Radiation Detection Technology and Methods 2022年第3期6卷 306-316页

作者： H.Kou Z.-A.Liu J.Zhao J.Song q.Hou W.Diao P.Cao W.Gong N.Wang A.Samalan M.Tytgat M.El Sawy G.A.Alves F.Marujo E.A.Coelho F.Torres Da Silva De Araujo E.M.Da Costa H.Nogima A.Santoro S.Fonseca De Souza D.De Jesus Damiao M.Thiel M.Barroso Ferreira Filho K.Mota Amarilo A.Aleksandrov R.Hadjiiska P.Iaydjiev M.Rodozov M.Shopova G.Sultanov A.Dimitrov L.Litov B.Pavlov P.Petkov A.Petrov E.Shumka S.J.q.an C.Avila D.Barbosa A.Cabrera A.Florez J.Fraga J.Reyes Y.Assran M.A.Mahmoud Y.Mohammed I.Laktineh G.Grenier M.Gouzevitch L.Mirabito K.Shchablo C.Combaret W.Tromeur G.Galbit A.Luciol X.Chen I.Bagaturia I.Lomidze Z.Tsamalaidze V.Amoozegar B.Boghrati M.Ebraimi E.Zareian M.Mohammadi Najafabadi M.Abbrescia G.Iaselli G.Pugliese F.Loddo N.De Filippis R.Aly D.Ramos W.Elmetenawee S.Leszki I.Margjeka D.Paesani L.Benussi S.Bianco D.Piccolo S.Meola S.Buontempo F.Carnevali L.Lista P.Paolucci F.Fienga A.Braghieri P.Salvini P.Montagna C.Riccardi P.Vitulo E.Asilar J.Choi T.J.Kim S.Y.Choi B.Hong K.S.Lee H.Y.Oh J.Goh I.Yu C.Uribe Estrada I.Pedraza H.Castilla-Valdez R.L.Fernandez A.Sanchez-Hernandez E.Vazq.ez M.Ramirez-Garcia N.Zaganidis A.Radi H.Hoorani S.Muhammad A.Ahmad I.Asghar M.A.Shah W.A.Khan J.Eysermans I.Crotty on behalf of the CMS Muon Group Department of Physics and Astronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium UniversitéLibre de Bruxelles Avenue Franklin Roosevelt50-1050 BruxellesBelgium Centro Brasileiro Pesq.isas Fisicas R.Dr.Xavier Sigaud150UrcaRio de JaneiroRio de Janeiro 22290-180Brazil Department de Fisica Nuclear e Altas Energias Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524Rio de JaneiroRio de Janeiro 20559-900Brazil Bulgarian Academy of Sciences Institute for Nuclear Researches and Nuclear EnergyTzarigradsko Shaussee Boulevard 721784 SofiaBulgaria Faculty of Physics University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria School of Physics Peking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences B325Main BuildingNo.19(A)Yuquan RoadShijingshan DistrictBeijing 100049China Universidad de Los Andes Carrera 1No.18A-12BogotáColombia Egyptian Network for High Energy Physics Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt Suez University SuezCairo RoadElsalam CitySuez 43522Egypt Center for High Energy Physics(CHEP-FU) Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance Georgian Technical University 77 Kostava Str.0175 TbilisiGeorgia School of Particles and Accelerators Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531 TehranIran School of Engineering Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso University Monte S.AngeloVia Cintia80126 NapoliItaly Dipartimento di Ingegneria Elettrica e delle Tecnologie dell’Informazione UniversitàDegli Studi di Napoli Federico II80126 NapoliI

Purpose The Large Hadron Collider(LHC)at European Organization for Nuclear Research is planned to be upgraded to the high luminosity *** the luminosity makes muon triggering reliable and ofﬂine reconstruction very *** enhance the redundancy of the Compact Muon Solenoid(CMS)Muon system and resolve the ambiguity of track reconstruction in the forward region,an improved Resistive Plate Chamber(iRPC)with excellent time resolution will be installed in the Phase-2 CMS *** iRPC will be eq.ipped with Front-End Electronics(FEE),which can perform high-precision time measurements of signals from both ends of the *** Back-End Electronics(BEE)need to be researched and developed to provide sophisticated functionalities such as interacting with FEE with shared links for fast,slow control(SC)and data,in addition to trigger primitives(TPs)generation and data acq.isition(DAq..Method The BEE prototype uses a homemade hardware board compatible with the MTCA standard,the back-end board(BEB).BEE interacts with FEE via a bidirectional 4.8 Gbps optical paired-link that integrates clock,data,and control *** clock and fast/slow control commands are distributed from BEB to the FEE via the *** uplink is used for BEB to receive the time information of the iRPC’sﬁred strips and the responses to the fast/slow control *** have a pipelined detector data for clusterﬁnding operation,recover(DeMux)the time relationship of which is changed due to the transmission protocol for the continuous incoming MUXed data from *** at each bunch crossing(BX),clusteringﬁred strips that satisfy time and spatial constraints to generate *** incoming raw MUXed detector data and TPs in a time window and latency based on the trigger signal are read out to the DAq.*** Ethernet(GbE)of SiTCP and commercial 10-GbE are used as link standards for SC and DAq.respectively,for the BEB to interact with the *** The joint test results of

关键词： CMS iRPC BEE TP DAq SC

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：