Epidemiological link between obesity,type 2 diabetes mellitus and cancer
作者机构：Department of Endocrinology and MetabolismPilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Medical OncologyVPS Lakeshore HospitalCochin 682040India Department of Internal MedicineAl-Azhar Medical CollegeThodupuzha 685605India Department of Endocrinology and MetabolismLancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of ScienceManchester Metropolitan UniversityManchester M156BHUnited Kingdom
出 版 物：《World Journal of Methodology》 (世界方法学杂志)
年 卷 期：2021年第11卷第3期
页 面：23-45页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Cancer Obesity Type 2 diabetes mellitus Hyperinsulinaemia Epidemiological link
摘 要：There exists a complex interaction between obesity,type 2 diabetes mellitus(T2DM)and cancer,and an increase in the incidence of cancer is expected with the growing obesity-diabetes *** association of cancer with diabetes mellitus and obesity appears to be site-specific,the highest risk being for postmenopausal breast cancer,endometrial cancer,and colorectal ***,there is worsening of hyperglycaemia with the onset of cancer,evidencing a bidirectional link between cancer and diabetes mellitus and the need for monitoring for diabetes in cancer *** this review,we look at the epidemiological evidence from observational studies and Mendelian randomization studies linking obesity,diabetes,and cancer,as well as the complex pathophysiological mechanisms involved,including insulin resistance with associated hyperinsulinaemia,the effect of chronic low-grade inflammation,and the effect of various adipokines that are associated with obesity and ***,we describe the novel therapeutic strategies,based on their role on the discrete pathophysiological mechanisms involved in the tumourigenesis.
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