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Quantitative characterization of polyacrylamide–shale interaction under various saline conditions

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Petroleum Science 2017年第3期14卷 586-596页

作者： Samyukta Koteeswaran jack c.pashin Josh D.Ramsey Peter E.clark School of chemical Engineering Oklahoma State UniversityStillwater OK 74078 USA Boone Pickens School of Geology Oklahoma State University Stillwater OK 74078 USA

Interaction of polymer-containing injected fluids with shale is a widely studied phenomenon, but much is still unknown about the interaction of charged polyacrylamides such as anionic and cationic polyacrylamides with shale. The nature of interaction of charged polyacrylamides with shale is not well understood, especially from the perspective of assessing the potential for polyacrylamides to cause formation damage. Zeta potential and rheological measurements were made for chattanooga and Pride Mountain shales suspended in polyacrylamide solutions with and without inorganic salts and tetramethyl ammonium chloride（TMAc）. The change in zeta potential and viscosity with time was recorded. The magnitude of decrease in the absolute value of zeta potential with time is indicative of adsorption of polymer on the surface of shale and serves as a measure of the extent of polymer interaction with shale. The salts that were used in this study are potassium chloride（Kcl）, sodium chloride（Na cl）. This study quantified the interaction of anionic and cationic polyacrylamide with different North American *** the experimental results, it was determined that the polyacrylamides can interact strongly with shale, particularly the cationic polyacrylamide. The objective of this study was to determine the extent of interaction of anionic and cationic polyacrylamide with each shale sample in the presence of additives such as salts.

关键词： Anionic and cationic polyacrylamides chattanooga shale Pride Mountain shale Zeta potentialSlurry rheology

“机械灌注+”应用于扩大标准供肝移植--肝尽其用

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Engineering 2024年第1期32卷 29-40页

作者： Zhoucheng Wang jack Martin Jiongjie Yu Kai Wang Kourosh Saeb-Parsy Xiao Xu Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Department of Surgery Cambridge University Hospitals&NHS Foundation TrustCambridge CB22QQ UK Department of Surgery University of Cambridge&NIHR Cambridge Biomedical Research CentreCambridge CB22QQUK Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China

Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor *** criteria donor(EcD)liver grafts are increasingly utilized in clinical practice to mitigate this ***,impaired ischemic tolerance of these grafts jeopardizes organ viability during cold *** perfusion(MP)was designed to improve organ preservation and reduce posttransplant ***,it is increasingly evident that MP alone may not preserve EcD grafts *** emphasis has thus been placed on modified MP strategies,including the use of different perfusates,modified perfusion modalities,and different therapeutic ***,we introduce a novel term,"MP Plus,"denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of EcD *** this review,we summarize the existing and potential modified MP strategies and discuss their advantages in reconditioning different EcD grafts in clinical settings.

关键词： Liver transplantation Extended criteria donor Machine perfusion plus Organ shortage

Application of the Shrinking Particle Model for the Evaluation of Molecular Recyclability of PET versus Semi-Aromatic Polyesters

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Open Journal of Physical chemistry 2024年第2期14卷 21-35页

作者： jack van Schijndel Sanne de Krom Dennis Molendijk Koen van Beurden Amarante Böttger Research Group Biopolymers/Green chemistry Centre of Expertise Safe & Resilient Society Avans University of Applied Science Breda Netherlands New Materials and Their Applications Centre of Expertise Safe & Resilient Society Avans University of Applied Science Breda Netherlands Department of Materials Science and Engineering Delft University of Technology Delft Netherlands

The molecular recyclability of poly (ethylene terephthalate) (PET) and three semi-aromatic polyesters poly (phloretic acid) (poly-H), poly (dihydroferulic acid) (poly-G), and poly (dihydrosinapinic acid) (poly-S) is evaluated in this study. PET is an extensively used aromatic polyester, and poly-H, poly-G, and poly-S can be considered semi-aromatic poly (lactic acid) modifications. All these polyesters have been depolymerized at neutral pH and by acid- and base-catalyzed hydrolysis at two temperatures, i.e., 50˚c and 80˚c. Base-catalyzed depolymerization of virgin PET leads to an isolated yield of 38% after 48 hours of reaction at 80˚c. contrary to these results for PET, almost all the monomers of the semi-aromatic polyesters poly-H, poly-G, and poly-S are recovered with isolated yields larger than 90% at the same temperature after 15 minutes in a facile manner. A shrinking particle model used to determine the global kinetics of the base-catalyzed depolymerization showed that the rate rises with increasing temperature. Using the shrinking particle model, the intrinsic reaction rate constants were determined. It has been demonstrated that the rate coefficients of the depolymerization of the semi-aromatic polyesters poly-H, poly-G, and poly-S are between 2 and 3 orders of magnitude higher than those for PET.

关键词： Depolymerization Molecular Recycling Poly-H Poly-G Poly-S PET circular Polymers

Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted cell Survival Factor that Drives Metabolic Disease

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Engineering 2023年第1期20卷 9-18页

作者： Tamana Yousof Jae Hyun Byun jack chen Richard c.Austin Department of Medicine Division of NephrologyMcMaster UniversityThe Research Institute of St.Joe’s Hamilton and the Hamilton Centre for Kidney ResearchHamiltonOntarioL8N 4A6Canada

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is a multifaceted intracellular protein belonging to the evolutionarily conserved pleckstrin homology-related domain family. Its murine homologue, T-cell death-associated 51 (TDAG51) gene, was initially discovered for its role in activation-induced apoptosis in T-cell hybridomas. In recent years, PHLDA1 has received increased attention due to its association with obesity, fatty liver disease, diabetes, atherosclerosis, and cancer. Accumulating evidence also supports its role in endoplasmic reticulum stress signaling pathways as a crucial mediator of apoptosis, autophagy, and cell proliferation. In this review, the current knowledge of PHLDA1 gene and protein regulation, localization, and function is summarized. This review highlights the pro- and anti-apoptotic roles of PHLDA1 that contribute to vast array of metabolic diseases.

关键词： ER-stress Metabolism Apoptosis cell survival PHLDA1

Physics-based,data-driven approach for predicting natural ventilation of residential high-rise buildings

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Building Simulation 2022年第1期15卷 129-148页

作者： Vincent J.L.Gan Boyu Wang c.M.chan A.U.Weerasuriya jack c.P.cheng Department of Building School of Design and EnvironmentNational University of SingaporeSingapore117566 Department of civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Natural ventilation is particularly important for residential high-rise buildings as it maintains indoor human comfort without incurring the energy demands that air-conditioning *** improve a building’s natural ventilation,it is essential to develop models to understand the relationship between wind flow characteristics and the building's *** more effort is still needed for developing such reliable,accurate,and computationally economical models instead of currently the most popular physics-based models such as computational fluid dynamics(cFD)*** paper,therefore,presents a novel model developed based on physics-based modelling and a data-driven approach to evaluate natural ventilation in residential high-rise *** model first uses cFD to simulate wind pressures on the exterior surfaces of a high-rise *** the surface pressures have been obtained,multizone modelling is used to predict the air change per hour(AcH)for different flats in various ***-driven prediction models are then developed using data from the simulation and deep neural networks that are based on mean absolute error,mean absolute percentage error,and a fusion algorithm *** data-driven models are used to predict the AcH of 25 *** results from multizone modelling and data-driven modelling are *** results imply a high accuracy of the data-driven prediction in comparison with physics-based *** fusion algorithm-based neural network performs best,achieving 96%accuracy,which is the highest of all models *** study contributes a more efficient and robust method for predicting wind-induced natural *** findings describe the relationship between building design(e.g.,plan layout),distribution of surface pressure,and the resulting AcH,which serve to improve the practical design of sustainable buildings.

关键词： computational fluid dynamics data-driven prediction machine learning multizone model natural ventilation residential building

Genetic parameters of drinking and feeding traits of wean-to-finish pigs under a polymicrobial natural disease challenge

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Journal of Animal Science and Biotechnology 2022年第1期13卷 17-35页

作者： Jian cheng Austin M.Putz John c.S.Harding Michael K.Dyck Frederic Fortin Graham S.Plastow Pig Gen canada jack c.M.Dekkers Department of Animal Science Iowa State UniversityAmesIA 50011USA Hendrix Genetics Swine Business UnitBoxmeerThe Netherlands 5831CK Department of Large Animal clinical Science University of SaskatchewanSaskatoonSK S7N 5A2Canada Department of Agriculture Food and Nutritional ScienceUniversity of AlbertaEdmontonAB T6G 2R3Canada centre de Developpement du Porc du Quebec Inc. Quebec City G1V 4M6Canada PigGen canada Research consortium GuelphOntario N1H4G8Canada

Background:The pork industry faces unprecedented challenges from disease,which increases cost of production and use of antibiotics,and reduces production efficiency,carcass quality,and animal *** solution is to improve the overall resilience of pigs to a broad array of common diseases through genetic *** changes in feeding and drinking are usually the very first clinical signs when animals are exposed to stressors such as *** in feeding and drinking behaviors in diseased pigs may reflect the way they cope with the challenge and,thus,could be used as indicator traits to select for disease *** objectives of this study were to estimate genetic parameters of feeding and drinking traits for wean-to-finish pigs in a natural polymicrobial disease challenge model,to estimate genetic correlations of feeding and drinking traits with growth rate and clinical disease traits,and to develop indicator traits to select for disease ***:In general,drinking traits had moderate to high estimates of heritability,especially average daily water dispensed,duration,and number of visits(0.44 to 0.58).Similar estimates were observed for corresponding feeding traits(0.35 to 0.51).Most genetic correlation estimates among drinking traits were moderate to high(0.30 to 0.92)and higher than among feeding traits(0 to 0.11).compared to other drinking traits,water intake duration and number of visits had relatively stronger negative genetic correlation estimates with treatment rate and mortality,especially across the challenge nursery and finisher(−0.39 and−0.45 for treatment rate;−0.20 and−0.19 for mortality).conclusion:Most of the recorded drinking and feeding traits under a severe disease challenge had moderate to high estimates of heritability,especially for feed or water intake duration and number of *** and genetic correlations among the recorded feeding traits under disease were generally low but drinking traits show

关键词： Disease resilience Feeding and drinking behavior Genetic parameters Pigs

Pathway engineering strategies for improved product yield in yeast-based industrial ethanol production

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Synthetic and Systems Biotechnology 2022年第1期7卷 554-566页

作者： Aafke c.A.van Aalsta Sophie c.de Valk Walter M.van Gulik Mickel L.A.Jansen jack T.Pronka Robert Mans Department of Biotechnology Delft University of TechnologyVan der Maasweg 92629HZ Delftthe Netherlands DSM Biotechnology centre Alexander Fleminglaan 12613AX Delftthe Netherlands

Product yield on carbohydrate feedstocks is a key performance indicator for industrial ethanol production with the yeast Saccharomyces *** paper reviews pathway engineering strategies for improving ethanol yield on glucose and/or sucrose in anaerobic cultures of this yeast by altering the ratio of ethanol production,yeast growth and glycerol *** attention is paid to strategies aimed at altering energy coupling of alcoholic fermentation and to strategies for altering redox-cofactor coupling in carbon and nitrogen meta-bolism that aim to reduce or eliminate the role of glycerol formation in anaerobic redox *** addition to providing an overview of scientific advances we discuss context dependency,theoretical impact and potential for industrial application of different proposed and developed strategies.

关键词： Saccharomyces cerevisiae Synthetic biology Metabolic engineering Biofuels Redox metabolism Energy metabolism

Effects of medium chain triglycerides on hepatic fatty acid oxidation in clofibrate-fed newborn piglets

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Animal Nutrition 2023年第1期12卷 334-344页

作者： Jinan Zhao Brandon Pike Jin Huang Zhihua Feng jack Odle Xi Lin Laboratory of Developmental Nutrition Department of Animal SciencesNorth Carolina State UniversityRaleighNC 27695USA Zinpro corporation Eden PrairieMN 55344USA college of Biological Engineering Henan University of TechnologyZhengzhou450001China college of Animal Science and Technology Agricultural University of HebeiBaoding071001China

To investigate whether increasing tricarboxylic acid(TcA)cycle activity and ketogenic capacity would augment fatty acid(FA)oxidation induced by the peroxisome proliferator-activated receptor-alpha(PPARα)agonist clofibrate,suckling newborn piglets(n=54)were assigned to 8 groups following a 2(±clofibrate)×4(glycerol succinate[SUc],triglycerides of 2-methylpentanoic acid[T2M],valeric acid[Tc5]and hexanoic acid[Tc6])factorial *** group was fed an isocaloric milk formula containing either 0%or 0.35%clofibrate(wt/wt,dry matter basis)with 5%SUc,T2M,Tc5 or Tc6 for 5 *** 6 pigs served as newborn *** acid oxidation was examined in fresh homogenates of liver collected on d 6 using[1-^(14)c]palmitic acid(1 mM)as a substrate(0.265μci/μmol).Measurements were performed in the absence or presence of L-carnitine(1 mM)or inhibitors of 3-hydroxy-3-methylglutaryl-coA synthase(L659699,1.6μM)or acetoacetate-coA deacylase(iodoacetamide,50μM).Without clofibrate stimulation,^(14)c accumulation in cO_(2) was higher from piglets fed diets containing T2M and Tc5 than SUc,but similar to those fed *** clofibrate stimulation,accumulation also was higher in homogenates from piglets fed Tc5 than all other dietary *** between clofibrate and carnitine or the inhibitors were observed(P=0.0004)for acid soluble products(ASP).In vitro addition of carnitine increased^(14)c-ASP(Pclofibrate *** percentage of^(14)c in cO_(2) was higher(P=0.0023)in Tc5 than in the control *** these results we suggest that dietary supplementation of anaplerotic and ketogenic FA could impact FA oxidation and modify the metabolism of acetyl-coA(product ofβ-oxidation)via alteration of TcA cycle activity,but the modification has no significant impact on the hepatic FA oxidative capacity induced by PPARα.In addition,the availability of carnitine is a critical element to maintain FA oxidation during the neonatal perio

关键词： PPARα clofibrate Newborn piglets Medium chain triglyceride(McT) Hepatic fatty acid oxidation

Energy-efficient virtual sensor-based deep reinforcement learning control of indoor cO_(2)in a kindergarten

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Frontiers of Architectural Research 2023年第2期12卷 394-409页

作者： Patrick Nzivugira Duhirwe jack Ngarambe Geun Young Yun Department of Architectural Engineering Kyung Hee UniversityYongin 17104Republic of Korea

High concentrations of indoor cO_(2)pose severe health risks to building ***,mechanical equipment is used to provide sufficient ventilation as a remedy to high indoor cO_(2)***,such equipment consumes large amounts of energy,substantially increasing building energy *** the end,the issue becomes an optimization problem that revolves around maintaining cO_(2)levels below a certain threshold while utilizing the minimum amount of energy *** that end,we propose an intelligent approach that consists of a supervised learning-based virtual sensor that interacts with a deep reinforcement learning(DRL)-based control to efficiently control indoor cO_(2)while utilizing the minimum amount of energy *** data used to train and test the DRL agent is based on a 3-month field experiment conducted at a kindergarten equipped with a heat recovery *** results show that,unlike the manual control initially employed at the kindergarten,the DRL agent could always maintain the cO_(2)concentrations below sufficient ***,a 58%reduction in the energy consumption of the ventilator under the DRL control compared to the manual control was *** demonstrated approach illustrates the potential leveraging of Internet of Things and machine learning algorithms to create comfortable and healthy indoor environments with minimal energy requirements.

关键词： Indoor air quality Indoor cO_(2)control Machine learning Virtual sensor Deep reinforcement learning