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Unilateral versus bilateral Y-type stent-in-stent metal stent insertions in inoperable malignant hilar biliary strictures:A multicenter retrospective study

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 561-567页

作者： Ik hyun Jo Chang-Nyol Paik Dae Bum Kim jaesin Lee Jong Yul Lee jae Hyuck Chang Kyu-hyun Paik Won-Suk park Department of Internal Medicine College of MedicineSt.Vincent’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineIncheon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineBucheon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineDaejeon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea

Background:To date,there is controversy regarding unilateral versus bilateral stent placement in patients with malignant hilar biliary strictures(MHBSs).The aim of this study was to compare the clinical outcomes and complications of unilateral and bilateral(stent-in-stent method)stent placements for these ***:We conducted a multicenter retrospective analysis of patients with inoperable MHBS who underwent endoscopic self-expandable metal stent(SEMS)placement from January 2009 to December *** groups classified according to the stent procedure method were compared for demographic,procedural,and postprocedure *** analysis for patency loss and overall survival was also ***:A total of 236 subjects were included.A superior technical success rate was found in the unilateral stent group(98.8%vs.82.5%,P<0.001),whereas the clinical success rate was higher in the bilateral group(85.7%vs.70.5%,P=0.028).There was no significant difference with respect to complications or patency loss,and the bilateral group had better overall survival(P<0.01).In the Cox proportional hazard model,MHBSs from lymph node compression were associated with a higher risk of death(HR=9.803,P=0.003).In contrast,bilateral SEMS insertion showed reduced postprocedural mortality(HR=0.316,P=0.001).Conclusions:Y-type stent-in-stent bilateral SEMSs are technically difficult but demonstrated more favorable overall survival for palliative bile drainage of inoperable MHBS patients compared to unilateral insertions.

关键词： Cholestasis Extrahepatic neoplasm Cholangiopancreatography Endoscopy Self-expandable metal stents

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Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients

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World Journal of Gastroenterology 2017年第28期23卷 5196-5205页

作者： Jung Won park Jin Ha Lee Ye hyun park Soo Jung park jae Hee Cheon Won Ho Kim Tae Il Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Cancer Prevention Center Yonsei University College of Medicine

To assess factors associated with the higher effect of metformin on mortality in diabetic colorectal cancer (CRC) patients, since the factors related to the effectiveness of metformin have not been identified *** January 2000 and December 2010, 413 patients diagnosed with both stage 3/4 CRC and diabetes mellitus were identified. Patients’ demographics and clinical characteristics were analyzed. The effect of metformin on CRC-specific mortality and the interactions between metformin and each adjusted factor were *** follow-up duration was median 50 mo (range: 1-218 mo). There were 85 deaths (45.9%) and 72 CRC-specific deaths (38.9%) among 185 patients who used metformin, compared to 130 total deaths (57.0%) and 107 CRC-specific deaths (46.9%) among 228 patients who did not use metformin. In multivariate analysis, survival benefit associated with metformin administration was identified (HR = 0.985, 95%CI: 0.974-0.997, P = 0.012). Interaction test between metformin and sex after adjustment for relevant factors revealed that female CRC patients taking metformin exhibited a significantly lower CRC-specific mortality rate than male CRC patients taking metformin (HR = 0.369, 95%CI: 0.155-0.881, P = 0.025). Furthermore, subgroup analysis revealed significant differences in CRC-specific mortality between the metformin and non-metformin groups in female patients (HR = 0.501, 95%CI: 0.286-0.879, P = 0.013) but not male patients (HR = 0.848, 95%CI: 0.594-1.211, P = 0.365). There were no significant interactions between metformin and other adjusted factors on CRC-specific *** showed a strong sex-dependent difference in the effect of metformin on CRC-specific mortality in advanced stage CRC patients with diabetes.

关键词： Colorectal cancer Metformin Survival Sex

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Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats

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Chinese Journal of Integrative Medicine 2019年第12期25卷 895-901页

作者： hyun-Jung park Ji hyun Kim Insop Shim Department of Physiology College of MedicineKyung Hee UniversitySeoul(130-701)Republic of Korea Department of Food Science&Biotechnology College of Science and EngineeringSuwon-si(16227)Republic of Korea

Objective: To examine the anti-obesity effects of ginsenosides in Korea Red Ginseng(KRG, Panax ginseng) in rats fed with a high-fat diet(HFD). Methods: Twenty-five 4-week-old obesity rats after receiving an HFD for 5 weeks;subsequently, they were additionally treated with ginsenosides Rb1, Rd, Rg1, or Re(10 mg/kg, intraperitoneal injection) for a further 3 weeks(n=5 in each group). The control rats were fed a normal diet. The food consumption, body weight, locomotor activity, serum lipids, adipose tissues, nitric oxide(NO) expression, leptin, neuropeptide Y(NPY), cholecystokinin(CCK) in the brains were measured. Results: In the HFD-fed rats, body weight, body fat mass, serum levels of leptin and NO were significantly higher than in the control rats(P<0.05 or P<0.01). However, the treatment of Rd, Re, and Rb1 markedly decreased body fat mass and body weight(P<0.05). The serum level of leptin and NO in ginsenoside-treated rats were markedly lower than the control group(P<0.01). The expression of NPY and CCK in the hypothalamic nuclei showed insignificant difference among groups. However, the expression of NPY immunoreactive neurons in the hypothalamus was significantly reduced in the Rb1-treated group(P<0.05). Conclusion: PD-type ginsenoside Rb1 from the crude saponins of KRG may be a useful compound for the treatment of obesity and related disorders through the modulation of peripheral and central appetite-regulating signals.

关键词： Panax ginseng ginsenosides hypothalamus obesity

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Comparison of the efficacy and safety of once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction

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Asian Journal of Andrology 2015年第1期17卷 143-148,I0011,I0012页

作者： Soon hyun park Sung Woo park Bong Yun Cha Ie Byung park Kyung Wan Min Yeon Ah Sung Tae Hwa Kim jae Min Lee Kang Seo park Department of Internal Medicine Eulji University School of Medicine Daejeon 302-799 South Korea Department of Endocrinology and Metabolism Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seou1110-746 South Korea Department of Endocrinology and Metabolism College of Medicine the Catholic University of Korea Seou1137-701 South Korea Department of Internal Medicine Gachon University of Medicine and Science Graduate School of Medicine Incheon 405-760 South Korea Department of Internal Medicine Eulji University School of Medicine Seou1139-872 South Korea Department of Endocrinology Ewha Woman's University School of Medicine Seoul 158-710 South Korea Department of Internal Medicine College of Medicine Hanyang University Seoul 133-792 South Korea.

We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-week study was conducted. 161 patients who improved with on-demand 200 mg of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatment-free period. The primary efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other domains of IIEF, Global Assessment Question, and shift to the normal rate （EFD 〉 26）. Vascular endothelial markers were also assessed. The IIEF-EFD score of both groups improved after 8 weeks of treatment （P 〈 0.0001）. There was no statistically significant difference between two groups. Improvement was not maintained after the treatment-free follow-up period. Similar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial markers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the most frequent adverse events. Both regimens improved ED in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatment in diabetic patients.

关键词： erectile dysfunction International Index of Erectile Function once-daily dosing ptiosphodiesterase type 5 inhibitor type 2 diabetes mellitus udenafil

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Fabrication and characterization of 3D scaffold using 3D plotting system

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Chinese Science Bulletin 2010年第1期55卷 94-98页

作者： LEE Jun-Hee park Su-A park KoEun KIM jae-hyun KIM Kyung-Shik LEE Jihye Kim WanDoo Bio-Mechatronics Team Division of Nano-Machinery Korea Institute of Machinery and Materials (KIMM) Nano-Mechanics Team Division of Nano-Machinery Korea Institute of Machinery and Materials (KIMM) Nano-Mechatronics Team Division of Nano-Machinery Korea Institute of Machinery and Materials (KIMM)

In this paper, we design and fabricate a 3D scaffold using rapid prototyping (RP) technology for tissue engineering. The scaffold should have a three-dimensional interconnected pore network. We fabricate a polycaprolactone (PCL) scaffold with interconnecting pores and uniform porosity for cell ingrowth using a 3D plotting system. In order to keep the three dimensional shape under mechanical loading while implanted, we design an oscillating nozzle system to increase elastic modulus and yield strength of PCL strand. We characterize the influence of pore geometry, compressive modulus of the scaffold, elastic modulus and yield strength of the strand using SEM, dynamical mechanical analysis (DMA) and Nano-UTM. Finally the cell responses on scaffolds are observed.

关键词：三维形状绘图系统表征支架制作动态机械分析弹性模量细胞反应

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Adaptive Electrospinning System Based on Reinforcement Learning for Uniform‑Thickness Nanofiber Air Filters

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Advanced Fiber Materials 2023年第2期5卷 617-631页

作者： Seok Hyeon Hwang Jin Yeong Song hyun Il Ryu jae Hee Oh Seungwook Lee Donggeun Lee Dong Yong park Sang Min park School of Mechanical Engineering Pusan National University63‑2 Busan University‑roGeumjeong‑guBusan 46241South Korea Smart Manufacturing Technology R&D Group Korea Institute of Industrial Technology320 Techno Sunhwan‑roYuga‑eupDalseong‑gunDaegu 42994Republic of Korea

Electrospinning is a simple and versatile method to produce nanofiber ***,owing to bending instability that occurs during the electrospinning process,electrospinning has frequently produced a non-uniform-thickness nanofiber filter,which deteriorates its air ***,an adaptive electrospinning system based on reinforcement learning(E-RL)was developed to produce uniform-thickness nanofiber *** E-RL accomplished a real-time thickness measurement of an electrospun nanofiber filter by measuring the transmitted light through the nanofiber filter using a camera placed at the bottom of the collector and converting it into thickness using the Beer–Lambert *** on the measured thickness,the E-RL detected the non-uniformity of the nanofiber filter thickness and manipulated the movable collector to alleviate the non-uniformity of the thickness by a pre-trained reinforcement learning(RL)*** the training of the RL algo-rithm,the nanofiber production simulation software based on the empirical model of the deposition of the nanofiber filter was developed,and the training process of the RL algorithm was repeated until the optimal policy was *** the training process with the simulation software,the trained model was transferred to the adaptive electrospinning *** the movement of the collector under the optimal strategy of RL algorithm,the non-uniformity of such nanofiber filters was significantly reduced by approximately five times in standard deviation and error for both simulation and *** finding has great potential in improving the reliability of electrospinning process and nanofiber filters used in research and industrial fields such as environment,energy,and biomedicine.

关键词： Electrospinning Nanofiber filter Uniform thickness Reinforcement learning Deep Q-network

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Multi-stage optimum design of magazine type automatic tool changer arm

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Journal of Central South University 2012年第1期19卷 174-178页

作者： KIM jae-hyun LEE Choon-Man School of Mechatronics Changwon National UniversityChangwon 641-773Korea

To enhance machining efficiency,tool change time has to be ***,for an automatic tool changer attached to a machining center,the tool change time is to be *** the automatic tool changer is a main part of the machining center as a driving *** static attributes of the automatic tool changer using the commercial code,ANSYS Workbench V12,were tried to *** the optimum design of automatic tool changer arm was proposed by performing the multi-stage optimum *** shape optimization of the automatic tool changer was proposed and the result was verified to obtain acceptable *** is possible to obtain an optimized model in which the maximum deformation,maximum stress,and mass are reduced by 10.46%,12.89% and 9.26%,respectively,compared with those of the initial ***,the results between conventional method by the design of experiments and proposed method by the multi-stage optimum design method were compared.

关键词： automatic tool changer optimum design structural analysis exchange arm

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Assessment of nutrient distributions in Lake Champlain using satellite remote sensing

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Journal of Environmental Sciences 2014年第9期26卷 1831-1836页

作者： Elizabeth M.Isenstein Mi-hyun park Department of Civil and Environmental Engineering University of Massachusetts AmherstMA01003USA

The introduction of nutrients to lakes causing eutrophic conditions is a major problem around the world. Proper monitoring and modeling are important to effectively manage eutrophication in lake waters. The goal is to develop remote sensing models for nutrients, total phosphorus and total nitrogen, in Lake Champlain. The remote sensing models were created using multivariate linear regression with the unique band combinations of Landsat Enhanced Thematic Mapper Plus （ETM＋） imagery based on the empirical relationship with the field observations. The resulting models successfully showed nutrient distributions in the most eutrophic part of Lake Champlain, Missisquoi Bay, with reasonable adjusted coefficient of determination values （R2 = 0.81 and 0.75 for total phosphorus and total nitrogen, respectively）. The results show the feasibility and the utility of satellite imagery to detect spatial distributions of lake water quality constituents, which can be used to better understand nutrient distributions in Lake Champlain. This approach can be applicable to other lakes experiencing eutrophication assisting decision making when implementing Best Management Practices and other mitigation techniques to lakes.

关键词： Remote sensingMonitoringNutrientsPhosphorus

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Investigation on static routing and resource assignment of elastic all-optical switched intra-datacenter networks

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Science China(Information Sciences) 2016年第10期59卷 60-75页

作者： Limei PENG Kiejin park Chan-hyun YOUN Department of Industrial Engineering Ajou University Department of Integrative Systems Engineering Ajou University Department of Electrical Engineering Korea Advanced Institute of Science and Technology

In this paper, we explore the issue of static routing and spectrum/IT resource assignment(RSIA)of elastic all-optical switched intra-datacenter networks(intra-DCNs) by proposing anycast- and manycastbased integer linear programming(ILP) models. The objective is to jointly optimize the DCN resources, i.e.,network transmission bandwidth and IT resources, under different situations. First, for given service-request matrices with unknown network transmission bandwidth and IT resources, we propose anycast and manycast ILP models to minimize the maximum numbers of required network and IT resources to accommodate all the service requests. For anycast RSIA issue, we proposed two different ILP models that are based on node-arc and link-path methods, respectively. Node-arc based manycast ILP model is also proposed for the first time to our knowledge. Second, for given network transmission bandwidth and IT resources and known servicerequest matrices, we propose node-arc based anycast ILP models to maximize the total number of successfully served service requests. To evaluate the efficiency of anycast and manycast models, all proposed ILP models are evaluated and compared with unicast ILP models. Simulation results show that anycast and manycast ILP models perform much better in efficiently using DCN resources and successfully accommodating more service requests when compared to unicast ILP models under the same network conditions.

关键词： datacenter networks(DCNs) intra-DCN RSIA ILP models anycast manycast

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Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients:A Randomized,Placebo-Controlled,Double-Blind Clinical Study

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Chinese Journal of Integrative Medicine 2016年第7期22卷 490-495页

作者： hyun Jun park Sangmin Choe Nam Cheol park Department of Urology Pusan National University School of MedicineBusan(602-739)Republic of Korea Medical Research Institute of Pusan National University Hospital Busan(602-739)Republic of Korea Division of Clinical Pharmacology Clinical Trial CenterPusan National University HospitalBusan(602-739)Republic of Korea

Objective： To investigate the effects of Korean red ginseng （KRG） on semen parameters in male infertility patients in a randomized, double-blind, placebo-controlled study. Methods： A total of 80 male infertility patients with varicocele were recruited from April 2011 to February 2012. The subjects were then divided into the following four groups： non-varicocelectomy （V）＋placebo （P） group, V＋P group, non-V＋KRG group （1.5-g KRG daily）, and V＋KGR group （1.5-g KRG daily）. Semen analysis was performed and hormonal levels were measured in each treatment arm after 12 weeks. Results： All groups but not the non-V＋P group, showed significant improvements in sperm concentrations, motility, morphology, and viability at the end of the study. However, there were no significant differences in serum follicle-stimulating hormone, luteinizing hormone, and testosterone among groups. The incidence of adverse events was low, and all events were assumed to be unrelated to the treatments administered. Conclusions： Although the exact mechanism by which KRG improves spermatogenesis remains unclear, KRG may be a useful agent for the treatment of male infertility. Nevertheless, additional studies to evaluate the optimal dose and duration of treatment are needed.

关键词： Panax ginseng male infertility spermatogenesis

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