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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua jo jonggeol Na j.jay Liu Young-ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

Hysteresis loop behaviors of ferroelectric thin films: A Monte Carlo simulation study

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Chinese Physics B 2015年第11期24卷 492-496页

作者： C.M.Bedoya-Hincapié H.H.ortiz-varez E.Restrepo-Parra j.j.Olaya-Flrez j.E.Alfonso PCM Computational Applications Universidad Nacional de Colombia Univesidad Santo Tomás Universidad de Caldas AFIS Análisis de Fallas Integridad y Superficies Universidad Nacional de Colombia Grupo de Ciencia de Materialesy superficies Departamento de Física Universidad Nacional de Colombia

The ferroelectric response of bismuth titanate Bi4Ti3O12 （BIT） thin film is studied through a Monte Carlo simulation of hysteresis loops. The ferroelectric system is described by using a Diffour Hamiltonian with three terms： the electric field applied in the z direction, the nearest dipole-dipole interaction in the transversal （x-y） direction, and the nearest dipole-dipole interaction in the direction perpendicular to the thin film （the z axis）. In the sample construction, we take into consideration the dipole orientations of the monoclinic and orthorhombic structures that can appear in BIT at low temperature in the ferroelectric state. The effects of temperature, stress, and the concentration of pinned dipole defects are assessed by using the hysteresis loops. The results indicate the changes in the hysteresis area with temperature and stress, and the asymmetric hysteresis loops exhibit evidence of the imprint failure mechanism with the emergence of pinned dipolar defects. The simulated shift in the hysteresis loops conforms to the experimental ferroelectric response.

关键词： ferroelectrics bismuth titanate hysteresis loop dipolar defects

Nuptial gifts and female fecundity in the neotropical katydid Conocephalus ictus （Orthoptera： Tettigonidae）

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Insect Science 2015年第1期22卷 106-110页

作者： Isabel ortiz-jimenez Raul Cueva del Castillo Laboratorio de Ecologia UBIPRO UNAM FES Iztacala M6xico Edo. Mexico M6xico

In general, female fitness is greatly increased in gift-giving insects. In katydids, this nuptial gift consists of a gelatinous mass produced by accessory glands： the spermato- phylax, which is attached to the ampulla. During mating, males of the neotropical katydid Conocephalus ictus transfer a spermatophylax that is ingested by the females. Fecundity, egg-laying rate and longevity were higher in females that consumed the spermatophylax than in those that did not. Also, female receptivity turned off after mating. Females actively rejected other males by hitting them with their forelegs and moving away. Their refractory period lasted as long as 17 d. Only a few females accepted a 2nd mating and died a few days later. In C. ictus, spermatophylax consumption can be beneficial for both males and females. On one hand, the compounds in the spermatophylax or the ejaculate could prevent or delay females from copulating with rivals, thus avoiding sperm competition. On the other hand, such compounds can improve the females＇ opportunity to increase their lifespan and fecundity. Moreover, a rise in egg-laying rate may lower the risk of female prereproductive death caused by rapid oviposition. In any case, the boost in female egg laying might also be beneficial for males because their number of offspring increases.

关键词： female fitness katydid neotropic spermatophylax

Output Second-order Sliding-mode Control for a Gecko Biomimetic Climbing Robot

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journal of Bionic Engineering 2019年第4期16卷 633-646页

作者： David Cruz-ortiz Mariana Ballesteros-Escamilla Isaac Chairez Alberto Luviano SEPl UPIITAInstitute Politecnico NationalAv.Institute Politecnico National 258007340Mexico Bioprocesses Department UPIBIInstitute Politecnico NationalAv.Acueducto 55007340Mexico

The aim of this study is to propose the output controller to solve the execution of the gait sequence for Gecko Bio-inspired Robotic Devices (GBRDs).The Twisting Controller (TC) serves as basis of the tracking trajectory designed *** TC uses both the tracking error and its estimated derivative,which is calculated by a set of distributed Super-Twisting Algorithms (STAs).Each STA is implemented as a robust and exact *** output-based controller structure corresponds to a sort of decentralized form for robotic ***,each articulation is controlled by an independent TC.A set of proposed references trajectories reproduce the gait cycle of a Real Gecko-Lizard (RG-L).The reference trajectories are proposed as the superposition of sigmoid functions ful-filling the conditions of the Bezzier *** simulations evaluate the GBRD movement enforced by the suggested controller in the horizontal as well as the vertical *** own 3D printed GBRD is the experimental platform aimed to test the distributed *** controlled vacuum pumps are used to adhere the GBRD to the wall surfaces.A set of experimental validations confirm the robustness and the reliability of the proposed controller when its performance is compared with classical output feedback controllers.

关键词： gecko robot biomimetic output-based controller twisting controller Super-Twisting Algorithm(STA)

Neurotrophic fragments as therapeutic alternatives to ameliorate brain aging

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Neural Regeneration Research 2023年第1期18卷 51-56页

作者： Itzel ortiz Flores Samuel Treviño Alfonso Díaz Department of Health Sciences School of MedicineUniversity of the Americas PueblaPueblaMexico Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico

Aging is a global phenomenon and a complex biological process of all living beings that introduces various *** this physiological process,the brain is the most affected organ due to changes in its structural and chemical functions,such as changes in plasticity and decrease in the number,diameter,length,and branching of dendrites and dendritic ***,it presents a great reduction in volume resulting from the contraction of the gray ***,aging can affect not only cognitive functions,including learning and memory,but also the quality of life of older *** a result of the phenomena,various molecules with notable neuroprotective capacity have been proposed,which provide a therapeutic alternative for people under conditions of aging or some neurodegenerative *** is important to indicate that in recent years the use of molecules with neurotrophic activity has shown interesting results when evaluated in in vivo *** review aims to describe the neurotrophic potential of molecules such as resveratrol(3,5,4′-trihydroxystilbene),neurotrophins(brain-derived neurotrophic factor),and neurotrophic-type compounds such as the terminal carboxyl domain of the heavy chain of tetanus toxin,cerebrolysin,neuropeptide-12,and *** of these molecules have been evaluated by our research *** suggest that these molecules exert an important therapeutic potential,restoring brain function in aging conditions or models of neurodegenerative ***,our interest is in describing the current scientific evidence that supports the therapeutic potential of these molecules with active neurotrophic.

关键词： Alzheimer’s disease brain cerebral cortex cognitive function dendritic spines HC-TeTx hippocampus neurodegeneration neuronal survival neurotrophins

Harnessing artificial intelligence for identifying conflicts of interest in research

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World journal of Methodology 2025年第1期15卷 6-8页

作者： Abdulqadir j Nashwan Department of Nursing&Midwifery Research Hamad Medical CorporationDoha 3050Qatar

This editorial explores the transformative potential of artificial intelligence(AI)in identifying conflicts of interest(COIs)within academic and scientific *** harnessing advanced data analysis,pattern recognition,and natural language processing techniques,AI offers innovative solutions for enhancing transparency and integrity in *** editorial discusses how AI can automatically detect COIs,integrate data from various sources,and streamline reporting processes,thereby maintaining the credibility of scientific findings.

关键词： Artificial intelligence Conflicts of interest Transparency Research integrity Natural language processing

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Soil ecosystem changes by vegetation on old-field sites over five decades in the Brazilian Atlantic forest

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journal of Forestry Research 2022年第2期33卷 667-677页

作者： Danielle Cristina ortiz Tancredo Augusto Feitosa de Souza Tatiani Maria Pech Marie Luise Carolina Bartz Dilmar Baretta Alexandre Siminski júlia Carina Niemeyer Federal University of Santa Catarina Ulysses Gaboardikm 3CuritibanosSC 89520-000Brazil Postgraduate Programme in Agricultural and Natural Ecosystems(PPGEAN) Federal University of Santa CatarinaUlysses Gaboardikm 3CuritibanosSC 89520-000Brazil Centre for Functional Ecology Department of Life SciencesUniversity of Coimbra3000-456 CoimbraPortugal Department of Animal Science UDESC OesteSanta Catarina State UniversityChapecóSC 89815-630Brazil

Vegetation types alter soil ecosystems by changing soil fauna community activities and soil physi-cal-chemical ***,it is unclear how tree species(natural forest,native and exotic tree plantations)promote changes in the soil ecosystem,and if these changes alter functional groups of soil fauna and ecosystem *** determine the effects of five decades of old-field veg-etation on soil ecosystems in the Brazilian Atlantic Forest,field sampling of three ecosystems(exotic tree species Pinus elliottii ***,endangered tree species Arau-caria angustifolia(Bertol.)Kuntze plantation,and a natural ecosystem)were carried out,as well using bait-lamina tests and bioassays with collembolans,earthworms and seeds of Lactuca sativa *** sampling evaluated the soil fauna community and soil physical-chemical *** bait-lamina test in situ was carried out for 14-days to deter-mine fauna feeding activity,and the bioassays evaluated the reproduction of Folsomia candida,the avoidance of Eisenia andrei,and germination of *** in the soil from each *** results are:(1)vegetation type altered the soil fauna community composition;(2)soil fauna feeding was reduced in the plantations compared to the natural eco-system;(3)a physical barrier was created by recalcitrant litter that compromised fauna community structure and seed bank germination in situ;and,(4)changes in soil physical-chemical properties promoted decomposers.

关键词： Endangered tree species Exotic tree species Forest ecosystem Soil fauna functional groups Soil invertebrates