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CCS Chemistry 2019年第3期1卷 251-260页

作者： yuanyuan Li Chuansheng Li Tao Jiang Lihua Zhou Pengfei Zhang Ryan T.K.Kwok jacky wing yip lam Ping Gong Lintao Cai Ben Zhong Tang Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonChina HKUST Shenzhen Research Institute Shenzhen 518057China Guangdong Key Laboratory of Nanomedicine CAS Key Laboratory of Health InformaticsShenzhen Bioactive Materials Engineering Lab for MedicineInstitute of Biomedicine and Biotechnology.Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Pharmaceutical Sciences Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Dongguan Key Laboratory of Drug Design and Formulation Technology Key Laboratory for NanomedicineGuangdong Medical UniversityDongguan 523808China Center for Aggregation-Induced Emission NSFC Center for Luminescence from Molecular AggregatesSCUT-HKUST Joint Research LaboratoryState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Fluorescence imaging has become an indispensable technique in cancer research because it can reveal informative molecular,cellular,anatomical,and func-tional *** of advanced fluores-cent probes with superior sensitivity and biological selectivity for fluorescence imaging is thus *** move forward in this direction,we developed an easy self-assembly method for fabricating apta-mer-anchored rubrene-loaded organic fluorescent *** aptamer-modified organic nanop-robes integrated the best features of the organic light-emitting materials and the aptamers,thus endowing them with excellent cell-targeting capabil-ity,high stability,and good *** using this general method,a variety of biocompatible and highly bright organic fluorescent nanoprobes based on novel organic light-emitting materials with specific recognition could be easily constructed for real-time biosensing and long-term biomedical imaging.

关键词： aptamer organic nanoprobes fluores-cence cancer imaging biomedicine

Development and Implementation of an Advanced Planning & Scheduling (APS) System for Semiconductor Backend Assembly

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厦门大学学报（自然科学版） 2002年第S1期41卷 189-190页

作者： T J Chua T X Cai F y wang william Liu X F yin w J yan J P Zhu Joanne lam Gintic Institute of Manufacturing Technology Gintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing Technology SingaporeSingaporeSingaporeSingaporeSingaporeSingaporeSingaporeSingapore

In this paper, the design, customization and implem en tation of an integrated Advanced Planning and Scheduling (APS) system for a Semi conductor Backend Assembly environment is described. The company is one of the w orldwide market leaders in semiconductor packaging technology. The project was d riven by the company’s quest to achieve a competitive edge as a manufacturing po werhouse by providing the shortest possible cycle time with a high degree of fle xibility through the application of Computer Integrated Manufacturing (CIM) tech nology. Gintic was responsible for the Planning & Scheduling functions through o ur APS tool kit, which is called Gintic Scheduling System (GSS). Our APS system is to be integrated with the other two key software systems, namely, the Enterpr ise Resource Planning (ERP) and Manufacturing Execution System (MES), with the C IM framework. The project was divided into four major execution phases. Phase One activities w ere focused on the gathering and analysis of the end users requirements in order to establish the ’As-Is’ situation and the wish list & the expectation of the ’To-Be’ system. Planning and Scheduling prototypes were built using GSS to iden tify the functionality gap between the existing GSS system and the ’To-Be’ mode l, in order to determine the customization effort needed. The project team perfo rmed detailed system analysis, design and development of the ’To-Be’ system dur ing Phase Two of the project. There are a total of four planning and scheduling modules, including Capacity Planning (CP), Daily Lot Release (DLR), Daily Produc tion Scheduling (DPS) and Dynamic Operation Scheduling (DOS). The detailed desig n specifications of each of the features and functionality were confirmed and ac cepted by the end users before the commencement of the development effort. The c ompleted and tested modules were delivered in stages for testing and acceptance by the end user during the Phase Three of the project. Pilot product line was

关键词： integrated planning scheduling semiconductor b ackend assembly

On the use of deep learning for phase recovery

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Light(Science & Applications) 2024年第2期13卷 190-235页

作者： Kaiqiang wang Li Song Chutian wang Zhenbo Ren Guangyuan Zhao Jiazhen Dou Jianglei Di George Barbastathis Renjie Zhou Jianlin Zhao Edmund y.lam Department of Electrical and Electronic Engineering The University of Hong KongHong Kong SARChina School of Physical Science and Technology Northwestern Polytechnical UniversityXi’anChina Department of Biomedical Engineering The Chinese University of Hong KongHong Kong SARChina School of Information Engineering Guangdong University of TechnologyGuangzhouChina Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA

Phase recovery(PR)refers to calculating the phase of the light field from its intensity *** exemplified from quantitative phase imaging and coherent diffraction imaging to adaptive optics,PR is essential for reconstructing the refractive index distribution or topography of an object and correcting the aberration of an imaging *** recent years,deep learning(DL),often implemented through deep neural networks,has provided unprecedented support for computational imaging,leading to more efficient solutions for various PR *** this review,we first briefly introduce conventional methods for ***,we review how DL provides support for PR from the following three stages,namely,pre-processing,in-processing,and *** also review how DL is used in phase image ***,we summarize the work in DL for PR and provide an outlook on how to better use DL to improve the reliability and efficiency of ***,we present a live-updating resource(https://***/kqwang/phase-recovery)for readers to learn more about PR.

关键词： networks phase optics

Simultaneous harvesting and cell disruption of microalgae using ozone bubbles:optimization and characterization study for biodiesel production

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Frontiers of Chemical Science and Engineering 2021年第5期15卷 1257-1268页

作者： wan N.A.Kadir Man K.lam yoshimitsu Uemura Jun w.Lim Peck L.Kiew Steven Lim Siti S.Rosli Chung y.wong Pau L.Show Keat T.Lee Chemical Engineering Department Universiti Teknologi PETRONASSeri Iskandar32610Malaysia HICoE-Centre for Biofuel and Biochemical Research Institute of Self-Sustainable BuildingUniversiti Teknologi PETRONASSeri Iskandar32610Malaysia NPO Kuramae Bioenergy Tokyo108-0023Japan Fundamental and Applied Sciences Department Universiti Teknologi PETRONASSeri Iskandar32610Malaysia Faculty of Engineering Technology&Built EnvironmentUniversity College Sedaya InternationalCheras Kuala Lumpur56000Malaysia Department of Chemical Engineering Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul RahmanSungai LongSelangor43000Malaysia Department of Chemical and Environmental Engineering Faculty of Science and EngineeringUniversity of Nottingham MalaysiaSemenyih43500Malaysia School of Chemical Engineering Universiti Sains MalaysiaEngineering CampusNibong Tebal14300Malaysia

In the present study, ozone was introduced as an alternative approach to harvest and disrupt microalgae cells (Chlorella vulgaris) simultaneously for biodiesel production. At the optimum ozonation conditions (6.14 g·h^(−1) ozone concentration, 30 min ozonation time, 1 L·min^(−1) of ozone flowrate at medium pH of 10 and temperature of 30℃), the sedimentation efficiency of microalgae cells increased significantly from 12.56% to 68.62%. It was observed that the microalgae cells aggregated to form flocs after pretreated with ozone due to the increment of surface charge from −20 to −6.59 mV. Besides, ozone had successfully disrupted the microalgae cells and resulted in efficient lipid extraction, which was 1.9 times higher than the control sample. The extracted microalgae lipid was mainly consisted of methyl palmitate (C16:0), methyl oleate (C18:1) and methyl linolenate (C18:3), making it suitable for biodiesel production. Finally, utilization of recycled culture media after ozonation pre-treatment showed robust growth of microalgae, in which the biomass yield was maintained in the range of 0.796 to 0.879 g ·h^(−1) for 5 cycles of cultivation.

关键词： microalgae biodiesel ozonation pre-treatment lipid

Automatic quantification of superficial foveal avascular zone in optical coherence tomography angiography implemented with deep learning

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Visual Computing for Industry,Biomedicine,and Art 2019年第1期2卷 205-213页

作者： Menglin Guo Mei Zhao Allen M.y.Cheong Houjiao Dai Andrew K.C.lam yongjin Zhou School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen University Xili CampusRoom 208Block A2Taoyuan StreetShenzhen 518055China Centre for Myopia Research School of OptometryFaculty of Health and Social SciencesThe Hong Kong Polytechnic UniversityKowloonHong KongChina

An accurate segmentation and quantification of the superficial foveal avascular zone(sFAZ)is important to facilitate the diagnosis and treatment of many retinal diseases,such as diabetic retinopathy and retinal vein *** proposed a method based on deep learning for the automatic segmentation and quantification of the sFAZ in optical coherence tomography angiography(OCTA)images with robustness to brightness and contrast(B/C)variations.A dataset of 405 OCTA images from 45 participants was acquired with Zeiss Cirrus HD-OCT 5000 and the ground truth(GT)was manually segmented subsequently.A deep learning network with an encoder–decoder architecture was created to classify each pixel into an sFAZ or non-sFAZ ***,we applied largestconnected-region extraction and hole-filling to fine-tune the automatic segmentation results.A maximum mean dice similarity coefficient(DSC)of 0.976±0.011 was obtained when the automatic segmentation results were compared against the *** correlation coefficient between the area calculated from the automatic segmentation results and that calculated from the GT was *** all nine parameter groups with various brightness/contrast,all the DSCs of the proposed method were higher than *** proposed method achieved better performance in the sFAZ segmentation and quantification compared to two previously reported *** conclusion,we proposed and successfully verified an automatic sFAZ segmentation and quantification method based on deep learning with robustness to B/C *** clinical applications,this is an important progress in creating an automated segmentation and quantification applicable to clinical analysis.

关键词： Optical coherence tomography angiography Deep learning Foveal avascular zone Automatic segmentation and quantification

Ophthalmology in the time of COVID-19: experience from Hong Kong Eye Hospital

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 851-859页

作者： Stephanie S.L.Cheung Cherie y.K.wong Jason C.K.Chan Carmen K.M.Chan N.M.lam Hunter K.L.yuen Victoria w.y.wong Chi wai Tsang Clement C.y.Tham Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong SARChina Hong Kong Eye Hospital Hong Kong SARChina

AIM:To review international guidelines and to share our infection control experience during the coronavirus disease 2019(COVID-19)pandemic at a tertiary eye centre in Hong ***:Infection control guidelines and recommendations from international ophthalmological bodies are reviewed and *** measures at our hospital were drawn up as per international and local health authorities’guidelines and implemented with the collaboration of doctors,nurses and administrative ***:The aims of our infection control measures are to 1)minimize cross-infection within the hospital;2)protect and support hospital staff;3)ensure environmental *** minimize the risk of cross-infection,outpatient attendance and elective surgery have been reduced by 40%,and general anesthesia procedures were reduced by 90%.Patients entering the hospital are screened for fever,travel history,contact and cluster history,and COVID-19 related *** protect and support hospital staff,we ensure provision of adequate personal protective equipment(PPE)and provide clear guidelines on the level of PPE needed,depending on the clinical *** protective measures include provision of work uniforms,easy access to alcohol-based hand rub,opening new lunch areas,implementation of self-monitoring and self-reporting systems,and communication via online education and ***,environmental control is achieved by ensuring regular disinfection of the hospital premise,enhancing ventilation,and usage of disposable ophthalmic ***:Our multi-pronged approach to infection control is,so far,successful in minimizing infection risks,while allowing the maintenance of essential ophthalmic services.

关键词： COVID-19 coronavirus SARS-CoV-2 ophthalmology infection control Hong Kong

用带不同侧链的双取代聚乙炔衍生物增溶多壁碳纳米管

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高分子学报 2007年第10期17卷 901-904页

作者：袁望章赵辉徐海鹏孙景志 lam J w.y.毛宇金佳科张双郑强唐本忠浙江大学高分子科学与工程学系教育部高分子合成与功能构造重点实验室杭州310027 香港科技大学化学系

采用不同的双取代聚乙炔与多壁碳纳米管复合,通过π-π相互作用和聚合物链缠绕实现了对碳纳米管的增溶.这种方法对碳纳米管的结构没有损害,而且包覆到碳纳米管表面的双取代聚乙炔也显示了自身的荧光发射特性.

关键词：双取代聚乙炔缠绕碳纳米管增溶

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进化

家庭影院技术 2008年第8期 45-47页

作者： jacky.lam

进化（Evolution），这个词汇最能联想到达尔文有关自然界生物为了回应环境压力、自然选择和基因突变而逐渐（经过好几百万年）产生由低级到高级的发展变化过程。回顾单枪影院投影机的发展，数码工业化生产将这一进程微缩到不到10年的... 详细信息

进化（Evolution），这个词汇最能联想到达尔文有关自然界生物为了回应环境压力、自然选择和基因突变而逐渐（经过好几百万年）产生由低级到高级的发展变化过程。回顾单枪影院投影机的发展，数码工业化生产将这一进程微缩到不到10年的演变过程，从480p到720p再到1080p Full HD大约不到5年时间，而实际上早在2003年6月JVCD—ILA3840×2048像素数码投影机已开启4K时代。2004年6月SONy SXRD—R110已完成Digital Cinema 4096×2160的4Kp技术发展。

关键词：数码投影机工业化生产环境压力基因突变自然选择

Grasping Motion Control of Robotic Hands Using MIDS

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Grasping Motion Control of Robotic Hands Using MIDS