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Bidirectional Benign Regulation of Acupuncture in the Treatment of Stroke

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Proceedings of Anticancer Research 2021年第6期5卷 78-82页

作者： long He Honglong Wu Anlai Liu Meikui zhang Shaanxi University of Chinese Medicine Xianyang 712046Shaanxi ProvinceChina Chinese PLA General Hospital Telemedicine Centre Beijing 100853China

Acupuncture is a traditional Chinese medicine therapy originated in *** recent years,acupuncture is widely used in the field of neurological diseases,especially in the acute stage of *** mechanism of action is becomin... 详细信息

关键词： Stroke Acupuncture Bidirectional benign regulation Brain network Clinical treatment

Effect of TMP combined with DDP on VEGF, KLF4 and ADAMTS1 in lewis lung cancer mice: an experimental study

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Effect of TMP combined with DDP on VEGF, KLF4 and ADAMTS1 in...

Capacity models on expressway near a bus bay stop with an access

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Bu Wang Zhi-Hua zhang Xiu-long zhang Department of Respiratory Medicine First Affiliated Hospital of Hebei Northern College

BACKGROUnD:Tumorigenesis and microvascular density is associated with a poorer prognosis for patients with lung cancer. A disintegrin and metallopeptidase with thrombospondin motif type 1(ADAMTS1) is a recently discovered metalloproteinase with antiangiogenic activity. The function of ADAMTS1 in lung carcinoma remains unknown. The KLF4 gene has been shown to be inactivated in lung carcinogenesis as a tumor suppressor. However, the functional status and significance of KLF4 in lung carcinogenesis is unknown. This study(is conducted to investigate) the expression of VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice before and after the treatment of Tetramethylpyrazin(TMP) combined with cisplatin(DDP), and to further explore the inhibitory effects and potential mechanism of TMP combined with DDP on tumor ***:Totally40 C57 BL/6 mice were randomly divided into the 4 model groups: the control group(A), DDP group(B), TMP group(C) and TMP combined with DDP group(D), 10 in each group. The models were established by subcutaneously injecting Lewis lung cancer cells from the right axilla of C57 BL/6 mice, per 0.2 mL. Mice in the A group were given with 0.2 mL by peritoneal injection, once daily. Mice in the B group were given with DDP 2 mg/kg, 0.2 mL by peritoneal injection, once daily. Those in the C group were given with TMP 100 mg/kg by peritoneal injection, once daily. Those in the D group were given with the same dose as above by peritoneal injection, per 0.2 mL, once daily. During the treatment, the toxic side reaction of chemotherapy and the life quality were observed. All medication was started from the 7 th day after innoculation, lasting 14 successive days. All the Mice were sacrificed at the nineteenth day of the experiment. Tumors were taken out, Subcutaneous tumors were processed for tumor weight and tumor growth inhibition rate and tumor necrosis rate of each group were calculated.(Subcutaneous Tumors were taken out,with the weight,the growth inhib

关键词： non-small cell lung cancer immunohistochemistry The microvascular density KLF4 ADAMTS1 VEGF

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journal of Central South University 2015年第8期22卷 3239-3246页

作者：张洪宾孙小端贺玉龙宇仁德 Beij.ng Key Laboratory of Traffic Engineering Beijing University of Technology School of Transportation and Vehicle Engineering Shandong University of Technology

To determinate the expressway capacity near a bus bay stop with an access, capacity models on the expressway near a bus stop with an access were developed on the basis of gap acceptance theory and queuing theory. Depending on a bus stop position to an entrance or an exit ramp, the capacity models were developed for four cases. Bus bay stops with overflow and bus bay stops without overflow were considered. A comparison of simulation experiment and model calculation was carried out. Results show that the suggested models have high accuracy and reliability, at bus arrival rate below 60 vehicles per hour(veh/h) or vehicle volumes at the entrance and the exit below 200 passenger cars units per hour(pcu/h), and there are no significant difference in the capacities for four cases. When bus arrival rate is above 240 veh/h, the capacities of all four cases will decline rapidly. With berth number increasing, the increasing of the capacities is no obvious for four cases. As the bus arrival rate and vehicle volumes at the entrance and the exit increase, bus stops located downstream of an entrance and upstream of an exit have a remarkably effect on the capacities. The latter case is much heavier than the former. Those results can be used to traffic design and optimization on urban expressway near a bus stop with an access.

关键词： capacity public transport entrance and exit traffic flow theory delay

Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model

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journal of Magnesium and Alloys 2024年第1期12卷 384-393页

作者： Baoxiang zhang Wen zhang Fei zhang Chao ning Mingyang An Ke Yang Lili Tan Qiang zhang Department of Sports Medicine Chinese PLA General HospitalBeijing 100853China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Medical School of PLA Beijing 100853China Institute of Orthopedics Chinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Lab of Musculoskeletal Trauma&War Injuries of Chinese PLABeijing 100853China

Despite transosseous rotator cuff tear repair using sutures is widely accepted for tendon-bone fixation,the fibrocartilaginous enthesis regeneration is still hardly achieved with the traditional *** the present work,degradable magnesium(Mg)alloy wire was applied to suture supraspinatus tendon in a rat acute rotator cuff tear model with Vicryl Plus 4±0 absorbable suture as *** shoulder joint humerus-supraspinatus tendon complex specimens were retrieved at 4,8,and 12 weeks after *** Mg alloy suture groups showed better biomechanical properties in terms of ultimate load to *** observation showed that hyperplastic response of the scar tissue at the tendon-bone interface is progressively alleviated over time in the both Mg alloy suture and Vicryl suture *** the histological analysis,for Mg alloy suture groups,chondrocytes appear to proliferate at 4 weeks postoperatively,and the tendon-bone interface showed an orderly structural transition zone at 8 weeks *** collagenous fiber tended to be aligned and the tendon-bone interlocking structures apparently formed,where transitional structure from unmineralized fibrocartilage to mineralized fibrocartilage was closer to the native fibrocartilaginous *** vivo degradation of the magnesium alloy wire was completed within 12 *** results indicated that Mg alloy wire was promising as degradable suture with the potential to promotes fibrocartilaginous interface regeneration in rotator cuff repair.

关键词： Rotator cuff repair Mg alloy wire Tendon-bone healing Fibrocartilaginous interface

Disulfide Crosslinking-Induced Aggregation:Towards Solid-State Fluorescent Carbon Dots with Vastly Different Emission Colors

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Chinese journal of Chemistry 2023年第9期41卷 1007-1014页

作者： Rui Fu Haoqiang Song Xingjiang Liu Yongqiang zhang Guanj.n Xiao Bo Zou Geoffrey I.n.Waterhouse Siyu Lu Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhouHenan 450000China State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchunJilin 130012China School of Chemical Sciences The University of AucklandAuckland 1142New Zealand

Solid-state fluorescent multi-color carbon dots(SFM-CDs),prepared using the same precursor(s)without the need for dispersion in a solid matrix,are highly demanded for a wide range of ***,we report a microwave-assisted strategy for the prepara-tion of SFM-CDs with blue,yellow and red emissions within 5 min from the same *** as-prepared B-CDs,Y-CDs,and R-CDs possessed bright fluorescence at 425 nm,550 nm,and 640 nm,and photoluminescence quantum yields(PLQYs)of 54.68%,17.93%,and 2.88%,*** structure of SFM-CDs consisted of 5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-7-carboxylic acid(TPCA)immobilized on the surface of a carbon core,with the size of the carbon core and degree of disulfide crosslinking between CDs both increasing on going from the B-CDs to the R-CDs,as verified by mechanochromic *** excellent solid-state fluorescence performance of the SFM-CDs allowed their utilization as the fluorescent converter layer in multi-color LEDs and white LEDs with a high color rendering index.

关键词： Solid-state fluorescence Multicolor Cross-linked aggregation Disulfide bond Carbon dots

Research progress on the defensin Acipensins1

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Microenvironment & Microecology Research 2022年第2期4卷 19-22页

作者： Qi-long Du Zu-Xin zhang Tao zhang Chun-Ming Dong College of Marine and Environmental Sciences Tianjin University of Science and TechnologyTianjin 300457China

Antimicrobial peptides (AMPs) are bioactive peptides with antibacterial activity, generally composed of 10-60 amino acid residues, and are cationic peptides with amphiphilic structures. It has broad-spectrum antibacterial properties, and also has antiviral, antitumor, antifungal and other effects, and is recognized as the most potential antibiotic alternative. This paper mainly takes the defensin Acipensins1 as an example to introduce the molecular structure of antimicrobial peptides, expounds and analyzes the mechanism of action of antimicrobial peptides that have been discovered, and summarizes the experiments of O. V. Shamova. The antimicrobial activity and safety of Acipensins1 are analyzed and compared, and the antimicrobial peptides are listed. Many applications of peptides, and finally put forward the prospect of designing and constructing hybrid antimicrobial peptides, hoping to provide some theoretical support for the research and application of antimicrobial peptides in the future.

关键词： Acipensins1 antimicrobial peptide molecular structure mechanism of action antibacterial activity

Investigation of MXenes as oxygen reduction electrocatalyst for selective H_(2)O_(2) generation

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nano Research 2022年第5期15卷 3927-3932页

作者： Xiao Huang Min Song jian zhang j.ngj.ng zhang Wei Liu Chang zhang Wang zhang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage(Huazhong University of Science and Technology) Ministry of EducationHubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518055China

Two-electron oxygen reduction reaction(ORR)catalysts are essential for the electrosynthesis of hydrogen peroxide(H_(2)O_(2)).MXenes,a rising family of two-dimensional(2D)transition metal carbides,have been extensively studied for energy storage and(photo)electrocatalysis due to their rich chemical compositions and tunable electronic *** this work,three representative MXenes of Ti_(3)C_(2)T_(x),V_(2)CTX,and nb_(2)CTX were selected for H_(2)O_(2)electrosynthesis and we found that MXenes are inherent two-electron ORR catalysts with high H_(2)O_(2)*** addition,this work critically evaluates their electrocatalytic activity and ***,nb_(2)CT_(x)catalyst maintains better electrocatalytic activity and higher stability for a long time test,although the stability of Ti_(3)C_(2)T_(x)and V_(2)CT_(x)catalysts is poor owing to the metal dissolution property of Ti and V in alkaline ***,the assembled device based on nb2CTx catalyst presents a high H2O2 production and a rapid organic dye decoloration ability.

关键词： electrosynthesis hydrogen peroxide oxygen reduction reaction MXenes

High thermoelectric performance of ZrTe_(2)/SrTiO_(3) heterostructure

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journal of Materiomics 2022年第3期8卷 570-576页

作者： Chun Hung Suen long zhang Kunya Yang M.Q.He Y.S.Chai K.Zhou Huichao Wang X.Y.Zhou ji-Yan Dai Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina College of Physics Chongqing UniversityChongqing401331China School of Physics Sun Yat-sen UniversityGuangzhou510275China

Achieving high thermoelectric pe rformance in thin fiIm heterostructures is essental for integrated and minlatured ther moelectric device *** this work,we d emonstrate a mechansm and device performance of enh anced themoelectnic perfomance induced by interfuclal effect in a tansitdon metal dichalcogenides SrTiO_(3)(STO)heterpstructure Owing to the fomed conductive interface and elevated *** ZrTe_(2)/STO he teras tructure presents large thermoelectric power factor of 3.7×10^(5)μWcm^(-1)K^(-2) at 10 *** ion of quasi-wo dimensional conductance at the interface s atributed for the lage Seebeck coffcent and high electnical conductivity leading to high thermoelectric perfor mance which is demonstrated by a prototype device attaining 3 K cooling with 100 mA current input to this heterostructure This supenior themoelectnic property makes this he teros tructure a promtsing candidate for future thermoelectric device.

关键词： Thermoelectric ZrTe_(2)thin film High mobility Interface Transition metal dichalcogenides

Enhanced electrical properties in bilayered ferroelectric thin films

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Science China Chemistry 2013年第3期56卷 551-555页

作者： zhang Hao long Weijie CHEn YaQing GUO Dongjie Institute of Bio-inspired Structure and Surface Engineering Nanjing University of Aeronautics and Astronautics Institute of nanoScience Nanjing University of Aeronautics and Astronautics

Sr2Bi4Ti5O18(SBTi) single layered and Sr2Bi4Ti5O18 /Pb(Zr0.53Ti0.47)O3(SBTi/PZT) bilayered thin films have been prepared on Pt/TiO2/SiO2/Si substrates by pulsed-laser deposition(PLD).The related structural characterizations and electrical properties have been comparatively investigated.X-ray diffraction reveals that both films have crystallized into perovskite phases and scanning electron microscopy shows the sharp *** films show well-saturated ferroelectric hysteresis loops,however,compared with the single layered SBTi films,the SBTi/PZT bilayered films have significantly increased remnant polarization(Pr) and decreased coercive field(Ec),with the applied field of 260 kV/*** measured Pr and Ec of SBTi and SBTi/PZT films were 7.9 C/cm 2,88.1 kV/cm and 13.0 C/cm 2,51.2 kV/cm,*** addition,both films showed good fatigue-free characteristics,the switchable polarization decreased by 9% and 11% of the initial values after 2.2 10 9 switching cycles for the SBTi single layered films and the SBTi/PZT bilayered films,*** results may provide some guidelines for further optimization of multilayered ferroelectric thin films.

关键词： bilayered films X-ray diffraction scanning electron microscopy ferroelectric properties