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Pregnancy and metabolic-associated Fatty Liver Disease:A Clinical Update

journal of Clinical and Translational Hepatology 2022年第5期10卷 947-954页

作者： Sherouk Fouda madhu mathew Vennikandam j.seph m.pappachan Cornelius j.Fernandez School of Health and Biomedical Sciences RMIT UniversityMelbourneVICAustralia Department of Gastroenterology and Hepatology Sparrow HospitalMichigan State University College of Human MedicineLansingMIUSA Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPrestonUK Faculty of Science Manchester Metropolitan UniversityManchesterUK Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Department of Endocrinology&metabolism Pilgrim HospitalBostonUK

The intricate relationship between metabolic-associated fatty liver disease(mAFLD)and maternal complications has rapidly become a significant health threat in pregnant *** presence of mAFLD in pregnancy increases the maternal risk of metabolic complications and comorbidities for both mother and *** preexistence or development of mAFLD in pregnancy is a complex multifactorial disorder that can lead to further complications for mother and ***,as pregnant women are severely underrepresented in clinical research,there is a great need for a fair inclusion of this group in clinical *** review aims to explore the effects of mAFLD during pregnancy in the context of maternal complications and outcomes and explore the effects of pregnancy on the development and progression of mAFLD within the context of maternal obesity,altered metabolic profiles,gestational diabetes and altered hormonal *** also addressed potential implications for the presence of mAFLD during pregnancy and its management in the clinical setting.

关键词： metabolic-associated fatty liver disease Pregnancy maternal complications Fatty liver

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Epidemiological link between obesity,type 2 diabetes mellitus and cancer

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World journal of methodology 2021年第3期11卷 23-45页

作者： Cornelius j Fernandez Annu Susan George Nikhila A Subrahmanyan j.seph m.pappachan Department of Endocrinology and metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of medical Oncology VPS Lakeshore HospitalCochin 682040India Department of Internal medicine Al-Azhar Medical CollegeThodupuzha 685605India Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom

There exists a complex interaction between obesity,type 2 diabetes mellitus(T2Dm)and cancer,and an increase in the incidence of cancer is expected with the growing obesity-diabetes *** association of cancer with diabetes mellitus and obesity appears to be site-specific,the highest risk being for postmenopausal breast cancer,endometrial cancer,and colorectal ***,there is worsening of hyperglycaemia with the onset of cancer,evidencing a bidirectional link between cancer and diabetes mellitus and the need for monitoring for diabetes in cancer *** this review,we look at the epidemiological evidence from observational studies and mendelian randomization studies linking obesity,diabetes,and cancer,as well as the complex pathophysiological mechanisms involved,including insulin resistance with associated hyperinsulinaemia,the effect of chronic low-grade inflammation,and the effect of various adipokines that are associated with obesity and ***,we describe the novel therapeutic strategies,based on their role on the discrete pathophysiological mechanisms involved in the tumourigenesis.

关键词： Cancer Obesity Type 2 diabetes mellitus Hyperinsulinaemia Epidemiological link

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