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Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVId-19

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World journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K jacobs Steven d Morley Kay Samuel Katie Morgan Lyndsey Boswell Timothy j Kendall david A dorward jonathan A Fallowfield Peter C Hayes john N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUNd Metabolic dysfunction-associated steatotic liver disease(MASLd),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and *** injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(COVId-19),while preexisting MASLd increases the risk of LI and the development of COVId-19-associated *** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVId-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic ACE2 levels are altered during progression of MASLd and in patients who died with severe *** ACE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLd were determined in formalin-fixed liver tissue sections across the MASLd pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe COVId-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** ACE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,ACE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but ACE2 and liver lipid droplet content are significantly correlated across the MASLd *** A

关键词： Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry COVId-19 COVId-19-associated cholangiopathy

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael j.Bannon Irma Alicia Martínez-dávila Luis O.Soto-Rojas david Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando j.Espadas-Alvarez Manuel A.Fernandez-Parrilla juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas jaime Santoyo-Salazar daniel Martinez-Fong departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico red de Medicina para la Educación y desarrollo y la Investigación Científica de Iztacala(red MEdICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-d-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-d-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-d-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

Four Late-type Galaxies with double Radio Lobes and Properties of Such Galaxies

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Research in Astronomy and Astrophysics 2024年第4期24卷 84-90页

作者： Z.S.Yuan X.Y.Gao Z.L.Wen j.L.Han National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanism for radio lobes from late-type galaxies is not fully *** samples are desired for a thorough investigation and *** utilizing the optical data from the newly released dark Energy Spectroscopic Instrument imaging surveys and the radio sources from the NRAO VLA Sky Survey and the Faint Images of the Radio Sky at Twenty-centimeter,we identify four Late-type Galaxies with double Radio Lobes(La GRLs):j0217-3645,j0947+6220,j1412+3723 and j1736+*** previously known La GRLs,we confirm the correlation between radio power P_(1.4GHz)and stellar mass M_(*)of host ***(25/35)La GRLs belong to the blue cloud galaxies,while the newly identified cases in this work are located within the region of the red *** find a clear correlation between the differential radio power,i.e.,the offset from the P_(1.4GHz)-M_(*)relation,and the galaxy color,indicating that bluer galaxies at a fixed M_(*)tend to host more powerful radio ***,the majority(31/36)of La GRLs are either located in a galaxy group or displaying a disturbed *** suggest that all of the galaxy mass,color and surrounding environment could play important roles in triggering radio lobes in late-type galaxies.

关键词： galaxies:active galaxies:jets galaxies:spiral radio continuum:galaxies

PARALLEL STABILIZATION

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Chinese Annals of Mathematics,Series B 1999年第1期20卷 29-38页

作者： j. L. LIONS(College de france,3,red’Ulm,75231 Paris Cedex 05,France) Collége de France 3 rue d'Ulm 75231 Paris Cedex 05 France

***thesolutionofaPartialdifferentialEquation(PdE)whichiswritten(formallyforthetimebeing)asIn(1.1),(1.2),whichmaybealinearoranonlinearPdE,ydenotesthestate,***,w... 详细信息

***thesolutionofaPartialdifferentialEquation(PdE)whichiswritten(formallyforthetimebeing)asIn(1.1),(1.2),whichmaybealinearoranonlinearPdE,ydenotesthestate,***,w...

关键词：平行稳定性运算法则线性抛物线方程分布系统

Characterization of gut microbiome and metabolome in Helicobacter pylori patients in an underprivileged community in the United States

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World journal of Gastroenterology 2021年第33期27卷 5575-5594页

作者： Brian White john d Sterrett Zoya Grigoryan Lauren Lally j.red d heinze Hyder Alikhan Christopher A Lowry Lark j Perez joshua deSipio Sangita Phadtare department of Biomedical Sciences Cooper Medical School of Rowan UniversityCamdenNJ 08103United States department of Integrative Physiology University of Colorado BoulderBoulderCO 80309United States department of Internal Medicine Lenox Hill HospitalNYCNY 10075United States department of Internal Medicine Thomas Jefferson University HospitalPhiladelphiaPA 19107United States department of Biological Sciences Rowan UniversityGlassboroNJ 08028United States department of Chemistry and Biochemistry Rowan UniversityGlassboroNJ 08028United States department of Gastroenterology Cooper University HospitalCamdenNJ 08103United States

BACKGROUNd Helicobacter pylori(***),a bacterium that infects approximately half of the world’s population,is associated with various gastrointestinal diseases,including peptic ulcers,non-ulcer dyspepsia,gastric adenocarcinoma,and gastric *** the burden of antibiotic resistance increases,the need for new adjunct therapies designed to facilitate *** eradication and reduce negative distal outcomes associated with infection has become more *** of the interactions between ***,the fecal microbiome,and fecal fatty acid metabolism,as well as the mechanisms underlying these interactions,may offer new therapeutic *** To characterize the gut microbiome and metabolome in *** patients in a socioeconomically challenged and underprivileged inner-city *** Stool samples from 19 *** patients and 16 control subjects were analyzed.16S rRNA gene sequencing was performed on normalized pooled amplicons using the Illumina MiSeq System using a MiSeq reagent kit *** and beta diversity analyses were performed in QIIME ***-targeted fatty acid analysis of the samples was carried out using gas chromatography-mass spectrometry,which measures the total content of 30 fatty acids in stool after conversion into their corresponding fatty acid methyl ***-dimensional scaling(MdS)was performed on Bray-Curtis distance matrices created from both the metabolomics and microbiome datasets and a Procrustes test was performed on the metabolomics and microbiome MdS *** Fecal microbiome analysis showed that alpha diversity was lowest in *** patients over 40 years of age compared to control subjects of similar age *** diversity analysis of the samples revealed significant differences in microbial community structure between *** patients and control subjects across all ***-eight and six taxa had lower and higher relative abundance in *** patients,*** that were e

关键词： Gut microbiome Metabolome Helicobacter pylori Antibiotic resistance dysbiosis Eradication

Interaction network between frugivorous birds and zoochorous plants in cloud forest riparian strips immersed in anthropic landscapes

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Avian Research 2022年第3期13卷 311-320页

作者： Omar A.Hernández-dávila javier Laborde Vinicio j.Sosa Cecilia díaz-Castelazo Instituto de Ecología A.C.Red de Ecología FunctionalCarretera Antigua a CoatepecNo.351El HayaXalapaVeracruz C.P91073Mexico Instituto de Ecología A.C.Red de Interacciones Multitr oficasCarretera Antigua a CoatepecNo.351El HayaXalapaVer.C.P91073Mexico

Worldwide,tropical montane cloud forest is one of the most important and biodiverse ecosystems;however,it is also one of those most threatened by anthropic *** activities lead to a fragmented,deforested landscape with narrow riparian forest strips immersed in an agricultural matrix dominated by ***,we characterize the interaction network between frugivorous birds and zoochorous plants in riparian strips of cloud forest in deforested landscapes of Central Veracruz,*** characterize the network of this mutualistic interaction,we estimated network-and species-level metrics using the Bipartite R ***,modularity and robustness were used to describe network *** measures of degree,closeness,betweenness centrality and their relative contribution to nestedness were used to determine the importance of each bird/plant species to the network’s *** interaction network has 24 species of birds and 30 species of plants,with low connectance(0.11),low nestedness(11.53),and intermediate but not significant modularity(0.49).The bird species most important to network stability were Chlorospingus flavopectus,Myadestes occidentalis,and Catharus *** most important plants were Conostegia xalapensis,***,and Rubus *** robustness varied from 0.36 to 0.86 and its stability is compromised when species of birds or plants with the highest values of centrality are removed,with plant removal more *** strips of cloud forest crossing deforested areas maintain a relatively rich set of birds that disperse the seeds of many forest plants,thus they are crucial to the preservation of this mutualistic network in anthropic *** stability is severely undermined by the loss of any of the few species—whether birds or plants—with high centrality *** most important plants for this stability are pioneer tree and shrub species that provide food for several bird species,and they

关键词： Frugivory Keystone species Riparian corridors Seed dispersal Vegetation corridors

Reagent-Loaded Annulus-Shaped Reactor on Filter-Paper with Virtual Colorimeter for Onsite Quick detection of Chlorogenic Acid

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journal of Analysis and Testing 2023年第1期7卷 25-32页

作者： Keane j.Tao Micah d.Castleman Shiquan Tao Princess Ann High School 4400 Virginia Beach BlvdVirginia BeachVA 23462USA department of Chemistry and Physics West Texas A&M UniversityBox 60732CanyonTX 79016USA

In this work,a field-applicable,simple method for quick detecting chlorogenic acid(CGA)was *** method is based on CGA’s antioxidant *** is reported to reduce a mixture solution of FeCl_(3)/K_(3)Fe(CN)_(6)to generate Fe_(4)[Fe(CN)_(6)]_(3),the Prussian blue,in an aqueous *** reaction was adopted in this work by using solid-ink printed annuli on a filter-paper as reaction *** reagent is pre-loaded and dried within the solid ink printed *** a field test,a drop of a sample solution is directly applied to a reagent-loaded *** reaction product within the circle shows a blue color,which is detected by using an iPad(or cellphone)camera as a detector and a light-emitting diode flashlight lamp as a light source.A freely available RGB colorimeter program from Apple store was used to read light intensity of three colors:red,green,blue,and absorbance signal of red and blue light is *** difference of absorbance signal of red light from that of blue light was found having linear relationship with CGA concentration in an aqueous sample *** simple method is sensitive with a detection limit of 1.0μg/mL for CGA in sample *** technique was used to analyze CGA concentration in green coffee extract,and the analytical results agree well with that obtained using a UV/Vis absorption spectrometric *** real sample test results demonstrate the usefulness of this simple method for quick detecting CGA in green coffee extract products in field test applications.

关键词： Chlorogenic acid Paper based analytical device FeCl_(3)/K_(3)Fe(CN)_(6)·iPad colorimetry Green coffee extract

Pharmaceutical and nutraceutical potential of natural bioactive pigment:astaxanthin

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Natural Products and Bioprospecting 2022年第1期12卷 367-392页

作者： Apurva d.Patil Pramod j.Kasabe Padma B.dandge department of Biochemistry Shivaji UniversityKolhapur 416004Maha-rashtraIndia School of Nanoscience and Biotechnology Shivaji UniversityKolhapurMaharashtraIndia

Astaxanthin(3,3′-dihydroxy-β,β-carotene-4,4′-dione)is an orange-red,lipophilic keto-carotenoid *** is majorly found in marine ecosystems particularly in aquatic animals such as salmon,shrimp,trout,krill,crayfish,and so *** is also synthesized in microalgae Heamatococcus pluvialis,Chlorococcum,Chlorella zofingiensis,red yeast Phaffia rhodozyma and bacterium Paracoccus *** aquatic and terrestrial creatures regarded as a primary and secondary sources of the astaxanthin producing and accumulating it through their metabolic ***-anthin is the powerful antioxidant,nutritional supplement as well as promising therapeutic compound,observed to have activities against different ravaging diseases and *** have reported remarkable bioactivities of astaxanthin against major non-communicable chronic diseases such as cardiovascular diseases,cancer,diabetes,neurodegenerative,and immune *** current review discusses some structural aspects of *** fur-ther elaborates its multiple potencies such as antioxidant,anti-inflammatory,anti-proliferative,anti-cancer,anti-obese,anti-diabetic,anti-ageing,anti-TB,anti-viral,anti-COVId 19,neuro-protective,nephro-protective,and fertility-enhanc-ing *** potencies make it a more precious entity in the preventions as well as treatments of prevalent systematic diseases and/or ***,the review is acknowledging and documenting its powerful bioactivities in relation with the pharmaceutical as well as nutraceutical applicability.

关键词： Astaxanthin Nutritional supplement Therapeutic compound Chronic diseases Fertility enhancer

Variable retention harvesting in Great Lakes mixed-pine forests: emulating a natural model in managed ecosystems

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Ecological Processes 2019年第1期8卷 210-224页

作者： Brian j.Palik Anthony W.d’Amato USdA Forest Service Northern Research StationGrand RapidsMN 55744USA Rubenstein School of Environment and Natural Resources University of VermontBurlingtonVT 05095USA.

Variable retention harvesting(VRH)systems have gained wide use in many different forest types across the globe,but largely have been implemented in forests characterized by severe,infrequent disturbance *** has been less attention given to developing VRH approaches in forests that are characterized as having a mixed-severity disturbance regime that often results in only partial mortality of canopy trees in spatially heterogeneous *** example of such a forest type is red pine(Pinus resinosa Ait.)-dominated ecosystem of the western Great Lakes region of North *** purpose of this review is to provide a conceptual foundation for developing VRH approaches in red pine ecosystems that are based on a mixed-severity disturbance *** contention is that red pine forests managed following a natural model are more resilient to disturbances and external threats such as climate *** the red pine ecosystem,VRH application should reflect the often severe,but partial canopy removal from natural disturbance that is characteristic of this ecosystem and that results in more than trivial numbers of surviving overstory trees across a range of spatial configurations in regenerating *** live trees should span a range of diameters,but favor the larger end of the diameter distribution,as this reflects the likely pattern of survival after natural disturbance and is often a key structural element lacking from managed *** should be applied in ways that vary the spatial pattern of legacy trees in and among stands,but largely in ways that reflect the pattern of spatially patchy canopy structure,with large openings surrounded by a less disturbed matrix,as occurs with a natural disturbance *** trees and deadwood structures should reflect the composition of the pre-disturbance forest,including species in addition to dominant red ***,retained structures should be viewed as dynamic entities that grow,die,and decay and that need

关键词： red pine Mixed-severity Variable retention Natural disturbance