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Molecular Evolution of the Substrate Specificity of Chloroplastic Aldolases/Rubisco Lysine Methyltransferases in Plants

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Molecular Plant 2016年第4期9卷 569-581页

作者： Sheng Ma jacqueline Martin-Laffon Morgane Mininno Oceane Gigarel Sabine Brugiere Olivier Bastien Marianne Tardift Stephane Ravanel Claude Alban Universite Grenoble Alpes Laboratoire de Physiologie Cellulaire & Vegetale 38041 Grenoble France CNRS UMR5168 38054 Grenoble France CEA iRTSV Laboratoire de Physiologie Cellulaire & Vegetale 38054 Grenoble France INRA USC1359 38054 Grenoble France Universite Grenoble Alpes 38041 Grenoble France CEA iRTSV Biologie & Grande Echelle 38054 Grenoble France INSERM U1038 38054 Grenoble France

Rubisco and fructose-1,6-bisphosphate aldolases （FBAs） are involved in CO2 fixation in chloroplasts. Both enzymes are trimethylated at a specific lysine residue by the chloroplastic protein methyltransferase LSMT. Genes coding LSMT are present in all plant genomes but the methylation status of the substrates varies in a species-specific manner. For example, chloroplastic FBAs are naturally trimethylated in both Pisum sati- vum and Arabidopsis thaliana, whereas the Rubisco large subunit is trimethylated only in the former spe- cies. The in vivo methylation status of aldolases and Rubisco matches the catalytic properties of AtLSMT and PsLSMT, which are able to trimethylate FBAs or FBAs and Rubisco, respectively. Here, we created chimera and site-directed mutants of monofunctional AtLSMT and bifunctional PsLSMT to identify the molecular determinants responsible for substrate specificity. Our results indicate that the His-Ala/Pro- Trp triad located in the central part of LSMT enzymes is the key motif to confer the capacity to trimethylate Rubisco. Two of the critical residues are located on a surface loop outside the methyltransferase catalytic site. We observed a strict correlation between the presence of the triad motif and the in vivo methylation status of Rubisco. The distribution of the motif into a phylogenetic tree further suggests that the ancestral function of LSMT was FBA trimethylation. In a recent event during higher plant evolution, this function evolved in ancestors of Fabaceae, Cucurbitaceae, and Rosaceae to include Rubisco as an additional substrate to the archetypal enzyme. Our study provides insight into mechanisms by which SET-domain protein methyltransferases evolve new substrate specificity.

关键词： SET-domain protein methyltransferase site-directed mutagenesis chimeric enzyme methylation,molecular evolution green lineage

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Experimental Pattern Sourcebook : 300 Inspired Designs From Around the World w/DVD

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2010年

作者： Herald, jacqueline

ISBN: (纸本)9781592535934;9781616738785

Author Jackie Herald''s selection is designed to inspire, provoke, amuse, and suggest new associations of ideas, materials, and imagery for further *** book features 40 contributors from 21 countries:Australia Austria Bulgaria Canada Colombia Denmark Estonia Finland Germany Iceland India Italy Japan Korea Netherlands Sweden Turkey Ukraine United Kingdom United States Venezuela

关键词： Decoration and ornament Pattern books

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Optical coherence tomography angiography in diabetic retinopathy: a review of current applications

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Eye and Vision 2019年第1期6卷 312-321页

作者： Kai Yuan Tey Kelvin Teo Anna C.S.Tan Kavya Devarajan Bingyao Tan jacqueline Tan Leopold Schmetterer Marcus Ang Hobart Clinical School Level 343 Collins StreetHobartTAS 7000Australia Singapore National Eye Centre 11 Third Hospital AveSingapore 168751Singapore Singapore Eye Research Institute 20 College Road Discovery TowerLevel 6 The AcademiaSingapore 169856Singapore Singapore National Eye Centre 11 Third Hospital AveSingapore 168751Duke-NUS Medical School8 College RdSingapore 169857Singapore

Background:Diabetic retinopathy(DR)is a leading cause of vision loss in ***,the standard imaging technique to monitor and prognosticate DR and diabetic maculopathy is dye-based *** the introduction of optical coherence tomography angiography(OCTA),it may serve as a potential rapid,non-invasive imaging modality as an *** text:Recent studies on the role of OCTA in DR include the use of vascular parameters e.g.,vessel density,intercapillary spacing,vessel diameter index,length of vessels based on skeletonised OCTA,the total length of vessels,vascular architecture and area of the foveal avascular *** quantitative measures may be able to detect changes with the severity and progress of DR for clinical *** may also serve as a non-invasive imaging method to detect diabetic macula ischemia,which may help predict visual ***,there are many limitations of OCTA in DR,such as difficulty in segmentation between superficial and deep capillary plexus;and its use in diabetic macula edema where the presence of cystic spaces may affect image *** applications of OCTA in the anterior segment include detection of anterior segment ischemia and iris neovascularisation associated with proliferative DR and risk of neovascular ***:OCTA may potentially serve as a useful non-invasive imaging tool in the diagnosis and monitoring of diabetic retinopathy and maculopathy in the *** studies may demonstrate how quantitative OCTA measures may have a role in detecting early retinal changes in patients with diabetes.

关键词： Optical coherence tomography angiography Fluorescein angiography Diabetic retinopathy Screening Monitoring

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Guys Are Gossips Too,Study Finds

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当代外语研究 2003年第3期 16-17页

作者： jacqueline Stenson 梁评

选注者言:英语里有个单词叫gossip,追踪它的词源,就会发现它最后总是落实到女性头上。如:gossip=god+sib(=related亲戚),原意是神的亲戚。词义演变过程是:神的亲戚→教父、教母→密友→酒肉朋友→边喝边聊→闲聊、闲话→长舌妇。但是,... 详细信息

选注者言:英语里有个单词叫gossip,追踪它的词源,就会发现它最后总是落实到女性头上。如:gossip=god+sib(=related亲戚),原意是神的亲戚。词义演变过程是:神的亲戚→教父、教母→密友→酒肉朋友→边喝边聊→闲聊、闲话→长舌妇。但是,本文欲还女性一个“清白”。

关键词： Guys Are Gossips Too,Study Finds

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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Geological Control upon Groundwater Flow and Major Ion Chemistry with Influence on Basin Management in a Coastal Aquifer, South Australia

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Journal of Water Resource and Protection 2013年第12期5卷 1170-1177页

作者： Nara Somaratne jacqueline Frizenschaf South Australian Water Corporation 250 Victoria Square Adelaide Australia

Estimation of natural recharge and potential for seawater intrusion are critical considerations for management of coastal freshwater aquifers. We show hydrochemical signatures of groundwater to identify the influence of geological control on chemical processes in a coastal groundwater system. We used dominant hydrochemical facies, salinity and magnesium ions to determine two main groundwater flow paths with different origins and ages. Mixing of groundwater with different origins and ages results in unreliable recharge estimates using chlorofluorocarbon (CFC) and chloride mass balance (CMB) methods, thus limiting available methods for recharge assessment. Interpretation of hydrochemical data suggests that calcium carbonate dissolution, ion exchange processes and mixing with sea aerosol in coastal zones are the main influencing factors on groundwater chemistry. Restricted groundwater flows due to occurrence of a basement high at the southern side of the basin boundary influence the distance to the toe of the saline wedge. Thus, knowledge of geological control over groundwater systems forms an important part of characterising basins and contributes toward effective management of groundwater resources.

关键词： Hydrochemistry Groundwater Mixing Groundwater Management Recharge

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Experts Discuss Children's Leisure Reading in China

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China Today 1997年第3期46卷 59-60页

作者： Weiss, jacqueline Shac

Reports on the conference held by the Chinese Board on Books for Young People focusing on children's literature in China in 1997. Findings about the problems confronting children's literature in the country; Discussio... 详细信息

关键词： In Experts Discuss Children’s Leisure Reading in China

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Climate Change Associated with Global Teleconnections, Volcanic Eruptions, and the Arctic’s Snow-Ice Albedo in Godthab, Greenland

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Atmospheric and Climate Sciences 2013年第1期3卷 31-40页

作者： Amber Penner jacqueline Binyamin University of Winnipeg Department of Geography Winnipeg Canada

To study the impact of climate change on Godthab(Greenland), temperature and precipitation gathered from the Global Historical Climatology Network (GHCN) were analyzed for patterns within 1866-2011. Both temperature and precipitation have experienced an overall increase throughout the past 146 years. Precipitation, however, has experienced a declining trend since 1985. North Atlantic Oscillation (NAO) and Arctic Oscillation (AO) indices showed strong correlations with average annual temperature (R = ?0.6) and smaller correlations with annual total precipitation (R = ?0.2). There are moderate correlations between temperature, precipitation, and Southern-Oscillation Index (SOI). The positive phases of Pacific-North American (PNA) led to increased winter and spring precipitation. The climate mode’s influential strength on Godthab’s temperature and precipitation, vary seasonally. In contrast with global average temperatures, Greenland has not experienced a continual warming trend since the 1950s;30- and 10-year trends show a cooling period between 1965 and 1995. From 1866 to 2011, Godthab’s average annual temperature has increased by 1.9?C, and is anticipated to continue to warm in accordance with the global warming trend and the Arctic’s associated feedback mechanisms.

关键词： Godthab (Greenland) Climate Modes Teleconnections Climate Change Climate Variability ENSO NAO AO PNA

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Climate Change Effect on Winter Temperature and Precipitation of Yellowknife, Northwest Territories, Canada from 1943 to 2011

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American Journal of Climate Change 2013年第4期2卷 275-283页

作者： Janelle Laing jacqueline Binyamin Department of Geography University of Winnipeg Winnipeg Canada

The correlation of the Southern Oscillation Index (SOI), Pacific Decadal Oscillation (PDO), Pacific North American Oscillation (PNA), Arctic Oscillation (AO), and Scandinavia (SCAND) indices with winter (DJF) temperature and precipitation for the period of 1943 to 2011 was analyzed to study climate change and variability of Yellowknife, NWT. SOI correlated negatively with both temperature (r = -0.14) and precipitation (r = -0.06) causing colder, drier conditions during La Nina and warmer, wetter conditions during El Nino. PDO was shown to have a strong positive correlation with both temperature (r = 0.60) and precipitation (r = 0.33) causing warmer, wetter weather in the positive phase and colder, drier weather in the negative phase. PNA showed the strongest positive correlation for both temperature (r = 0.69) and precipitation (r = 0.37) causing very warm and wet conditions in the positive phase and very cold and dry conditions during the negative phase. AO correlated negatively with temperature (r = -0.04) and positively with precipitation (r = 0.24) causing colder, wetter conditions in the positive phase and warmer, drier conditions in the negative phase. Finally SCAND was shown to have a weak negative correlation with both temperature (r = -0.10) and precipitation (r = -0.18). Sunspot area showed a strong negative correlation (r = -0.30) with temperature and a very weak positive correlation (r = 0.07) with total annual precipitation. Yellowknife’s average annual temperature and precipitation has increased by 2.5°C and 120 mm, respectively throughout the past 69 years.

关键词： Yellowknife Climate Change Climate Variability Climate Modes Teleconnections ENSO SOI PDO PNA AO SCAND Sunspot Area

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Characterization of yttria-stabilized zirconia films deposited by dip-coating on La_(0.7)Sr_(0.3)MnO_(3) substrate:Influence of synthesis parameters

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Journal of Advanced Ceramics 2013年第1期2卷 55-62页

作者： jacqueline C.MARRERO Nielson F.P.RIBEIRO Célia F.MALFATTI Mariana M.V.M.SOUZA Escola de Química-Universidade Federal do Rio de Janeiro(UFRJ) Centro de TecnologiaBloco Esala 206Ilha do FundãoCEP 21941-909Rio de JaneiroRJBrazil Departamento de Metalurgia Universidade Federal do Rio Grande do Sul(UFRGS)Campus do ValeSetor 4Prédio 75Sala 234CEP 91501-970Porto AlegreRSBrazil

Yttria-stabilized zirconia(YSZ,ZrO_(2)-8%Y2O_(3))films were deposited onto lanthanum strontium manganite(LSM,La_(0.7)Sr_(0.3)MnO_(3))substrates using dip-coating process aiming for the application in solid oxide fuel cells(SOFCs).YSZ precursor was prepared by sol-gel method;three values of the organic/inorganic concentration ratio(1,3 and 5)were utilized and the sol viscosity was adjusted(60 mPa·s and 100 mPa·s)before deposition on the *** influence of these synthesis parameters on the structure and morphology of the deposited films was examined by X-ray diffraction(XRD)and scanning electron microscopy(SEM).The films showed characteristic peaks of LSM,YSZ(with cubic structure)and secondary phases of SrZrO_(3) and La_(2)O_(3).Depending on the synthesis conditions,crack-free,homogeneous and well adhered films were obtained,with thickness of 11-24μm.

关键词： YSZ films LSM sol-gel dip-coating

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