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Macroscopic Ag nanostructure array patterns with high-density hotspots for reliable and ultra-sensitive SERS substrates

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Nano Research 2019年第10期12卷 2554-2558页

作者： Taeksu lee Soongeun Kwon San ghee Jung Hyungjun Lim jae-Jong lee Department of Nano Manufacturing Technology Korea Institute of Machinery and Materials(KIMM)156 Gajeongbuk-RoYuseong-GuDaejeon 34103Republic of Korea

Syn thesis of metal nano structures arrays with large amounts of small nano-gaps on a homoge nous macroscale is of significant in terest and importa nee in chemistry,biotech no logy,physics,and nan otech no logy because of their enhan ced ***,the fabricatio n of uncovered nano-gaps with high-density and uniformity is rather difficult due to the complex and multiple synthetic *** this research,a facile and low-cost approach is demonstraind for the synthesis of high-density small nano-gaps(about 3.4 nm)between silver nanostructure array patter ns(SNAPs)over a large *** nan o?hole patter ns were periodically gen erated over an entire substrate using nano-impri nt *** reacti on at the high over-potential produced multiple silver nano crystals inside the nano-hole patter ns,gen erati ng a high-de nsity of small and un covered ***,we fully dem on strate their applicati on in the rapid detectio n of rhodamine 6G(R6G)molecules by surface-enhaneed Raman scattering(SERS)spectroscopy with a very low detection limit(1 fM)as well as excellent signal uniformity(RSD<8.0%±2.5%),i ndicati ng an extra ordinary capability for single-molecule detecti on.

关键词： nanoImprint lithography surface-enhanced Raman scattering(SERS)spectroscopy electrodeposition nano patterning gold silver

Enhancement of magnetic properties of hot pressed/die-upset Dy-free Nd-Fe-B magnets with Cu/Nd coating by wet process

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Rare Metals 2020年第1期39卷 48-54页

作者： Jeehye Kwon Dajeong lee Dayoung Yoo Seongkyu Park hee-Ryoung Cha Hae-Woong Kwon Junggoo lee Dongyun lee Department of Advanced Circuit Interconnection Pusan National UniversityBusan46241Republic of Korea Department of Nano Fusion Technology Pusan National UniversityBusan46241Republic of Korea Powder and Ceramics Department Korea Institute of Machinery and MaterialsChangwon51508Republic of Korea Department of Materials Science and Engineering Pukyong National UniversityBusan48513Republic of Korea Department of Nanoenergy Engineering Pusan National UniversityBusan46241Republic of Korea

A grain boundary diffusion process(GBDP)was adopted to improve magnetic properties of Dy-free highly coercive Nd-Fe-B permanent magnet by coating thin layers of Nd and Cu in grain *** GBDP of Nd and Cu,Nd and Cu were coated by wet process,e.g.,electrochemical and electroless on Nd-Fe-B magnets,which was fabricated by hot-deformed/die-upset with meltspun *** treatment was performed for 20 min at 600℃followed by several different cooling *** cooling conditions after heat treatment were varied to understand distribution and micros tructural effects of Nd and Cu species in grain *** coercivity increased from 1.565 to 1.637 T in oil cooling rate but remanence decreased,while remanence jumped with little decrease in coercivity in furnace *** tructure analyses suggested that the coercivity was closely related to the cooling rate as well as distribution of *** mechanism of coercivity enhancement due to the cooling rate was discussed based on the results presented here and those in the literature.

关键词： Magnetic materials Electrochemical deposition Diffusion Scanning electron microscopy Coercivity

Numerical simulation for dendrite growth in directional solidification using LBM-CA(cellular automata)coupled method

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Journal of Materials Science & Technology 2020年第14期47卷 15-24页

作者： Wonjoo lee Yuhyeong Jeong jae-Wook lee Howon lee Seong-hoon Kang Young-Min Kim Jonghun Yoon Department of Mechanical Design Engineering Hanyang University222Wangsimni-roSeongdong-guSeoul 04763Republic of Korea Materials Deformation Department Korea Institute of Materials Science797 ChangwondaeroSeongsan-guChangwon-siGyeongnam-do 51508Republic of Korea Department of Mechanical Engineering Hanyang University55 Hanyangdaehak-roSangnok-guAnsan-siGyeonggi-do 15588Republic of Korea

To predict the dendrite morphology and microstructure evolution in the solidification of molten metal,numerically,lattice Boltzmann method(LBM)-cellular automata(CA)model has been developed by integrating the LBM to solve the mass transport by diffusion and convection during solidification and the CA to determine the phase transformation with respect to the solid fraction based on the local equilibrium *** is successfully validated with analytic solutions such as Lipton-Glicksman-Kurz(LGK)model in static melt,and Oseen-Ivantsov solution under the fluid flow conditions in terms of tip radius and velocity of the dendrite *** proposed LBM-CA model does not only describe different types of dendrite formations with respect to various solidification conditions such as temperature gradient and growth rate,but also predict the primary dendrite arm spacing(PDAS)and the secondary dendrite arm spacing(SDAS),quantitatively,in directional solidification(DS)experiment with Ni-based superalloy.

关键词： Cellular automata(CA) Lattice Boltzmann method(LBM) Dendritic growth Directional solidification

Utility of a deep learning model and a clinical model for predicting bleeding after endoscopic submucosal dissection in patients with early gastric cancer

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World Journal of Gastroenterology 2022年第24期28卷 2721-2732页

作者： Ji Eun Na Yeong Chan lee Tae Jun Kim Hyuk lee Hong-hee Won Yang Won Min Byung-Hoon Min Jun Haeng lee Poong-Lyul Rhee jae J Kim Department of Internal Medicine Inje University Haeundae Paik HospitalBusan 48108South Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan UniversitySeoul 06351South Korea

BACKGROUND Bleeding is one of the major complications after endoscopic submucosal dissection(ESD)in early gastric cancer(EGC)*** are limited studies on estimating the bleeding risk after ESD using an artificial intelligence *** To derivate and verify the performance of the deep learning model and the clinical model for predicting bleeding risk after ESD in EGC *** Patients with EGC who underwent ESD between January 2010 and June 2020 at the Samsung Medical Center were enrolled,and post-ESD bleeding(PEB)was investigated *** split the entire cohort into a development set(80%)and a validation set(20%).The deep learning and clinical model were built on the development set and tested in the validation *** performance of the deep learning model and the clinical model were compared using the area under the curve and the stratification of bleeding risk after *** A total of 5629 patients were included,and PEB occurred in 325 *** area under the curve for predicting PEB was 0.71(95%confidence interval:0.63-0.78)in the deep learning model and 0.70(95%confidence interval:0.62-0.77)in the clinical model,without significant difference(P=0.730).The patients expected to the low-(leeding rate of 2.2%,3.9%,and 11.6%,respectively,in the deep learning model;4.0%,8.8%,and 18.2%,respectively,in the clinical *** A deep learning model can predict and stratify the bleeding risk after ESD in patients with EGC.

关键词： Clinical model Deep learning model Post-endoscopic submucosal dissection bleeding Stratification of bleeding risk

What Causes the Springtime Tropospheric Ozone Maximum over Northeast Asia?

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Advances in Atmospheric Sciences 2010年第3期27卷 543-551页

作者： jae H.KIM Hyunjin lee Department of Atmospheric Science Pusan National University

Scientists have long debated the relative importance of tropospheric photochemical production versus stratospheric influx as causes of the springtime tropospheric ozone maximum over northern mid-latitudes. This paper investigates whether or not stratospheric intrusion and photochemistry play a significant role in the springtime ozone maximum over Northeast Asia, where ozone measurements are sparse. We examine how tropospheric ozone seasonalities over Naha （26°N, 128°E）, Kagoshima （31°N, 131°E）, and Pohang （36°N, 129°E）, which are located on the same meridional line, are related to the timing and location of the jet stream. The ozone seasonality shows a gradual increase from January to the maximum ozone month, which corresponds to April at Naha, May at Kagoshima, and June at Pohang. In order to examine the occurrence of stratospheric intrusion, we analyze a correlation between jet stream activity and tropospheric ozone seasonality. From these analyses, we did not find any favorable evidence supporting the hypothesis that the springtime enhancement may result from stratospheric intrusion. According to trajectory analysis for vertical and horizontal origins of the airmass, a gradual increasing tendency in ozone amounts from January until the onset of monsoon was similar to the increasing ozone formation tendency from winter to spring over China's Mainland, which has been observed during the build-up of tropospheric ozone over Central Europe in the winter-spring transition period due to photochemistry. Overall, the analyses suggest that photochemistry is the most important contributor to observed ozone seasonality over Northeast Asia.

关键词： tropospheric ozone photochemistry, stratospheric intrusion, jet stream activity, trajectory

Micro-accelerometer Based on Vertically Movable Gate Field Effect Transistor

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Nano-Micro Letters 2015年第3期7卷 282-290页

作者： Heung Seok Kang Kang-hee lee Dong-Youk Yang Byoung hee You In-Hyouk Song Korea Atomic Energy Research Institute LOGTECH Co. Ltd 914 Gumgang Hightech Valley 1st Department of Engineering Technology Texas State University601 University Dr. San Marcos TX 78666 USA

A vertically movable gate field effect transistor(VMGFET) is proposed and demonstrated for a microaccelerometer application. The VMGFET using air gap as an insulator layer allows the gate to move on the substrate vertically by external forces. Finite element analysis is used to simulate mechanical behaviors of the designed structure. For the simulation, the ground acceleration spectrum of the 1952 Kern County Earthquake is employed to investigate the structural integrity of the sensor in vibration. Based on the simulation, a prototype VMGFET accelerometer is fabricated from silicon on insulator wafer. According to current–voltage characteristics of the prototype VMGFET, the threshold voltage is measured to be 2.32 V, which determines the effective charge density and the mutual transconductance of1.545910-8C cm-2and 6.59 m A V-1, respectively. The device sensitivity is 9.36–9.42 m V g-1in the low frequency,and the first natural frequency is found to be 1230 Hz. The profile smoothness of the sensed signal is in 3 d B range up to1 k Hz.

关键词： MEMS Micro-accelerometer Suspended gate FET Vertically movable gate FET VMGFET

Endoscopic features suggesting gastric cancer in biopsy-proven gastric adenoma with high-grade neoplasia

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World Journal of Gastroenterology 2014年第34期20卷 12233-12240页

作者： Jung Ho Kim Yoon jae Kim Jungsuk An Jong Joon lee jae hee Cho Kyoung Oh Kim Jun-Won Chung Kwang An Kwon Dong Kyun Park Ju Hyun Kim Department of Internal Medicine Gachon University Gil Medical CenterNamdong-guIncheon 405-760South Korea Department of Pathology Gachon University Gil Medical Center21 Namdong-daero 774 beon-gilNamdong-guIncheon 405-760South Korea

AIM: To elucidate the endoscopic features that predict the cancer following endoscopic submucosal dissection (ESD) in patients with high-grade neoplasia (HGN).

关键词： Stomach Neoplasms Carcinoma Adenoma Endoscopy Dissection Risk factors

Gost effectiveness of crack treatment methods:A field study

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 598-607页

作者： Mithil Mazumder Hyun Hwan Kim Soon-jae lee Moon-Sup lee Materials Science Engineeringand Commercialization ProgramTexas State UniversitySan MarcosTX 78666USA Department of Engineering Technology Texas State UniversitySan MarcosTX 78666USA Korea Institute of Civil Engineering and Building Technology Gyeonggi-do 10223South Korea

In the United States,more than 94%highways are paved with asphalt materials and placing crack sealant materials has been a common pavement maintenance for *** sealing treatment includes the use of a router to create a reservoir on the intended cracks whereas crack filling is given without doing any modification to the crack *** the initial cost of crack sealing is higher,it is expected to have a longer service period compared to crack *** is little research on comparison of short and long term cost effectiveness between these two treatments using the real field cost data *** this study four test sites in Texas were treated with crack filling and sealing using the same sealant material and finishing *** effectiveness of both treatments was measured in terms of initial,annual average and life cycle cost based on the cost inputs during *** general,the results of this study indicated that(1)on an average approximately 45%initial cost increase was estimated with the two routing configurations of crack sealing;(2)material and labor cost is found to have the most significant effect on the higher initial cost of crack sealing compared to other associated costs;(3)annual average and life cycle costs have shown that crack sealing is more cost effective pavement maintenance compared to crack filling over a long period of time;(4)agency cost is observed to be reduced by approximately 24%with crack sealing treatment based on the35 year analysis period.

关键词： Crack sealing Crack filling Initial cost Annual average cost Life cycle cost

Ameliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells

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World Journal of Stem Cells 2019年第11期11卷 990-1004页

作者： Kee-Hwan Kim jae Im lee Ok-hee Kim Ha-Eun Hong Bong Jun Kwak Ho Joong Choi Joseph Ahn Tae Yun lee Sang Chul lee Say-June Kim Department of Surgery Uijeongbu St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 11765South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Daejeon St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 34943South Korea

BACKGROUND Recently,the exclusive use of mesenchymal stem cell(MSC)-secreted molecules,called secretome,rather than cells,has been evaluated for overcoming the limitations of cell-based therapy,while maintaining its ***,the use of na?ve secretome may not fully satisfy the specificity of each ***,it appears to be more advantageous to use the functionally reinforced secretome through a series of processes involving physico-chemical adjustments or genetic manipulation rather than to the use na?ve *** To determine the therapeutic potential of the secretome released from miR-122-transfected adipose-derived stromal cells(ASCs).METHODS We collected secretory materials released from ASCs that had been transfected with antifibrotic miR-122(MCM)and compared their antifibrotic effects with those of the na?ve secretome(CM).MCM and CM were intravenously administered to the mouse model of thioacetamide-induced liver fibrosis,and their therapeutic potentials were *** MCM infusion provided higher therapeutic potential in terms of:(A)Reducing collagen content in the liver;(B)Inhibiting proinflammatory cytokines;and(C)Reducing abnormally elevated liver enzymes than the infusion of the na?ve *** proteomic analysis of MCM also indicated that the contents of antifibrotic proteins were significantly elevated compared to those in the na?ve *** We could,thus,conclude that the secretome released from miR-122-transfected ASCs has higher antifibrotic and anti-inflammatory properties than the na?ve *** miR-122 transfection into ASCs provides a specific way of potentiating the antifibrotic properties of ASC secretome,it could be considered as an enhanced method for reinforcing secretome effectiveness.

关键词： Adipose-derived stem cells Liver fibrosis MicroRNAs miR-122 Mesenchymal stem cells Secretome