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Vitamin A supplementation downregulates ADH1C and ALDH1A1 mRNA expression in weaned beef calves

Animal Nutrition 2022年第3期10卷 372-381页

作者： Xue Cheng Jin Dong Qiao Peng Seong Jin Kim Na Yeon Kim jalil Ghassemi Nejad Danil Kim Stephen B.Smith Hong Gu Lee Department of Animal Science and Technology Sanghvi College of Life SciencesKonkuk UniversitySeoul 05029Republic of Korea Asia Pacific Ruminant Institute Icheon 17385Republic of Korea Farm Animal Clinical Training and Research Center Institute of Green-Bio Science and TechnologySeoul National UniversityPyeongchang 25354Republic of Korea Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA

Our previous studies demonstrated that oral vitamin A supplementation during late-stage pregnancy and the neonatal stage enhances birth weight,growth performance,and mRNA expression related to muscle and preadipocyte development in beef *** alcohol dehydrogenase 1C(ADH1C)c.-64T>C genotype also correlated with vitamin A concentration in beef *** study aimed to investigate the effects of vitamin A supplementation on the muscle development and vitamin A metabolism in weaned beef calves with different ADH1C *** male calves(90 d of age;initial BW:89.03 kg[SD 8.60])were stratified according to ADH1C genotype and vitamin A treatment(duration:3 months)and randomly assigned to 4 groups with a 22 factorial *** A treatments included the following:control(10,000 IU/kg of as-fed,*** type;*** type);treatment(40,000 IU/kg of as-fed,*** type;and *** type).Parameters including BW,FI,blood,longissimus dorsi muscle,and liver status during the experimental period were analyzed using the generalized linear model(GLM)procedure and Tukey's test by SAS 9.4 *** vitamin A was significantly increased(P<0.05)in the vitamin A treatment group at 4 and 6 months of *** type calves showed higher serum vitamin A concentration(P<0.05)than the TC type *** triglyceride and non-esterified fatty acid(NEFA)levels increased(P<0.05)in the treatment group compared with the control at 6 months of ***,BW,ADG and FI showed no differences between the *** addition,mRNA expression in longissimus dorsi muscle revealed upregulation of paired box 7(PAX7)(P<0.05)after the vitamin A treatment period based on biopsy *** ADH1C and aldehyde dehydrogenase(ALDH)1A1 mRNA expression was downregulated(P<0.01)by vitamin A *** TC type of ADH1C showed higher mRNA expression than the TT ***,no effect was observed on adipogenic mRNA expression(preadipocyte factor-1[PREF-1],peroxisome proliferator-activated rece

关键词： Vitamin A ADH1C genotype Muscle development Korean native calves

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Non Linear Image Restoration in Spatial Domain

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Journal of Signal and Information Processing 2011年第3期2卷 211-217页

作者： Bushra jalil Fauvet Eric Laligant Olivier 不详

In the present work, a novel image restoration method from noisy data samples is presented. The restoration was performed by using some heuristic approach utilizing data samples and smoothness criteria in spatial domain. Unlike most existing techniques, this approach does not require prior modelling of either the image or noise statistics. The proposed method works in an interactive mode to find the best compromise between the data (mean square error) and the smoothing criteria. The method has been compared with the shrinkage approach, Wiener filter and Non Local Means algorithm as well. Experimental results showed that the proposed method gives better signal to noise ratio as compared to the previously proposed denoising solutions. Furthermore, in addition to the white Gaussian noise, the effectiveness of the proposed technique has also been proved in the presence of multiplicative noise.

关键词： Restoration Nonlinear Filtering Mean Square Error Signal Smoothness

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二目标优化中锥面积进化算法理论分析与验证

二目标优化中锥面积进化算法理论分析与验证

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作者： Hassan jalil 华南理工大学

学位级别：硕士

在现实世界的管理与工程领域,存在着诸多多目标优化问题。一个多目标优化问题通常存在多个而不是单个最优解。而基于群体的进化算法(evolutionary algorithms,EAs)在一次运行中就可以同时搜索到这多个最优解。虽然大多数已存在的多目标... 详细信息

在现实世界的管理与工程领域,存在着诸多多目标优化问题。一个多目标优化问题通常存在多个而不是单个最优解。而基于群体的进化算法(evolutionary algorithms,EAs)在一次运行中就可以同时搜索到这多个最优解。虽然大多数已存在的多目标进化算法(MOEAs)都是基于帕累托占优的算法,近些年提出的一些基于分解的多目标进化算法表现得越来越成功和流行。尤其是一种采用锥形分解方法的锥面积进化算法(Conical area evolutionary algorithm,CAEA)已被提出用来进一步改进基于分解的二目标优化算法的运行效率与种群多样性。锥面积进化算法中的锥形分解方法将二目标空间划分为一系列锥形子区域,并使用锥面积指标作为在每个对于锥形子区域中每个标量子问题的标量目标。锥形分解方法的全局Pareto最优性已经得到了证明,这意味着锥形分解中在对应的锥形子区域中存在连续的前沿段的条件下每个锥形子问题的最优解在整个二目标空间中一定是Pareto最优的。但是所有μ个锥形子问题的解作为一个整体是否能近似收敛到完整的Pareto前沿仍然是一个待研究的课题。本文则进一步从理论上证明了并从实验上验证了锥形分解方法在求解二目标问题时具有近似最优μ分布收敛性的良好性质与能力。在锥形分解方法的全局Pareto最优性基础上,本文首先利用超体积的单调性和可加性性质、极限的夹逼定理以及极限的罗比塔法则法则证明了,在子问题个数μ足够大并且Pareto前沿是连续的条件下,锥形分解方法中所有μ个子问题的最优解的集合可以收敛到最优的μ-分布,也就是在Pareto前沿上的能最大化超体积值的有限μ个解的集合。同时,本文也对原始CAEA进行了进一步改进,以更好地逼近锥形子问题的最优解。本文在5个二目标MOP基准问题进行了一些实验,来验证锥面积进化算法中锥形分解方法的近似最优μ分布收敛性性质。实验结果表明,相比其他四种流行的多目标金源算法NSGA-II(nondominated sorting genetic algorithm II)、NSGA-III(non-dominated sorting genetic algorithm III)、MOEA/D、MOEA/D-DE(MOEA/D with differential evolution),通过改进的CAEA(CAEA-II)得到的锥形子问题的解的集合依据超体积误差度量指标取得了更好的前沿质量。

关键词：进化算法双目标优化帕累托前沿最优μ分布分解

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巴基斯坦拉合尔市附近贫民区的OTC药品分配系统的指定

巴基斯坦拉合尔市附近贫民区的OTC药品分配系统的指定

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作者： Fazila jalil 北京交通大学

学位级别：硕士

产品分销的零售商选择是供应链交易活动的重要组成部分。公司的成败取决于配送中心的性质和特点。当供应链变得更加资本主义化时,配送中心在决策时需要意识到边界的变化。候选人的选择是基于既定的规范的,这些规范可以在公司和集团之间... 详细信息

产品分销的零售商选择是供应链交易活动的重要组成部分。公司的成败取决于配送中心的性质和特点。当供应链变得更加资本主义化时,配送中心在决策时需要意识到边界的变化。候选人的选择是基于既定的规范的,这些规范可以在公司和集团之间重叠,候选人的特征作重要性是决定决策过程的选择标准这项研究的主要目标是在拉合尔附近的贫民窟地区找到新的医疗设施中心,在那里人们没有任何廉价和快捷的设施来购买治疗自然疾病的药物。本研究设计了一个药品配送系统,由一些现有的药房、书店和商店组成,为OTC药品的柜台安排小空间。在这个系统中,药房、经销商和公司都可以赚钱。另一方面,贫民窟有一个廉价渠道,可以用更少的钱快速获得药品。报告中使用了混合方法来完成本研究的预期目标。采用定性和定量分析方法。定性方法采用访谈法,定量方法采用问卷法。分销决策者也参与了研究。数据是从分销中心获得,通过进行电话采访会议和填写调查问卷的访谈问题。对定性资料进行分析,定量资料采用层次分析法（AHP）进行分析。当前研究集中在根据成本、时间、距离和能力作为主要标准和不同的子标准,来选择候选人,另一方面,组织希望选择一个有专业的、完全了解消费者的需求和弱势群体的领域的经销商。本研究的结果提高了我们对配送选择参数和文化对决策过程影响的认识,特别是在促进医疗服务方面。

关键词：分销系统 OTC药品层次分析法(AHP)

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高价碘试剂介导的氘代异苯并呋喃-1（3H）-酮类化合物的合成

高价碘试剂介导的氘代异苯并呋喃-1（3H）-酮类化合物的合成

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作者： Ayesha jalil 天津大学

学位级别：硕士

杂环化学的研究始于19世纪,伴随着有机化学的发展,杂环化学体现的重要性越来越明显。杂环化学是有机化学的重要组成部分,有关杂环化合物的文献约占有机化学的65%。杂环化合物广泛存在于自然界中,是生命所必需的物质之一。杂环化合物具... 详细信息

杂环化学的研究始于19世纪,伴随着有机化学的发展,杂环化学体现的重要性越来越明显。杂环化学是有机化学的重要组成部分,有关杂环化合物的文献约占有机化学的65%。杂环化合物广泛存在于自然界中,是生命所必需的物质之一。杂环化合物具有广泛的药理活性,在众多药物分子中均能发现其显著的治疗作用。杂环化合物可以分为脂肪类杂环化合物和芳香类杂环化合物。最新的研究数据表明,有超过60%的已批准上市的药物来源于天然产物。苯酞又称3H-异苯并呋喃-1-酮,属于一类γ内酯环与苯环胼合形成的含氧杂环化合物。苯酞类化合物广泛存在于天然产品、药剂、生物分子、膳食补充剂中,其也可以用于构建更为复杂的分子。苯酞类化合物具有抗菌、抗炎、抗肿瘤、抗微生物、抗癌和抗HIV等生物活性。由于苯酞化合物骨架具有重要的潜在药用价值,其相关合成方法策略的开发也越来越受到化学家的重视。根据文献研究,现有的方法有其优点,但也有一定的局限性。因此,开发合成苯酞化合物骨架的新策略,特别是非金属介导的合成方法具有重要意义。有机高价碘化学在过去的几十年里发展迅速,已发展成为有机化学的一个重要研究领域。高价碘试剂作为一类低毒、易制备、温和、高选择性、环境友好、符合绿色化学要求的氧化剂,被广泛应用于各种氧化反应中。高价碘试剂是一类非金属氧化剂,通过C-C、C-O、C-N、C-S键的形成,已被成功地应用于各种杂环化合物骨架的构建。本论文在文献研究的基础上,选择使用2-(1-苯基乙烯基)苯甲酸为底物,高价碘为氧化剂,考察反应条件,以期获得苯酞类化合物的合成新方法。经过条件筛选,确定了最佳反应条件:反应温度为45℃,2-(1-苯基乙烯基)苯甲酸(1.0当量),Ph IO(1.5当量),CDOD(8.0当量),反应溶剂为二氯甲烷。基于课题组前期工作,我们推测发挥氧化作用的可能不是Ph IO,而是Ph IO与CDOD原位生成的二氘代甲氧基碘苯。由于该高价碘化合物的不稳定性,需要1.5当量的Ph IO才能实现原料的完全消耗。在最佳条件下,我们制备了一系列3-((氘代甲氧基)甲基)-3-苯基异苯并呋喃-1(3H)-酮衍生物,以验证该方法的适用性。反应底物和得到的苯酞类化合物均通过H-NMR、C-NMR和X-射线衍射进行了结构确证。通过文献研究、前人工作和实验研究结果,我们提出了我们提出了反应底物在Ph IO/CDOD体系下通过分子内酯化、芳基重排、氘代甲氧基化构建苯酞类化合物的反应机理。综上所述,我们开发了一种利用Ph IO/CDOD体系通过分子内酯化构建了苯酞类化合物骨架的新方法。该方法的主要创新之处是在非金属条件使用温和的反应条件合成了具有潜在药理活性的苯酞类化合物,并且在其中引入了氘代甲氧基。

关键词：苯酞高价碘非金属氧化剂分子内酯化

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High Refractive Index Ti3O5 Films for Dielectric Metasurfaces

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Chinese Physics Letters 2017年第8期34卷 141-143页

作者： Sohail Abdul jalil Mahreen Akram Gwanho Yoon Ayesha Khalid Dasol Lee Niloufar Raeis-Hosseini Sunae So Inki Kim Qazi Salman Ahmed Junsuk Rho Muhammad Qasim Mehmoo Department of Electrical Engineering Information Technology University of the Punjab Lahore 54000 Pakistan Department of Mechanical Engineering Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea Centre for Advanced Studies in Physics GCU Lahore 54000 Pakistan

Ti33O55 films are deposited with the help of an electron beam evaporator for their applications in metasurfaces. The film of subwavelength （632nm） thickness is deposited on a silicon substrate and annealed at 400℃. The ellipsometry result shows a high refractive index above 2.5 with the minimum absorption coefficient in the visible region, which is necessary for high efficiency of transparent metasurfaces. Atomic force microscopy analysis is employed to measure the roughness of the as-deposited films. It is seen from micrographs that the deposited films are very smooth with the minimum roughness to prevent scattering and absorption losses for metasurface devices. The absence of grains and cracks can be seen by scanning electron microscope analysis, which is favorable for electron beam lithography. Fourier transform infrared spectroscopy reveals the transmission and reflection obtained from the film deposited on glass substrates. The as-deposited film shows high transmission above 60%, which is in good agreement with metasurfaces.

关键词： High Refractive Index Ti3O5 Films for Dielectric Metasurfaces Ti

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Inhibition of human esophageal squamous cell carcinomas by targeted silencing of tumor enhancer genes: an overview

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Cancer Biology & Medicine 2014年第2期11卷 78-85页

作者： jalil Pirayesh Islamian Mohsen Mohammadi Behzad Baradaran Tabriz University of Medical Sciences School of Medicine Department of Radiation MedicineShahid Beheshti University of Medical Sciences Immunology Research Center Tabriz University of Medical Sciences

Esophageal cancer has been reported as the ninth most common malignancy and ranks as the sixth most frequent cause of death worldwide. Esophageal cancer treatment involves surgery, chemotherapy, radiation therapy, or combination therapy. Novel strategies are needed to boost the oncologic outcome. Recent advances in the molecular biology of esophageal cancer have documented the role of genetic alterations in tumorigenesis. Oncogenes serve a pivotal function in tumorigenesis. Targeted therapies are directed at the unique molecular signature of cancer cells for enhanced efficacy with low toxicity. RNA interference(RNAi) technology is a powerful tool for silencing endogenous or exogenous genes in mammalian cells. Related results have shown that targeting oncogenes with siRNAs, specifically the mRNA, effectively reduces tumor cell proliferation and induces apoptotic cell death. This article will briefly review studies on silencing tumor enhancer genes related to the induction of esophageal cancer.

关键词： Esophageal carcinoma ionizing radiation(IR) oncogene targeted therapy siRNA

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Regression of cardiovascular remodeling in hypertension:Novel relevant mechanisms

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World Journal of Hypertension 2016年第1期6卷 1-17页

作者： Jorge E jalil María P Ocaranza P Universidad Católica de Chile School of Medicine Division of Cardiovascular Diseases P Universidad Católica de Chile School of Medicine Division of Cardiovascular Diseases and Advanced Center for Chronic Diseases (ACCDiS)

Asymptomatic organ damage due to progressive kidney damage, cardiac hypertrophy and remodeling put hypertensive patients at high risk for developing heart and renal failure, myocardial infarction and stroke. Current antihypertensive treatment normalizes high blood pressure, partially reverses organ damage, and reduces the incidence of heart and renal failure. Activation of the renin-angiotensin system(RAS) is a primary mechanism of progressive organ damage and, specifically, a major cause of both renal and cardiovascular fibrosis. Currently, inhibition of the RAS system [mainly with angiotensin I converting enzyme inhibitors or angiotensin II(Ang II) receptor antagonists] is the most effective antihypertensive strategy for normalizing blood pressure and preventing target organ damage. However, residual organ damage and consequently high risk for cardiovascular events and renal failure still persist. Accordingly, in hypertension, it is relevant to develop new therapeutic perspectives, beyond reducing blood pressure to further prevent/reduce target organ damage by acting on pathways that trigger and maintain cardiovascular and renal remodeling. We review here relevant novel mechanisms of target organ damage in hypertension, their role and evidence in prevention/regression of cardiovascular remodeling and their possible clinical impact as well. Specifically, we focus on the signaling pathway Rho A/Rho kinase, on the impact of the vasodilatory peptides from the RAS and some insights on the role of estrogens and myocardial chymase in cardiovascular hypertensive remodeling.

关键词： Remodeling Hypertrophy Rho kinase Myosin phosphatase target subunit 1 Angiotensin Angiotensin1-9 Chymase Angiotensin1-7

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Effects of bismuth on structural and dielectric properties of cobalt-cadmium spinel ferrites fabricated via micro-emulsion route

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Chinese Physics B 2019年第8期28卷 408-416页

作者： Furhaj Ahmed Sheikh Muhammad Khalid Muhammad Shahzad Shifa H M Noor ul Huda Khan Asghar Sameen Aslam Ayesha Perveen jalil ur Rehman Muhammad Azhar Khan Zaheer Abbas Gilani Department of Physics Balochistan University of Information TechnologyEngineering & Management SciencesQuetta 87300Pakistan Department of Physics Government College UniversityFaisalabad 38000Pakistan Department of Physics The Islamia University of Bahawalpur 63100Pakistan

Spinel ferrites have a significant role in high-tech *** the present work nano-crystalline ferrites having general formula Co0.5Cd0.5BixFe2-xO4 with(x=0.0,0.05,0.1,0.15,0.2,and 0.25)are synthesized via micro-emulsion *** x-ray diffraction(XRD)studies discover the FCC spinel *** size is calculated in a range of 11 nm-15 *** parameter calculations are reduced due to its substitution which leads to the exchange of large ionic radius of Fe^3+for small ionic radius of Bi^3+.The x-ray density is analyzed to increase with *** transform infrared spectroscopy(FTIR)is performed to analyze absorption band *** two absorption bands are observed in a range of 400 cm^-1-600 cm^-1,and they are the characteristic feature of spinel ***-gravimetric analysis(TGA)reveals the total weight loss of nearly 1.98%.Dielectric analysis is carried out by impedance analyzer in a frequency span from 1 MHz to 3 GHz by using the Maxwell Wagner *** studies reveal the decrease of dielectric *** alternating current(AC)conductivity exhibits a plane behavior in a low frequency range and it increases with the applied frequency *** is attributed to the grain effects in a high frequency range or may be due to the reduction of *** and imaginary part of impedance show the decreasing trend which corresponds to the grain boundary *** imaginary modulus shows the occurrence of peak that helps to understand the interfacial ***-Cole graph shows a single semicircle which confirms that the conduction mechanism is due to the grain boundaries at low *** studies reveal the applicability of these ferrites in high frequency equipment,microwave applications,high storage media,and semiconductor devices.

关键词： Co-ferrite nanocrystalline ferrites XRD microemulsion dielectric properties

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Detection of ROS and translocation of ERP-57 in apoptotic induced human neuroblastoma(SH-SY5Y)cells

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BIOCELL 2019年第3期43卷 167-174页

作者： ATIF KAMIL MUBARAK ALI KHAN MUHAMMAD AASIM NADIR ZAMAN KHAN RAHAM SHER KHAN MUHSIN JAMAL WAQAR AHMAD MIR AZAM KHAN FAZAL jalil Department of Biotechnology Abdul Wali Khan University Mardan(AWKUM)Garden CampusToru RoadMardanKPKPakistan Department of Biotechnology University of Malakand(UOM)ChakdaraLower DirPakistan Department of Microbiology Abdul Wali Khan University Mardan(AWKUM)Garden CampusToru RoadMardanKPKPakistan Department of Pharmacy University of Malakand(UOM)ChakdaraLower DirPakistan

Several toxic compounds are known to induce apoptosis in mammalian cell *** human neuroblastoma cells(SHSH-SY5Y)were exposed to the phosphatase inhibiting toxin okadaic acid(OA)or hydrogen peroxide(H2O2)to induce apoptosis as well as generate reactive oxygen species(ROS).Mitoxantrone(MXT)was used as a positive control for *** SHSH-SY5Y cells were transfected with eukaryotic expression plasmid pHyPer-dMito encoding mitochondrial-targeted fluorescent or pHyPer-dCito encoding cytoplasmic-targeted fluorescent sensor for hydrogen peroxide(HyPer).The ERp57,also called GRP58(Glucose-regulated protein 58),is a stress protein induced in conditions like glucose starvation and viral *** ERp57 was shown to translocate from the endoplasmatic reticulum to the cell surface in anthracycline-induced apoptotic ***57 co-translocation together with calreticulin has been suggested to be crucial for recognizing tumor cells to induce immunogenic cell ***57 translocation after exposure to okadaic acid was studied using immunofluorescence and confocal *** studies indicated that okadaic acid has induced the translocation of ERp57 to the cellular membrane.

关键词： Apoptosis Cytoplasm Endoplasmic recticulum(ER) ERP-57 Human neuroblastoma cell(SHSH-SY5Y) Immunofluorescence Mitochondria Reactive oxygen species(ROS) Transfection

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