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A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia

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Asian Journal of Andrology 2020年第2期22卷 222-226页

作者： Scott J Morin Brent M Hanson Caroline R Juneau Shelby A neal Jessica n Landis Richard T Scott Jr james M Hotaling Reproductive Medicine Associates of new Jersey 140 Allen RoadBasking RidgeNJ 07920USA Division of Reproductive Endocrinology and Infertility Department of Obstetrics and GynecologySidney Kimmel Medical College at Thomas Jefferson University833 Chestnut StreetPhiladelphiaPA 19107USA Foundation for Embryonic Competence 140 Allen RoadBasking RidgeNJ 07920USA Division of Urology Department of SurgeryUniversity of Utah School of Medicine30 N 1900 ESalt Lake CityUT 84132USA Department of Obstetrics and Gynecology University of Utah School of Medicine30 N 1900 ESalt Lake CityUT 84132USA.An abbreviated version of this manuscript was published and presented as an abstract at the American Society for Reproductive Medicine(ASRM)2017 Scientific Congress.

This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive *** cases at a single center between 2012 and 2016 were *** approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm *** culture was exclusively utilized prior to *** primary outcome was live birth *** outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was ***-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were *** live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,Pno *** rates were no different through the first transfer ***,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per ***,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort.

关键词： azoospermia intracytoplasmic sperm injection male infertility testicular sperm extraction

The Interaction of Spinach nitrite Reductase with Ferredoxin： A Site-Directed Mutation Study

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Molecular Plant 2009年第3期2卷 407-415页

作者： Masakazu Hirasawa Jatindra n. Tripathy Ramasamy Somasundaram Michael K. Johnson Megha Bhalla james R Allen David B. Knaff Department of Chemistry and Biochemistry Texas Tech University Lubbock TX 79409-1061 USA Department of Chemistry University of Georgia Athens GA 30602 USA Department of Chemistry and Biochemistry Arizona State University Tempe AZ 85287-1604 USA Institute for Biotechnology and Genomics Texas Tech University Lubbock TX 79409-1061 USA

A series of site-directed mutants of the ferredoxin-dependent spinach nitrite reductase has been characterized and several amino acids have been identified that appear to be involved in the interaction of the enzyme with ferredoxin. In a complementary study, binding constants to nitrite reductase and steady-state kinetic parameters of site-directed mutants of ferredoxin were determined in an attempt to identify ferredoxin amino acids involved in the interaction with nitrite reductase. The results have been interpreted in terms of an in-silico docking model for the 1：1 complex of ferredoxin with nitrite reductase.

关键词： Electron transport enzymology nitrogen metabolism molecular biology.

Isolated left ventricular apical hypoplasia:Systematic review and analysis of the 37 cases reported so far

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世界临床病例杂志 2023年第23期11卷 5494-5503页

作者： Pier Paolo Bassareo Sophie Duignan Adam james Esme Dunne Colin J McMahon Kevin P Walsh University College of Dublin School of Medicine and Department of Cardiology at Mater Misericordiae University HospitalDublin D07 R2WYIreland Department of Cardiology Children's Health CrumlinDublin D12 N512Ireland University College of Dublin School of Medicine and Department of CardiologyChildren's Health IrelandDublin D12 N512Ireland

BACKGROUnD Isolated left ventricular apical hypoplasia(ILVAH),also known as truncated left ventricle(LV),is a very unusual *** is characterised by a truncated,spherical,and non-apex forming *** true apex is occupied by the right *** to the rarity of the disease,just a few case reports and limited case series have been published in the *** To analysing the so far 37 reported ILVAH cases *** The electronic databases PubMed and Scopus were investigated from their establishment up to December 13,*** The majority of cases reported occurred in males(52.7%).Mean age at diagnosis was 26.1±19.6 *** than a third of the patients were asymptomatic(35.1%).The most usual clinical presentation was breathlessness(40.5%).The most commonly detected electrocardiogram changes were T wave abnormalities(29.7%)and right axis deviation with poor R wave progression(24.3%).Atrial fibrillation/flutter was detected in 24.3%.Echocardiography was performed in 97.3%of cases and cardiac MRI in 91.9%of *** fraction was reduced in more than a half of patients(56.7%).An associated congenital heart disease was found in 16.2%.Heart failure therapy was administered in 35.1%of *** outcome was favorable in the vast majority of patients,with just one *** ILVAH is a multifaceted entity with a so far unpredictable course,ranging from benign until the elderly to sudden death during adolescence.

关键词： Isolated left ventricular apical hypoplasia Truncated left ventricle Electrocardiography Echocardiography Cardiac magnetic resonance imaging Heart failure

Unintended nutrient imbalance induced by wastewater effluent inputs to receiving water and its ecological consequences

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Frontiers of Environmental Science & Engineering 2022年第11期16卷 273-275页

作者： Yindong Tong Xuejun Wang james J.Elser School of Environmental Science and Engineering Tianjin UniversityTianjin 300072China College of Urban and Environmental Sciences Peking UniversityBeijing 100871China Flathead Lake Biological Station University of MontanaPolsonMT 59860USA

Eutrophication is the most widespread water quality issue *** date,most efforts to control eutrophication have focused on reductions of external nutrient inputs,yet importance of nutrient stoichiometry and subsequent shift in plankton composition in aquatic ecosystem has been largely *** address eutrophication,improved sanitation is one of the United nations Sustainable Development Goals,spurring the constructions of wastewater treatment facilities that have improved water quality in many lakes and ***,control measures are often targeted at and effective in removing a single nutrient from sewage and thus are less effective in removing the others,resulting in the changes of nutrient *** general,more effective phosphorus removal relative to nitrogen has occurred in wastewater treatment leading to substantial increases in n/P ratios in effluent relative to the ***,high n/P ratios in receiving waters can impose negative influences on ***,longterm strategies for domestic wastewater management should not merely focus on the total reduction of nutrient discharge but also consider their stoichiometric balances in receiving waters.

关键词： nutrient stoichiometry Wastewater treatment Ecosystem functioning Water quality management

Facile synthesis of n-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases

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Chinese Chemical Letters 2011年第12期22卷 1439-1442页

作者： Wei Hong james Dowden School of Chemistry and Chemical Engineering Beifang University of Nationalities Yinchuan 750021 China School of Chemistry University of NottinghamNottingham NG7 2RDUK

Chemically modified cellular co-factors that provide function,such as immobilization or incorporation of fluorescent dyes,are valuable probes of biological activity.A convenient route to obtain S-adenosyl methionine（AdoMet） analogues modified at n-6 adenosine to feature a linker terminating in azide functionality is described *** decoration of such AdoMet analogues with guanidinium terminated linkers leads to novel potential bisubstrate inhibitors for protein arginine methyltrans-ferases, PRMTs.

关键词： Protein arginine methyltransferases S-Adenosyl methionine nucleosides

Efficiency and superefficiency in one-parameter two-sided truncated distribution families

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Chinese Science Bulletin 1997年第21期42卷 1771-1774页

作者： james C. Fu Department of Statistics University of Manitoba Winnipeg R3T 2N2 Canada

whereθis an unknown parameter, φ(θ) is a continuous differentiable function such that θ0, θ∈R, and f(x;θ) is a positive continuous density func-tion on [θ,φ(θ)]. The one-parameter two-sided truncated distrib... 详细信息

关键词： one-parameter two-sided truncated family super-efficiency a new efficiency asymptotically median unbiased efficient estimate.

Pest management with biopesticides

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Frontiers of Agricultural Science and Engineering 2018年第3期5卷 295-300页

作者： james n.SEIBER Joel COATS Stephen O.DUKE Aaron D.GROSS Department of Environmental Toxicology University of CaliforniaDavis Department of Entomology Iowa State University natural Products Utilization Research Agricultural Research Service United States Department of AgricultureUniversityMS Department of Entomology Virginia Polytechnic Institute and State University

Biopesticides are attracting interest as alternatives to conventional pesticides but without many of the non-target effects, promising a better record of safety and sustainability in pest control practices. In this article we summarize and discuss the current status and future promise of biopesticides, including how biopesticides use may increase the quality and safety of the food supply.

关键词： biopesticide GMO crops pest management

Participation in cooperative prey capture and the benefits gained from it are associated with individual personality

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Current Zoology 2017年第5期63卷 561-567页

作者： james L.L. LICHTEnSTEIn Colin M. WRIGHT Lauren P. LUSCUSKIE Graham A. MOnTGOMERY PInTER-WOLLMAn Jonathan n. PRUITT Department of Biological Sciences University of Pittsburgh Pittsburgh PA 15260 USA Department of Ecology and Evolutionary Biology University of California Los Angeles CA 90095 USA Department of Ecology Evolution and Marine Biology University of California Santa Barbara Santa Barbara CA 93106 USA

In animal societies, behavioral idiosyncrasies of the individuals often guide which tasks theyshould perform. Such personality-specific task participation can increase individual task efficiency,thereby improving group performance. While several recent studies have documented group-levelbenefits of within-group behavioral （i.e., personality） diversity, how these benefits are realized atthe individual level is unclear. Here we probe the individual-level benefits of personality-driven taskparticipation in the social spider Stegodyphus dumicola. In S. dumicola, the presence of at leastone highly bold individual catalyzes foraging behavior in shy colony members, and all group con-stituents heavily compete for prey. We assessed boldness by examining how quickly spidersresumed normal movement after a simulated predator attack. We test here whether （1） participantsin collective foraging gain more mass from prey items and （2） whether bold individuals are less re-sistant to starvation than shy spiders, which would motivate the bold individuals to forage ***, we assembled colonies of shy spiders with and without a bold individual, added one preyitem, and then tracked the mass gain of each individual spider after this single feeding event. Wefound that spiders that participated in prey capture （whether bold or shy） gained more mass thannonparticipators, and colonies containing a single bold spider gained more total mass than purelyshy colonies. We also found that bold spiders participated in more collective foraging events andwere more susceptible to starvation than shy spiders, suggesting that the aggressive foraging ofbold individuals may represent a strategy to offset starvation risk. These findings add to the bodyof evidence that animal personality can shape social organization, individual performance, andgroup success.

关键词： animal personality, keystone individuals, social behaviour, task allocation.

Quantifying key factors for optimised manufacturing of Li-ion battery anode and cathode via artificial intelligence

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能源与人工智能(英文) 2022年第1期7卷 75-90页

作者： Mona Faraji niri Kailong Liu Geanina Apachitei Luis A.A Román-Ramírez Michael Lain Dhammika Widanage james Marco Warwick Manufacturing Group University of WarwickCV47AL CoventryUK The Faraday Institution Quad OneHarwell Science and Innovation CampusDidcotUK

Li-ion battery is one of the key players in energy storage technology empowering electrified and clean transportation ***,it is still associated with high costs due to the expensive material as well as high fluctuations of the manufacturing *** production processes involving mechanical,chemical,and electrical operations makes the predictability of the manufacturing process a challenge,hence the process is optimised through trial and error rather systematic *** establish an in-depth understanding of the interconnected processes and manufacturing parameters,this paper combines data-mining techniques and real production to offer a method for the systematic analysis,understanding and improving the Li-ion battery electrode manufacturing *** novelty of this research is that unlike most of the existing research that are focused on cathode manufacturing only,it covers both of the cathode and anode case ***,it is based on real manufacturing data,proposes a systematic design of experiment method for generating high quality and representative data,and leverages the artificial intelligence techniques to identify the dependencies in between the manufacturing parameters and the key quality factors of the *** this study,machine learning models are developed to quantify the predictability of electrode and cell properties given the coating process control ***,the manufacturing parameters are ranked and their contribution to the electrode and cell characteristics are quantified by *** systematic data acquisition approach as well as the quantified interdependencies are expected to assist the manufacturer when moving towards an improved battery production chain.

关键词： Li-ion battery electrodes Anode Cathode Battery manufacturing Machine learning Artificial intelligence