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World Journal of Gastroenterology 2005年第6期11卷 810-816页

作者： jae-sung bae Kwang-Ho Jang Hee-Kyung Jin Department of Surgery Department of Laboratory Animal Medicine

AIM: To assess the adhesion- and abscess-reducing capacities of various concentrations of polysaccharides derived from fungus, Phellinus gilvus (PG) or Phellinus linteus (PL) in a rat peritonitis ***: In 96 SD rats, experimental peritonitis was induced using the cecal ligation and puncture model (CLP).Rats were randomly assigned to 8 groups; Ringer's lactate solution (RL group), hyaluronic acid (HA group), 0.025%,0.25%, and 0.5% polysaccharides from PG (PG0.025, 0.25,and 0.5 groups), and PL (PL0.025, 0.25, and 0.5 groups).Adhesions and abscesses were noted at 7 d after ***-PCR assay was performed to assess the cecal ***: Adhesion formation was significantly reduced in PG0.25, 0.5, PL0.25, 0.5, and HA groups (2.5±0.7,2.4±0.7, 3.8±1.0, 3.6±0.8, and 2.7±1.1, P＜0.05). The incidence of abscesses was significantly reduced in all treated groups compared to RL group (58%, P＜0.05). The urokinase-type plasminogen activator (uPA) gene expression was greatly up-regulated by increasing the concentration of polysaccharides. The urokinase-type plasminogen activator receptor (uPAR) and tumor necrosis factor (TNF)-α mRNA were highly expressed in PG0.25, 0.5, PL0.25, and ***: We concluded that 0.5% polysaccharide derived from PG and PL was the optimal concentration in preventing adhesion and abscess formation and may act by modulating activity of uPA and TNF-α in a rat peritonitis model.

关键词： Adhesion Abscess Phellinus gilvus, Phellinus linteus Polysaccharides

Multi-faceted small molecule for Alzheimer’s disease

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Neural Regeneration Research 2023年第10期18卷 2198-2199页

作者： Min Hee Park Hee Kyung Jin jae-sung bae KNU Alzheimer’s Disease Research Institute Department of PhysiologySchool of MedicineKyungpook National UniversityDaeguSouth Korea KNU Alzheimer’s Disease Research Institute Department of Laboratory Animal MedicineCollege of Veterinary MedicineKyungpook National UniversityDaeguSouth Korea

The main pathologies of Alzheimer’s disease(AD)are the accumulation of amyloid-B(AB)and tau ta ngles,and these two fundamental pathologies accompany the va rious neuropathological features,such as neuroinfla mmation,... 详细信息

关键词： Alzheimer tau amyloid

Inhibitory effects of polysaccharides isolated from Phellinus gilvus on benzo(a)pyrene-induced forestomach carcinogenesis in mice

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World Journal of Gastroenterology 2005年第4期11卷 577-579页

作者： jae-sung bae Kwang-Ho Jang Hyunee Yim Seung-Chun Park Hee-Kyung Jin College of Veterinary Medicine Kyungpook National University Daegu 702-701 Republic of Korea Department of Pathology Ajou University School of Medicine Suwon Republic of Korea

AIM: Although polysaccharides from Phellinus mushrooms are a well-known material with anti-tumor properties, there is no information about the effect of polysaccharides from Phellinus gilvus (PG) on tumor. The modulating effect of polysaccharides isolated from PG on the benzo(a)pyrene (BaP)-induced forestomach carcinogenesis in ICR female mice was investigated in this ***: A forestomach carcinogenesis model was established in 40 ICR female mice receiving oral administration of BaP for 4 wk. The mice were randomly assigned to 4 groups (10 each). The mice in each group were treated with sterile water or PG for 4 and 8 wk (SW4,PGW4, SW8, and PGW8 groups). Eight or 12 wk after the first dose of BaP, forestomachs were removed for histopathological and RT-PCR ***: In histopathological changes and RT-PCR analysis, sterile water-treated mice showed significant hyperplasia of the gastric mucosa with a significantly increased expression of mutant p53 mRNA compared to mice treated with PG for 8 ***: Polysaccharides isolated from PG may inhibit BaP-induced forestomach carcinogenesis in mice bydown-regulating mutant p53 expression.

关键词： Forestomach carcinogenesis Phellinus gilvus Polysaccharides p53 Gene

Bone marrow stem cells ameliorate brain pathology and rescue memory deficits in Alzheimer's disease mice by modulation of immune responses

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Bone marrow stem cells ameliorate brain pathology and rescue...

Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

第十届中国实验动物科学年会

作者： Jong Kil Lee Hee Kyung Jin jae-sung bae

Objective Alzheimer’s disease(AD) is the most common form of *** increased life expectancy, this number is expected torise in the *** is characterized by progressive memorydeficits,cognitive impairment,and personalitychanges associated with the degeneration of multiple neuronal types andpathologically by the presence of neuritic plaques and neurofibrillary *** of bone marrow stem cells(BMSCs) has been suggested as a potential therapeutic approach to preventneurodegenerativediseases including ***,the actual therapeutic impact of BMSCs and their mechanism of action in AD have not yet been *** aim of this study was therefore to examine the effects of BMSCs therapy in *** one strategy of BMSC therapy is pharmacological-induced recruitment of endogenous BMSCs into an injured site by systemic administration of growth factors or *** examine the effects of endogenous BMSC therapy,we injected granulocyte colony stimulating factor(G-CSF)/AMD3100(CXCR4 antagonist) and stromal cell-derived factor- 1α(SDF-1α) on endogenous BM-hematopoietic progenitor cell(BM-HPC)recruitment into the brain of an AD mouse *** mobilize BM-HPCs,G-CSF was injected intraperitoneally,and boosted by ***, these micereceived an intracerebral injection with SDF-1αto induce migrationof mobilized BM-HPCs into *** found that the memory deficit in the AD micewas significantly improved by these treatments,butamyloidβ(Aβ) deposition was ***,microglial activation was increased with alternative activation of microglia to a neuroprotective ***,by generating anAPP/PS1-GFP chimeric mouse we ascertained that the GFP positive microglia identified in the brain were ***,increased hippocampal neurogenesis and improved memory was observed in mice receivingcombined G-CSF/AMD3100 and SDF-la,but not in controls or animals receiving each treatment *** results suggest

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo Park Jong-Seong bae Taehyun Park Il Tae Kim jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Artificial layer Dielectric constant Zn metal anode Zinc aqueous battery

Effects of Al addition on microstructure and mechanical properties of extruded Mg-3Bi alloy

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Journal of Magnesium and Alloys 2022年第7期10卷 1887-1898页

作者： Sang-Cheol Jin jae Won Cha Jun Ho bae Hui Yu sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

Effects of Al addition to a Mg±Bi binary alloy on its microstructural characteristics and tensile properties after extrusion are investigated via extrusion of Mg-3Bi±x Al(x=0,1,and 2 wt%)billets and analysis of the extruded *** Al addition negligibly affects the second-phase particles of the extruded alloy;however,an increase in the Al content causes significant decreases in the average grain size and maximum texture intensity of the extruded material owing to an increase in the area fraction of dynamically recrystallized(DRXed)*** Al addition improves the strength of the extruded alloy;this improvement is attributed to the enhanced grain-boundary hardening and solid-solution hardening effects induced by grain refinement and Al solute atoms,*** the Al content increases from 0 wt%to 1 wt%and 2 wt%,the tensile elongation increases substantially from 2.8%to 9.4%and 16.9%,*** reduction in the number and size of un DRXed grains with increasing Al content suppresses the formation and coalescence of cracks in the un DRXed grains during tension,which results in a significant improvement in the tensile ductility of the extruded *** tensile deformation,large undesirable twins that act as crack initiation sites are locally formed in the un DRXed grains of the Mg-3Bi alloy,whereas relatively smaller twins are uniformly formed in both the DRXed and the un DRXed grains of the Mg-3Bi-2Al ***,the extruded Mg-3Bi-2Al alloy has a substantially higher tensile yield strength±elongation product(2924 MPa%)than the extruded Al-free B3 alloy(381 MPa%).

关键词： Mg-Bi-Al alloy Extrusion Microstructure Strength Ductility

Comparative study of extrudability, microstructure, and mechanical properties of AZ80 and BA53 alloys

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Journal of Magnesium and Alloys 2023年第1期11卷 249-258页

作者： Sang-Cheol Jin jae Won Cha Jongbin Go Jun Ho bae sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Kyoto UniversityKyoto 606-8501Japan Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

The extrudability,microstructural characteristics,and tensile properties of the Mg–5Bi–3Al(BA53)alloy are investigated herein by comparing them with those of a commercial Mg–8Al–0.5 Zn(AZ80)*** AZ80 is extruded at 400℃,severe hot cracking occurs at exit speeds of 4.5 m/min or *** contrast,BA53 is successfully extruded without any surface cracking at 400℃ and at high exit speeds of 21–40 m/*** extruded at 3 m/min(AZ80–3)and 40 m/min(BA53–40),both AZ80 and BA53 exhibited completely recrystallized microstructures with abasal ***,BA53–40 has a coarser grain structure owing to grain growth promoted by the high temperature in the deformation ***80–3 contains a continuous network of Mg_(17)Al_(12) particles along the grain boundaries,which form via static precipitation during natural air-cooling after the material exits the extrusion ***53–40 contains coarse Mg_(3)Bi_(2) particles aligned parallel to the extrusion direction along with numerous uniformly distributed fine Mg_(3)Bi_(2) ***80–3 has higher tensile strength than BA53–40 because the relatively finer grains and larger number of solute atoms in AZ80–3 result in stronger grain-boundary and solid-solution hardening effects,*** BA53 is extruded at a high temperature and extrusion speed of 400℃ and 40 m/min,respectively,the extruded material has a high tensile yield strength of 188 *** can be primarily attributed to the large particle hardening effect resulting from the numerous fine Mg_(3)Bi_(2) particles.

关键词： Mg-Bi-Al alloy Extrusion Hot cracking Second phase Tensile properties

Impact of uneven distribution of grain characteristics on yield strength and martensitic transformation of as-hot-rolled medium-entropy alloys

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Journal of Materials Science & Technology 2024年第10期177卷 234-245页

作者： Jungwan Lee Hyojin Park Sujung Son jae Wung bae Jin You Kim sung Kyu Kim jae-il Jang Hyoung Seop Kim Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Metallurgical Engineering Pukyong National UniversityBusan 48513Republic of Korea Technical Research Laboratories Energy and Shipbuilding Steel Research GroupPOSCOPohangRepublic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Graduate Institute of Ferrous&Eco Materials Technology(GIFT) Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Center for Heterogenic Metal Additive Manufacturing Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan

As-hot-rolled medium-entropy alloys(MEAs)with unevenly distributed grain sizes of face-centered cubic grains exhibit better yield strength without uniform elongation loss compared to cold-rolled and an-nealed *** operation of dynamic recrystallization(DRX)during several hot rolling passes leads to a wide range of grain sizes from submicrons to tens of micrometers due to the grain growth after nucleation:early recrystallized grains are coarser than recently recrystallized *** only the grain size but internal dislocation density of the recently recrystallized grain is *** the tensile deformation of the hot-rolled MEAs at-196 ℃,dislocation pile-ups in the relatively soft and fine DRX grains enhance yield stress and hetero-deformation-induced strain *** to the enhanced yield stress of the as-hot-rolled MEAs,stress-induced martensitic transformation easily ***,partially DRXed MEAs hot-rolled at 800 ℃ have lower yield stress than fully DRXed ones,hot-rolled at 900 and 1000 ℃.This is attributed to the softening effect of the stress-induced body-centered cubic martensitic transformation in unrecrystallized coarse grains prior to the yielding,which lowers the yield stress of the partially DRXed *** yielding,the martensitic transformation facilitates strain hard-ening and early necking is *** study presents a fresh outlook on the uneven distribution of grain sizes by hot rolling beneficial to mechanical responses of uniform elongation of~45%despite the as-rolled states with an advantage of simplified thermo-mechanical processes.

关键词： Dynamic recrystallization Nucleation and growth Heterogeneity Grain size distribution Deformation-induced martensitic transformation

On the stacking fault forming probability and stacking fault energy in carbon-doped 17 at%Mn steels via transmission electron microscopy and atom probe tomography

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Journal of Materials Science & Technology 2022年第20期115卷 177-188页

作者： Hyo Ju bae Kwang Kyu Ko Muhammad Ishtiaq Jung Gi Kim Hyokyung sung jae Bok Seol Department of Materials Engineering and Convergence Technology Center for K-metalGyeongsang National University(GNU)Jinju 52828South Korea

Assessing the stacking fault forming probability(P_(sf)) and stacking fault energy(SFE)in medium-or highMn base structural materials can anticipate and elucidate the microstructural evolution before and after ***,these two parameters have been determined from theoretical calculations and empirical ***,the estimation of SFE values in Fe–Mn–C ternary systems is a longstanding debate due to the complicated nature of carbon:that is,whether the carbon doping indeed plays an important role in the formation of stacking faults;and how the amount of carbon atoms exist at grain boundaries or at internal grains with respect to the nominal carbon doping ***,the use of atom probe tomography and transmission electron microscopy(TEM)unveils the influence of carbondoping contents on the structural properties of dual-phase Fe–17 Mn–x C(x=0–1.56 at%)steels,such as carbon segregation free energy at grain boundaries,carbon concentration in grain interior,interplanar D-spacings,and mean width of intrinsic stacking faults,which are essential for SFE *** next determined the Psfvalues by two different methods,viz.,reciprocal-space electron diffraction measurements and stacking fault width measurements in real-space TEM ***,SFEs in the Fe–17 Mn–x C systems were calculated on the basis of the generally-known SFE *** found that the high amount of carbon doping gives rise to the increased SFE from 8.6 to 13.5 m J/m^(2)with non-linear *** SFE trend varies inversely with the mean width of localized stacking faults,which pass through both other stacking faults and pre-existingε-martensite plates without much difficulty at their intersecting *** high amount of carbon doping acts twofold,through increasing the segregation free energy(due to more carbon at grain boundaries)and large lattice expansion(due to increased soluble carbon at internal grains).The experimental data obtained here strengthens the composition-

关键词： Stacking fault formation probability Stacking fault energy High-Mn steel Electron diffraction

Simulation of water entry of an elastic wedge using the FDS scheme and HCIB method

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Journal of Hydrodynamics 2013年第3期25卷 450-458页

作者： SHIN Sangmook bae sung Yong Department of Naval Architecture and Marine Systems Engineering Pukyong National University Busan608-737 Korea

The hydroelasticity of water entry of an elastic wedge is simulated using a code developed using the flux-difference splitting scheme for immiscible and incompressible fluids and the hybrid Cartesian/immersed boundary method. The free surface is regarded as a moving contact discontinuity and is captured without any additional treatment along the interface. Immersed boundary nodes are distributed inside a fluid domain based on the edges that cross an instantaneous body boundary. Dependent variables are reconstructed at each immersed boundary node with the help of an interpolation along a local normal line for providing a boundary condition for a discretized flow problem. A dynamic beam equation is used for modeling the elastic deformation of a wedge. The developed code is validated through comparisons with other experimental and computational results for a free-falling wedge. The effects of the elastic deformation of the wedge on the pressure fields and time histories of the impact force are investigated in relation to the stiffness and density of the structure. Grid independence test is carried out for the computed time history of the force acting on an elastic wedge.

关键词： hydroelasticity free surface capturing non-boundary conforming method dynamic beam equation free falling impactforce