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Development ofα-synuclein as a potential molecular marker for Parkinson's Disease

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Development ofα-synuclein as a potential molecular marker f...

2011全国老年痴呆与衰老相关疾病学术会议第三届山东省神经内科医师（学术）论坛

作者： Penelope Foulds Gerwyn Green Peter Diggle David M.A.Mann j.douglas Mitchell David Allsop Division of Biomedical and Life Sciences Lancaster University Division of Medicine School of Health and Medicine Lancaster University Neurodegeneration and Mental Health Research Group University of Manchester Hope Hospital Salford M6 8HD UK

Objectives:We aim to use immunoassay methods for the measurement of total and soluble oligomeric forms of alpha-synuclein(a-syn),and phosphorylated a-syn(pS-a-syn) in;a) longitudinal blood plasma samples,and b) post-mortem cerebral spinal fluid(CSF). Background:Parkinson s disease(PD) is characterised pathologically by selective loss of dopaminergic neurones from the substantia nigra,and the presence of Lewy bodies in surviving *** major protein

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美国普利策奖金内幕

1993年

作者：（美）贝茨（Bates j.douglas）贾宗谊译

书名原文:The Pulitzer prize:the inside story of America's most Prestigious award:普利策,美国报业大王,“普利策奖金”是1917年开始颁发的美国新闻奖。本书介绍了普利策传奇般的一生和设立普利策奖金的前后经过、评选方法、组织... 详细信息

ISBN: (数字)7501118582

ISBN: (纸本)7501118582

书名原文:The Pulitzer prize:the inside story of America's most Prestigious award:普利策,美国报业大王,“普利策奖金”是1917年开始颁发的美国新闻奖。本书介绍了普利策传奇般的一生和设立普利策奖金的前后经过、评选方法、组织机构、颁奖情况等。

关键词：普利策学科:传记新闻事业史地点:美国年代:现代

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弱非线性橢圓型差分方程的交替方向迭代法

计算机研究与发展 1963年第2期 34-38页

作者： j.douglas 鮑信烱金旦华

1.引言.椭圆型微分方程的有限差分数值解法,导至求解线性或非线性高阶代数方程组的问题。最简单的这种问题是矩形域的Di-richlet问题: {（△+△）w=f,（x,y）=（i△x,j△y）∈R,w=g,（x,y）∈R,（1.1）其中△是关于x的二阶中心差商。如... 详细信息

1.引言.椭圆型微分方程的有限差分数值解法,导至求解线性或非线性高阶代数方程组的问题。最简单的这种问题是矩形域的Di-richlet问题: {（△+△）w=f,（x,y）=（i△x,j△y）∈R,w=g,（x,y）∈R,（1.1）其中△是关于x的二阶中心差商。如果在R中,

关键词：交替方向迭代法差分方程逐次超松弛法

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心理神探美国联邦调查局系列犯罪破案揭秘

心理神探美国联邦调查局系列犯罪破案揭秘

Seasonal variation and host sex affect bat–bat fly interaction networks in the Amazonian savannahs

1999年

作者：（美）约翰·道格拉斯（j.douglas）（美）马克·奥尔谢克（M.Olshaker）阎卫平王春生译

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Integrative Zoology 2024年第3期19卷 400-416页

作者： Paulo MEjIA Gustavo Lima URBIETA Bruna da Silva XAVIER Isaíjorge de CASTRO joséjúlio DE TOLEDO Gustavo GRACIOLLI Lucio AndréVIANA DIAS William douglas CARVALHO Programa de Pós-Graduação em Biodiversidade Tropical Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil Programa de Pós-Graduação em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil Laboratório de Mamíferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil Programa de Pós-Graduação em Biologia Animal Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil Terrestrial Ecology Group(TEG-UAM) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain

Bats are the second-most diverse group of mammals in the world,and bat flies are their main ***,significant knowledge gaps remain regarding these antagonistic interactions,especially since diverse factors such as seasonality and host sex can affect their network ***,we explore the influence of such factors by comparing species richness and composition of bat flies on host bats,as well as specialization and modularity of bat–bat fly interaction networks between seasons and adult host *** captured bats and collected their ectoparasitic flies at 10 sampling sites in the savannahs of AmapáState,northeastern region of the Brazilian *** female bats being more parasitized and recording greater bat fly species richness in the wet season,neither relationship was statistically *** pooled network could be divided into 15 compartments with 54 links,and all subnetworks comprised>12 *** total number of links ranged from 27 to 48(for the dry and wet seasons,respectively),and female and male subnetworks had 44 and 41 links,*** values were very low for the pooled network and for all *** results revealed higher bat fly species richness and abundance in the wet season,whereas specialization and modularity were higher in the dry ***,the subnetwork for female bats displayed higher specialization and modularity than the male ***,both seasonality and host sex contribute in different ways to bat–bat fly network *** studies should consider these factors when evaluating bat–bat fly interaction networks.

关键词： Amapá Amazon biome bat flies bats interaction networks

Oxidized organic molecules in the tropical free troposphere over Amazonia

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National Science Review 2024年第1期11卷 174-184页

作者： Qiaozhi Zha Diego Aliaga Radovan Krejci Victoria A.Sinclair Cheng Wu Giancarlo Ciarelli Wiebke Scholz Liine Heikkinen Eva Partoll Yvette Gramlich Wei Huang Markus Leiminger joonas Enroth Otso Per?kyl? Runlong Cai Xuemeng Chen Alkuin Maximilian Koenig Fernando Velarde Isabel Moreno Tuukka Pet?j? Paulo Artaxo Paolo Laj Armin Hansel Samara Carbone Markku Kulmala Marcos Andrade douglas Worsnop Claudia Mohr Federico Bianchi Institute for Atmospheric and Earth System Research/Physics University of Helsinki joint International Research Laboratory of Atmospheric and Earth System Sciences Nanjing University Department of Environmental Science & Bolin Centre for Climate Research Stockholm University Department of Chemistry and Molecular Biology University of Gothenburg Institute for Ion and Applied Physics University of Innsbruck Ionicon Analytik GmbH Laboratory for Atmospheric Physics Institute for Physics Research Universidad Mayor de San Andrés Institute of Physics University of Sao Paulo Institute for Geosciences and Environmental Research (IGE) University of Grenoble Alpes Agrarian Sciences Institute Federal University of Uberl?ndia Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Department of Atmospheric and Oceanic Sciences University of Maryland Aerodyne Research Inc. Department of Environmental System Science ETH Zürich Switzerland and Laboratory of Atmospheric Chemistry Paul Scherrer Institute

New particle formation(NPF) in the tropical free troposphere(FT) is a globally important source of cloud condensation nuclei, affecting cloud properties and climate. Oxidized organic molecules(OOMs)produced from biogenic volatile organic compounds are believed to contribute to aerosol formation in the tropical FT, but without direct chemical observations. We performed in situ molecular-level OOMs measurements at the Bolivian station Chacaltaya at 5240 m above sea level, on the western edge of Amazonia. For the first time, we demonstrate the presence of OOMs, mainly with 4–5 carbon atoms, in both gas-phase and particle-phase(in terms of mass contribution) measurements in tropical FT air from Amazonia. These observations, combined with air mass history analyses, indicate that the observed OOMs are linked to isoprene emitted from the rainforests hundreds of kilometers away. Based on particle-phase measurements, we find that these compounds can contribute to NPF, at least the growth of newly formed nanoparticles, in the tropical FT on a continental scale. Thus, our study is a fundamental and significant step in understanding the aerosol formation process in the tropical FT.

关键词： oxidized organic molecules tropical aerosol formation Amazon free troposphere

Free perforation of the small intestine in collagenous sprue

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World journal of Gastroenterology 2009年第35期15卷 4446-4448页

作者： Hugh j Freeman douglas L Webber Departments of Medicine(Gastroenterology) University of British ColumbiaVancouverBC V6T 1W5Canada Departments of Pathology University of British ColumbiaVancouverBC V6T 1W5Canada

A 67-year-old man with celiac disease developed recurrent diarrhea,profound weakness and weight loss, with evidence of marked protein *** clinical course was refractory to a strict gluten-free diet and steroid *** studies led to definition of unrecognized collagenous sprue that caused ulceration and small intestinal *** PCR showed identical monoclonal T-cell populations in antemortem duodenal biopsies and postmortem jejunum,careful pathological evaluation demonstrated no frank ***,overt or even cryptic T-cell lymphoma may complicate collagenous sprue,however, small intestinal ulcers and perforation may also develop *** dramatic findings here may reflect an underlying or early molecular event in the eventual clinical appearance of overt T-cell lymphoma.

关键词： Collagenous sprue Intestinal perforation Celiac disease Refractory sprue Intestinal neoplasms Lymphoma

Potential influence of wildfire in modulating climate-induced forest redistribution in a central Rocky Mountain landscape

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Ecological Processes 2017年第1期6卷 52-68页

作者： john L.Campbell douglas j.Shinneman Department of Forest Ecosystems and Society Oregon State UniversityCorvallisORUSA U.S.Geological Survey Forest and Rangeland Ecosystem Science CenterBoiseIDUSA.

Introduction:Climate change is expected to impose significant tension on the geographic distribution of tree ***,tree species range shifts may be delayed by their long life spans,capacity to withstand long periods of physiological stress,and dispersal *** could theoretically break this biological inertia by killing forest canopies and facilitating species redistribution under changing *** investigated the capacity of wildfire to modulate climate-induced tree redistribution across a montane landscape in the central Rocky Mountains under three climate scenarios(contemporary and two warmer future climates)and three wildfire scenarios(representing historical,suppressed,and future fire regimes).Methods:Distributions of four common tree species were projected over 90 years by pairing a climate niche model with a forest landscape simulation model that simulates species dispersal,establishment,and mortality under alternative disturbance regimes and climate ***:Three species(douglas-fir,lodgepole pine,subalpine fir)declined in abundance over time,due to climate-driven contraction in area suitable for establishment,while one species(ponderosa pine)was unable to exploit climate-driven expansion of area suitable for *** fire frequency accelerated declines in area occupied by douglas-fir,lodgepole pine,and subalpine fir,and it maintained local abundance but not range expansion of ponderosa ***:Wildfire may play a larger role in eliminating these conifer species along trailing edges of their distributions than facilitating establishment along leading edges,in part due to dispersal limitations and interspecific competition,and future populations may increasingly depend on persistence in locations unfavorable for their establishment.

关键词： Forest disturbance Wildfire Climate change Central Rocky Mountains Climate niche Species migration Species distribution

Parallel boron nitride nanoribbons and etch tracks formed through catalytic etching

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Nano Research 2018年第9期11卷 4874-4882页

作者： Armin Ansary Mohsen Nasseri Mathias j. Boland douglas R. Strachan Department of Physics &Astronomy University of Kentucky Lexington KY40506 USA

One-dimensional （1D） catalytic etching was investigated in few-layer hexagonal boron nitride （hBN） films. Etching of hBN was shown to share a number of similarities with that of graphitic films. As in graphitic films, etch tracks in hBN commenced at film edges and occurred predominantly along certain crystal directions of its lattice, though it was shown that the tracks were generally narrower than those of few-layer graphene under similar processing conditions. It was also shown that catalytic hydrogenation can occur completely through a few-layer hBN film, demonstrating that this process can be used in the formation of isolated low-dimensional nanoscale structures from other layered 2D materials beyond graphene. This ability for thin hBN films to be etched completely through allowed for a crystalline substrate to guide the etching process, which was demonstrated with the successful etch track formation of few-layer hBN on single-crystalline sapphire substrates. The substrate-guided etching resulted in parallel few-layer hBN nanoribbons having an average width of 32 nm and spacing of 13 nm.

关键词： hexagonal(hBN) one-dimensional catalytic etching hydrogenation etch tracks nanoribbons