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Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus

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Neural Regeneration Research 2015年第6期10卷 944-950页

作者： Eun Joo Bae Bai Hui Chen Bing Chun Yan Bich Na Shin Jeong Hwi cho In Hye Kim Ji Hyeon Ahn Jae Chul Lee Hyun-Jin Tae Seongkweon Hong Dong Won Kim Jun Hwi cho Yun Lyul Lee Moo-Ho Won Joon Ha Park Department of Pediatrics Chuncheon Sacred Heart HospitalCollege of MedicineHallym University Department of Physiology College of MedicineInstitute of Neurodegeneration and NeuroregenerationHallym University Institute of Integrative Traditional & Western Medicine Medical CollegeYangzhou University Department of Neurobiology School of MedicineKangwon National University Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Department of Surgery School of MedicineKangwon National University Department of Emergency Medicine Chuncheon Sacred Heart HospitalCollege of MedicineHallym University Department of Emergency Medicine School of MedicineKangwon National University

The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet. In this study, we first compared ischemia-induced effects on p63 expression in the hippocampal regions （CA1-3） between the young and adult gerbils subjected to 5 minutes of transient global cerebral ischemia. Neuronal death in the hippocampal CA1 region of young gerbils was significantly slow compared with that in the adult gerbils after transient global cerebral ischemia, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons in the sham-operated young group was significantly low compared with that in the sham-operated adult group, p63 immunoreactivity was apparently changed in ischemic hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. In the ischemia-operated adult groups, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons was significantly decreased at 4 days post-ischemia; however, p63 immunoreactivity in the ischemia-operated young group was significantly higher than that in the ischemia-operated adult group. At 7 days post-ischemia, p63 immunoreactivity was decreased in the hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. Change patterns of p63 level in the hippocampal CA1 region of adult and young gerbils after ischemic damage were similar to those observed in the immunohistochemical results. These findings indicate that higher and longer-term expression of p63 in the hippocampal CA1 region of the young gerbils after ischemia/reperfusion may be related to more delayed neuronal death compared to that in the adults.

关键词： p53 tumor suppressor gene family cerebral ischemia/reperfusion pyramidal neurons CA1 region delayed neuronal death immunohistochemistry western blotting neural regeneration

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边行驶边充电

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科技纵览 2013年第4期 44-49页

作者： Seung young Ahn Nam Pyo Suh Dong-Ho cho

如果电动汽车能边行驶边充电，很难估计他们能走多远。想象一下纯电动车在高速路上行驶的场景，噪音小，无污染。这显然是一个巨大的进步，那么大家会问，为什么只有极少数纯电动车投放到大众市场呢？一个重要的原因是：设想开这辆车的... 详细信息

如果电动汽车能边行驶边充电，很难估计他们能走多远。想象一下纯电动车在高速路上行驶的场景，噪音小，无污染。这显然是一个巨大的进步，那么大家会问，为什么只有极少数纯电动车投放到大众市场呢？一个重要的原因是：设想开这辆车的人接到一个住得很远的亲戚打来的电话，称急需帮助。突然，司机注意到仪表盘上最重要的指标：剩余电量的预估续航里程。剩余的电量能支撑到亲戚家吗？即使能，能找到充电站充足电回家吗？

关键词：充电站行驶剩余电量纯电动车电动汽车高速路无污染仪表盘

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Risk factors for hepatocellular carcinoma in patients with drug-resistant chronic hepatitis B

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World Journal of Gastroenterology 2013年第40期19卷 6834-6841页

作者： Chung Hwan Jun Hyoung Ju Hong Min Woo Chung Seon young Park Sung Bum cho Chang Hwan Park young Eun Joo Hyun Soo Kim Sung Kyu choi Jong Sun Rew Department of Internal Medicine Chonnam National University Medical SchoolGwangju 501-757South Korea

AIM:To investigate the risk factors and characteristics of hepatocellular carcinoma(HCC) in the patients with drug-resistant chronic hepatitis B(CHB).METHODS:A total of 432 patients with drug-resistant CHB were analyzed retrospectively from January 2004to December 2012. The patients were divided into two groups:the HCC group(n = 57) and the non-HCC group(n = 375). Two groups compared using logistic regression for various patients and viral characteristics in order to identify associated risk factors for ***,patient and tumor characteristics of HCC patients with na ve CHB(N group,n = 117) were compared to the HCC group(R group,n = 57) to identify any difference in HCC characteristics between ***:A significant difference was found for age,platelet count,alpha-fetoprotein(AFP),positivity of HBeAg,seroconversion rate of HBeAg,virologic response,the Child-Pugh score,presence of rtM204I,and the duration of antiviral treatment in non-HCC and HCC group. Cirrhosis,age(> 50 years),HBeAg(+),virologic non-responder status,and rtM204I mutants were independent risk factors for the development of HCC. The R group had lower serum C-reactive protein(CRP) and AFP levels,earlier stage tumors,and a shorter mean tumor surveillance period than the N group. However,the total follow-up duration was not significantly different between the two ***:13.2% of patients with drug-resistant CHB developed HCC. Age,cirrhosis,YIDD status,HBeAg status,and virologic response are associated with risk of HCC. Patients with drug-resistant CHB and these clinical factors may benefit from closer HCC surveillance.

关键词： Carcinoma Hepatocellular Hepatitis B Drug resistance Risk factors Characteristics

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聚丙烯酸盐的助洗性能研究

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日用化学工业 2002年第3期32卷 8-11,33页

作者：夏咏梅吕拴锁 cho Heon-young 蒋玲华方云刘晓亚 Suh Jung-mok 江南大学化工学院江苏无锡214036 公州国立大学工学院化工系

研究了聚丙烯酸盐 (PAA)及其改性聚合物 (马来酸酐 -丙烯酸甲酯 -丙烯酸的三元共聚物 )的组成、结构及相对分子质量对钙束缚力、分散力、絮凝性的影响。以两种商品PAA为参照 ,通过正交实验筛选出了无磷洗衣粉的最佳配方。实验结果表明 ,... 详细信息

研究了聚丙烯酸盐 (PAA)及其改性聚合物 (马来酸酐 -丙烯酸甲酯 -丙烯酸的三元共聚物 )的组成、结构及相对分子质量对钙束缚力、分散力、絮凝性的影响。以两种商品PAA为参照 ,通过正交实验筛选出了无磷洗衣粉的最佳配方。实验结果表明 ,Ca2 + 束缚值随着聚合物相对分子质量的增加而增大 ,共聚物中单体组成对Ca2 + 束缚值影响不大。以聚合物与CaCl2 的螯合物的沉淀量表征其絮凝性 ,发现聚合物加入量和Ca2 + 总量相同时 ,沉淀量随着聚合物相对分子质量的增大而增大。饱和沉淀量只与CaV有关而与聚合物类型无关 ,达到饱和沉淀量时所对应的聚合物加入量也近似正比与相应聚合物的CaV。实验条件下PAA对碳黑的分散力均优于STPP ,均聚PAA对碳黑的分散力随相对分子质量增大而下降 ,改性PAA且随相对分子质量的增大其分散力仅略有下降。

关键词：聚丙烯酸盐助洗性能研究洗涤剂助剂配方

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早产儿脑室周围白质软化与低碳酸血症的关系

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中华围产医学杂志 2003年第6期6卷 329-332页

作者：吴本清 young-You Ch oi Chang-Yee cho 暨南大学第二附属医院(深圳市人民医院)新生儿科深圳518020 Department of neonatology Chonnam University Hospital

目的　探讨早产儿脑室周围白质软化 (PVL)与机械通气下低碳酸血症的关系。　方法　对合并PVL和未合并PVL的胎龄 2 6～ 3 2周早产儿各 2 5例 ,进行对照研究。对生后前 3d机械通气参数和血气指标进行比较。　结果　两组生后前 3d机械通气... 详细信息

目的　探讨早产儿脑室周围白质软化 (PVL)与机械通气下低碳酸血症的关系。　方法　对合并PVL和未合并PVL的胎龄 2 6～ 3 2周早产儿各 2 5例 ,进行对照研究。对生后前 3d机械通气参数和血气指标进行比较。　结果　两组生后前 3d机械通气参数吸气峰压、呼气末正压、平均气道压、呼吸频率差异均无显著性。PVL组和对照组低氧血症的持续时间分别为 (3 .7± 1.1)和(4.1± 1.3 )h ,两组差异无显著性 (P >0 .0 5)。PVL组和对照组生后 72h最低PaCO2 分别为 (2 3 0±1.2 )mmHg (1mmHg =0 .13 3kPa)和 (3 1 0± 7.6)mmHg ;低碳酸血症的持续时间分别为 (2 6.3±7.8)和 (1.7± 0 .4)h ;两组差异有非常显著性 (P <0 .0 1)。最低PaCO2 ≤ 2 5mmHg时 ,病例对照研究的比值比 (OR)为 16.6(95% ,可信限为 4.1～ 67.4,P <0 .0 1)。　结论　机械通气下的低碳酸血症与早产儿PVL密切相关。生后 72h内PaCO2 低于 2 5mmHg 。

关键词：早产儿脑室周围白质软化低碳酸血症机械通气合并症

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Growth-inhibitory effect of neurotrophin-3-secreting adipose tissue-derived mesenchymal stem cells on the D283-MED human medulloblastoma cell line

Growth-inhibitory effect of neurotrophin-3-secreting adipose...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Chae-Yong Kim young-Hoon Kim Seung Hee cho Soo Jung Lee Seung Ah choi Ji Hoon Phi Seung-Ki Kim Kyu-Chang Wang Byung-Kyu cho Department of Neurosurgery Seoul National University College of Medicine Department of Neurosurgery Seoul National University Bundang Hospital Division of Pediatric Neurosurgery Seoul National University Children's Hospital

Medulloblastoma（MBL）,the most common malignant pediatric brain tumor,is incurable in about one-third of patients and can lead to long-term disabilities despite current multimodal *** purpose of this study was to demonstrate in vitro biological effects of neurotrophins-3（NT-3） on MBL cells and to evaluate the growth-inhibitory effect of neurotrophin-3（NT-3）-secreting stem cells on tumor *** confirmed by western blotting that D283-MED cells express tyrosine kinase C,a specific receptor for *** the biological effects of NT-3 on MBL cells,we evaluated autophagy,apoptosis,senescence,and differentiation of tumor cells with *** NT-3 induced a concentrationdependent increase in apoptosis in the tumor cell line（P ＜ 0.001）.The high concentrations of NT-3 increased the expression of class III β-tubulin（P ＜ 0.001） and decreased the expression of Nestin（P ＜ 0.05）.NT-3-secreting stem cells were produced by nucleofecting ***-NT3 into human adipose tissue-derived mesenchymal stem cells（hAT-MSCs） and were confirmed by fluorescence microscopy and ***-layered co-culture experiments with the NT-3-secreting hAT-MSCs and D283-MED MBL cells were performed,and NT-3-induced cell death was studied by 3-（4,5-dimethylathiazol-2-yl）-2,5-dephenyltetrazolium bromide（MTT） ***,the high concentrations of NT-3-secreting hAT-MSCs significantly（P ＜ 0.05） increased the death of D283-MED cells in *** present study demonstrated that both apoptotic cell death and neuronal differentiation of tumor cells were the mechanisms of growth-inhibitory effect of NT-3-secreting hAT-MSCs on MBL cell line.

关键词： neurotrophin-3 adipose tissue-derived mesenchymal stem cell medulloblastoma apoptosis differentiation

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Unilateral pulmonary hemorrhage caused by negative pressure pulmonary edema:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1408-1415页

作者： Hyung Joon Park Seung Ho Park Un Tak Woo Sang Yun cho Woo Jae Jeon Woo Jong Shin Department of Anesthesia and Pain Medicine Hanyang UniversityGuri HospitalGuri 11923Gyeonggi-doSouth Korea

BACKGROUND Unilateral pulmonary hemorrhage is typically reported in young and healthy men with upper respiratory tract obstruction during anesthesia in special *** pressure in the lungs is created,resulting in negative pressure pulmonary edema(NPPE).CASE SUMMARY A 78-year-old male patient diagnosed with spinal stenosis was admitted to receive a unilateral laminectomy with bilateral *** patient had been diagnosed with hypertension four years earlier and asthma more than 70 years *** experienced a unilateral alveolar hemorrhage associated with NPPE that occurred in a longstanding asthma patient who bit the intubated endotracheal tube for a short period during posture change at the end of *** diffuse alveolar hemorrhage accompanied by NPPE was caused in this case by airway obstruction in an older patient with asthma without known risk factors,anesthesiologists should be careful not to induce airway irritation during anesthesia awakening in asthma *** Because diffuse alveolar hemorrhage accompanied by NPPE can occur,anesthesiologists should take care not to induce airway irritation.

关键词： Airway Anesthesia Asthma Hemorrhage Pulmonary edema Case report Surgery

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In vitro Cyto and Blood Compatibility of Titanium Containing Diamond-Like Carbon Prepared by Hybrid Sputtering Method

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Plasma Science and Technology 2012年第9期14卷 829-836页

作者： Krishnasamy NAVANEETHA PANDIYARAJ Jan HEEG Andreas LAMPKA Fabian JUNGE Torsten BARFELS Marion WIENECKE young Ha RHEE Hyoung Woo KIM Department of Physics Sri Shakthi Institute of Engineering and Technology Institute of Surface and Thin Film Technology Hochschule WismarGermany Department of Microbiology College of Bioscience&BiotechnologyChungnam National University

In recent years, diamond-like carbon films （DLC） have been given more attention in research in the biomedical industry due to their potential application as surface coating on biomedical materials such as metals and polymer substrates. There are many ways to prepare metal containing DLC films deposited on polymeric film substrates, such as coatings from car- bonaceous precursors and some means that incorporate other elements. In this study, we in- vestigated both the surface and biocompatible properties of titanium containing DLC （Ti-DLC） films. The Ti-DLC films were prepared on the surface of poly （ethylene terephthalate）（PET） film as a function of the deposition power level using reactive sputtering technique. The films＇ hydrophilicity was studied by contact angle and surface energy tests. Their surface morphology was studied by scanning electron microscopy （SEM） and atomic force microscopy （AFM）. Their elemental chemical composition was analyzed using energy dispersive X-spectra （EDX） and X-ray photoelectron spectroscopy （XPS）. Their blood and cell compatibility was studied by in vitro tests, including tests on platelet adhesion, thrombus formation, whole blood clotting time and osteoblast cell compatibility. Significant changes in the morphological and chemical composition of the Ti-DLC films were observed and found to be a function of the deposition level. These morphological and chemical changes reduced the interfacial tension between Ti-DLC and blood proteins as well as resisted the adhesion and activation of platelets on the surface of the Ti-DLC films. The cell compatibility results exhibited significant growth of osteoblast cells on the surface of Ti incorporated DLC film compared with that of DLC film surface.

关键词： Ti-DLC hybrid reactive sputtering technique surface analysis cyto and blood compatibility

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Formation of Stable Lamellar Gel Structure Containing Pseudoceramide and Its Evaluation of Barrier Recovery Function

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China Detergent & Cosmetics 2017年第2期2卷 42-48页

作者： Dong-Hyuk Jang Kyungmi Joo Sung-II Park June Whan Park Eunjoo Kim younguk cho Byung-young Kang Fan Bo Jongsuk Lee Aeho Yeon Amorepacific Co.R&D Center Amorepacific (Shanghai) R&I Center Co. Ltd.

We formulated new skin care cosmetics with lamella structure in which high amount of pseudo-ceramides were incorporated. Consistency of this lamellar gel creams were checked for 1 month on various temperatures and for 1 year on RT. Generally, multi-lamellar emulsion shows typical Maltese cross on polarized microscope, but Maltese cross was not found in case of these creams; Multi-lamellar structure of the creams could be identifed by small-angle X-ray scattering （SAXS）. To evaluate skin barrier recovery function, we applied one of this creams and a vehicle cream to forearm skin which is tape-stripped to remove barrier layer to see if they infuence mass of molecules related to barrier function. 96 h after application, we found that this lamellar gel cream promoted synthesis of ceramides, amino acids and NMFs, thereby enhanced barrier recovery function.

关键词： pseudoceramide lamellar gel structure skin barrier

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Clinical significance and risk factors of postembolization fever in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第2期19卷 284-289页

作者： Chung Hwan Jun Ho Seok Ki Hoon Ki Lee Kang Jin Park Seon young Park Sung Bum cho Chang Hwan Park young Eun Joo Hyun Soo Kim Sung Kyu choi Jong Sun Rew Division of Gastroenterology Department of Internal MedicineChonnam National University Medical SchoolGwangju 501-757South Korea

AIM:To investigate tumor response and survival in patients with postembolization fever(PEF) and to determine the risk factors for ***:Four hundred forty-three hepatocellular carcinoma(HCC) patients who underwent the first session of transcatheter arterial chemoembolization(TACE) between January 2005 and December 2009 were analyzed *** was defined as a body temperature greater than 38.0 ℃ that developed within 3 d of TACE without evidence of *** tumor progression-free interval was defined as the interval from the first TACE to the second TACE based on mRECIST *** staging was based on the American Joint Committee on Cancer tumor,node,metastases(TNM) classification of malignant *** patients were admitted before their 1 st TACE treatment,and blood samples were obtained from all patients before and after *** variables and host-related variables were compared between two groups:patients with PEF vs patients without ***,variables related to 20-mo mortality and tumor progression-free survival were ***:The study population comprised 370(85.4%) men and 73(14.6%) women with a mean age of 62.29 ± 10.35 years.A total of 1836 TACE sessions were conducted in 443 patients,and each patient received between 1 and 27(mean:4.14 ± 3.57) TACE *** mean follow-up duration was 22.23 ± 19.6 mo(range:0-81 mo).PEF developed in 117 patients(26.41%) at the time of the first TACE *** was not associated with 20-mo survival(P = 0.524) or computed tomography(CT) response(P = 0.413) in a univariate analysis.A univariate analysis further indicated that diffuse-type HCC(P = 0.021),large tumor size(≥ 5 cm)(P = 0.046),lipiodol dose(≥ 7 mL,P = 0.001),poor blood glucose control(P = 0.034),alanine aminotransferase(ALT) value after TACE(P = 0.004) and C-reactive protein(CRP) value after TACE(P = 0.036) served as possible risk factors correlated with *** ALT value after TACE(P = 0.02

关键词： Chemoembolization Therapeutic Fever Carcinoma Hepatocellular Prognosis Progression-free survival

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