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Exercise training maintains cardiovascular health:signaling pathways involved and potential therapeutics

Signal Transduction and Targeted Therapy 2022年第10期7卷 3709-3726页

作者： huihua chen chen chen Michail Spanos Guoping Li Rong Lu Yihua Bei junjie Xiao School of Basic Medical Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai 200444China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General hospital and harvard Medical School BostonMA 02114USA

Exercise training has been widely recognized as a healthy lifestyle as well as an effective non-drug therapeutic strategy for cardiovascular diseases(CVD).Functional and mechanistic studies that employ animal exercise models as well as observational and interventional cohort studies with human participants,have contributed considerably in delineating the essential signaling pathways by which exercise promotes cardiovascular fitness and ***,this review summarizes the beneficial impact of exercise on multiple aspects of cardiovascular *** then discuss in detail the signaling pathways mediating exercise’s benefits for cardiovascular *** exercise-regulated signaling cascades have been shown to confer myocardial protection and drive systemic *** signaling molecules that are necessary for exercise-induced physiological cardiac hypertrophy have the potential to attenuate myocardial injury and reverse cardiac ***-regulated noncoding RNAs and their associated signaling pathways are also discussed in detail for their roles and mechanisms in exercise-induced cardioprotective ***,we address the exercise-mediated signaling pathways and molecules that can serve as potential therapeutic targets ranging from pharmacological approaches to gene therapies in *** also discuss multiple factors that influence exercise’s effect and highlight the importance and need for further investigations regarding the exercise-regulated molecules as therapeutic targets and biomarkers for CVD as well as the cross talk between the heart and other tissues or organs during *** conclude that a deep understanding of the signaling pathways involved in exercise’s benefits for cardiovascular health will undoubtedly contribute to the identification and development of novel therapeutic targets and strategies for CVD.

关键词： cardiovascular protective organs

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活饵与饲料投喂对幼鳜肠肽酶活力及小肽转运、吸收的影响

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水生生物学报 2024年第1期48卷 53-62页

作者：曾萌冬马晨夕赵亮亮赵金良上海海洋大学农业农村部淡水水产种质资源重点实验室上海201306 水产动物遗传育种中心上海市协同创新中心上海201306 水产科学国家级实验教学示范中心上海201306

以初始体重(6.77±0.64)g的鳜(Siniperca chuatsi)为实验对象,从消化道肠肽酶活力和小肽转运吸收方面比较研究鳜对活饵与饲料消化吸收能力的差异。实验采用3种分组投食策略,将鳜分活饵组(仅投喂活饵鱼)、饲料组(仅投喂饲料)、复投活饵组... 详细信息

以初始体重(6.77±0.64)g的鳜(Siniperca chuatsi)为实验对象,从消化道肠肽酶活力和小肽转运吸收方面比较研究鳜对活饵与饲料消化吸收能力的差异。实验采用3种分组投食策略,将鳜分活饵组(仅投喂活饵鱼)、饲料组(仅投喂饲料)、复投活饵组(以下简称复投组,先投喂饲料后活饵鱼)。活饵组、饲料组分别饲养22d,复投组经5d驯饲、15d饲料和2d活饵喂养。饲养结束时在各组进食0.5h、1h、2h、3h、6h、12h、16h时分别取样肠和幽门盲囊,测定氨肽酶和羧肽酶含量与活力,小肽转运载体基因Pept1a、Pept1b和Pept2 mRNA表达水平,及进食12h后肠内容物及粪便中残余小肽含量。结果表明:各组羧肽酶、氨肽酶含量变化无显著性规律,酶活力总体呈先升后降趋势;活饵组肽酶活力峰值显著高于复投组高于饲料组(Ph,复投组肠内容物小肽含量显著高于活饵组和饲料组,小肽吸收效率随消化时间延长而上升。饲料组粪便中小肽含量显著高于活饵组与复投组,未转运的小肽中含必需氨基酸居高。综上所述,投喂鳜配合饲料,对肠肽酶活力、小肽转运载体基因表达和小肽吸收速率均产生不利影响,鳜对饲料蛋白的分解和小肽转运吸收效率显著低于活饵鱼。

关键词：活饵饲料投喂肠肽酶小肽转运吸收鳜

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Investigation of Linear Tetra-Atomic Negative Ion by Photodetached-Electron Spectra

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Chinese Physics Letters 2011年第8期28卷 87-90页

作者： A.Rahman Iftikhar Ahmad A.Afaq M.haneef h.j.Zhao Department of Physics Hazara UniversityMansehraPakistan Department of Physics University of MalakandChakdaraPakistan Centre of Excellence in Solid State Physics University of the PunjabQuid-e-Azam CampusLahore-54590Pakistan School of Physics and Information Science Shanxi Normal UniversityLinfen 041004

Photodetachment spectra from a linear tetra-atomic negative ion is investigated by treating the detached-electron wave function quantum mechanically.A plane polarized laser light,perpendicular to the axis of the ion,is used to detach the electron from the *** expressions for the electron flux and total photodetachment cross section are *** electron flux on screen shows strong-energy-dependent oscillations with different *** total cross section of the tetra-atomic negative ion reduces the cross section of mono-atomic,diatomic and triatomic negative ions for high energy photons,while for low energy photons it becomes four times the cross section of mono-atomic negative ions.

关键词： Electron polarized Investigation

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hepatitis E: Epidemiology and prevention

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World journal of hepatology 2011年第12期3卷 285-291页

作者： Eyasu h Teshale Dale j hu Division of Viral hepatitis Centers for Disease Control and Prevention National Center for HIV Viral Hepatitis STD TB Prevention Atlanta GA 30333 United States

hepatitis E is caused by the hepatitis E virus (hEV), the major etiologic agent of enterically transmitted non-A hepatitis worldwide. hEV is responsible for major outbreaks of acute hepatitis in developing countries, especially in many parts of Africa and Asia. The hEV is a spherical, non-enveloped, single-stranded, positive sense RNA virus that is approximately 32 nm to 34 nm in diameter and is the only member in the family hepeviridae and genus hepevirus. There are four distinct genotypes of hEV (genotypes 1-4). While genotype 1 is predominantly associated with large epidemics in developing countries, genotype 3 has recently emerged as a significant pathogen in developed countries. The clinical manifestations and the laboratory abnormalities of hepatitis E are not distinguishable from that caused by other hepatitis viruses. however, high mortality among pregnant women particularly during the third trimester distinguishes hEV from other causes of acute viral hepatitis. Specific etiologic diagnosis among infected cases can be made by serological testing or detection of viral nucleic acid by reverse transcription polymerase chain reaction. Although there are vaccine candidates that had been shown to be safe and efficacious in clini-cal trials, none are approved currently for use. There is no specific therapy for acute hepatitis E as treatment remains supportive.

关键词： hepatitis E virus Acute viral hepatitis Outbreak Epidemiology Serology Prevention

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Leader-following consensus criteria for multi-agent systems with time-varying delays and switching interconnection topologies

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Chinese Physics B 2012年第11期21卷 144-153页

作者： M.j.Park O.M.Kwon ju h.Park S.M.Lee E.j.Cha School of Electrical Engineering Chungbuk National University Department of Electrical Engineering Yeungnam University School of Electronic Engineering Daegu University Department of Biomedical Engineering School of MedicineChungbuk National University

We consider multi-agent systems with time-varying delays and switching interconnection topologies. By con- structing a suitable Lyapunov-Krasovskii functional and using the reciprocally convex approach, new delay-dependent consensus criteria for the systems are established in terms of linear matrix inequalities （LMIs）, which can be easily solved by using various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed methods.

关键词： consensus multi-agent systems time delay Lyapunov method

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滋阴明目方调控GRP78/IRE1/ATF6通路改善视网膜色素变性的体外研究

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北京中医药大学学报 2024年第6期47卷 773-781页

作者：欧晨宋厚盼谢薇彭俊曾梅艳彭清华湖南中医药大学第一附属医院长沙410007 湖南中医药大学

目的探讨滋阴明目方改善视网膜色素变性的作用机制。方法将20只SD大鼠按随机数字表法分为空白血清组和滋阴明目方含药血清组,每组10只。滋阴明目方含药血清组大鼠灌胃滋阴明目方(46.875 g/kg),空白血清组大鼠灌胃蒸馏水。制备滋阴明目... 详细信息

目的探讨滋阴明目方改善视网膜色素变性的作用机制。方法将20只SD大鼠按随机数字表法分为空白血清组和滋阴明目方含药血清组,每组10只。滋阴明目方含药血清组大鼠灌胃滋阴明目方(46.875 g/kg),空白血清组大鼠灌胃蒸馏水。制备滋阴明目方含药血清及空白血清,采用液质联用技术分析滋阴明目方含药血清的化学成分。采用衣霉素干预人视网膜色素上皮(ARPE-19)细胞构建内质网应激损伤模型。CCK-8法筛选滋阴明目方含药血清最优体积分数。将ARPE-19细胞分为空白组、模型组、空白血清组、滋阴明目方含药血清组、牛磺熊去氧胆酸组,分别进行干预。干预24 h后,采用多时间动态细胞功能分析系统对细胞进行形态观察,CCK-8法检测各组细胞存活率,Annexin V-FITC/PI法检测各组细胞凋亡率,蛋白质印迹法和微滴式数字PCR法检测各组细胞葡萄糖调节蛋白78(GRP78)、1型内质网转膜蛋白激酶(IRE1)、活化转录因子6(ATF6)的蛋白及mRNA表达。结果液质联用分析得到滋阴明目方含药血清中包含熊果苷、水杨酸、木犀草素、丹酚酸A、刺桐碱、牛磺酸、檞皮素、麦芽酚、黄芩苷、丹参素等主要化学成分。与模型组比较,滋阴明目方含药血清组细胞数量增多,生长较均匀,漂浮的死亡ARPE-19细胞及碎片减少;滋阴明目方含药血清组和牛磺熊去氧胆酸组的细胞存活率均升高,细胞凋亡率均下降(均P<0.05);滋阴明目方含药血清组GRP78、IRE1、ATF6蛋白表达降低,牛磺熊去氧胆酸组IRE1、ATF6蛋白表达降低(均P<0.05);滋阴明目方含药血清组和牛磺熊去氧胆酸组GRP78、IRE1、ATF6 mRNA表达降低(均P<0.05)。结论滋阴明目方可以减少ARPE-19细胞内质网应激损伤模型的细胞凋亡,其分子机制可能与下调GRP78、IRE1、ATF6的表达,抑制细胞内质网应激反应有关。

关键词：滋阴明目方人视网膜色素上皮细胞系-19 内质网应激葡萄糖调节蛋白78/1型内质网转膜蛋白激酶/活化转录因子6通路凋亡

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Enhancing the high-temperature creep properties of Mo alloys via nanosized La_(2)O_(3) particle addition

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journal of Materials Science & Technology 2022年第35期130卷 53-63页

作者： P.M.cheng C.Yang P.Zhang j.Y.Zhang h.Wang j.Kuang G.Liu j.Sun State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

Molybdenum(Mo) alloys with different La_(2)O_(3)particle additions(0.6,0.9,1.5 wt.%) were prepared by powder metallurgy to investigate the effect of La_(2)O_(3)particles on microstructural evolution and creep behavior of the *** Mo,annealed at 1500℃ for 1 h,presented a fully recrystallized microstructure characterized by equiaxed *** alloys doped with La_(2)O_(3)particles(Mo-La_(2)O_(3)alloys),on the other hand,exhibited fibrous grains elongated in the rolling direction of the *** contrast to the shape of the grains,the average grain size of the alloys was found to be insensitive to the addition of La_(2)O_(3)*** La_(2)O_(3)particles with diameters ranging from 65 to 75 nm were distributed within the grain *** creep tests showed that dislocation creep was the predominant deformation mode at intermediate creep rate(10^(-7)s^(-1)-10^(-4)s^(-1)) in the present *** creep stress exponent and activation energy were found to decrease with increasing temperature,particularly within the low creep rate regime(he Mo-La_(2)O_(3)alloys exhibited remarkably greater apparent stress exponent and activation energy than pure Mo.A creep constitutive model based on the interaction between particles and dislocations was utilized to rationalize the nanoparticle-improved creep *** was demonstrated that low relaxed efficiency of dislocation line energy,which is responsible for an enhanced climb resistance of dislocations,is the major creep strengthening mechanism in the Mo-La_(2)O_(3)*** addition,the area reduction and creep fracture mode of the Mo-La_(2)O_(3)alloys were found to be a function of the creep rate and temperature,which can be explained by the effect of the two parameters on the creep and fracture mechanisms.

关键词： Mo alloys Nanosized particles Creep strength Deformation and fracture

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New progress of the miniaturized microwave ion source at Peking University

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Radiation Detection Technology and Methods 2023年第4期7卷 545-549页

作者： S.X.Peng T.h.Ma W.B.Wu B.j.Cui A.L.Zhang Y.X.jiang Z.Y.Guo j.E.chen State Key Laboratory of Nuclear Physics and Technology and Institute of heavy Ion Physics Peking UniversityBeijingChina State Key Laboratory of Particle Detection and Electronics Department of Modern PhysicsUniversity of Science and Technology of ChinaHefei230026China

The generation of plasma in a microwave ion source involves confining electrons using a static magnetic field and energizing them with an electromagnetic field that transmitted into the plasma ***,according to electromagnetics theory,there is always a cut-off size in circular wave guides for a given *** a 2.45 Ghz microwave,this dimension is 72 mm,which should theoretically prevent transmission of the microwave into the discharge chamber and no plasma can be *** 2006 Peking University(PKU)has successfully developed a series of permanent magnet 2.45 Ghz microwave ion sources(PKU PMECRs)with a discharge chamber less than 50 mm,capable of delivering tens of mA beams for *** explain this anomalous phenomenon,a hybrid discharge heating(hDh)mode that combines surface wave plasma and electron cyclotron heating has been *** hDh mode not only successfully explains PKU PMECRs,but also predicts that the optimized inner diameter of the plasma chamber is 24 mm,which is confirmed by experiments involving different liners in the miniaturized microwave ion source.

关键词： Miniaturized 2.45 Ghz ECR source hybrid discharge mode hydrogen plasma

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Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress

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World journal of Gastroenterology 2021年第30期27卷 5060-5075页

作者： jing-hong chen Ying Sun Pei-jun ju jin-Bao Wei Qing-jie Li john h Winston Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Internal Medicine University of Texas Medical BranchGalvestonTX 77555United States

BACKGROUND Chronic stress during pregnancy may increase visceral hyperalgesia of offspring in a sex-dependent *** adult stress in offspring will increase this *** on the evidence implicating estrogen in exacerbating visceral hypersensitivity in female rodents in preclinical models,we predicted that chronic prenatal stress(CPS)+chronic adult stress(CAS)will maximize visceral hyperalgesia;and that estrogen plays an important role in colonic *** The aim was to illuminate the role of estrogen in colonic hyperalgesia and its underlying *** We established a CPS plus CAS rodent model in which the balloon was used to distend the *** single-fiber recording in vivo and patch clamp experiments in vitro were used to monitor the colonic neuron’s *** reverse transcription-polymerase chain reaction,western blot,and immunofluorescence were used to study the effects of CPS and CAS on colon primary afferent *** used ovariectomy and letrozole to reduce estrogen levels of female rats respectively in order to assess the role of estrogen in female-specific enhanced primary afferent *** Spontaneous activity and single fiber activity were significantly greater in females than in *** enhanced sensitization in female rats mainly came from lowthreshold *** significantly increased single-unit afferent fiber activity in L6-S2 dorsal roots in *** was further enhanced by *** addition,the excitability of colon-projecting dorsal root ganglion(DRG)neurons increased in CPS+CAS rats and was associated with a decrease in transient Atype K+*** with ovariectomy,treatment with the aromatase inhibitor letrozole significantly reduced estrogen levels in female rats,confirming the gender ***,mice treated with letrozole had decreased colonic DRG neuron *** intrathecal infusion of estrogen increased brain-derived neurotrophic factor(BDNF)p

关键词： Chronic prenatal stress Estrogen Visceral pain Neuronal sensitization Excitability Letrozole

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聚(对苯乙烯磺酸钠)/单宁酸/海藻酸钠三元复合水凝胶球对磷酸氯喹的高效吸附去除

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中国科学：化学 2024年第6期54卷 935-949页

作者：陶蔻蔻施霄宇孙思宇陈炜杨琥南京大学环境学院污染控制与资源化研究国家重点实验室南京210023

本文以海藻酸钠、单宁酸和聚(对苯乙烯磺酸钠)为原料,通过一步共沉淀法制备了一种新型三元复合水凝胶珠状小球(SA/TA/PSS),用于去除水中一种常见抗病毒药物磷酸氯喹(CQ).详细考察了溶液p h、吸附时间、CQ初始浓度、水体中常见的无机和... 详细信息

本文以海藻酸钠、单宁酸和聚(对苯乙烯磺酸钠)为原料,通过一步共沉淀法制备了一种新型三元复合水凝胶珠状小球(SA/TA/PSS),用于去除水中一种常见抗病毒药物磷酸氯喹(CQ).详细考察了溶液p h、吸附时间、CQ初始浓度、水体中常见的无机和有机共存物及不同实际水体等因素对其吸附性能的影响. SA/TA/PSS能在3.0~10.0 p h范围内保持良好且稳定的CQ吸收去除效率.在初始p h值为7.0时,最大实验吸附量为0.766 mmol/g.共存二价阳离子会因竞争吸附而抑制对CQ的吸附,而腐殖酸对CQ吸附的影响很小. SA/TA/PSS经过六次吸附-解吸循环后,对CQ的吸附量仍保持90%左右. SA/TA/PSS还能有效吸附硫酸羟氯喹和磷酸奥司他韦等其他抗病毒药物.文章通过对吸附剂吸附前后红外光谱和X射线光电子能谱谱图变化进行分析,并结合吸附动力学、等温吸附及吸附热力学分析,深入探究了SA/TA/PSS对CQ的多重吸附机制, SA/TA/PSS可通过静电吸引、氢键、π-π电子供体-受体相互作用(π-πEDA)及螯合作用等与CQ有效结合,实现其在较宽p h范围内对抗病毒药物的高效去除.本文为设计和制备新型绿色高效吸附剂材料提供了一定的有益参考.

关键词：海藻酸钠复合水凝胶单宁酸聚(对苯乙烯磺酸钠) 磷酸氯喹去除吸附性能多重吸附机制

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