Development ofα-synuclein as a potential molecular marker for Parkinson's Disease
作者单位：Division of Biomedical and Life Sciences Lancaster University Division of Medicine School of Health and Medicine Lancaster University Neurodegeneration and Mental Health Research Group University of Manchester Hope Hospital Salford M6 8HD UK
会议名称：《2011全国老年痴呆与衰老相关疾病学术会议第三届山东省神经内科医师（学术）论坛》
会议日期：2011年
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
摘 要：Objectives:We aim to use immunoassay methods for the measurement of total and soluble oligomeric forms of alpha-synuclein(a-syn),and phosphorylated a-syn(pS-a-syn) in;a) longitudinal blood plasma samples,and b) post-mortem cerebral spinal fluid(CSF). Background:Parkinson s disease(PD) is characterised pathologically by selective loss of dopaminergic neurones from the substantia nigra,and the presence of Lewy bodies in surviving *** major protein