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Molecular mechanisms of ZD1839 (Iressa)-induced apoptosis in human leukemic U937 cells

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Acta Pharmacologica Sinica 2007年第8期28卷 1205-1214页

作者： dong-oh MOON Moon-ok KIM jae-dong lee Yung-hyun CHOI Min-ki lee Gi-young KIM Faculty of Applied Marine Science Cheju National UniversityJeju Special Self-Governing Province 690-756Republic of Korea Department of Microbiology Pusan National UniversityBusan 614-052Republic of Korea Department of Biochemistry Dongeui University College of Oriental MedicineBusan 614-052Republic of Korea Department of Internal Medicine Pusan National University College o MedicineBusan 602-739Republic of Korea

Aim:To investigate the molecular mechanisms of ZD1839-induced apoptosis inhuman leukemic U937 ***:The inhibition of human leukemic U937 cellgrowth was assessed by 3-（4,5-dimethyl-2-thiazolyl）-2,5-diphnyl-2H-tetrazolimbromide（MTT）assays,lactate dehydrogenase（LDH）release,and cell *** expression of anti- and pro-apoptotic proteins was detected byWestern blot ***:This study demonstrated that ZD 1839 inducedapoptosis in leukemic U937 cells by the downregulation of Bcl-2,caspase activa-tion and subsequent apoptotic *** with ZD 1839 and the caspase-3 inhibitor z-DEVD-fmk blocked apoptosis,indicating that caspase-3 activation isat least partially responsible for ZD1839-induced *** ectopic expres-sion of Bcl-2 attenuated caspase-3 activation,PARP cleavage,and subsequentindicators of apoptosis,including sub-G1DNA content and LDH *** indicate that the downregulation of Bcl-2 plays a major role in the initiationof ZD1839-induced apoptosis,and that the activation of a caspase cascade isinvolved in the execution of ***,ZD 1839 treatment triggeredthe activation of p38 mitogen-activated protein kinase（MAPK）and the down-regulation of c-Jun-N-terminal kinase（JNK）,extracellular signal-regulated kinase（ERK）and phosphatidyl inositol 3-kinase（PI3K）/*** inhibition of the ERKand PI3K/Akt pathways also significantly increased cellular ***:ZD 1839 activated caspase-3 and the inhibited Bcl-2 in human leukemic U937 cellsthrough the downregulation of the ERK and PI3K/Akt pathways.

关键词： ZD1839(Iressa) apoptosis caspase-3 Bcl-2 mitogen-activated protein kinases

M-IDM: A Multi-Classication Based Intrusion Detection Model in Healthcare IoT

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Computers, Materials & Continua 2021年第5期67卷 1537-1553页

作者： jae dong lee Hyo Soung Cha Shailendra Rathore Jong Hyuk Park Healthcare AI Team National Cancer CenterGoyang-si10408Korea Department of Computer Science and Engineering Seoul National University of Science and Technology(SeoulTech)Seoul01811Korea

In recent years,the application of a smart city in the healthcare sector via loT systems has continued to grow exponentially and various advanced network intrusions have emerged since these loT devices are being *** studies focused on security threat detection and blocking technologies that rely on testbed data obtained from a single medical IoT device or simulation using a well-known dataset,such as the NSL-KDD ***,such approaches do not reect the features that exist in real medical scenarios,leading to failure in potential threat *** address this problem,we proposed a novel intrusion classication architecture known as a Multi-class Classication based Intrusion Detection Model(M-IDM),which typically relies on data collected by real devices and the use of convolutional neural networks(i.e.,it exhibits better performance compared with conventional machine learning algorithms,such as naïve Bayes,support vector machine(SVM)).Unlike existing studies,the proposed architecture employs the actual healthcare IoT environment of National Cancer Center in South Korea and actual network data from real medical devices,such as a patient’s monitors(i.e.,electrocardiogram and thermometers).The proposed architecture classies the data into multiple classes:Critical,informal,major,and minor,for intrusion ***,we experimentally evaluated and compared its performance with those of other conventional machine learning algorithms,including naïve Bayes,SVM,and logistic regression,using neural networks.

关键词： Smart city healthcare IoT neural network intrusion classication machine learning

Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis

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World Journal of Gastroenterology 2017年第13期23卷 2396-2403页

作者： Soon Kyu lee Myeong Jun Song Seok Hyun Kim Byung Seok lee Tae Hee lee Young Woo Kang Suk Bae Kim Il Han Song Hee Bok Chae Soon Young Ko jae dong lee Division of Hepatology Department of Internal MedicineDaejeon St.Mary's HospitalCollege of MedicineThe Catholic University of Korea Department of Internal Medicine Chungnam University Hospital Department of Internal Medicine Konyang University Hospital Department of Internal Medicine Dankook University Hospital Department of Internal Medicine Chung Buk University Hospital Department of Internal Medicine Konkuk University Chungju Hospital

AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate(TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosis group. We followed the patients for 12 mo and evaluated clinical outcomes, including biochemical, virological, and serological responses. We also evaluated changes in hepatic and renal function and compared the decompensated and compensated cirrhosis groups. RESULTS The 1-year complete virological response(CVR) and Hepatitis B e antigen(HBe Ag) seroconversion were seen in 70.2% and 14.2% in the decompensated cirrhosis group, respectively. The rates of HBe Ag seroconversion/loss and ALT normalization at month 12 were similar in both groups. TDF treatment was also effective for decreasing the level of hepatitis B virus(HBV) DNA in both groups, but CVR was higher in the compensated group(88.9% vs 70.2%, P = 0.005). Tenofovir treatment for 12 mo resulted in improved Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD) scores in decompensated group(P < 0.001). Of the 57 decompensated patients, 39(68.4%) achieved CTP class A and 27(49.1%) showed improvement in the CTP score of 2 points after 12 mo of TDF. The observed rate of confirmed 0.5 mg/d L increases in serum levels of creatinine in the decompensated and compensated cirrhosis group were 7.0% and 2.5%, respectively(P < 1.000).CONCLUSION TDF therapy in decompensated cirrhosis patients was effective for decreasing HBV DNA levels and improving hepatic function with relatively lower CVR than in compensated cirrhosis. Thus, physicians should carefully monitor not only renal function but also treatment responses when using TDF in decompensated cirrhosis patients.

关键词： Tenofovir Decompensated liver cirrhosis Compensated liver cirrhosis Virological response Renal safety

The modulation of radiation-induced cell death by genistein in K562 cells:Activation of thymidine kinase 1

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Cell Research 2004年第4期14卷 295-302页

作者： Min Ho JEONG,Young Hee JIN,Eun Young KANG,Wol Soon JO,Hwan Tae PARK,jae dong lee,Yeo Jin YOO,Soo Jin JEONG Research Supporting Center for Medical Science (BK21 program) dong-A University College of Medicine Busan Korea Research Supporting Center for Medical Science (BK21 program) dong-A University College of Medicine Busan Korea Research Supporting Center for Medical Science (BK21 program) dong-A University College of Medicine Busan Korea Research Supporting Center for Medical Science (BK21 program) dong-A University College of Medicine Busan Korea Research Supporting Center for Medical Science (BK21 program) dong-A University College of Medicine Busan Korea Department of Microbiology Pusan National University Busan Korea Research Supporting Center for Medical Science (BK21 program) dong-A University College of Medicine Busan Korea Research Supporting Center for Medical Science (BK21 program) dong-A University College of Medicine Busan Korea Virus Tumor Biology Section Laboratory of Cellular Oncology Center for Cancer Research National Cancer Institutes National Institute of Health Bethesda MD 20892 USA

Ionizing radiation is one of the most effective tools in cancer therapy. In a previous study, we reported that protein tyrosine kinase (PTK) inhibitors modulate the radiation responses in the human chronic myelogenous leukemia (CML) cell line K562. The receptor tyrosine kinase inhibitor, genistein, delayed radiation-induced cell death, while non-recepter tyrosine kinase inhibitor, herbimycin A (HMA) enhances radiation-induced apoptosis. In this study, we focused on the modulation of radiation-induced cell death by genistein and performed PCR-select suppression subtractive hybridization (SSH) to understand its molecular mechanism. We identified human thymidine kinase 1 (TK1), which is cell cycle regulatory gene and confirmed expression of TK1 mRNA by Northern blot analysis. Expression of TKl mRNA and TK1 enzymatic activity were parallel in their increase and decrease. TK1 is involved in G1-S phase transition of cell cycle progression. In cell cycle analysis, we showed that radiation induced G2 arrest in K

关键词： K562 radiation cell death genistein thymidine kinase 1 cell cycle.

Anxiety and depression propensities in patients with acute toxic liver injury

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World Journal of Gastroenterology 2013年第47期19卷 9069-9076页

作者： Jeong Ill Suh Jeong Kyu Sakong Kwan lee Yong Kook lee Jeong Bae Park dong Joon Kim Yeon Seok SeoDepartment of Internal Medicine Korea University Anam Hospital Korea University College of Medicine Seoul 136-705 South Korea jae dong lee Soon Young Ko Byung Seok lee Seok Hyun Kim Byung Seok Kim Young Seok Kim Heon Ju lee In Hee Kim Joo Hyun Sohn Tae Yeob Kim Byung Min Ahn Department of Internal Medicine Dongguk University Gyeongju HospitalDongguk University College of MedicineGyeongju 780-350South Korea Department of Psychiatry Dongguk University Gyeongju HospitalDongguk University College of MedicineGyeongju 780-350South Korea Department of Preventive Medicine Dongguk University College of MedicineGyeongju 780-350South Korea Department of Internal Medicine Hallym University Medical CenterHallym University College of MedicineChuncheon 200-704South Korea Department of Internal Medicine Konkuk University Chungju HospitalKonkuk University College of MedicineChungju 380-704South Korea Department of Internal Medicine Chungnam National University HospitalChungnam University College of MedicineDaejeon 301-721South Korea Department of Internal Medicine Daegu Catholic University Medical CenterDaegu Catholic University College of MedicineDaegu 705-718South Korea Department of Internal Medicine Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 420-767South Korea Department of Internal Medicine Yeungnam University Medical CenterYeungnam University College of MedicineDaegu 705-703South Korea Department of Internal Medicine Chonbuk National University HospitalChonbuk National University College of MedicineJeonju 561-712South Korea Department of Internal Medicine Hanyang University Guri HospitalHanyang University College of MedicineGuri 471-701South Korea Department of Internal Medicine Hwain Metro HospitalChunan 331-959South Korea

AIM:To investigate anxiety and depression propensities in patients with toxic liver ***:The subjects were divided into three groups:a healthy control group(Group 1,n=125),an acute non-toxic liver injury group(Group 2,n=124),and a group with acute toxic liver injury group caused by noncommercial herbal preparations(Group 3,n=126).These three groups were compared and evaluated through questionnaire surveys and using the Hospital Anxiety-Depression Scale(HADS),Beck Anxiety Inventory(BAI),Beck Depression Inventory(BDI),and the hypochondriasis ***:The HADS anxiety subscale was 4.9±2.7,5.0±3.0 and 5.6±3.4,in Groups 1,2,and 3,*** HADS depression subscale in Group 3 showed the most significant score(5.2±3.2,6.4±3.4 and 7.2±3.4in Groups 1,2,and 3,respectively)(P<0.01 vs Group 1,P<0.05 vs Group 2).The BAI and BDI in Group 3showed the most significant score(7.0±6.3 and 6.9±6.9,9.5±8.6 and 8.8±7.3,10.7±7.2 and 11.6±8.5in Groups 1,2,and 3,respectively)(BAI:P<0.01 vs Group 1,P<0.05 vs Group 2)(BDI:P<0.01 vs Group1 and 2).Group 3 showed a significantly higher hypochondriasis score(8.2±6.0,11.6±7.5 and 13.1±6.5in Groups 1,2,and 3,respectively)(P<0.01 vs Group 1,P<0.05 vs Group 2).CONCLUSION:Psychological factors that present vulnerability to the temptation to use alternative medicines,such as herbs and plant preparations,are important for understanding toxic liver injury.

关键词： Liver injury Herb Toxic Anxiety Depression

Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： Md Ahasan Habib Shusen Lin Mehedi Hasan Joni Sumiya Akter Dristy Rutuja Mandavkar jae-Hun Jeong Jihoon lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Advanced electrocatalyst High current Corrosion resistance Industrial requirement

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： jae-Hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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新药KHBJ-9B在人软骨培养和兔关节炎模型中对软骨细胞的保护作用

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新药KHBJ-9B在人软骨培养和兔关节炎模型中对软骨细胞的保护作用

世界针灸学会联合会成立20周年暨世界针灸学术大会

作者： Jeong-Eun Huh Yong-Hyeon Baek jae-dong lee Do-Young Choi dong-Suk Park Oriental Medicine Research Center for Bone and Joint Disease Korea Department of Acupuncture and Moxibustion College of Oriental MedicineKyung Hee UniversityKorea

＜正＞目的:KHBJ-9B 是由两种韩医中具有软骨保护和消炎作用的草药提取而成。本研究旨在确定 KHBJ- 9B 在人骨关节炎软骨培养与兔骨关节的胶原诱导性关节炎模型（CIA）中,治疗关节炎的疗效及其作用机制。

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观察BHH9促进骨折愈合的机制

观察BHH9促进骨折愈合的机制