Genetic variation of human cytochrome P450 reductase as a potential biomarker for mitomycin C-induced cytotoxicity

作     者：Wang, S. L. Han, J. F. He, X. Y. Wang, X. R. Hong, J. Y. 

作者机构：Univ Med ＆ Dent New Jersey Sch Publ Hhh Environm ＆ Occupat Hhh Sci Inst Piscataway NJ 08854 USA. Nanjing Med Univ Inst Toxicol Nanjing Peoples R China. 

出 版 物：《南京医科大学学报（自然科学版）》 (Journal of Nanjing Medical University(Natural Sciences))

年 卷 期：2007年第27卷第10期

页      面：1171-1171页

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

主　　题：遗传变异 细胞色素P450还原酶 生物标记 丝裂酶C 细胞毒性 

摘      要：The importance of genetic variation in clinical response to various drugs is now well *** of genetic biomarkers that can predict efficacy and toxicity of chemotherapeutic drugs in cancer patients holds great promise in treatment improvement and cost *** C (MMC) is a common anticancer drug used for the treatment of numerous types of ***-mediated activation, by either one-electron or two-electron reduction, plays a critical role in the chemotherapeutic action of ***-cytochrome P450 (oxido) reductase (POR) is a major enzyme responsible for MMC activation through the one-electron reductive pathway, which leads to the production of semiquinone anion radicals and subsequent DNA damage in the cells.