New perspectives for mesenchymal stromal cells as an adjuvant therapy for infectious disease-associated encephalopathies

作     者：Maiara N.Lima Maria C.Barbosa-Silva Tatiana Maron-Gutierrez Maiara N.Lima;Maria C.Barbosa-Silva;Tatiana Maron-Gutierrez

作者机构：Laboratory of ImmunopharmacologyOswaldo Cruz InstituteOswaldo Cruz FoundationFiocruzRio de JaneiroRJBrazil National Institute of Science and Technology on NeuroimmunomodulationRio de JaneiroBrazil 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第1期

页      面：48-52页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：This work was supported by the Brazilian Council for Scientific and Technological Development(grant number 406110/2016-6) Inova Fiocruz/Oswaldo Cruz Foundation(grant number VPPCB-008-FIO-18-2-56-30,to TMG) 

主　　题：behavior cell therapy cognition encephalopathy malaria mesenchymal stromal cell sepsis 

摘      要：Knowledge of the mechanisms that trigger infection-related encephalopathies is still very limited and cell therapies are one of the most promising alternatives for neurodegenerative diseases,and its application in infectious diseases can be of great *** stromal cells are cells with great immunomodulatory potential;therefore,their use in clinical and preclinical studies in a variety of diseases,including central nervous system diseases,increased in the last *** stromal cells can exert their beneficial effects through several mechanisms,such as direct cell contact,through surface receptors,and also through paracrine or endocrine *** paracrine mechanism is widely accepted by the scientific community and involves the release of soluble factors,which include cytokines,chemokines and trophic factors,and extracellular *** mini review discusses mesenchymal stromal cells mechanisms of action in neurological disorders,the neuroinflammatory process that takes place in the brain as a result of peripheral inflammation and changes in the brain’s cellular scenario as a common factor in central nervous system diseases,and mesenchymal stromal cells therapy in *** stromal cells have been shown to act in neuroinflammation processes,leading to improved survival and mitigating behavioral *** recently,these cells have been tested in preclinical models of infectious diseases-associated encephalopathies(e.g.,cerebral malaria and sepsis associated encephalopathy)and have shown satisfactory results.