Isotretinoin for the treatment of nonobstructive azoospermia: a pilot study

作     者：John K Amory Charles H Muller Thomas J Walsh John K Amory;Charles H Muller;Thomas J Walsh

作者机构：Department of MedicineUniversity of WashingtonSeattleWA 98195USA Department of UrologyUniversity of WashingtonSeattleWA 98195USA 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2021年第23卷第5期

页      面：537-540页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：The Eunice Kennedy Shriver National Institute of Child Health and Human Development supported this work through grant K24HD082231 to John K Amory 

主　　题：treatment injection pregnancy 

摘      要：The treatment of men with infertility from azoospermia is *** some men with severe oligozoospermia improve sperm output during treatment with isotretinoin,we treated nine men with azoospermia with isotretinoin to determine if azoospermic men would also respond to isotretinoin *** of these men who had a previous negative testicular sperm extraction(TESE)was found to have an area of sperm production on a postisotretinoin testicular *** man achieved a pregnancy and a live birth of a healthy,term daughter after in vitro fertilization coupled with intracytoplasmic sperm injection(IVF/ICSI).A second subject had a positive TESE after treatment as *** study of isotretinoin therapy in men with azoospermia undergoing testicular sperm harvesting procedures is warranted.