Vitamin A supplementation downregulates ADH1C and ALDH1A1 mRNA expression in weaned beef calves

作     者：Xue Cheng Jin Dong Qiao Peng Seong Jin Kim Na Yeon Kim Jalil Ghassemi Nejad Danil Kim Stephen B.Smith Hong Gu Lee Xue Cheng Jin;Dong Qiao Peng;Seong Jin Kim;Na Yeon Kim;Jalil Ghassemi Nejad;Danil Kim;Stephen B.Smith;Hong Gu Lee

作者机构：Department of Animal Science and TechnologySanghvi College of Life SciencesKonkuk UniversitySeoul 05029Republic of Korea Asia Pacific Ruminant InstituteIcheon 17385Republic of Korea Farm Animal Clinical Training and Research CenterInstitute of Green-Bio Science and TechnologySeoul National UniversityPyeongchang 25354Republic of Korea Department of Animal ScienceTexas A&M UniversityCollege StationTX 77843USA 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2022年第10卷第3期

页      面：372-381页

核心收录：

学科分类：0710[理学-生物学] 090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 0906[农学-兽医学] 09[农学] 

基　　金：the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(2020R1A2B5B02001843) 

主　　题：Vitamin A ADH1C genotype Muscle development Korean native calves 

摘      要：Our previous studies demonstrated that oral vitamin A supplementation during late-stage pregnancy and the neonatal stage enhances birth weight,growth performance,and mRNA expression related to muscle and preadipocyte development in beef *** alcohol dehydrogenase 1C(ADH1C)c.-64TC genotype also correlated with vitamin A concentration in beef *** study aimed to investigate the effects of vitamin A supplementation on the muscle development and vitamin A metabolism in weaned beef calves with different ADH1C *** male calves(90 d of age;initial BW:89.03 kg[SD 8.60])were stratified according to ADH1C genotype and vitamin A treatment(duration:3 months)and randomly assigned to 4 groups with a 2
2 factorial *** A treatments included the following:control(10,000 IU/kg of as-fed,*** type;*** type);treatment(40,000 IU/kg of as-fed,*** type;and *** type).Parameters including BW,FI,blood,longissimus dorsi muscle,and liver status during the experimental period were analyzed using the generalized linear model(GLM)procedure and Tukey s test by SAS 9.4 *** vitamin A was significantly increased(P0.05)in the vitamin A treatment group at 4 and 6 months of *** type calves showed higher serum vitamin A concentration(P0.05)than the TC type *** triglyceride and non-esterified fatty acid(NEFA)levels increased(P0.05)in the treatment group compared with the control at 6 months of ***,BW,ADG and FI showed no differences between the *** addition,mRNA expression in longissimus dorsi muscle revealed upregulation of paired box 7(PAX7)(P0.05)after the vitamin A treatment period based on biopsy *** ADH1C and aldehyde dehydrogenase(ALDH)1A1 mRNA expression was downregulated(P0.01)by vitamin A *** TC type of ADH1C showed higher mRNA expression than the TT ***,no effect was observed on adipogenic mRNA expression(preadipocyte factor-1[PREF-1],peroxisome proliferator-activated rece