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一种新的力值测量方法

中国检验检测 1990年第3期 30-31+7页

作者： Walter e.jacobson 张克敏

1.前言以前,为了测量结构上承受的载荷,是把负荷敏感元件固结在结构的外表面上。因此,能够把敏感元件做成一种简易的传感器,当把它装入结构中,其输出将准确地与结构上承受的负荷成比例关系,这种新的力值测量方法是

关键词：力值测量传感器换能器电子技术敏感元件电子元件

伴上皮肿瘤内PTCH杂合子缺失的1型神经纤维瘤病患者的特征性临床表现

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 55-56页

作者： jacobson e Toms C H. Skelton 潘敏 Department of Dermatopathology Quest Diagnostics 1777 Montreal Circle Tucker GA 30084 United StatesDr

Although patients with neurofibromatosis (NF) have an increased incidence of tumors, there is only one study that suggests that NF1 patients may have an incre ased risk for epithelial malignancies. We present a patient with known NF1 who h ad developed multiple epithelial tumors since early in his life. All but one of these tumors were morphologically most consistent with trichoepitheliomas. Loss of heterozygosity (LOH) for Patched 1 gene (PTCH) was demonstrated within two of the trichoepitheloma-like tumors and one tumor diagnosed as basal cell carcino ma, and the patient was show to have a PTCH gene deletion. To our knowledge, a p atient presenting with both NF1 and multiple trichoepitheliomas (MTe) has not pr eviously been reported. The dysregulation in cellular proliferation and signalin g induced by decreased NF1 along with the PTCH gene mutation may explain the pat tern of immunohistochemical staining within these tumors, and the rare associati on of NF1 with epithelial neoplasms.

关键词：神经纤维瘤病 PTCH 上皮肿瘤杂合子毛发上皮瘤基底细胞癌免疫组化染色基因突变细胞增殖

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成像过程的机理和应用

成像过程的机理和应用

Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

作者： K.I.·雅各布森(K.I. jacobson) R.e.·雅各布森(R.e. jacobson)

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo Patricia T.jacobson Brandon J.Vilarello Tiana M.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.Gary David A.Gudis Paule V.Joseph D.P.Devanand Terry e.Goldberg Jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving Medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

The aggressive invasion of exotic reptiles in Florida with a focus on prominent species： A review

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Current Zoology 2011年第5期57卷 599-612页

作者： Richard eNGeMAN elliott jacobson Michael L. AVeRY Walter e. MeSHAKA, Jr. USDA/APHIS/Wildlife Services/National Wildlife Research Ctr 4101 LaPorte Ave. Fort Collins CO 80521-2154 USA College of Veterinary Medicine University of Florida Gainesville FL 32610 USA USDA/APHIS/Wildlife Services/National Wildlife Research Ctr 2820 East University Ave. Gainesville FL 32641 USA The State Museum of Pennsylvania 300 North Street Harrisburg Pennsylvania 17120 USA

Florida, along with Hawaii, has among the two worst invasive species problems in the USA, and the state is espe-cially susceptible to establishment by alien reptiles. Besides the large numbers of established non-native reptile species in Florida, many of these species present novel difficulties for management, or have other characteristics making effective management ex-tremely challenging. Moreover, initiation of management action requires more than recognition by experts that a potentially harmful species has become established. It also requires the political will along with concomitant resources and appropriate per-sonnel to develop effective methods and apply them. We review the situation in Florida, including assessment of risk for estab- lishment, and we use a subset of prominent species to illustrate in more detail the array of invasive reptile species circumstances in Florida, including routes of introduction, impacts, and potential and implemented management actions. These examples not only highlight the severity of the invasive reptile problems in the state, but they also show the diversity in resolve and response towards them and the motivating factors [Current Zoology 57 （5）： 599-612, 2011].

关键词： Argentine black and white tegus Biophysical ecology Burmese pythons Control Green and spiny-tailed iguanas,Invasive species Nile monitors Northern curlytail lizards

evaluation of natural goethite on the removal of arsenate and selenite from water

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Journal of environmental Sciences 2019年第2期31卷 133-141页

作者： Andrew T.jacobson Maohong Fan Department of Chemical engineering University of Wyoming

elevated arsenic and selenium concentrations in water cause health problems to both humans and wildlife. Natural and anthropogenic activities have caused contamination of these elements in waters worldwide, making the development of efficient cost-effective methods in their removal essential. In this work, removal of arsenate and selenite from water by adsorption onto a natural goethite(α-FeO OH) sample was studied at varying conditions. The data was then compared with other arsenate, selenite/goethite adsorption systems as much of literature shows discrepancies due to varying adsorption conditions. Characterization of the goethite was completed using inductively coupled plasma mass spectrometry, X-ray diffraction, Fouriertransform infrared spectroscopy, scanning electron microscopy, and Brunauer–emmett–Teller surface area analysis. Pseudo-first order(PFO) and pseudo-second order(PSO) kinetic models were applied; including comparisons of different regression methods. Various adsorption isotherm models were applied to determine the best fitting model and to compare adsorption capacitates with other works. Desorption/leaching of arsenate and selenite was studied though the addition of phosphate and hydroxyl ions. Langmuir isotherm modeling resulted in maximum adsorption capacities of 6.204 and 7.740 mg/g for arsenate and selenite adsorption,respectively. The PSO model applied with a non-linear regression resulted in the best kinetic fits for both adsorption and desorption of arsenate and selenite. Adsorption decreased with increasing pH. Phosphate induced desorption resulted in the highest percentage of arsenate and selenite desorbed, while hydroxide induced resulted in the fastest desorption kinetics.

关键词： Arsenic Selenium Adsorption Desorption FeOOH Water treatment

Physicochemical properties of proton-conducting SmNiO3 epitaxial films

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Journal of Materiomics 2019年第2期5卷 247-251页

作者： Xing Xu Chen Liu Jing Ma Allan J.jacobson Cewen Nan Chonglin Chen School of Material Science and engineering Tsinghua UniversityBeijing100086China Department of Chemistry and Texas Center for Superconductivity University of HoustonHoustonTX77204USA Department of Physics and Astronomy University of Texas at San AntonioSan AntonioTX78249USA

Proton conducting SmNiO_(3)(SNO)thin films were grown on(001)LaAlO_(3)substrates for systematically investigating the proton transport properties.X-ray Diffraction and Atomic Force Microscopy studies reveal that the as-grown SNO thin films have good single crystallinity and smooth surface *** electrical conductivity measurements in air indicate a peak at 473 K in the temperature dependence of the resistance of the SNO films,probably due to oxygen loss on heating.A Metal-Insulator-Transition occurs at 373 K for the films after annealing at 873 K in *** a hydrogen atmosphere(3%H_(2)/97%N_(2)),an anomalous peak in the resistance is found at 685 K on the first heating *** Impedance Spectroscopy studies as a function of temperature indicate that the SNO films have a high ionic conductivity(0.030 S/cm at 773 K)in a hydrogen *** activation energy for proton conductivity was determined to be 0.23 eV at 473-773 K and 0.37 eV at 773e973 K *** findings demonstrate that SNO thin films have good proton conductivity and are good candidate electrolytes for low temperature proton-conducting Solid Oxide Fuel Cells.

关键词： SmNiO_(3) Thin film Transport properties Ionic conductivity Impedance measurements

Improved gastrointestinal health for irritable bowel syndrome with metagenome-guided interventions

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Precision Clinical Medicine 2020年第2期3卷 136-146页

作者： Cem Meydan ebrahim Afshinnekoo Nate Rickard Guy Daniels Laura Kunces Theresa Hardy Loukia Lili Sarah Pesce Paul jacobson Christopher e.Mason Joel Dudley Bodi Zhang Onegevity Health 152 W 57thNew YorkNY 10019USA Thorne Research 152 W 57thNew YorkNY 10019USA

Irritable bowel syndrome(IBS)is the most prevalent functional gastrointestinal disorder worldwide,and the most common reason for referral to gastroenterology ***,the pathophysiology is still not fully understood and consequently current management guidelines are very symptom-specific,leading to mixed *** we present a study of 88 individuals with IBS who had baseline sequencing of their gut microbiome(stool samples),received targeted interventions that included dietary,supplement,prebiotic/probiotic,and lifestyle recommendations for a 30-day period,and a follow-up sequencing of their gut *** study’s objectives were to demonstrate unique metagenomic signatures across the IBS phenotypes and to validate whether metagenomic-guided interventions could lead to improvement of symptom scores in individuals with *** subjects also completed a baseline and post-intervention questionnaire that assessed their symptom *** average symptom score of an individual with IBS at baseline was 160 and at the endpoint of the study the average symptom score of the cohort was *** mixed IBS subtype showed the most significant reduction in symptom scores across the different subtypes(average decrease by 102 points,P=0.005).The metagenomics analysis reveals shifts in the microbiome post-intervention that have been cross-validated with the literature as being associated with improvement of IBS *** the complex nature of IBS,further studies with larger sample sizes,more targeted analyses,and a broader population cohort are needed to explore these results further.

关键词： irritable bowel syndrome microbiome metagenomics

Temperature variable and the efficiency of sperm mediated transfection of HPV16 DNA into cells

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Asian Journal of Andrology 2002年第3期4卷 169-173页

作者： Ruslana Kadze Philip J.Chan John D.jacobson Johannah U.Corselli Alan King Center for Fertility and In Vitro Fertilization Department of Gynecology and Obstetricsand Department of Physiology and PharmacologyLoma Linda University School of MedicineLoma LindaCalifornia 92350USA

Aim:To pretreat sperm at various temperatures before exposure to human papillomavirus(HPV)16 DNA fragments and to assess the efficiency of HPV carrier sperm to transfect cumulus ***:Cumulus cells from follicular aspirates were obtained,pooled and divided into culture dishes containing Sybr Gold-stained HPV DNA carrying sperm that were either pretreated at 4℃,37℃or 40℃(n=5).The cells were incubated in 5%CO_(2) in air mixture at 37℃for 24 *** efficiency of sperm to take up fluorescent HPV DNA was determined at hour *** incubation,cumulus cell viability was assessed using the e0sin method and the percentages of fluorescent cumulus cells ***:Over half of all the cumulus cells became fluorescent with the highest percentage in the 37℃*** pretreated at 4℃had the greatest amount of HPV DNA *** sperm motility was similar for the 3 pretreatment *** were no differences in cumulus viability among the ***:Sperm pretreated at 37℃transferred the greatest amount of fluorescent HPV DNA fragments to the cumulus *** HPV DNA was observed in the nuclear and cytoplasmic *** data suggested the possibility of sperm as a vector for the transmission of HPV DNA to the cumulus cells surrounding ovulated oocytes,which might lead to early implantation failures.

关键词： spermatozoa human papillomavirus gene transfer cumulus fertility