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苍白球刺激可缓解肌阵挛-肌张力障碍综合征

世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 29-30页

作者： Magarios-Ascone C.M. Regidor I. Martnez-Castr-illo j.C. 邓剑平 Neurologa Experimental Dipartimento di Investigación Hospital Ramón Y Cajal Madrid 28034 Spain Dr.

A patient with myoclonus- dystonia syndrome was treated by implanting electr odes in the internal segment of the globus pallidus (GPi) and applying deep brai n stimulation. surgery was done in two sessions. The most affected limb was trea ted first and the other limb one year later. Neuronal recordings showed that mos t pallidal neurones discharged in bursts at a relatively low firing rate (mean ( sD), 46 (18) Hz) compared with cells in the GPi in patients with Parkinson’ s d isease. Neurones modified the rate and mode of discharge with dystonic postures and rapid involuntary contractions of limb muscles. Neurological examination at 24 months after surgery showed a decline of 47.8% and 78.5% in the Burke- F ahn- Marsden and disability rating scales, respectively.

关键词：苍白球肌阵挛爆发式放电帕金森病神经元放电深部脑刺激内侧部植入电极放电频率张力障碍

Methods and parameters of melting curve analysis for identification of Leishmania species:A scoping review

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Asian Pacific journal of Tropical Medicine 2021年第12期14卷 528-542页

作者： juliana j G Ferreira Fernanda s Nascimento Glaucia E B Marcon Eros A de Almeida sandra C B Costa Laboratório de Diagnóstico de Doenças Infecciosas por Técnicas de Biologia Molecular Departamento de Clínica MédicaFaculdade de Ciências MédicasUniversidade Estadual de Campinas(UNICAMP)Campinas13083-887SPBrazil Fundação Oswaldo Cruz Mato Grosso do sul(FIOCRUZ Ms) Rua Gabriel Abrão92Jardim das NaçõesCampo Grande79081-746 MSBrazil Grupo de Estudos em Doença de Chagas Departamento de Clínica MédicaFaculdade de Ciências MédicasUniversidade Estadual de Campinas(UNICAMP)Campinas13083-887SPBrazil

Leishmaniasis is a set of diseases with a worldwide distribution that affects mainly economically underprivileged populations in developing countries. It has a major impact on public health, with a global cost of billions of dollars per year. The treatment and control of leishmaniasis vary according to the Leishmania species involved, which require reliable methods for species identification. since most of the currently used methods have limitations, there is a need for assays that allow rapid, precise identification of the offending species. Real-time polymerase chain reactions in conjunction with dissociation curve analysis have been used to detect differences in the DNA composition of selected genes of Leishmania spp. Kinetoplast DNA is the main molecular target used because of its high copy number per parasite, but other targets have also been studied. As part of an effort to establish melting temperature standards for each target gene, we have reviewed the pertinent literature available in public databases, including Pub Med, Web of science, sci ELO and LILACs, using the keywords "Leishmania", "leishmaniasis", "realtime PCR", "melting temperature", and "melting curve", alone or in combination. After applying eligibility criteria, 27 articles were selected for analysis. A considerable variation in the methodologies analyzed was found regarding molecular targets, standardization of the methods, reproducibility and specificity. Because of this, statistical analysis was not performed. In most cases, the methods were able to differentiate the parasite at the subgenus level or few species regardless of the target chosen.

关键词： Leishmaniasis Melting temperature Real-time PCR

Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World journal of Gastrointestinal surgery 2024年第3期16卷 740-750页

作者： Phillip Gu shishir Dube Norman Gellada so Yung Choi susan Win Yoo jin Lee shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav syal Andres j Yarur david Ziring shervin Rabizadeh Phillip Fleshner Cindy Kallman suzanne Devkota stephan R Targan dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(por)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(por)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate por,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTEs Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube s and Choi sY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win s,Lee Yj and Yang s were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

The largest dengue outbreak in Argentina and spatial analyses of dengue cases in relation to a control program in a district with sylvan and urban environments

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Asian Pacific journal of Tropical Medicine 2018年第3期11卷 227-234页

作者： Aníbal E Carbajo Alejandra Rubio María j Viani María R Colombo Laboratorio de Eoclogía de Enfermedades Transmitidas por Vectores Instituto de Investigación e Ingeniería AmbientalUniversidad Nacional de General San Martín Consejo Nacional de Investigaciones Científicas y Técnicas secretaria de Política sanitaria y Desarrollo Humano Municipio de Tigre

Objective: To analyze the largest outbreak of dengue in Argentina in the municipality of Tigre during 2016, through detailed spatial analyses of the occurrence of cases in relation to demographic factors and vector control actions. Methods: Detailed and georreferenced data on dengue cases with laboratory results(Ns1 or IgM) were analyzed. The occurrences of imported and autochthonous cases by census tract were modeled using demographic variables(population by age class, proportion of foreigners, proportion with university grade, proportion of males), dwelling variables(number of homes, proportion of dwellings with latrine, number of dwellings, proportion of houses, proportion of flats, proportion of slums) and census tract area as explanatory variables. The probability of occurrence of autochthonous and imported cases was modeled separately. The spatio-temporal occurrence of cases was studied in relation to focal and perifocal control actions(involving education campaigns, removal of Aedes aegypti breeding sites and exhaustive insecticide spraying) to assess the efficiency in stopping autochthonous cases spreading. Results: All autochthonous cases occurred in the urban environment with no sylvan cases. The majority of the imported cases registered came from Paraguay and Northeastern Argentina. The age structure of imported and autochthonous cases did not differ from the age structure of the municipality, while that of the negative cases *** studied spatially, the occurrence of imported cases by census tract was mildly associated with a higher proportion of foreign population and more people at active age, while occurrence of autochthonous cases was not significantly associated with any of the studied *** census tracts with laboratory confirmed results, the models showed higher probability of autochthonous cases related to higher population density and population age structure. The clustering of autochthonous cases was generally mild, with prevailing i

关键词： Aedes aegypti Vector-borne diseases Vector control Dengue epidemic

Irritable bowel syndrome: A microbiome-gut-brain axis disorder?

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World journal of Gastroenterology 2014年第39期20卷 14105-14125页

作者： Paul j Kennedy john F Cryan Timothy G Dinan Gerard Clarke 1.15 Biosciences Institute Department of Psychiatry Alimentary Pharmabiotic Centre University College Cork Cork Ireland Department of Anatomy and Neuroscience Alimentary Pharmabiotic CentreUniversity College CorkCork Ireland

Irritable bowel syndrome(IBs) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBs, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBs. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions.

关键词： Irritable bowel syndrome Microbiome Anxiety Tryptophan Abdominal pain Gastrointestinal motility Cognition

Genetic variation of human cytochrome P450 reductase as a potential biomarker for mitomycin C-induced cytotoxicity

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南京医科大学学报（自然科学版） 2007年第10期27卷 1171-1171页

作者： Wang, s. L. Han, j. F. He, X. Y. Wang, X. R. Hong, j. Y. Univ Med ＆ Dent New jersey Sch Publ Hhh Environm ＆ Occupat Hhh Sci Inst Piscataway NJ 08854 USA. Nanjing Med Univ Inst Toxicol Nanjing Peoples R China.

The importance of genetic variation in clinical response to various drugs is now well *** of genetic biomarkers that can predict efficacy and toxicity of chemotherapeutic drugs in cancer patients holds great promise in treatment improvement and cost *** C (MMC) is a common anticancer drug used for the treatment of numerous types of ***-mediated activation, by either one-electron or two-electron reduction, plays a critical role in the chemotherapeutic action of ***-cytochrome P450 (oxido) reductase (por) is a major enzyme responsible for MMC activation through the one-electron reductive pathway, which leads to the production of semiquinone anion radicals and subsequent DNA damage in the cells.

关键词：遗传变异细胞色素P450还原酶生物标记丝裂酶C 细胞毒性

取代基对卟啉分子自组装聚集体纳米结构的调节

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济南大学学报（自然科学版） 2011年第1期25卷 47-51页

作者：游遨陈丽娜陈艳丽李达攀济南大学化学化工学院山东济南250022

运用简单的"one-step"法自组装技术,将Meso位具有不同取代基团的卟啉分子Meso-5,10,15,20-四(对甲氧基苯基)卟啉(Ⅰ),Meso-5,10,15,20-四苯基卟啉(Ⅱ)和Meso-5,10,15,20-四(对氯苯基)卟啉(Ⅲ)组装成有机纳米聚集体。利用多种表征手段系... 详细信息

运用简单的"one-step"法自组装技术,将Meso位具有不同取代基团的卟啉分子Meso-5,10,15,20-四(对甲氧基苯基)卟啉(Ⅰ),Meso-5,10,15,20-四苯基卟啉(Ⅱ)和Meso-5,10,15,20-四(对氯苯基)卟啉(Ⅲ)组装成有机纳米聚集体。利用多种表征手段系统研究化合物(Ⅰ),(Ⅱ)和(Ⅲ)在水溶液中的自组装性质。结果表明,在自组装过程中,3种卟啉分子均形成j型聚集体,从化合物(Ⅰ),(Ⅱ)到(Ⅲ),随着卟啉Meso位取代基供电子能力依次下降,分子间相互作用程度减弱,其纳米聚集体形貌由二维四方片状逐渐变成一维纳米带。这表明通过调节卟啉Meso位取代基的供/吸电子能力,可以调节分子间非共价键相互作用程度,从而控制卟啉分子自组装纳米结构的形貌。

关键词：卟啉自组装纳米结构供/吸电子取代基

simetal Eaf QuantumTM-The Future Approach For Efficient scrap Melting

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Simetal Eaf QuantumTM-The Future Approach For Efficient Scra...

Dental pulp stem cells and BonelikeVR for bone regeneration in ovine model

Asia steel International Conference 2012(Asia steel 2012)

作者： Markus Abel Markus Dorndorf Michel Hein Hans-jrg Huber Product Lifecycle Manager EAF Head of Research & Development Head of Metallurgy & Process Technology Head of Layout department

＜正＞Only 280 kWh per ton scrap? The future is now with sIMETAL EAF Quantum?.This new furnace stands for minimum conversion costs,maximized output and environmental compliance.100%of the charged scrap is preheated through the utilization of the furnace offgas during the heat *** leads to energy and cost savings with a reduction of the tap-to-tap time to 33 minutes. Pure flat bath operation with lowest flicker is the result of an adequate hot heel and a new tapping *** this patent pending tapping system,a renewed variant of scrap charging and retaining technology as well as a revolutionary design of the offgas-processing system,this furnace is the melting aggregate of the *** energy consumption of 280kWh/t in combination with reduced consumptions of oxygen and fuel stands for itself. Apenas 280 por kWh tonelada de sucata? O future e agora,com sIMETAL EAF Quantum?.Este novo fomo representa custos minimos de conversao,producao maximizada e confbrmidade com meio ambiente.100%da sucata carragada e pre-aquecida atraves da utilizacao dos gases gerados no fomo durante a *** leva a uma economia de energia e dos custos com a reducao do tempo tap-to-tap para 33 minutos. A operacao continua em fase liquida e menor flicker e o resultado de um pe liquido adequado e sistema de vazamento eficiente. Com este sistema de vazamento（patente pendente）,o novo conceito de carregamento de sucata e tecnologia de retencao da carga, bem como um design revolucionario do sistema de processamento dos gases de exaustao,este forno e a inovacao em fusao para o *** consumo de energia de 280kWh/t em combinacao com consumos reduzidos de oxigenio e combustivel falam por si so.

关键词： EAF preheating efficiency flicker FEA pre-aquecimento eficiencia

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Regenerative Biomaterials 2019年第1期6卷 49-59页

作者： j.M.Campos A.C.sousa A.R.Caseiro s.s.Pedrosa P.O.Pinto M.V.Branquinho I.Amorim j.D.santos T.Pereira C.M.Mendonca A.Afonso L.M.Atayde A.C.Maurı´cio Departamento de Clı´nicas Veterina´rias Instituto de Cieˆncias Biome´dicas de Abel Salazar(ICBAS)Universidade do Porto(UP)Rua de Jorge Viterbo Ferreirano 2284050-313 PortoPortugal Centro de Estudos de Cieˆncia Animal(CECA) Instituto de CieˆnciasTecnologias e Agroambiente da Universidade do Porto(ICETA)Rua D.Manuel IIApartado 551424051-401 PortoPortugal Escola Universita´ria Vasco da Gama(EUVG) Hospital Veterina´rio Universita´rio de Coimbra(HVUC)Campo Universita´rio–Bloco BLordem~aoCoimbraPortugal REQUIMTE/LAQV–U.porto–porto/portugal Departamento de Engenharia Metalu´rgica e MateriaisFaculdade de EngenhariaUniversidade do PortoRuaDr.Roberto Friass/n4200-465 PortoPortugal Faculdade de Engenharia da Universidade do porto(FEUP) Rua Dr.Roberto Frias4200-465 PortoPortugal Department of Pathology and Molecular Immunology of the Institute of Biomedical sciences Abel salazar(ICBAs) University of Porto4050-313 PortoPortugal Institute for Research and Innovation in Health (i3S)University of PortoPortoPortugal Institute of Molecular Pathology and Immunology of the University of porto(IPATIMUP) 4200-135 PortoPortugal Faculdade de Medicina Denta´ria da Universidade do porto(FMDUP) 4200-393 PortoPortugal

Development of synthetic bone substitutes has arisen as a major research interest in the need to find an alternative to autologous bone *** an ovine model,the present pre-clinical study presents a synthetic bone graft(BonelikeVR)in combination with a cellular system as an alternative for the regeneration of non-critical *** association of biomaterials and cell-based therapies is a promising strategy for bone tissue *** stem cells(MsCs)from human dental pulp have demonstrated both in vitro and in vivo to interact with diverse biomaterial systems and promote mineral deposition,aiming at the reconstruction of osseous ***,these cells can be found and isolated from many ***-critical bone defects were treated with BonelikeVR with or without MsCs obtained from the human dental *** showed that BonelikeVR and MsCs treated defects showed improved bone regeneration compared with the defects treated with BonelikeVR ***,it was observed that the biomaterial matrix was reabsorbed and gradually replaced by new bone during the healing *** therefore propose this combination as an efficient binomial strategy that promotes bone growth and vascularization in non-critical bone defects.

关键词： biomaterial BonelikeVR bone regeneration,dental pulp human bone hydroxyapatite mesenchymal stem cells ovine model tissue regeneration tricalcium phosphate