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pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus

World journal of Gastroenterology 2007年第11期13卷 1728-1731页

作者： Simone S contu Paulo c contu Daniel c Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa joo c Prolla Luis F Moreira Post-Graduate Program in Surgery Hospital de Clínicas de Porto Alegre Federal University of Rio Grande do Sul Brazil University Hospital-Division of Gastroenterology Federal University of Santa Maria Brazil

AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P creased in a stepwise fashion according to the severity of the histological findings (P cosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). cONcLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy.

关键词： Esophageal cancer Squamous cell carcinoma Risk factors pRB carcinogenesis

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A regionalized IO-model to value seasonal recreational ecosystem services in a mountain National Park in Spain

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journal of Mountain Science 2022年第1期19卷 211-227页

作者： Víctor MARTIN BARROSO Mónica de cASTRO-PARDO Pascual FERNÁNDEZ MARTÍNEZ joão c.AZEVEDO Department of Applied Economics I and history and economic institutions Faculty of Law and Social SciencesUniversidad Rey Juan CarlosCampus of VicálvaroTulipanMóstoles 28933Spain Department of Financial and Actuarial Economics and Statistics-Statistics and Operational Research Complutense University of MadridCampus of SomosaguasPozuelo de Alarcon 28223Spain centro de Investigação de Montanha Instituto Politécnico de BragançaCampus de Santa ApolóniaBragança 5300-253Portugal

Recreational Ecosystem Services(RES)are among the most frequently evaluated ecosystem *** are seen as a major opportunity for sustainable development in areas of high ecological value resulting from the presence of emblematic species,habitats or scenery,often integrated in conservation areas,in particular in mountain areas affected by depopulation,rising environmental risks and ***,the assessment of RES has been based on contingent Valuation and choice Experiments,methods with limitations related to their ***,Input-Output(IO)models provide a very accurate and effective way of valuation of RES with regional information regarding interindustry *** data on nature tourist expenditure may be only available annually,tourism inflows have a strong seasonal behavior,which impacts the profitability of several local economic *** this paper,we firstly constructed a novel regionalized IO-model based on cross-Industry Location Quotients using employment data and,secondly,based on Monte carlo simulation,we estimated nature tourist expenditure monthly using data on nature tourism *** method allowed for a more precise RES evaluation,estimating direct,indirect and induced monthly economic impacts of nature-based *** method was applied to the Ordesa and Monte Perdido(OMP)National Park in the Spanish *** estimate the average tourist expenditure,we collected and analyzed spending on commerce,hospitality and restaurants,leisure,and transport of 385 *** suggest that using a regionalized IO model leads to a considerable reduction of over-estimation of the economic impact of tourist expenditure estimated by conventional *** into consideration the direct,indirect and induced effects of tourist expenditure in 2016-2018,the total annual output effect in the OMP National Park amounted to€208.8 million,while the total income effect amounted to€86.29 ***,a total of

关键词： Input-Output Monte carlo Simulation Location quotients Recreational Ecosystem Services Nature tourism Sustainable mountain development

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Assessment of postcombustion carbon capture technologies for power generation

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Frontiers of chemical Science and Engineering 2010年第2期4卷 184-195页

作者： Mikel c.DUKE Bradley LADEWIG Simon SMART Victor RUDOLPH joão c.Diniz da cOSTA Institute for Sustainability and Innovation Victoria UniversityWerribee CampusPO Box 14428MelbourneVictoria 8001Australia Department of chemical Engineering Monash UniversityClayton Vic 3182Australia School of chemical Engineering The University of QueenslandBrisbane Qld 4072Australia

A significant proportion of power generation stems from coal-combustion processes and accordingly represents one of the largest point sources of cO_(2)emissions *** power plants are major assets with large infrastructure and engineering units and an operating life span of up to 50 ***,any process design modification to reduce greenhouse gas emissions may require significant *** of the best options to utilize existing infrastructure is to retrofit the power station fleet by adding a separation process to the flue gas,a practice known as postcombustion capture(Pcc).This review examines the recent Pcc development and provides a summary and assessment of the state of play in this area and its potential applicability to the power generation *** major players including the various institutes,government,and industry consortia are identified along with flue gas Pcc demonstration scale *** the Pcc technologies reviewed,amine-based absorption is preeminent,being both the most mature and able to be adapted immediately,to the appropriate scale,for power station flue gas with minimal technical ***,current commercial applications serve niches in the merchant cO_(2)market,while a substantial number of smaller scale test facilities are reported in the literature with actual cO_(2)capture motivated demonstrations now *** membrane/absorption systems,also known as membrane contactors,offer the potential for the lowest energy requirements,possibly 10%of current direct scrubbers but are at an early stage of *** methods being actively pursued as R&D projects include solid absorbents,solid adsorbents,gas membrane separators,and cryogenic *** variety and different maturities of these competing technologies make technical comparison largely subjective,but useful insights could be gained through the development and application of econometric techniques such as‘real options’within this ***

关键词： post-carbon capture amine absorption adsorption membranes technology assessment

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AN AUTOMATED REFERENcE POINT-LIKE APPROAcH FOR MULTIcRITERIA SHORTEST PATH PROBLEMS

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journal of Systems Science and Systems Engineering 2006年第3期15卷 314-329页

作者： joo c. N.cLíMAcO josé M.F.cRAVEIRINHA Marta M.B.PAScOAL Faculdade de Economia da Universidade de coimbra Avenida Dias da Silva 165 3004-512 CoimbraPortugal.Instituto de Engenharia de Sistemas e Computadores-CoimbraRua Antero de Quental 199 3000-033 Coimbra Portugal Instituto de Engenharia de Sistemas e computadores-coimbra Rua Antero de Quental 199 3000-033 Coimbra Portugal.Departamento de Engenharia Electrotécnica e ComputadoresPolo II da Universidade de Coimbra Pinhal de Marrocos3030-290 CoimbraPortugal Instituto de Engenharia de Sistemas e computadores-coimbra Rua Antero de Quental 1993000-033 CoimbraPortugal.Departamento de MatemáticaPolo I da Universidade de CoimbraApartado 30083001-454 CoimbraPortugal

In this paper we introduce a method of analysis for the automated ordenng and selection or solutions of a multicriteria shortest path model. The method is based on a reference point approach, where the paths in a specific priority region are ranked by non-decreasing order of a chebyshev metric. In order to list paths according with this objective function a labelling algorithm is proposed. The developed method is applied in a video-traffic routing context. computational results are presented and analysed, for randomly generated networks of significant dimension.

关键词： Routing automated decision multicriteria reference point

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Improved dark ambient degradation of organic pollutants by cerium strontium cobalt perovskite

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journal of Environmental Sciences 2020年第4期32卷 110-118页

作者： Huihuang chen Julius Motuzas Wayde Martens joao c.Diniz da costa The University of Queensland FIM^2 Lab-Functional Interfacial Materials and Membranes LaboratorySchool of Chemical EngineeringBrisbaneQld 4072Australia Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaAnhui 230026China Science and Engineering Faculty Queensland University of TechnologyBrisbaneQld 4000Australia LAQV-REQUIMTE (Bio)Chemical Process EngineeringDepartment of ChemistryFaculty of Science and TechnologyUniversidade NOVA de LisboaCaparica 2829-516Portugal

This work investigates the effect of cerium substation into strontium cobalt perovskites(ceSrcoO)for the oxidative degradation of OrangeⅡ(OII)in dark ambient conditions without the aid of any external stimulants such as light,heating or chemical *** OII degradation rate by ceSrcoO reached 65%in the first hour,whilst for the blank sample without cerium(SrcoO)took over 2 hr to reach the same level of OII ***,the cerium substitution improved the catalytic activity of the perovskite material,mainly associated with the ce0.1Sr0.9coO3 perovskite *** contacting ceSrcoO,the-N=Nazo bonds of the OII molecules broke down resulting in electron donation and the formation of *** electrons are injected into the ceSrcoO and resulted in a redox pair of co3+/co2+,establishing a bridge for the electron transfer between OII and the ***,the electrons also formed reactive species(·OH)responsible for OII degradation as evidenced by radical trapping *** species were formed via the reaction between 02 and donated electrons from OII with the aid of cobalt redox *** the prepared materials dispensed with the need for light irradiation and additional oxidants,it opens a window of environmental applications for treating contaminated wastewaters.

关键词： Dark catalysis Acid orange degradation cerium substituted perovskite catalytic activity

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Review on inorganic and polymeric materials-coordinated metal-organic-framework photocatalysts for green hydrogen evolution

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journal of Energy chemistry 2024年第5期92卷 322-356页

作者： Dong-Eun Lee Mohtaram Danish Umair Alam Wan-Kuen jo School of Architecture CivilEnvironmental and Energy Engineering Kyungpook National University80 Daehak-roBuk-guDaegu 41566Republic of Korea School of chemical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea

Metal-organic frameworks(MOFs)possess a distinct advantage over conventional heterogeneous photocatalysts because of their carefully defined architecture and particular pores,which facilitate the targeted incorporation of other efficient cocatalysts or semiconductor *** integration of MOFs with other materials has resulted in significant breakthroughs,as the coupled materials improve the performance due to the combined *** unique MOF structures allow them to host foreign materials,which results in harvesting the visible region of the solar spectrum and effectively mitigating charge recombination by promoting charge *** review presents an evaluation of the latest developments in the utilization of surface and/or pore chemistry of MOF-supported heterojunctions for photocatalytic green-hydrogen generation with a basic understanding of the mechanism *** review begins with the basic principles of photocatalysis,the significance of MOFs,their optical properties,the methods used for synthesizing MOFs,and their coordination with other inorganic and polymeric ***,methods to increase photocatalytic H2 evolution using MOF-supported heterojunction have been proposed as standard ***,to address environmental challenges,we highlight the future potential of MOF-supported heterojunctions for use in green-energy *** hope that this review provides guidance to researchers in the development of effective heterojunctions based on MOFs to address challenges in energy applications and catalytic processes.

关键词： Renewable energy Environmental challenge Heterojunction Water splitting Photocatalysis

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Direct 4D printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： Soo Young cho Dong Hae Ho Sae Byeok jo Jeong Ho cho Department of chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4D)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4D printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

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Structural insights on anti-biofilm mechanism of heated slightly acidic electrolyzed water technology against multi-resistant Staphylococcus aureus biofilm on food contact surface

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Food Science and Human Wellness 2024年第3期13卷 1556-1566页

作者： Pianpian Yan Ramachandran chelliah Kyoung Hee jo Xiuqin chen Akanksha Tyagi Hyeon Yeong jo Fazle Elahi Nam chan Woo Min Seung Wook Deog Hwan Oh Department of Food Science and Biotechnology College of Agriculture and Life SciencesKangwon National UniversityChuncheon 24341South Korea Kangwon Institute ofInclusive Technology(KIIT) Kangwon National UniversityChuncheon 24341South Korea Saveetha School of Engineering (SIMATS)UniversitySriperumbudur 600124India Seoulin Bioscience company Seongnam-si 13488South Korea

Slightly acidic electrolyzed water(SAEW)has proven to be an efficient and novel sanitizer in food and agriculture *** study assessed the efficacy of SAEW(30 mg/L)at 40℃on the inactivation of foodbome pathogens and detachment of multi-resistant Staphylococcus aureus(MRSA)*** underlying mechanism of MRS A biofilm under heated SAEW at 40℃treatment on metabolic profiles was *** results showed that the heated SAEW at 40℃significantly effectively against foodbome pathogens of 1.96-7.56(lg(cFU/g))reduction in pork,chicken,spinach,and *** heated SAEW at 40℃treatment significantly reduced MRS A biofilm cells by 2.41(lg(cFU/cm^(2))).The synergistic effect of SAEW treatment showed intense anti-biofilm activity in decreasing cell density and impairing biofilm cell *** metabolic response of MRSA biofilms,treated by SAEW at 40℃,revealed the alterations of intracellular metabolites,including amino acids,organic acid,fatty acid,and ***,signaling pathways involved in amino acid metabolism,energy metabolism,nucleotide synthesis,carbohydrate metabolites,and lipid biosynthesis were functionally disrupted by the SAEW at 40℃*** per our knowledge,this is the first research to uncover the potential mechanism of heated SAEW treatment against MRSA biofilm on food contact surface.

关键词： Multi-resistant Staphylococcus aureus Metabolic profile SAEW Biofilm Hurdle technology Electrode material

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Effect of characteristics and distribution of Mg_(17)Al_(12)precipitates on tensile and bending properties of high-Al-containing Mg alloys

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journal of Magnesium and Alloys 2024年第2期12卷 779-793页

作者： Sumi jo Gyo Myeong Lee jong Un Lee Young Min Kim Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Magnesium Korea Institute of Materials ScienceChangwon 51508Republic of Korea

This study investigates the effect of characteristics and distribution of Mg_(17)Al_(12)precipitates on the uniaxial tensile and three-point bending properties of extruded Mg alloys containing high Al *** extruded Mg–9Al–1Zn–0.3Mn(AZ91)alloy contains lamellar-structured Mg_(17)Al_(12)discontinuous precipitates along the grain boundaries,which are formed via static precipitation during natural air *** extruded Mg–11Al–1Zn–0.3Mn(AZ111)alloy contains spherical Mg_(17)Al_(12)precipitates at the grain boundaries and inside the grains,which are formed via dynamic precipitation during *** to inhomogeneous distribution of precipitates,the AZ111 alloy consists of two different precipitate regions:precipitate-rich region with numerous precipitates and finer grains and precipitate-scarce region with a few precipitates and coarser *** AZ111 alloy exhibits a higher tensile strength than the AZ91 alloy because its smaller grain size and more abundant precipitates result in stronger grain-boundary hardening and precipitation hardening effects,***,the tensile elongation of the AZ111 alloy is lower than that of the AZ91 alloy because the weak cohesion between the dynamic precipitates and the matrix facilitates the crack initiation and *** bending,a macrocrack initiates on the outer surface of bending specimen in both *** AZ111 alloy exhibits higher bending yield strength and lower failure bending strain than the AZ91 *** bending specimens of the AZ91 alloy have similar bending formability,whereas those of the AZ111 alloy exhibit considerable differences in bending formability and crack propagation behavior,depending on the distribution and number density of precipitates in the *** bending specimens of the AZ111 alloy,it is found that the failure bending strain(ε_(f,bending))is inversely proportional to the area fraction of precipitates in the outer zone of bending specimen(A_(ppt)),with a relation

关键词： Mg–Al alloy Extrusion Bending Precipitation Microstructure

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Determination of critical state line(cSL)for silty-sandy iron ore tailings subjected to low-high confining pressures

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journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1684-1695页

作者： Nilo cesar consoli joão Vítor de Azambuja carvalho Alexia cindy Wagner Hugo carlos Scheuermann Filho Inácio carvalho Pedro Pazzoto cacciari joão Paulo de Sousa Silva civil Engineering Universidade Federal do Rio Grande do SulPorto AlegreRS90035-190Brazil Exploration and Mineral Projects-Mineral Development centre VALE S.A.Santa LuziaMG33040-900Brazil Department of civil Geological and Mining EngineeringPolytechnique MontrealQuebecH3C 3A7Canada

The disposal of filtered tailings in high dry stacks can induce particle breakage,changing the material's behaviour during the structure's *** grading changes influence material properties at the critical state,and this is not mature for intermediate artificial soils(tailings)in a broad range of confining *** this paper,it aims to describe the behaviour of iron ore tailings in a spectrum of confining pressures broader than the reported in previous studies.A series of consolidated drained(cD)triaxial tests was carried out with confining pressures ranging from 0.075 MPa to 120 *** results show that the amount of breakage plays an essential role in the response of iron ore *** existence of curved critical state line(cSL)in both specific volume(ν)-logarithm of mean effective stress(p′)and deviatoric stress(q)-mean effective stress(p′)planes,and different responses in the deviatoric stress-axial strain-volumetric strain curves were *** inverse S-shaped equation was proposed to represent the silty-sandy tailings'behaviour up to high pressures onν-lnp′*** proposed equation provides a basis for enhancing constitutive models and considers the evolution of the grading up to severe loading *** adjustment considered three regions with different responses associated with particle breakage at different pressure levels.

关键词： Tailings Iron ore tailings dry stacking Silty-sandy material critical state soil mechanics High confining pressures Particle breakage

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