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随着创利压力的不断增加,大多数工业品公司开始把注意力渐渐转移到一些短期的经营目标上:如降低成本、提高资产利用率以及争取更廉价的生产力等.这样的做法是必要的,但却不是最充分的.在竞争日益加剧的今天,经理们需要同时以可操作性和战略性的眼光来考虑问题--完善现行的工作并寻找增长的机会.而发现增长机会的最佳途径莫过于让自己成为一家真正以客户为中心的企业.

关键词：工业品公司经营策略客户

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激发多业务公司增长的潜能

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商学院 2006年第5期 71-72页

作者： james p.andrew Meldon Wolfgang Kunal J.Mehra William Turner 波士顿咨询公司芝加哥办公室波士顿咨询公司波士顿办公室

综合业务公司在追求增长时总是利用两个传统战略：通过兼并和收购来扩张他们的业务组合，或通过有机增长来扩展各项业务。这两个战略现在看起来都颇具挑战性。首先是并购战略在大多数情况下注定充满风险和艰辛：BCG的研究显示，近三分... 详细信息

综合业务公司在追求增长时总是利用两个传统战略：通过兼并和收购来扩张他们的业务组合，或通过有机增长来扩展各项业务。这两个战略现在看起来都颇具挑战性。首先是并购战略在大多数情况下注定充满风险和艰辛：BCG的研究显示，近三分之二的并购案对公司价值造成重创。另一方面，促进各个业务的有机增长虽然看起来非常重要，却不能产生足够的增长来满足公司（和股东）的总体目标。

关键词：公司价值业务组合传统战略综合业务并购战略挑战性并购案

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Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus:A systematic review

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World Journal of Orthopedics 2024年第6期15卷 585-592页

作者： Katherine Esser james J Butler Mackenzie Roof Nathaniel p Mercer Michael C Harrington Alan p Samsonov andrew J Rosenbaum John G Kennedy Department of Orthopaedic Surgery University of Toledo Medical Center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Department of Orthopedic Surgery NYU Langone HealthNew YorkNY 10002United States Department of Orthopedic Surgery Albany Medical CenterAlbanyNY 12208United States

BACKGROUND Cheilectomy of the 1^(st)metatarsophalangeal joint(MTpJ)is one of the most common procedures for the management of hallux ***,there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy(MIDC)for the management of hallux *** To evaluate outcomes following MIDC for the management of hallux *** During November 2023,the pubMed,EMBASE and Cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDC for the management of hallux *** Six studies were *** total,348 patients(370 feet)underwent MIDC for hallux rigidus at a weighted mean follow-up of 37.9±16.5 *** distribution of patients by Coughlin and Shurna's classification was recorded in 4 studies as follows:Ⅰ(58 patients,27.1%),Ⅱ(112 patients,52.3%),Ⅲ(44 patients,20.6%).Three studies performed an additional 1^(st)MTpJ arthroscopy and debridement following *** intra-articular bone debris was observed in 100%of patients in 1 *** weighted mean American orthopedic foot and ankle society score improved from a preoperative score of 68.9±3.2 to a postoperative score of *** complication rate was 8.4%,the most common of which was persistent joint pain and ***-two failures(8.7%)were ***-three secondary procedures(8.9%)were performed at a weighted mean time of 8.6±3.2 months following the index *** This systematic review demonstrated improvements in subjective clinical outcomes together with a moderate complication rate following MIDC for the management of hallux rigidus at short-term follow-up.A moderate reoperation rate at short-term follow-up was *** marked heterogeneity between included studies and paucity of high quality comparative studies limits the generation of any robust conclusions.

关键词： Minimally invasive dorsal cheilectomy Hallux rigidus The first metatarsophalangeal joint Cheilectomy Minimally invasive surgery

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CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of pKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand p.Sharda Mackenzie M.Lieberman Caitlin M.james Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin p.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and pathogenesis program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA present address:University of Colorado Boulder BoulderCO 80309USA present address:Dana Farber Cancer Institute BostonMA 02215USA present address:Massachusetts Institute of Technology BostonMA 02139USA present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of pKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,pKM alternative splicing occurred independently of CD28-driven pI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 pKM2

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Estimation of peanut Maturity Using Color Image Analysis

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American Journal of plant Sciences 2024年第8期15卷 617-635页

作者： Wei-Zhen Liang Kendall R. Kirk james S. Thomas andrew C. Warner Department of Biological Systems Engineering University of Nebraska-Lincoln Lincoln NE USA panhandle Research and Extension Center University of Nebraska-Lincoln Scottsbluff NE USA Department of plant Environmental Science Clemson University Clemson SC USA Edisto Research and Education Center Clemson University Blackville SC USA University of Georgia-Athens Cooperative Extension Athens GA USA

peanuts pods grow underground and mature unevenly, resulting that choosing the correct time to harvest is more complicated than other crops. pod maturity can be determined by blasting with a pressure washer to remove outer skin of the pod (exocarp) to expose the color of the middle layer (mesocarp). The mesocarp color changes with maturity from white to yellow, orange, brown and finally black. The sum of percentage from orange, brown, and black mesocarp (OBB) color and black color (BL) represents the kernels that are mature enough to harvest. The goal of this research is to identify methodologies to estimate OBB and BL of the pods using RGB images taken in the field and validate the proposed model using other pod images. The Mahalanobis distance classification method was used to process sets of images and calculate pod area (number of pixels) corresponding to two classes (mesocarp and background) with nine different color groups. The results showed a performance of 94% effectiveness for mesocarp using Mahalanobis distance classification. Statistical regression for OBB and BL was developed based on 315 images of peanut pods taken from the field. The R2 and root mean square error of predicted and actual OBB were 0.93 and 4.1%, respectively. The R2 and root mean square error of predicted and actual BL were 0.88 and 1.8%, respectively. The validation of OBB using other images provided reasonable estimation (R2 = 0.98 and RMSE = 2.73%). This study introduces a novel, cost-effective, and non-destructive method for estimating peanut maturity using RGB imagery and Mahalanobis distance classification in the field. This innovative approach addresses the limitations of traditional methods and offers a robust alternative for real-time maturity assessment.

关键词： peanut Maturity Mesocarp Exocarp Mahalanobis Distance Statistical Regression

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