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虾青素聚集体的研究进展

现代食品科技 2021年第7期37卷 327-334页

作者：赵英源王昭萱薛文杰舒澳王高伟张胜梦贾慧慧李瑞芳河南工业大学生物工程学院河南郑州450001

虾青素是一种天然的萜烯类不饱和化合物,其分子结构中含有2个β-紫罗酮环和11个共轭双键。虾青素是自然界中唯一能够通过人体血脑屏障的类胡萝卜素,具有许多对人类健康有益的生理活性。近年来,虾青素因其分子结构所具有极强的抗氧化性... 详细信息

虾青素是一种天然的萜烯类不饱和化合物,其分子结构中含有2个β-紫罗酮环和11个共轭双键。虾青素是自然界中唯一能够通过人体血脑屏障的类胡萝卜素,具有许多对人类健康有益的生理活性。近年来,虾青素因其分子结构所具有极强的抗氧化性在食品、医药、生物、化妆品等领域备受关注。虾青素作为脂溶性小分子在一定环境中会自聚集,从而呈现出不同的存在形式,如黄色的H聚集体、橘色的m单体、粉紫色的j聚集体,不同聚集体的颜色、结构、光学特性、生理活性等都会有巨大差异。本文主要对近十年来虾青素聚集体的形成机理、影响因素、检测方法(紫外可见光光谱法、透射电镜观察法、圆二色光法、拉曼光谱法、荧光光谱法、分子模拟法以及其他研究方法)及应用前景进行总结,以期为今后虾青素聚集体在生理活性和应用方面的研究奠定基础。

关键词：虾青素 H聚集体 j聚集体影响因素研究方法

抗氧化剂和皮质激素治疗重症酒精性肝病的疗效比较:一项随机临床试验

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 54-55页

作者： Phillips m. Curtis H. Portmann B. j.O' Grady 宋平 Institute of Liver Studies King's College HospitalDenmark HillLondon SE5 9RSUnited Kingdom

Background/Aims:Severe alcoholic hepatitis is associated with high morbidity and short-term *** are the only widely used therapy but established contraindications to treatment or the risk of serious side-effects limit their *** perceived need for alternative treatments together with the theoretical benefits of anti-oxidant therapy triggered the design of a randomised clinical trial comparing these treatment ***:One hundred and one patients were randomized into a clinical trial of corticosteroids or a novel antioxidant cocktail with a primary endpoint of 30-day ***:At 30 days there were 16 deaths(30%)in the corticosteroid treated group compared with 22 deaths(46%)in the antioxidant treated group(P=0.05).The odds of dying by 30 days were 2.4 greater for patients on antioxidants(95%confidence interval 1.0-5.6).A diagnosis of sepsis was made more frequently in the ao group(P=0.05),although microbiologically proven episodes of infection occurred more often in the CS group(P m of prednisolone 30 mg daily are superior to a broad antioxidant cocktail in the treatment of severe alcoholic hepatitis.

关键词：皮质激素治疗随机临床试验酒精性肝病抗氧化剂疗效比较重症短期死亡率治疗药物

Internet of things:Conceptual network structure,main challenges and future directions

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Digital Communications and Networks 2023年第3期9卷 677-687页

作者： Leonardo B.Furstenau Yan Pablo Reckziegel Rodrigues michele Kremer Sott Pedro Leivas michael S.Dohan josé Ricardo López-Robles manuel j.Cobo Nicola Luigi Bragazzi Kim-Kwang Raymond Choo Department of Industrial Engineering Federal University of Rio Grande do SulPorto Alegre 90035-190Brazil University of Santa Cruz do Sul Av.Independencia2293Santa Cruz do SulRSBrazil Business School Unisinos UniversityAv.Dr.Nilo Peçanha 160091330-002Porto AlegreBrazil Lakehead University Thunder BayONP7B 5E1Canada Academic Unit of Accounting and management Autonomous University of ZacatecasCalle Comercio y Administracion S/NFracc.ProgresoC.P.98066ZacatecasZacatecasMexico Department of Computer Science and Artificial Intelligence University of Granada18071 GranadaSpain York University ONM3J 1P3Canada Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Internet of Things(IoT)is a key technology trend that supports our digitalized society in applications such as smart countries and smart *** this study,we investigate the existing strategic themes,thematic evolution structure,key challenges,and potential research opportunities associated with the *** this study,we conduct a Bibliometric Performance and Network Analysis(BPNA),supplemented by an exhaustive Systematic Literature Review(SLR).Specifically,in BPNA,the software ScimAT is used to analyze 14,385 documents and 30,381 keywords in the Web of Science(WoS)database,which was released between 2002 and *** results reveal that 31 clusters are classified according to their importance and development,and the conceptual structures of key clusters are presented,along with their performance analysis and the relationship with other *** thematic evolution structure describes the important cluster(s)over *** the SLR,23 documents are *** SLR reveals key challenges and limitations associated with the *** expect the results will form the basis of future research and guide decision-making in the IoT and other supporting industries.

关键词： Internet of things Strategic intelligence Industry 4.0 ScimAT Bibliometric analysis Science mapping

Community‑based screening of Chagas disease among Latin American migrants in a non‑endemic country: an observational study

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Infectious Diseases of Poverty 2021年第5期10卷 14-27页

作者： Violeta Ramos‑Sesma miriam Navarro jara Llenas‑García Concepción gil‑Anguita Diego Torrus‑Tendero Philip Wikman‑jorgensen maría García‑López Concepción Amador‑Prous maría‑Paz Ventero‑martín Pedro Guevara‑Hernández Ana Garijo‑Saiz Ares Sanchez‑Sanchez Cristina Bernal‑Alcaraz Ana‑Isabel Pujades‑Tarraga Roser muñoz‑Perez maría Flores‑Chávez josé‑manuel Ramos‑Rincón Internal medicine Service HLA Inmaculada HospitalGranadaSpain Public Health Science History and Gynecology DepartmentUniversidad Miguel Hernández de ElcheAlicanteSpain Epidemiology Unit Public Health Center of Elche AlicanteSpain Internal medicine Department Hospital Vega Baja de Orihuela(AlicanteSpain)-Foundation for the Promotion of Health and Biomedical Research of the Valencia Region(FISABIO)AlicanteSpain Clinical medicine Department University Miguel Hernández of ElcheSant Joan d’AlacantSpain Internal medicine Department Hospital Marina BaixaLa Vila Joiosa(AlicanteSpain)-FISABIOAlicanteSpain Internal medicine Department General University Hospital of Alicante–Biomedical and Health Research Institute of Alicante(ISABIAL)AlicanteSpain Parasitology Area University Miguel Hernández of ElcheSant Joan d’AlacantSpain Internal medicine Department University Hospital of Sant Joan(Sant Joan d’AlacantSpain)–FISABIOAlicanteSpain microbiology Service General University Hospital of Alicante–ISABIALAlicanteSpain Pediatric Department General University Hospital of Alicante–ISABIALAlicanteSpain Digestive Service General University Hospital of Alicante–ISABIALAlicanteSpain Reference and Research Laboratory in Parasitology National Center of Microbiology/Mundo Sano FoundationMadridSpain

Background:Chagas disease is a parasitic disease endemic to Latin America,but it has become a disease of global concern due to migration *** carriers may host the parasite for years,without knowing they are *** aim of this study is to assess prevalence of Chagas disease and evaluate the participants’level of knowl‑edge between Latin American migrants attending a community-based screening ***:Three community-based campaigns were performed in Alicante(Spain)in 2016,2017 and 2018,including educational chats and blood tests for Trypanosoma cruzi *** completed a questionnaire assessing knowledge about the mechanisms of transmission,disease presentation,diagnosis,and *** seroposi‑tive for *** underwent diagnostic confrmation by two diferent *** were analyzed by multivariable logistic regression and expressed as adjusted odds ratios(aoRs),adjusting for age,sex,and time in ***:A total of 596 participants were included in the study;17%were aged under 18 *** in adults was 11%[54/496;95%confdence interval(CI):8.3–14.5%]versus 0%among *** but one case were in *** was independently associated with having been born in Bolivia(aoR:102,95%CI:13–781)and a primary school-level education(aoR:2.40,95%CI:1.14–5.06).Of 54 people diagnosed with Chagas disease(most of whom were asymptomatic),42(77.7%)returned to the clinic at least once,and 24(44.4%)received *** analysis showed that coming from Argentina(aoR:13,95%CI:1.61–1188)or Bolivia(aoR:1.90,95%CI:1.19–3.39)and having received information about Chagas disease in Spain(aoR:4.63,95%CI:2.54–8.97)were associ‑ated with a good level of knowledge on the *** primary level studies(aoR:0.59,95%CI:0.34–0.98)and coming from Ecuador(aoR:4.63,95%CI:2.52–847)were independently associated with a lower level of ***:Community-based interventions are a good strategy for diagnosi

关键词： Chagas disease Trypanosoma cruzi Knowledge Community-based intervention migrant Early diagnosis Screening

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非卒中患者的反向推挤

世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 20-21页

作者： Santos- Pontelli T.E.G. Pontes- Neto O.m. Colaf.emina j.F. j.P. Leite 高中宝 Dept. of Neurology University of S.ao Paulo Sch. of Med. at Ribeir.ao Preto ao Preto Ribeir.CEP 14049- 900 Brazil Dr.

Background: Pusher syndrome is a disorder of postural control observed in patients with right or left brain damage associated with hemiparesis. Those patients show a peculiar behavior of actively pushing away from the nonhemiparetic side and resisting against passive correction, with a tendency to fall toward the paralyzed side. Thus far this phenomenon has been exclusively associated with stroke patients. Abstract:Objective: We investigate the occurrence, imaging features and clinical evolution of pusher behavior in patients with acute encephalic lesions at a tertiary emergency hospital. methods: Pusher patients were identified from 530 inpatients during a 1 year period. Patients were evaluated using a standardized Scale for Contraversive Pushing (SCP), neurological examination, assessment of neuropsychological symptoms, activities of daily living function and neuroimaging studies. Results: We found eight patients (1.5% ) with severe contraversive pushing, three female and five male. Age at symptoms onset ranged from 48 to 80 years (mean 65.4). All patients had scores equal or above 1.5 in each tested parameter of the SCP. Six patients (75% ) had right- hemisphere brain damage. A stroke etiology was found in four patients. The other four patients had non- stroke etiology (three traumatic, one metastatic tumor). Stroke patients showed complete recovery of pusher behavior at a mean duration of 15.3 weeks. In patients with brain trauma, pushing behavior was completely resolved in a mean time of 5 weeks. Conclusions: The results demonstrate that contraversive pushing may also occur in patients with non- stroke neurological lesions and suggest that resolution of symptoms may vary according to the underlying etiology.

关键词：神经系统查体影像学检查右侧脑症状评估神经系统损伤轻偏瘫急性脑损伤标准化量表脑外伤患者发病年龄

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丙纶纤维自增强聚丙烯树脂的研究

化学工程师 2011年第4期25卷 10-13页

作者：敖玉辉孙阳阳陈刚陈丽岩李连贵长春工业大学化学与生命科学学院吉林长春130012

以丙纶纤维为增强体,聚丙烯树脂为基体,采用热压成型的方法制备丙纶纤维/PP复合材料板材。研究了不同热压温度、不同纤度的丙纶纤维用量对复合材料力学性能的影响。结果表明:本实验最佳热压温度为195℃,在此温度下,随着纤维用量的增加,... 详细信息

以丙纶纤维为增强体,聚丙烯树脂为基体,采用热压成型的方法制备丙纶纤维/PP复合材料板材。研究了不同热压温度、不同纤度的丙纶纤维用量对复合材料力学性能的影响。结果表明:本实验最佳热压温度为195℃,在此温度下,随着纤维用量的增加,复合材料的拉伸强度呈先升后降的趋势,在用量为15%时达到最高点,纤度为240D的丙纶纤维/PP复合材料拉伸强度为25.46mPa,纤度为900D的丙纶纤维/PP复合材料拉伸强度为26.88mPa。冲击强度随纤维用量增加有小幅度降低,但强度保持在400 j.m-1以上,仍呈现韧性断裂。SEm照片表明:两种材料间的不同界面结合对丙纶纤维/PP复合材料的力学性能具有显著影响,良好的界面结合会提高材料的力学性能。

关键词：丙纶纤维聚丙烯热压复合材料力学性能

术前心脏CT对成人先天性心脏间隔缺损的诊断价值

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国际医学放射学杂志 2015年第4期 400-401页

作者： H.j.Eom D.H.Yang jW.Kang D.H.Kim j.-m.Song D.H.Kang 俞翔 Department of Radiology and Research Institute of Ra diology Cardiac Imaging Center Asan Medical Center University of Ul san College of Medicine Asanbyeongwon-gil 86Seoul 138-736 South Korea

摘要目的评估术前心脏CT对成人先天性心脏间隔缺损(CSD)的诊断价值。方法本研究共纳入行术前心脏CT检查和手术治疗的CSD病人65例。以手术结果作为参照标

关键词：术前心脏诊断价值 CT 成人

Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration

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Bioactive materials 2021年第10期6卷 3097-3108页

作者： Penghui Zhang Xizhe Liu Peng Guo Xianlong Li Zhongyuan He Zhen Li martin j.Stoddart Sibylle Grad Wei Tian Dafu Chen Xuenong Zou Zhiyu Zhou Shaoyu Liu Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen518107China Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Orthopaedic Research Institute/Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510080China ao Research Institute Davos Clavadelerstrasse 8Davos7270Switzerland Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing JiShuiTan HospitalBeijing100035China

It has been proven that the mechanical microenvironment can impact the differentiation of mesenchymal stem cells(mSCs).However,the effect of mechanical stimuli in biofabricating hydroxyapatite scaffolds on the inflammatory response of mSCs remains *** study aimed to investigate the effect of mechanical loading on the inflammatory response of mSCs seeded on *** mechanical loading was applied to biofabricate the cell-scaffold composite for 15 min/day over 7,14,or 21 *** the predetermined time points,culture supernatant was collected for inflammatory mediator detection,and gene expression was analyzed by *** results showed that the expression of inflammatory mediators(IL1B and IL8)was downregulated(pmechanical *** cell-scaffold composites biofabricated with or without mechanical loading were freeze-dried to prepare extracellular matrix-based scaffolds(ECm-based scaffolds).murine macrophages were seeded on the ECm-based scaffolds to evaluate their *** ECm-based scaffolds that were biofabricated with mechanical loading before freeze-drying enhanced the expression of m2 polarization-related biomarkers(Arginase 1 and mrc1,pmacrophages in vitro and increased bone volume/total volume ratio in ***,these findings demonstrated that mechanical loading could dually modulate the inflammatory responses and osteogenic differentiation of ***,the ECm-based scaffolds that were biofabricated with mechanical loading before freeze-drying facilitated the m2 polarization of macrophages in vitro and bone regeneration in *** loading may be a promising biofabrication strategy for bone biomaterials.

关键词： Bioreactor Biofabrication Inflammatory microenvironment Bone biomaterials macrophage polarization

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便捷式老人过马路安全车硬件系统设计

自动化技术与应用 2018年第10期37卷 147-151页

作者：何晓媛何秋生付悦吕奥贾美英太原科技大学电子信息工程学院山西太原030024

以AT89C51单片机为控制器设计了一款可以自动检测识别交通信号灯、感应车体前行人及其他障碍物并按要求移动的安全车系统模型。交通信号灯的识别通过光敏电阻实现;安全车移动轨道的识别采用红外光电循迹传感器实现;采用人体感应模块HC-S... 详细信息

以AT89C51单片机为控制器设计了一款可以自动检测识别交通信号灯、感应车体前行人及其他障碍物并按要求移动的安全车系统模型。交通信号灯的识别通过光敏电阻实现;安全车移动轨道的识别采用红外光电循迹传感器实现;采用人体感应模块HC-SR505检测并判断安全车车体前方100°锥角3m范围内是否有行人,车体前方其他障碍物的检测采用红外避障传感器实现;在安全车行驶过程中使用提前录好提示音的录放模块ISD1820提醒车体周围的行人躲避安全车。实验测试结果表明,安全车系统模型可以准确地检测交通信号灯、识别车体周围障碍物以及自动循迹前行,模拟帮助老人通过十字路口。

关键词：循迹交通信号灯检测障碍检测录放模块