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Aerosol jet printing of surface acoustic wave microfluidic devices

Microsystems & Nanoengineering 2024年第1期10卷 231-242页

作者： Joseph Rich Brian Cole Teng Li Brandon Lu Hanyu Fu Brittany N.Smith Jianping Xia Shujie Yang Ruoyu Zhong james L.doherty Kanji Kaneko Hiroaki Suzuki Zhenhua Tian Aaron D.Franklin Tony Jun Huang Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA Department of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Deptartment of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan Department of Chemistry Duke UniversityDurhamNC 27708USA

The addition of surface acoustic wave(SAW)technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes,including high-precision manipulation,versatility,integrability,biocompatibility,contactless nature,and rapid ***,the development of SAW microfluidic devices is limited by complex and time-consuming micro/nanofabrication techniques and access to cleanroom facilities for multistep photolithography and vacuum-based *** simplify the fabrication of SAW microfluidic devices with customizable dimensions and functions,we utilized the additive manufacturing technique of aerosol jet *** successfully fabricated customized SAW microfluidic devices of varying materials,including silver nanowires,graphene,and poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS).To characterize and compare the acoustic actuation performance of these aerosol jet printed SAW microfluidic devices with their cleanroom-fabricated counterparts,the wave displacements and resonant frequencies of the different fabricated devices were directly measured through scanning laser Doppler ***,to exhibit the capability of the aerosol jet printed devices for lab-on-a-chip applications,we successfully conducted acoustic streaming and particle concentration ***,we demonstrated a novel solution-based,direct-write,single-step,cleanroom-free additive manufacturing technique to rapidly develop SAW microfluidic devices that shows viability for applications in the fields of biology,chemistry,engineering,and medicine.

关键词： printing wave fluid

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Vertebrate pesticide risk assessment by indigenous communities in New Zealand

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Integrative Zoology 2010年第1期5卷 37-43页

作者： Shaun C.OGILVIE james M.ATARIA james WAIWAI james doherty Aroha MILLER james G.ROSS Charles T.EASON Ecology Department Lincoln UniversityLincolnCanterburyNew Zealand Landcare Research LincolnCanterburyNew Zealand Lake Waikaremoana Hapu Restoration Trust TuaiNew Zealand Tuhoe Tuawhenua Trust MuruparaNew Zealand

In New Zealand,the vertebrate pesticide sodium fluoroacetate(Compound 1080)is aerially applied in baits for control of the brush-tailed possum Trichosurus vulpecula(Kerr,1792).Maori,the indigenous people of New Zealand,have raised concerns about 1080 impacts on culturally-important ***,we outline two steps taken to help Maori assess 1080 ***,field research was undertaken to determine if naturally-occurring plants utilized by a Maori community for food and medicine would take up 1080 from *** baits were placed at the base of individual plants of two species,pikopiko(Asplenium bulbiferum)and karamuramu(Coprosma robusta).Plants were sampled at various times up to 56 days,and samples were analyzed for 1080 *** 1080 was detected in any of the pikopiko samples,whereas 1080 was detected in karamuramu,at a maximum concentration of 5 ppb after seven days,and 2.5 ppb after 14 *** concentration decreased to 0 at 28 days,indicating that 1080 was not *** results of the present study suggest there is negligible risk of humans being poisoned by consum-ing plants that have taken up 1080 from *** allay community concerns that minute concentrations of 1080 might influence the medicinal properties of plants,it is suggested that a withholding period of 30 days after 1080 control operations could be ***,after further consultation we undertook a review of the scientific literature relating to 1080 impacts on additional non-target species of cultural importance to *** information was presented on an interactive foodweb database that allowed the collection and presentation of a large volume of complex information about 1080 in a holistic and pictorial *** database was presented to many Maori communities throughout New Zealand,and feedback was overwhelmingly *** database is likely to play a key role in informing these communities about 1080,and is seen as an important new tool to help these communities

关键词： 1080 indigenous communities Maori risk assessment sodium fluoroacetate

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Understanding the impact of disease and vaccine mechanisms on the importance of optimal vaccine allocation

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Infectious Disease Modelling 2023年第2期8卷 539-550页

作者： Isobel R.Abell james M.McCaw Christopher M.Baker School of Mathematics and Statistics The University of MelbourneMelbourneAustralia Melbourne Centre for Data Science The University of MelbourneMelbourneAustralia Centre for Epidemiology and Biostatistics Melbourne School of Population and Global HealthThe University of MelbourneMelbourneAustralia Peter doherty Institute for Infection and Immunity The Royal Melbourne Hospital and the University of MelbourneMelbourneAustralia Centre of Excellence for Biosecurity Risk Analysis The University of MelbourneMelbourneAustralia

Vaccination is an important epidemic intervention ***,it is generally unclear how the outcomes of different vaccine strategies change depending on population characteristics,vaccine mechanisms and allocation *** this paper we develop a conceptual mathematical model to simulate strategies for pre-epidemic *** extend the SEIR model to incorporate a range of vaccine mechanisms and disease *** then compare the outcomes of optimal and suboptimal vaccination strategies for three public health objectives(total infections,total symptomatic infections and total deaths)using numerical *** comparison shows that the difference in outcomes between vaccinating optimally and suboptimally depends on vaccine mechanisms,disease characteristics,and objective *** modelling finds vaccines that impact transmission produce better outcomes as transmission is reduced for all *** vaccines that impact the likelihood of symptomatic disease or dying due to infection,the improvement in outcome as we decrease these variables is dependent on the strategy *** a principled model-based process,this work highlights the importance of designing effective vaccine allocation *** conclude that efficient allocation of resources can be just as crucial to the success of a vaccination strategy as the vaccine effectiveness and/or amount of vaccines available.

关键词： Mathematical modelling Epidemiology

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Infection-acquired versus vaccine-acquired immunity in an SIRWS model

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Infectious Disease Modelling 2018年第1期3卷 118-135页

作者： Tiffany Leung Patricia T.Campbell Barry D.Hughes Federico Frascoli james M.McCaw School of Mathematics and Statistics University of MelbourneParkvilleVictoria 3010Australia Victorian Infectious Diseases Reference Laboratory Epidemiology Unit Peter Doherty Institute for Infection and ImmunityUniversity of Melbourne and Royal Melbourne HospitalParkvilleVictoria 3010Australia Infection and Immunity Research Theme Murdoch Children's Research InstituteRoyal Children's HospitalParkvilleVictoria 3052Australia Department of Mathematics Faculty of ScienceEngineering and TechnologySwinburne University of TechnologyHawthornVictoria 3122Australia Melbourne School of Population and Global Health University of MelbourneParkvilleVictoria 3010Australia

In some disease systems,the process of waning immunity can be subtle,involving a complex relationship between the duration of immunitydacquired either through natural infection or vaccinationdand subsequent boosting of immunity through asymptomatic *** present and analyse a model of infectious disease transmission where primary and secondary infections are distinguished to examine the interplay between infection and *** we allow the duration of infection-acquired immunity to differ from that of vaccine-acquired immunity to explore the impact on long-term disease patterns and prevalence of infection in the presence of immune *** model demonstrates that vaccination may induce cyclic behaviour,and the ability of vaccinations to reduce primary infections may not lead to decreased *** the boosting of vaccine-acquired immunity delays a primary infection,the driver of transmission largely remains primary *** contrast,if the immune boosting bypasses a primary infection,secondary infections become the main driver of transmission under a sufficiently long duration of *** results show that the epidemiological patterns of an infectious disease may change considerably when the duration of vaccine-acquired immunity differs from that of infection-acquired *** study highlights that for any particular disease and associated vaccine,a detailed understanding of the waning and boosting of immunity and how the duration of protection is influenced by infection prevalence are important as we seek to optimise vaccination strategies.

关键词： Infectious disease modelling Vaccination Waning immunity Immune boosting

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支持地球科学的软件复用

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计算机科学与探索 2008年第3期2卷 296-310页

作者： MARSHALL james J DOWNS Robert R SAMADI Shahin GERARD Neil S WOLFE Robert E Innovim/NASA Goddard Space Flight Center Mailstop 614.9 Greenbelt MD 20771 USA Columbia University Center for International Earth Science Information Network (CIESIN) 202 Geoseienees Lamont-Doherty Earth Obs Palisades NY 10964 USA NASA Goddard Space Flight Center Mailstop 614.5 Greenbelt MD 20771 USA

地球科学研究中数据的准备、分发、访问、处理和分析都依赖于计算机软件。科学结果的重复通常需要复用同样的软件。同样,科学数据的有效分发、访问或者分析也都需要进行软件复用。地球科学软件开发社区已经意识到了软件复用的价值,并且... 详细信息

地球科学研究中数据的准备、分发、访问、处理和分析都依赖于计算机软件。科学结果的重复通常需要复用同样的软件。同样,科学数据的有效分发、访问或者分析也都需要进行软件复用。地球科学软件开发社区已经意识到了软件复用的价值,并且在社区内大力鼓励和培育软件复用。因此,他们成立了 NASA 地球科学数据系统( ESDS) 软件复用工作组( WG) 来支持社区成员之间的软件复用。工作组开发了软件复用门户来发布软件复用相关的信息、资源,并且提供培训来提高和改进整个社区的软件复用实践。工作组还开发了一个复用支持系统( RES) 原型系统来支持可复用软件的访问。此外, 工作组还制定了复用成熟度级别, 从而提高了评估和选择可复用软件的能力。

关键词：软件复用社区科学软件数据管理地球科学复用支持复用成熟度

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Advances in tropical cyclone prediction on subseasonal time scales

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Tropical Cyclone Research and Review 2023年第2期12卷 136-150页

作者： Carl J.Schreck III Frederic Vitart Suzana J.Camargo Joanne Camp james Darlow Russell Elsberry Jon Gottschalck Paul Gregory Kurt Hansen Justyn Jackson Matthew A.Janiga Philip J.Klotzbach Chia-Ying Lee Lindsey Long Masuo Nakano Kazuto Takemura Yuhei Takaya Michael J.Ventrice Zhuo Wang Cooperative Institute for Satellite Earth System Studies North Carolina State UniversityUSA European Centre for Medium-Range Weather Forecasts UK Lamont-doherty Earth Observatory Columbia UniversityUSA Bureau of Meteorology Australia Joint Typhoon Warning Center USA Naval Postgraduate School USA Climate Prediction Center NOAAUSA hNational Research CouncilUSA U.S.Air Force USA Naval Research Laboratory USA Colorado State University USA ERT Inc.USA Japan Agency for Marine-Earth Science and Technology Japan Climate Prediction Division Japan Meteorological AgencyJapan Meteorological Research Institute Japan Meteorological AgencyJapan DRW Holdings USA University of Illinois at Urbana-Champaign USA

This review describes advances in understanding and forecasting tropical cyclone(TC)subseasonal variability during the past four years.A large effort by the scientiﬁc community has been in understanding the sources of predictability at subseasonal timescales beyond the well-known modulation of TC activity by the Madden-Julian Oscillation(MJO).In particular,the strong modulation of TC activity over the western North Paciﬁc by the Boreal Summer Intra-Seasonal Oscillation(BSISO)has been *** has also been realized in understanding the role of tropical-extratropical interactions in improving subseasonal *** addition,several recent publications have shown that extratropical wave breaking may have a role in the genesis and development of *** of multi-model ensemble data sets such as the Subseasonal to Seasonal(S2S)and Subseasonal Experiment(SubX)have shown that the skill of S2S models in predicting the genesis of TCs varies strongly among models and regions but is often tied to their ability to simulate the MJO and its *** skill in select models has led to an increase over the past four years in the number of forecasting centers issuing subseasonal TC forecasts using various techniques(statistical,statistical-dynamical and dynamical).More extensive veriﬁcation studies have been published over the last four years,but often only for the North Atlantic and eastern North Paciﬁc.

关键词： Tropical cyclones Subseasonal Forecasts Hurricanes MJO

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