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CD24 expression predicts distant metastasis in extrahepatic bile duct cancer

World Journal of Gastroenterology 2013年第9期19卷 1438-1443页

作者： Kyubo Kim Hye Sook Min Eui Kyu Chie Jin-Young jang Sun Whe Kim Sae-Won Han Do-Youn Oh Seock-Ah Im Tae-You Kim Yung-Jue Bang ja-june jang Sung W Ha Department of Radiation Oncology Seoul National University College of Medicine Seoul 110-744 South Korea Department of Pathology Seoul National University College of Medicine Seoul 110-744 South Korea Institute of Radiation Medicine Medical Research Center Seoul National University Seoul 151-742 South Korea Department of Surgery Seoul National University College of Medicine Seoul 110-744 South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul 110-744 South Korea

AIM: To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer. METHODS: Eighty-four patients with EHBD cancer who underwent curative resection followed by adjuvant chemoradiotherapy were enrolled in this study. Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes up to a median of 40 Gy (range: 40-56 Gy). All patients also received fluoropyrimidine chemotherapy for radiosensitization during radiotherapy. CD24 expression was assessed with immunohistochemical staining on tissue microarray. Clinicopathologic factors as well as CD24 expression were evaluated in multivariate analysis for clinical outcomes including loco-regional recurrence, distant metastasisfree and overall survival. RESULTS: CD24 was expressed in 36 patients (42.9%). CD24 expression was associated with distant metastasis, but not with loco-regional recurrence nor with overall survival. The 5-year distant metastasis-free survival rates were 55.1% and 29.0% in patients with negative and positive expression, respectively (P=0.0100). On multivariate analysis incorporating N stage, histologic differentiation and CD24 expression, N stage was the only significant factor predicting distant metastasis-free survival (P=0.0089), while CD24 expression had borderline significance (P=0.0733). In subgroup analysis, CD24 expression was significantly associated with 5-year distant metastasis-free survival in node-positive patients (38.4% with negative expression vs 0% with positive expression, P=0.0110), but not in nodenegative patients (62.0% with negative expression vs 64.0% with positive expression,P=0.8599). CONCLUSION: CD24 expression was a significant predictor of distant metastasis for patients undergoing curative resection followed by adjuvant chemoradiotherapy especially for node-positive EHBD cancer.

关键词： CD24 Tissue microarray Extrahepatic bile duct cancer Adjuvant chemoradiotherapy Distant metastasis

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14-Day Repeated Dose Toxicity and Genotoxicity Studies of Cimicifuga heracleifolia Komarov Water Extract

14-Day Repeated Dose Toxicity and Genotoxicity Studies of Ci...

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亚洲实验动物学会联合会（AFLAS）第三次会议暨中国实验动物学会（CALAS）第八届学术年会

作者： Jong-Rhan Kim Ji-Ran You Seung-Hyun Kim Euna Kwon Yun-Soon Kim Eun-Young Cho Jung-Hee Yoon Soon-Duk Lee Yoon-Mi Hwang Hye-Jung Jeong Dae-Young Seok Jung-Gi Kim Hyun-Il Won ja-june jang Doo-Hyun Jeong Hee-Chan Kim Byeong-Cheol Kang Kook-Hyun Lee Jeong-Hwan Che Clinical Research Institute Seoul National University Hospital Seoul National University College of Medicine Seoul 110-744KOREA

Cimicifuga heracleifolia Komarov(CH) is used traditionally as a herbal remedy for many ***,published literature suggests that large doses of cimicifuga racemosa might be associated with ***,its long-term toxicity was not evaluated *** study was performed to evaluate 14-day repeated dose toxicity(RDT) and genotoxicity of CH extract according to the USNTP protocol and GLP guideline. To determine the appropriate dosage of CH extract administration,14-days RDT study were performed.14-days repeated dose study was performed to dosage levels of 0.125,0.25,0.5,1 and 2g/kg/day in F344/N *** test substance-related effect were observed in some criteria included mortality;clinical signs;body weight changes;urinalysis,organ weight,gross findings and histopathological findings. In reverse mutation assay of CH extract using Salmonella typhimurium TA98,TA100,TA102,TA1535 and TA1537,test substance was diluted to 5 dosage levels of 312.5,625,1,250,2,500 and 5,000μg/plate with D.D.W..Each tester strain was exposed to the test item with and without metabolic activation *** extract might not have reverse mutagenicity under the condition of this study. Chromosome aberration test of CH extract was performed to evaluate its clastogenic potential in Chinese Hamster Lung fibroblast(CHL) cell *** test substance was diluted to 3 dosage levels of 2,500,1,250,625fig/*** were exposed to test items for 6 or 24 hours in the absence of metabolic activation system,or for 6 hours in the presence of metabolic activation *** was no statistically significant increase in the number of structural or numeric aberrant metaphases at any dose both in the presence and absence of metabolic activation. A micronucleus test o{ CH extract was performed using ICR *** test substance was orally administered to 3 groups of 8-week old male ICR mice at dosage levels of 2,1,and 0.5g/kg *** 3 *** male mice were used in each test *** anim

关键词： Good Laboratory Practice(GLP) Cimicifuga heracleifolia water extract Korea National Toxicology Program

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Materials property mapping from atomic scale imaging via machine learning based sub-pixel processing

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npj Computational Materials 2022年第1期8卷 1868-1876页

作者： Junghun Han Kyoung-june Go Jinhyuk jang Sejung Yang Si-Young Choi Department of Biomedical Engineering Yonsei UniversityWonju26493Republic of Korea Department of Materials Science and Engineering Pohang University of Science and TechnologyPohang37673Republic of Korea

Direct visualization of the atomic structure in scanning transmission electron microscopy has led to a comprehensive understanding of the structure-property ***,a reliable characterization of the structural transition on a picometric scale is still challenging because of the limited spatial resolution and ***,we demonstrate that the primary segmentation of atomic signals from background,succeeded by a denoising process,enables structural analysis in a sub-pixel *** noise is eliminated using the block matching and three-dimensional filtering with Anscombe transformation,and remnant noise is removed via morphological filtering,which results in an increase of peak signal-to-noise ratio from 7 to 11 *** the centroids of atomic columns segmented via K-means clustering,an unsupervised method for robust thresholding,achieves an average error of less than 0.7 pixel,which corresponds to 4.6 *** study will contribute to a profound understanding of the local structural dynamics in crystal structures.

关键词： property filtering removed

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MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function

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Cellular & Molecular Immunology 2011年第5期8卷 380-387页

作者： Li Zhou jang-june Park Quanhui Zheng Zheng Dong Qingsheng Mi Henry Ford Immunology Program Henry Ford Health SystemDetroitMIUSA Department of Dermatology Henry Ford Health SystemDetroitMIUSA Department of Internal Medicine Henry Ford Health SystemDetroitMIUSA Department of Cellular Biology and Anatomy Medical College of GeorgiaAugustaGAUSA

MicroRNAs(miRNAs)are an abundant class of evolutionarily conserved,small,non-coding RNAs that post-transcriptionally regulate expression of their target *** evidence indicates that miRNAs are important regulators that control the development,differentiation and function of different immune *** CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells and invariant natural killer T(iNKT)cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and ***,we review the important roles of miRNAs in the development and function of iNKT and Treg cells.

关键词： invariant natural killer T cells microRNA regulatory T cells

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Plasmid DNA-loaded asymmetrically porous membrane for guided bone regeneration

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Journal of Materials Science & Technology 2021年第4期63卷 161-171页

作者： Se Heang Oh june-Ho Byun So Young Chun Young-Joo jang Jin Ho Lee Department of Nanobiomedical Science Dankook UniversityCheonan 31116Republic of Korea Department of Oral and Maxillofacial Surgery Gyeongsang National University School of MedicineGyeongsang National University HospitalInstitute of Health SciencesGyeongsang National UniversityJinju 52727Republic of Korea BioMedical Research Institute Kyungpook National University HospitalDaegu 41404Republic of Korea Department of Advanced Materials Hannam UniversityDaejeon 34054Republic of Korea

Although bone defects can be restored spontaneously,bone reconstruction with sufficient strength and volume continues to be a challenge in clinical *** recent years,the use of a variety of biomaterials with bioactivity has been attempted to compensate for this ***,we fabricated a pDNA(encoding for BMP-2)-loaded asymmetrically porous polycaprolactone(PCL)/Pluronic F127 membrane as a bioactive guided bone regeneration(GBR)membrane,using a modified immersion-precipitation *** was observed that the GBR membrane allows continuous release of pDNA for more than20 *** pDNA was sufficiently transfected into human bone marrow stem cells(h BMSCs)without significant cytotoxicity and the gene-transfected cells showed prolonged synthesis of *** in vitro osteogenic differentiation and in vivo animal studies,the effective induction of osteogenic differentiation of h BMSCs and enhanced bone regeneration by the pDNA-loaded asymmetrically porous PCL/Pluronic F127 membrane was observed,suggesting that the pDNA-loaded membrane as a bioactive GBR membrane can be an alternative therapeutic technique for effective bone regeneration.

关键词： loaded porous attempted

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High-performance and current crowding-free InGaN-GaN- based LEDs integrated by an electrically-reverse-connected Schottky diode and a Mg-delta doped p-GaN

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Frontiers of Optoelectronics 2012年第2期5卷 127-132页

作者： Sei-Min KIM Seon-Ho jang ja-Soon jang Department of Electronic Engineering LED-IT Fusion Technology Research Center (LIFTRC) Yeungnam University Gyeongbuk 712 749 Korea

This work demonstrates high-performance and current crowding-free InGaN/GaN light-emitting diodes （LEDs） using an electrically-reverse-connected Schottky diode （SD） and an Mg-delta （δ） doped layer. Possible mechanism of carrier transport at the interface between transparent conducting electrode （TCE） and p-GaN with the δ-doped layer is also investigated. Results show that the LED with the SD and Mg delta （δ）-doping layer yields lower series resistance, higher output power, and lower reverse leakage current compared to normal LEDs. In addition, unlike the normal LED, there is no occurrence for the current crowding effect in the proposed LED even at high current density of 380mA/cm2. These remarkable behaviours clearly indicate that the use of the SD and δ- doping in the p-GaN region is very promising to achieve high-brightness and excellent-reliability GaN-based LEDs.

关键词： GaN light-emitting diode (LED) Schottkydiode (SD) integration current crowding

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Presence of CCK-A, B receptors and effect of gastrin and cholecystokinin on growth of pancreatobiliary cancer cell lines

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World Journal of Gastroenterology 2005年第6期11卷 803-809页

作者： Jin-Young jang Sun-Whe Kim ja-Lok Ku Yong-Hyun Park jae-Gahb Park Department of Surgery

AIM: To investigate the effects of gastrin and cholecystokinin (CCK) and their specific antagonists on the growth of pancreatic and biliary tract cancer cell lines. METHODS: Five pancreatic and 6 biliary cancer cell lines with 2 conrtol cells were used in this study. Cell proliferation study was done using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) test and direct cell count method. Reverse transcription-polymerase chain reaction (RT-PCR) and slot blot hybridization were performed to examine and quantify the expression of hormonal receptors in these cell lines. RESULTS: SNU-308 showed a growth stimulating effect by gastrin-17, as did SNU-478 by both gastrin-17 and CCK-8. The trophic effect of these two hormones was completely blocked by specific antagonists (L-365, 260 for gastrin and L-364, 718 for CCK). Other cell lines did not respond to gastrin or CCK. In RT-PCR, the presence of CCK-A receptor and CCK-B/gastrin receptor mRNA was detected in all biliary and pancreatic cancer cell lines. In slot blot hybridization, compared to the cell lines which did not respond to hormones, those that responded to hormones showed high expression of receptor mRNA. CONCLUSION: Gastrin and CCK exert a trophic action on some of the biliary tract cancers.

关键词： Bile duct cancer Gallbladder cancer Pancreatic cancer Gastrin Cholecystokinin

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Segmented tomographic evaluation of structural degradation of carbon support in proton exchange membrane fuel cells

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Journal of Energy Chemistry 2022年第11期31卷 359-367,I0010页

作者： Jung A.Hong Min-Hyoung Jung Sung Yong Cho Eun-Byeol Park Daehee Yang Young-Hoon Kim Sang-Hyeok Yang Woo-Sung jang jae Hyuck jang Hyo june Lee Sungchul Lee Hu Young Jeong Young-Min Kim Department of Energy Science Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Fuel Cell Core Parts Development Cell Hyundai Mobis Co.Ltd.Uiwang 16082Republic of Korea Electron Microscopy&Spectroscopy Team Korea Basic Science Institute(KBSI)Daejeon 34133Republic of Korea Graduate School of Semiconductor Materials and Devices Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

The variation of the three-dimensional(3D)structure of the membrane electrode of a fuel cell during proton exchange cycling involves the corrosion/compaction of the carbon *** increasing degradation of the carbon structure continuously reduces the electrocatalytic performance of proton exchange membrane fuel cells(PEM-FCs).This phenomenon can be explained by performing 3D tomographic analysis at the ***,conventional tomographic approaches which present limited experimental feasibility,cannot perform such evaluation and have not provided sufficient structural information with statistical significance thus ***,a reliable methodology is required for the 3D geometrical evaluation of the carbon ***,we propose a segmented tomographic approach which employs pore network analysis that enables the visualization of the geometrical parameters corresponding to the porous carbon structure at a high *** approach can be utilized to evaluate the 3D structural degradation of the porous carbon structure after cycling in terms of local surface area,pore size distribution,and their 3D *** geometrical parameters of the carbon body were demonstrated to be substantially reduced owing to the cycling-induced *** information enables a deeper understanding of the degradation phenomenon of carbon supports and can contribute to the development of stable PEM-FC electrodes.

关键词： Electron tomography Fuel cell Proton exchange membrane Membrane electrode assembly Carbon corrosion

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GSK-LSD1,an LSD1 inhibitor,quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro

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Signal Transduction and Targeted Therapy 2020年第1期5卷 255-257页

作者： Kyung Soo Hong june Hong Ahn Jong Geol jang Jong Ho Lee Hong Nam Kim Dongha Kim Wonhwa Lee Division of Pulmonology and Allergy Department of Internal MedicineCollege of MedicineYeungnam University and Regional Center for Respiratory DiseasesYeungnam University Medical CenterDaegu 42415Republic of Korea Department of Laboratory Medicine College of MedicineYeungnam UniversityYeungnam University Medical CenterDaegu 42415Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Department of Anatomy College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Aging Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea

Dear Editor,Since the COVID-19 demonstrated a remarkable transmission speed and a high mortality risk,COVID-19 is currently declared as a pandemic by the World Health *** is the first time that the WHO has declared a pandemic since H1N1 in *** of 6 September 2020,the total number of COVID-19 patients is 26,763,217(876,616 deaths),and it continues to rise(https://***/).In spite of the urgent demand for the vaccines and therapeutics,global efforts are primarily focused on the utilization of the existing anti-viral drugs,such as remdesivir,hydroxychloroquine,and dexamethasone,to relieve the symptoms due to the limited development of renovative therapeutics.

关键词： drugs mortality cytokine

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Component-Based Software Development Framework for 3rd Party Logistics Business

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Intelligent Information Management 2010年第4期2卷 278-285页

作者： Yang-ja jang Taehan Lee Seungkil Lim 不详

This paper suggests a component-based software development framework for 3rd party logistics (3PL) business. This framework integrates two engineering methodologies in order to identify the most reusable software components that can be used in several types of 3PL business models. UML (Unified Modeling Language) is used to design lower-level software components and DEMO (Design and Engineering Methodology for Organization), one of the business engineering methodologies based on the communication theory, is used to identify core business processes for 3PL business models. By using the methodologies, we develop a 3PL management solution by applying the framework into a C2C type of 3PL business model, specifically the door-to-door (D2D) service.

关键词： 3PL DEMO UML Software Development

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