检索结果-南通市图书馆

A novel viewpoint in glaucoma therapeutics: enriched environment

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2022年第7期17卷 1431-1439页

作者： María F.González Fleitas Damián Dorfman Ruth E.Rosenstein Laboratory of Retinal neurochemistry and Experimental Ophthalmology Department of Human BiochemistrySchool of Medicine/CEFyBOUniversity of Buenos Aires/CONICETBuenos AiresArgentina

Glaucoma is one of the world’s most frequent visual impairment causes and leads to selective damage to retinal ganglion cells and their *** glaucoma’s most accepted risk factor is increased intraocular pressure(IOP),the mechanisms behind the disease have not been fully *** date,IOP lowering remains the gold standard;however,glaucoma patients may still lose vision regardless of effective IOP ***,the exclusive IOP control apparently is not enough to stop the disease progression,and developing new resources to protect the retina and optic nerve against glaucoma is a goal of vast clinical *** pharmacological treatments,environmental conditions have been shown to prevent neurodegeneration in the central nervous *** this review,we discuss current concepts on key pathogenic mechanisms involved in glaucoma,the effect of enriched environment on these mechanisms in different experimental models,as well as recent evidence supporting the preventive and therapeutic effect of enriched environment exposure against experimental glaucomatous ***,we postulate that stimulating vision may become a non-invasive and rehabilitative therapy that could be eventually translated to the human disease,preventing glaucoma-induced terrible sequelae resulting in permanent visual disability.

关键词： brain-derived neurotrophic factor chondroitin sulfate enriched environment glaucoma optic nerve axons optic nerve glia retinal ganglion cells visual stimulation

Hydrological setting of infertile species-rich wetland——a case study in the warm temperate japan

在线全文

学校读者我要写书评

暂无评论

journal of Environmental Sciences 2003年第2期15卷 279-283页

作者： Kikuchi A. nakagoshi n. Onda Y. Graduate School for International Development and Cooperation Hiroshima UniversityGraduate School for International Development and Cooperation Hiroshima UniversityInstitute of Geoscience University of Tsukuba Higashi-Hiroshima City 739_8529 JapanHigashi-Hiroshima City 739_8529 JapanIbaraki 305_8571 Japan

The detailed groundwater flow and water chemistry to illustrate landscape structure of the infertile peatless mire by using piezometers and groundwater wells were measured. The instruments were installed in lines through a small spring-fed wetland underlying little peat from the hillslope to the valley bottom in southwestern japan. Flow net and EC data clearly indicated that the wetland was situated in a high-EC groundwater upspring area. The low-productivity graminous vegetation was related with four hydrological factors such as: (1) high water level; (2) low-EC(ndwater; (3) weakly upward hydraulic gradient; and (4) overflowing of negatively pressured groundwater. In other words, the “old or deep groundwater” constructed the foundation of slope-wetland, and maintained the high groundwater level. In contrast, overflowing “youthful groundwater” is supplied from head of slope-wetland preferentially through the shallow substratum. The plant communities of the peatless mire in southwestern japan are similar to those of raised bog in northern cool temperate japan. There have been some reports verifying that the underlying mineral substrata of such wetlands were quartzile rocks such as granite, rhyolite, chart and well-leached sand. Results showed (1) low cation availability affects the water acidity; (2) upward seepage of high-EC groundwater composed the foundation of the investigated peatless mire; and (3) the poor mineral condition seems to play a similar role to northern ombrotrophic(rain-fed) condition.

关键词： eco-hydrology electrical conductivity groundwater flow plant community wetland

The Opioid Growth Factor Inhibits Established Ovarian Cancer in nude Mice and Can Be Combined with Taxol or Cisplatin to Enhance Growth Inhibition

在线全文

学校读者我要写书评

暂无评论

journal of Cancer Therapy 2011年第2期2卷 110-124页

作者： Renee n. Donahue Ian S. Zagon Patricia j. McLaughlin Department of neural and Behavioral Sciences The Pennsylvania State University College of Medicine Hershey PA

Ovarian cancer is the 5th leading cause of cancer-related mortality in women. Seventy-five percent of ovarian cancer patients present in advanced stages, and receive cytoreductive surgery and adjuvant chemotherapy. However, within 2 years 65% of these patients relapse and thereafter only receive palliative care. novel therapies based on the biology of these cancers are urgently needed. The opioid growth factor (OGF)-OGF receptor (OGFr) axis is an endogenous opioid system known to inhibit proliferation of human ovarian cancer cells in tissue culture, but does not affect cell survival. The present study determined whether OGF in combination with standard of care chemotherapy, provides an inhibitory effect on the growth of human ovarian cancer cells in vitro. In addition, this investigation assessed whether OGF biotherapy, alone or in combination with taxol or cisplatin, inhibits tumor growth in mice with xenografts of ovarian cancer. The combination of OGF (10–6 M) with taxol (10–9 M or 10–10 M) or cisplatin (0.01 ug/ml or 0.001 ug/ml) markedly reduced cell number and DnA synthesis in vitro to a greater extent than individual compounds. OGF, but not taxol or cisplatin, altered growth in an opioid receptor mediated and reversible manner. Female nu/nu mice inoculated subcutaneously with SKOV-3 cells, and treated with OGF (10 mg/kg) for 5 weeks commencing at the time tumors became measurable, had tumor volumes and weight that were reduced by up to 50% from animals receiving saline. The combination of OGF with taxol (3 mg/kg, weekly) or cisplatin (4 mg/kg, weekly for 2 weeks) for 37 days reduced tumor volumes and weight in contrast to mice receiving individual agents alone. Moreover, OGF treatment in mice receiving cisplatin provided protection against the weight loss associated with cisplatin alone. All treatments suppressed DnA synthesis and angiogenesis, whereas exposure to taxol or cisplatin, but not OGF, induced apoptosis. Additive inhibitory effects on DnA synthesis

关键词： Cell Proliferation [Met5]-Enkephalin Opioid Growth Factor OGFr Ovarian Cancer

Statins for primary cardiovascular prevention in the elderly

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Geriatric Cardiology 2015年第4期12卷 431-438页

作者： juan Pedro-Botet Elisenda Climent juan j Chillarón Rocio Toro David Benaiges juana A Flores-Le Roux Lipid and Vascular Risk Unit Endocrinology department Hospital del Mar. Spain Department of Medicine School of Medicine. Cáldiz University Cádiz Spain

The elderly population is increasing worldwide, with subjects 〉 65 years of age constituting the fastest-growing age group. Furthermore, the elderly face the greatest risk and burden of cardiovascular disease mortality and morbidity. Although elderly patients, particularly those older 〉 75, have not been well represented in randomized clinical trials evaluating lipid-lowering therapy, the available evidence supporting the use of statin therapy in primary prevention in older individuals is derived mainly from subgroup analyses and post-hoc data. On the other hand, elderly patients often have multiple co-morbidities that require a high number of concurrent medications; this may increase the risk for drug-drug interactions, thereby reducing the potential benefits of statin therapy. The aim of this review was to present the relevant literature regarding statin use in the elderly for theft primary cardiovascular disease, with the associated risks and benefits of treatment.

关键词： Cardiovascular disease Dyslipidaemia Elderly Primary prevention Statins

The Sensitivity of the Critical Resistance Model to Detect Sex-Related Differences in Fatigue During Submaximal Muscular Contractions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Science in Sport and Exercise 2019年第2期1卷 151-158页

作者： Taylor K.Dinyer M.Travis Byrd Ashley n.Vesotsky Pasquale j.Succi jody L.Clasey Haley C.Bergstrom Department of Kinesiology and Health Promotion University of Kentucky1210 University DriveSeaton CenterLexingtonKY 40502USA

Purpose Critical resistance(CR)is a fatigue threshold that,theoretically,estimates the highest sustainable resistance for repeated skeletal muscle *** are typically more susceptible to fatigue than women during sustained muscular ***,the purpose of this study was to compare the CR between men and women to determine the sensi-tivity of the CR model to detect sex-related differences in fatigue at submaximal *** Ten men and 10 women completed one-repetition maximum(1RM)testing for the deadlift and repetitions to failure at 50%,60%,70%,and 80%of 1RM for the determination of *** to failure were then performed at the estimated *** The men had a greater absolute 1RM(168±27 kg vs.115±11 kg)and CR(62±14 kg vs.48±6 kg),but a lower relative CR(percent of 1RM;37±6%vs.41±2%)and completed fewer repetitions at CR(45±14 repetitions vs.58±12 repetitions)compared to the *** The CR model was sensitive to detect sex-related differences in fatiguing muscular contractions of the *** addition,the men were more susceptible to fatigue than the women during performance of submaximal muscular contractions at CR,which may be related to sex-dependent physiological responses during fatiguing muscular contractions.

关键词： Resistance training Repetitions to failure Women Deadlift Sex differences

new perspectives for mesenchymal stromal cells as an adjuvant therapy for infectious disease-associated encephalopathies

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

neural Regeneration Research 2022年第1期17卷 48-52页

作者： Maiara n.Lima Maria C.Barbosa-Silva Tatiana Maron-Gutierrez Laboratory of Immunopharmacology Oswaldo Cruz InstituteOswaldo Cruz FoundationFiocruzRio de JaneiroRJBrazil national Institute of Science and Technology on neuroimmunomodulation Rio de JaneiroBrazil

Knowledge of the mechanisms that trigger infection-related encephalopathies is still very limited and cell therapies are one of the most promising alternatives for neurodegenerative diseases,and its application in infectious diseases can be of great *** stromal cells are cells with great immunomodulatory potential;therefore,their use in clinical and preclinical studies in a variety of diseases,including central nervous system diseases,increased in the last *** stromal cells can exert their beneficial effects through several mechanisms,such as direct cell contact,through surface receptors,and also through paracrine or endocrine *** paracrine mechanism is widely accepted by the scientific community and involves the release of soluble factors,which include cytokines,chemokines and trophic factors,and extracellular *** mini review discusses mesenchymal stromal cells mechanisms of action in neurological disorders,the neuroinflammatory process that takes place in the brain as a result of peripheral inflammation and changes in the brain’s cellular scenario as a common factor in central nervous system diseases,and mesenchymal stromal cells therapy in *** stromal cells have been shown to act in neuroinflammation processes,leading to improved survival and mitigating behavioral *** recently,these cells have been tested in preclinical models of infectious diseases-associated encephalopathies(e.g.,cerebral malaria and sepsis associated encephalopathy)and have shown satisfactory results.

关键词： behavior cell therapy cognition encephalopathy malaria mesenchymal stromal cell sepsis

REITERATED HOMOGEnIZATIOn OF DEGEnERATE nOnLInEAR ELLIPTIC EQUATIOnS

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2002年第3期23卷 325-334页

作者： j.BYSTRM j.EnGSTRM P.WALL Dedicated to the memory of jacques-Louis Lions Dedicated to the memory of Jacques-Louis LionsDedicated to the memory of Jacques-Louis Lions

The authors study homogenization of some nonlinear partial differential equations of the form -div (?(hx, h2x,Duh)) =f, where a is periodic in the first two arguments and monotone in the third. In particular the case where a satisfies degenerated structure conditions is studied. It is proved that uh converges weakly in W01,1 (?) to the unique solution of a limit problem as h ? '. Moreover, explicit expressions for the limit problem are obtained.

关键词： Homogenization Reiterated Monotone Degenerated

Sicilian serpentinite xenoliths containing abiotic organics with nanodiamond clusters as key model for prebiotic processes

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2021年第1期12卷 255-263页

作者： Sergei K.Simakov Vittorio Scribano nikolai n.Mel’nik Germana Barone LLC“ADAMAnT”Skolkovo Participant Tikhoretsky 10/1-61St.Petersburg194064Russia Department of Biological Geological and Environmental SciencesUniversity of CataniaCorso Italia 55-I-95129 CataniaItaly Lebedev Physics Institute Russian Academy of SciencesLeninsky Pr.53Moscow119991Russia

Rock fragments from the deepest parts of a buried hydrothermal system belonging to the Mesozoic Tethys Ocean entered as xenoliths in a Miocenic diatreme,hence brought to the surface,in the Hyblean Plateau(Sicily).Some xenoliths consist of strongly serpentinized ultramafic rocks bearing blebs of abiotic organic matter,where clusters of amorphous carbon nanoparticles,including nanodiamonds,are *** an occurrence conjures up established hypotheses that diamond surfaces are suitable catalytic platforms stimulating the assemblage of complex bio-organic molecules relevant to the emergence of life on *** appearance of bio-organic molecules under primitive Earth conditions is one of the major unsolved questions on the origin of *** we report new micro-Raman spectra on blebs of abiotic organic matter from a selected *** bands were related to hydrogenated nanocrystalline diamonds,with size of nearly 1-1.6 nm,formed from organics at low pressures and *** particular,diamond surfaces can give rise to crystalline interfacial water layers that may have played a fundamental role in the early biosphere evolution as a good medium for rapidly transporting positive charges in the form of hydrated ***,proton gradients in alkaline hydrothermal vents along oceanic ridges are generally viewed as key pre-biotic *** general,serpentinites span the entire geological record,including prebiotic *** hydrous ultramafic rocks often display evidence of abiotic carbon species,both organic and inorganic,including nanodiamonds,being also capable to give rise to chemiosmotic processes and proton gradients necessary to the organisms,such as the"Last Universal Common Ancestor"(LUCA),in the prebiotic Earth.

关键词： Hydrothermal systems nanocarbons Sulfides Fr-t synthesis Abiogenesis LUCA,Sicily Micro-Raman

Delayed Bleeding of Coronary Artery after Thoracoscopic Intradiaphragmatic Bronchogenic Cyst Resection

在线全文

学校读者我要写书评

暂无评论

中国肺癌杂志 2018年第8期21卷 649-651页

作者： Yuanda CHEnG Yang GAO Abdillah n.jUMA Chunfang ZHAnG Department of Thoracic Surgery Xiangya Hospital Central South University Changsha China Department of Surgery Kilosa Clinical Officer Training College Morogoro Tanzania

Bronchogenic cyst occurring in the diaphragm is rare and thoracoscopic cyst resection is mainly effective treatment. The coronary artery bleeding after video-assisted thoracoscopic surgery(VATS) has never been described; here we report a case of left coronary artery injury after thoracoscopic itradiaphragmatic bronchogenic cyst resection, which may be caused by metallic troca or chest tube.

关键词：肺癌患者临床治疗放射学治疗