检索结果-南通市图书馆

Isotretinoin for the treatment of nonobstructive azoospermia: a pilot study

在线全文

学校读者我要写书评

暂无评论

Asian journal of Andrology 2021年第5期23卷 537-540页

作者： john K Amory Charles H Muller thomas j Walsh Department of Medicine University of WashingtonSeattleWA 98195USA Department of Urology University of WashingtonSeattleWA 98195USA

The treatment of men with infertility from azoospermia is *** some men with severe oligozoospermia improve sperm output during treatment with isotretinoin,we treated nine men with azoospermia with isotretinoin to determine if azoospermic men would also respond to isotretinoin *** of these men who had a previous negative testicular sperm extraction(TESE)was found to have an area of sperm production on a postisotretinoin testicular *** man achieved a pregnancy and a live birth of a healthy,term daughter after in vitro fertilization coupled with intracytoplasmic sperm injection(IVF/ICSI).A second subject had a positive TESE after treatment as *** study of isotretinoin therapy in men with azoospermia undergoing testicular sperm harvesting procedures is warranted.

关键词： treatment injection pregnancy

Can inhibition of telomerase increase pancreatic cancer cell's susceptibility to chemotherapeutic reagents?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2002年第1期1卷 155-160页

作者： thomas j.Ⅲ Fahey Department of Surgery Cornell University Medical College New York NY USA

Objectives: To clarify the inhibition of pancreatic can-cer cells by interference with the hTR component of thetelomerase reverse transcriptase enzymatic complexand evaluate susceptibility of antisense hTR pancreaticcancer cells to chemotherapeutic ***: A 593 bp of full length hTR cDNA was sub-cloned into a mammalian expression vector pcDNA3.1(-) in antisense orientation to construct an antisensehTR expression plasmid. The plasmids were introducedinto Pancl cells, a human pancreatic carcinoma cellline, by lipofectin, and G418-resistant stable trans-formants were expanded. Resulting stable clones werescreened for the presence of hTR insert by PCR withT7 and BGH reverse primers located on the flanks ofthe multiclonal site of pcDNA3.1 vector. Cell growth rate,hTR expression, telomerase activity, and anchorage-in-dependent growth property were analyzed. Finally, sus-ceptibility of antisense hTR cells to chemotherapeuticreagents was ***: Significant downregulation of endogenous hTRwas evident in the antisense-hTR transformed cells,and telomerase activity was markedly decreased com-pared to control cells in standard TRAP assays. Fur-thermore, the proliferation and the anchorage-inde-pendent growth ability in antisense-hTR expressingcells were significantly decreased compared with thecontrol parental cells. However, no crisis or senescencephenomena was observed. Antisense hTR appears toincrease Pancl cell's susceptibility to chemotherapeuticreagent cDDP, but not to differentiation reagent DM-SO, COX2 inhibitor sulinbac, NS-398, curcumin, andchemotherapeutic reagent adriamycin(ADM).Conclusions: These data indicate that hTR is probablya critical component of human telomerase activity andthat downregulation of the RNA component of humantelomerase is an effective target for anticancer strategyand antisense hTR can increase Pancl cell's susceptibilityto cDDP.

关键词： Telomerase hTR Antisense Pancreatic carcinoma cellline chemotherapeutic reagents

The impact of vitamin D deficiency on neurogenesis in the adult brain

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第3期12卷 393-394页

作者： Natalie j.Groves thomas H.j.Burne Queensland Brain Institute The University of QueenslandSt.LuciaAustralia Queensland Centre for Mental Health Research The Park Centrefor Mental HealthWacolAustralia

There is increasing evidence from epidemiological studies indicating that vitamin D deficiency during adulthood is associated with adverse brain outcomes in humans（Ginde et al.,2009）and rodents（Groves et al.,2014）... 详细信息

关键词： The impact of vitamin D deficiency on neurogenesis in the adult brain GAD

在线全文

学校读者我要写书评

暂无评论

一九八一年核燃料概况

地球与环境 1983年第3期 17-18页

作者： j.thomas Nash ,姚振凯 ,刘艳平

1981年总的形势是铀、钍供应过剩。情况比较简单,但引起的原因却颇为复杂,是几年来所累积的社会、政治、经济等因素交织在一起的结果。后果要比预料的严重得多。在过去的两年里,铀的价格下跌到每磅23美元—实际美元值下跌了60％。美国约... 详细信息

1981年总的形势是铀、钍供应过剩。情况比较简单,但引起的原因却颇为复杂,是几年来所累积的社会、政治、经济等因素交织在一起的结果。后果要比预料的严重得多。在过去的两年里,铀的价格下跌到每磅23美元—实际美元值下跌了60％。美国约有60个(总共240个)铀矿山和16家铀工厂关闭,约三分

关键词：铀矿床铀矿资源矿床品位核燃料

Multiscale Domain Decomposition Methods for Elliptic Problems with High Aspect Ratios

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2002年第1期18卷 63-76页

作者： jφrgAarnes thomas Y.Hou Department of Mathematics University of BergenJohs.Brunsgt.125008 BergenNorwayApplied Mathematics217-50CaltechPasadenaCA 91125

In this paper we study some nonoverlapping domain decomposition methods for solving a class of elliptic problems arising from composite materials and flows in porous media which contain many spatial scales. Our preconditioner differs from traditional domain decomposition preconditioners by using a coarse solver which is adaptive to small scale heterogeneous features. While the convergence rate of traditional domain decomposition algorithms using coarse solvers based on linear or polynomial interpolations may deteriorate in the presence of rapid small scale oscillations or high aspect ratios, our preconditioner is applicable to multiple-scale problems without restrictive assumptions and seems to have a convergence rate nearly independent of the aspect ratio within the substructures. A rigorous convergence analysis based on the Schwarz framework is carried out, and we demonstrate the efficiency and robustness of the proposed preconditioner through numerical experiments which include problems with multiple-scale coefficients, as well problems with continuous scales.

关键词： Multiscale elliptic problems Domain decomposition Schwarz methods Porous media

Particle flow simulations with homogenised lattice Boltzmann methods

在线全文

学校读者我要写书评

暂无评论

Particuology 2017年第5期15卷 1-13页

作者： Mathias j. Krause Fabian Klemens thomas Henn Robin Trunk Hermann Nirschl Institute for Applied and Numerical Mathematics Karlsruhe Institute of Technology 76021 Karlsruhe Germany Institute for Mechanical Process Engineering and Mechanics Karlsruhe Institute of Technology 76021 Karlsruhe Germany

An alternative approach to simulating arbitrarily shaped particles submersed in viscous fluid in two dimensions is proposed, obtained by adapting the velocity parameter of the equilibrium distribution function of a standard lattice Boltzmann method （LBM）. Comparisons of exemplifying simulations to results in the literature validate the approach as well as the convergence analysis. Pressure fluctuations occurring in Ladd＇s approach are greatly reduced. In comparison with the immersed boundary method, this approach does not require cost intensive interpolations. The parallel efficiency of LBM is retained. An intrinsic momentum transfer is observed during particle-particle collisions. To demonstrate the capa- bilities of the approach, sedimentation of particles of several shapes is simulated despite omitting an explicit particle collision model.

关键词： Particulate flow simulationsArbitrarily shaped particlesLattice Boltzmann methodsValidationSedimentation processes

Recent Increased Warming of the Alaskan Marine Arctic Due to Midlatitude Linkages

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2018年第1期35卷 75-84页

作者： james E.OVERLAND Muyin WANG thomas j.BALLINGER NOAA/Pacific Marine Environmental Laboratory Seattle WA 98115USA joint Institute for the Study of Atmosphere and Oceans University of Washington Seattle WA 98115USA Department of Geography Texas State UniversitySan Marcos TX 78666USA

Alaskan Arctic waters have participated in hemispheric-wide Arctic warming over the last two decades at over two times the rate of global warming. During 2008–13, this relative warming occurred only north of the Bering Strait and the atmospheric Arctic front that forms a north–south thermal barrier. This front separates the southeastern Bering Sea temperatures from Arctic air masses. Model projections show that future temperatures in the Chukchi and Beaufort seas continue to warm at a rate greater than the global rate, reaching a change of +4℃ by 2040 relative to the 1981–2010 mean. Offshore at 74°N, climate models project the open water duration season to increase from a current average of three months to five months by 2040. These rates are occasionally enhanced by midlatitude connections. Beginning in August 2014, additional Arctic warming was initiated due to increased SST anomalies in the North Pacific and associated shifts to southerly winds over Alaska, especially in winter 2015–16. While global warming and equatorial teleconnections are implicated in North Pacific SSTs, the ending of the 2014–16 North Pacific warm event demonstrates the importance of internal, chaotic atmospheric natural variability on weather conditions in any given year. Impacts from global warming on Alaskan Arctic temperature increases and sea-ice and snow loss, with occasional North Pacific support, are projected to continue to propagate through the marine ecosystem in the foreseeable future. The ecological and societal consequences of such changes show a radical departure from the current Arctic environment.

关键词： Alaska North Pacific Arctic warm advection polar vortex

Microbial roles equivalent to geological agents of high temperature and pressure in deep Earth

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2016年第11期59卷 2098-2104页

作者： XIE ShuCheng LIU Deng QIU Xuan HUANG XianYu thomas j.ALGEO State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences Laboratory of Critical Zone Evolution School of Earth Sciences China University of Geosciences State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Department of Geology University of Cincinnati

Microbes not only show sensitive responses to environmental changes but also play important roles in geochemical and geophysical systems. It is well known that microbes have caused major changes in surface environments and biogeochemical cycles through Earth history. Microbial processes can also induce the synthesis of certain minerals under Earth-surface conditions that previously were believed to form only under high temperatures and pressures in the deep Earth. For example, microbes can promote the conversion of smectite to illite, synthesis of authigenic plagioclase, precipitation of dolomite, and biotransformation of geolipids. These effects of microbes are due to their large surface/volume ratios, enzyme production, and abundant functional groups. Microbial catalyzation of chemical reactions proceeds through reaction-specific enzymes, a decrease in Gibbs' s free energy, and/or break through the dynamics reaction thresholds via their metabolisms and physiology. Microbes can lower the surface free energy of mineral nuclei via biophysical adsorption due to their large surface/volume ratios and abundant functional groups. The mineral precipitation and transformation processes induced by microbes are functionally equivalent to geological processes operating at high temperatures and pressures in the deep Earth, suggesting that microbial processes can serve as analogs to deep abiotic processes that are difficult to observe.

关键词： Geobiology Microbial functional groups Illitization Plagioclase Dolomite Geolipids

Semi-transparent,flexible,and electrically conductive silicon mesh by capillarity-driven welding of vapor-liquid-solid-grown nanowires over large areas

在线全文

学校读者我要写书评

暂无评论

Nano Research 2020年第5期13卷 1465-1471页

作者： thomas A.Celano Seokhyoung Kim David j.Hill james F.Cahoon Department of Chemistry University of North Carolina at Chapel HillChapel HillNC 27599-3290USA

Bottom-up synthesis of semiconductor nanowires(NWs)by the vapor-liquid-solid(VLS)mechanism has enabled diverse technological applications for these *** metallic NWs,however,it has been challenging to form large-area interconnected NW ***,we generate centimeter-scale meshes of mechanically and electrically interconnected Si NWs by sequentially growing,collapsing,and joining the NWs using a capillarity-driven welding *** fabricate meshes from VLS-grown NWs ranging in diameter from 20 to 100 nm and find that the meshes are three-dimensional with a thickness ranging from^1 to^10 microns depending on the NW *** extinction measurements reveal that the networks are semi-transparent with a color that depends on the absorption and scattering characteristics of individual ***,active voltage contrast imaging of both centimeter-and micron-scale meshes reveals widespread electrical *** a sacrificial layer,we demonstrate that the mesh can be liberated from the growth substrate,yielding a highly flexible and transparent *** transport measurements both on the growth substrate and on liberated,flexible films reveal electrical conduction across a centimeter scale with a sheet resistance of^160-180 kΩ/square that does not change significantly upon *** the ability to encode complex functionality in semiconductor NWs through the VLS process,we believe these meshes of networked NWs could find application as neuromorphic memory,electrode scaffolds,and bioelectronic interfaces.

关键词： semiconductor nanowire conductive network flexible electronics welding thermal annealing active-voltage contrast