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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： sharon j.Brown Rafael j.yáñez-Muñoz Heidi R.Fuller school of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

spinal muscular atrophy(sMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of sMA was understood in 1995 when loss or impairment of the survival motor neuron 1(sMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,sMN2,which can produce low levels(approximately 10%)of the full-length functional sMN protein,has led to the generation of sMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,sMN2 copy number is used as a proxy for the prediction of disease severity,with higher sMN2 copy number typically being associated with reduced severity of sMA,although this relationship is not absolute:some individuals with low sMN2 copy number have less severe sMA phenotypes and vice ***,the etiology of sMA is further complicated by other factors,such as non-typical nucleotide variants and sMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang sonata s y yau Kwok-Fai so Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNs Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina state Key Laboratory of Brain and Cognitive science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex David j.Calkins Vanderbilt Eye institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title iX and 25 years since the New york Times revealed bias against female faculty members at the Massachusetts institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye institute(NEi)provided the first round of research funding for its Audacious Goals initiative(AGi)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEi,the Blue Ridge institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research institute(iCVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal iCVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Experimental and finite element analysis for fracture of coating layer of galvannealed steel sheet

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Transactions of Nonferrous Metals society of China 2011年第A01期21卷 111-116页

作者： s.i.KiM j.U.HER y.C.jANG y.LEE sheet Products and Process Research Group POSCO Techology Research Laboratory Department of Mechanical Engineering Chung-Ang University

Mechanical properties of galvannealed (GA) steel sheet used for automotive exposed panel and predicted failure phenomenon of its coating layer were evaluated using finite element method. V-bending test was performed to understand better the fracture of coating layer of GA steel sheet during plastic deformation. yield strength of the coating layer was calculated by using a relative difference between hardness of coating layer measured from the nano-indentation test and that of substrate. To measure shearing strength at the interface between substrate and coating layer, shearing test with two specimens attached by an adhesive was carried out. Using the mechanical properties measured, a series of finite element analyses coupled with a failure model was performed. Results reveal that the fracture of coating layer occurs in an irregular manner at the region where compressive deformation is dominant. Meanwhile, a series of vertical cracks perpendicular to material surface are observed at the tensile stressed-region. it is found that 0.26-0.28 of local equivalent plastic strain exists at the coating and substrate at the beginning of failure. The fracture of coating layer depends on ductility of the coating layer considerably as well.

关键词： galvannealed steel sheet fracture simulation coating layer finite element analysis, failure model

Enhanced acetone sensing performance of nanostructured sm2O3 doped snO2 thick films

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journal of Rare Earths 2017年第8期35卷 813-823页

作者： F.i.shaikh L.P.Chikhale j.y.Patil i.s.Mulla s.s.suryavanshi school of Physical sciences Solapur University Solapur 413255 (M.S.) lndia Council of scientific and industrial Research Pashan Pune 411008 India

in the present work, we synthesized sm2O3 doped snO2 in order to prepare a selective acetone sensor with fast response, quick recovery and good repeatability. Pure as well as 2 mol.%, 4 mol.%, 6 mol.% and 8 mol.% sm2O3 doped snO2 nanostructured samples were synthesized by using a co-precipitation method. The characterization of the samples was done by thermogravimetric and differential thermo-gravimetric analysis（TG-DTA）, X-ray diffraction（XRD）, field emission gun-scanning electron microscopy（FEG-sEM）, energy dispersive analysis by X-rays（EDAX）, high resolution scanning electron microscopy（HR-TEM）, selected area X-ray diffraction（sAED）, Brunauer-Emmet-Teller（BET） and ultraviolet-visible-near infrared（UV-Vis-NiR） spectroscopy techniques. The gas response studies of liquid petroleum gas, ammonia, ethanol and acetone vapor were carried out. The results showed that sm doping systematically lowered operating temperature and enhanced the gas response and selectivity for acetone. The response and recovery time for 6 mol.% sm2O3 doped snO2 thick film at the operating temperature of 250 °C were 15 and 24 s, respectively.

关键词： tin oxide samarium oxide screen printing thick film acetone sensor rare earths

Nanocrystalline silicon Thin Films Fabricated at 80℃ by Using Electron Cyclotron Resonance Chemical Vapor Deposition

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Plasma science and Technology 2010年第5期12卷 608-613页

作者： i.y.y.BU A.j.FLEWiTT W.i.MiLiNE Department of Microelectronics Engineering National Kaohsiung Marine University Electrical Engineering Division Engineering Department Cambridge University

Deposition of nanocrystalline silicon （nc-si） on glass at very low temperatures by electron cyclotron resonance （ECR） plasma enhanced chemical vapour deposition （PECVD） was investigated. it was shown that nc-si could be deposited from hydrogen diluted silane gas at a substrate temperature of 80℃ with a crystalline fraction up to 80% and a lateral grain size of around 50 nm. This was achieved by growing the nc-si in a low pressure regime which ensured that mono-silyl species were the dominant deposition precursor. Furthermore, a high flux of energetic hydrogen ions was required to induce crystallisation of the silicon material through a chemical annealing process.

关键词： low temperature nanocrystalline silicon ECR

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Near-surface Correction on seismic and Gravity Data

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journal of Earth science 2015年第6期26卷 851-857页

作者： s.Bychkov i.y.Mityunina Perm state University Mining Institute of Ural Branch of Russian Academy of Sciences

it is important and urgent to work out better statics correction methods to facilitate seismic prospecting. This paper presents a new method of statics correction calculation based on development of a seismic-gravity model of the near surface. Gravity interpretation includes determination of the local component caused by the near surface effects and calculation of the near-surface rock density by solving the linear inverse gravity problem. To obtain the near-surface velocities, priori seismic data such as time fields of the first waves recorded in the initial part of common depth point（CDP） seismograms are used. An optimal near-surface model is retrieved on the basis of the successive solution of the inverse and forward seismic problems, correlating with the observed seismic data. Matching of seismic and gravity model of the near surface yields the maximum coefficient of correlation between the values of velocities and densities. At the end of the interactive iterative process we get values of the near-surface seismic wave velocities, used for statics evaluation, and values of gravity anomalies, calculated with a variable density of the interbedded layer. The applications of the proposed method at geophysical exploration of oil and gas confirm the possibility of calculation of statics correction using the gravimetric data by constructing a coherent seismic-gravity model of the near surface.

关键词： gravity near-surface velocity seismic-gravity model statics correction.

Relation between etching profile and voltage-current shape of sintered siC etching by atmospheric pressure plasma

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Plasma science and Technology 2019年第4期21卷 137-144页

作者： D C sEOK s R yOO K i LEE y s CHOi y H jUNG Plasma Technology Research Center National Fusion Research InstituteGunsan City 54004Republic of Korea

sintered silicon carbide(siC)was etched by a dielectric barrier discharge source.A high voltage bipolar pulse was used with helium gas for the plasma *** stable filament plasma was generated and could be used for siC *** the processing gas(NF3)mixing rate increased,the width and depth of the etching profile became narrower and *** differentiated V-Q Lissajous method was used for measuring the capacitances(Ceq)of the electrode after the plasma turned *** width of the etching profile was proportional to *** the current peak value/smx of the substrate current in creased,the volume removal rate of siC *** etch depth was proportional to the ratio of/smx to ***,because of the different characteristics of the plasma disks on siC substrate by the voltage polarity,the etching profile was ***,in high NF3 mixing process,the etching profile became stable and deeper.

关键词： dielectric barrier discharge silicon carbide plasma etching、filament discharge,surface charge