检索结果-南通市图书馆

plasma Edge Kinetic-MHD Modeling in Tokamaks Using Kepler Workflow for Code Coupling,Data Management and Visualization

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Computational physics 2008年第8期4卷 675-702页

作者： j.cummings A.pankin N.podhorszki G.park S.Ku R.Barreto S.Klasky C.S.Chang H.Strauss L.Sugiyama p.Snyder D.pearlstein B.Ludascher G.Bateman A.Kritz the CpES Team California Institute of Technology PasadenaCA 91125 Lehigh University BethlehemPA 18015 University of California at Davis DavisCA 95616 Courant Institute of Mathematical Sciences New York UniversityNY 10012 Oak Ridge National Laboratory Oak RidgeTN 37830 Massachusetts Institute of Technology CambridgeMA 02139 General Atomics San DiegoCA 92186 Lawrence Livermore National Laboratory LivermoreCA 94550 SciDAC FSp Center for plasma Edge Simulation

A new predictive computer simulation tool targeting the development of the H-mode pedestal at the plasma edge in tokamaks and the triggering and dynamics of edge localizedmodes(ELMs)is presented in this *** tool brings together,in a coordinated and effective manner,several first-principles physics simulation codes,stability analysis packages,and data processing and visualization tools.A Kepler workflow is used in order to carry out an edge plasma simulation that loosely couples the kinetic code,XGC0,with an ideal MHD linear stability analysis code,ELITE,and an extended MHD initial value code such as M3D or ***0 includes the neoclassical ion-electron-neutral dynamics needed to simulate pedestal growth near the *** Kepler workflow processes the XGC0 simulation results into simple images that can be selected and displayed via the Dashboard,a monitoring tool implemented in AjAX allowing the scientist to track computational resources,examine running and archived jobs,and view key physics data,all within a standard Web *** XGC0 simulation is monitored for the conditions needed to trigger an ELM crash by periodically assessing the edge plasma pressure and current density profiles using the ELITE *** an ELM crash is triggered,the Kepler workflow launches the M3D code on a moderate-size Opteron cluster to simulate the nonlinear ELM crash and to compute the relaxation of plasma profiles after the *** process is monitored through periodic outputs of plasma fluid quantities that are automatically visualized with AVS/Express and may be displayed on the ***,the Kepler workflow archives all data outputs and processed images using HpSS,as well as provenance information about the software and hardware used to create the *** complete process of preparing,executing and monitoring a coupled-code simulation of the edge pressure pedestal buildup and the ELM cycle using the Kepler scientific workflow system is described

关键词： plasma simulation magnetohydrodynamic and fluid equation gyrofluid and gyrokinetic simulations hybrid methods

Management information systems: ed.

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insights into A Novel Molecular Based Recognition of 6’-sulfo sLex

2002年

作者： Stephen Haag Maeve cummings Donald j. McCubbrey.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Insights into A Novel Molecular Based Recognition of 6’-sul...

Testing for selection on color and pattern in a mimetic radiation

2019中国化学会第十五届全国计算（机）化学学术会议

作者：王晓聪 Melinda Hanes Richard cummings Robert j.Woods 华中农业大学 Department of Surgery Beth Israel Deaconess Medical Center Harvard Medical School Complex Carbohydrate Research Center University of Georgia

The binding of sialylated glycans to selectins and siglecs mediates inflammatory responses. While the selectins prefer to bind to sialyl Lewis X（sLex）, the siglec ligands show a wider diversity in glycan motifs. Many siglecs either do not tolerate the presence of fucose in sLex or prefer to have a 6-O-sulfate moiety in the epitope. In contrast, fucose is essential for selectin binding, while the presence of 6-O-sulfation abrogates binding. Elucidating the molecular mechanisms for their binding specificities is crucial for understanding their biological functions and specificities. Here we used molecular modeling to design a double mutant of E-selectin（E92 A＆E107 A） that when expressed showed binding preference for 6’-sulfo s Lex that were indistinguishable from that displayed by siglec-8. The result confirmed the theoretical prediction that the aversion of endogenous E-selectin for 6’-sulfo sLex arises from strong electrostatic repulsions between the conserved acidic residues in the binding site and the sulfate group at the galactose 6-O position. Structural analyses of the E-selectin/siglec-8 – 6’-sulfo sLex complexes indicated that the glycan ligand maintains the same conformation in each, but forms completely unique set of protein-glycan interactions in each system. Therefore, a new binding scheme for 6’-sulfo sLex was discovered in E-selectin, which is different from that in siglec-8. The results indicate that identical specificities may be displayed through completely different binding motifs, and indicate a role for computational studies in the design of high-specificity carbohydrate-binding proteins.

关键词： E-selectin 6’-sulfo sLex recognition mechanism siglec carbohydrate-binding protein design

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Current Zoology 2012年第4期58卷 668-676页

作者： justin YEAGER jason L. BROWN Victor MORALES Molly cummings Kyle SUMMERS Department of Biology East Carolina University Greenville NC 27858 Department of Ecology and Evolutionary Biology Tulane University New Orleans LA 70118 Department of Biology Duke University Durham NC 27708 Universidad de Ricardo palma Lima Peru Department of Integrative Biology University of Texas Austin Texas 78712

In this paper, we analyze variation in spectral reflectance and color pattern among populations to demonstrate dra-matic divergence between four distinct morphs of the mimic poison frog Ranitomeya imitator. We also analyze genetic diver-gence in d-loop mtDNA sequences between populations. We then use coalescent-based simulations to demonstrate that the high levels of observed phenotypic divergence are not consistent with levels of genetic divergence expected under neutral drift among populations, implying an important role for selection in driving divergence between these populations .

关键词： Mullerian Mimicry Natural Selection population Divergence Coalescent

Regulation of Mucin-type O-Glycan Biosynthesis Through the Cosmc and T-synthase—Implications in Human Diseases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regulation of Mucin-type O-Glycan Biosynthesis Through the C...

21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

作者： Tongzhong ju Yingchun Wang Xiaokun Ding Rajindra p.Aryal Wenyl Wang Caleb j.Stowell Richard D.cummings Department of Biochemistry Emory University School of MedicineAtlantaGA 30322USA

＜正＞The T-synthase（core 1 3-galactosyltransferase） is a glycosyl transferase responsible for converting GalNAcl-Ser/Thr（Tn antigen） to ***1- Ser/Thr（core 1 structure,T antigen）,which is a precursor for many mucin type O-glycans on animal *** of T-synthase in mice results in embryonic lethality due to impaired ***,

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

神经精神科问卷知情者版中文译本的信效度

中国心理卫生杂志 2010年第5期24卷 338-342,361页

作者：马万欣王华丽 jeffrey L.cummings 于欣北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学)北京100191 北京市朝阳区第三医院北京100121 美国加州大学洛杉矶分校美国加利福尼亚州90095

目的:评价神经精神科问卷知情者版(Neuropsychiatric Inventory-Questionnaire,NpI-Q)中文译本的信度与效度。方法:从北京大学精神卫生研究所记忆中心的病例库中,选取51例符合NINCDS-ADR-DA诊断标准的阿尔茨海默病(probable AD)患者,接... 详细信息

目的:评价神经精神科问卷知情者版(Neuropsychiatric Inventory-Questionnaire,NpI-Q)中文译本的信度与效度。方法:从北京大学精神卫生研究所记忆中心的病例库中,选取51例符合NINCDS-ADR-DA诊断标准的阿尔茨海默病(probable AD)患者,接受简明智能精神状况检查(Mini-mental Status Exami-nation,MMSE)、日常生活活动量表(Activities of Daily Living,ADL)、阿尔茨海默病评定量表(Alzheimer'sdisease Assessment Scale-Cognitiveportion,ADAS-cog)、神经精神科问卷(Neuropsychiatric Inventory,NpI)评定,并由其知情者进行NpI-Q评分。其中16例在临床干预3个月后进行重测。结果:(1)NpI-Q克朗巴赫系数α=0.851,Guttman分半系数为0.825;NpI-Q总分重测信度为ICC=0.860(ppI-Q苦恼程度总分重测信度ICC=0.480(p>0.05)。(2)NpI-Q各条目评分之间的相关系数为0.01～0.97,均与总分呈正相关(r=0.33～0.87,ppI-Q各条目苦恼程度评分之间的相关系数为0.05～0.72,与苦恼程度总分正相关(r=0.47～0.90,ppI-Q严重程度总分与苦恼程度总分相关(r=0.78,ppI-Q严重程度评分与MMSE总分呈负相关(r=-0.39,ppI总分、NpI苦恼程度评分均相关(r=0.47～0.82,均ppI-Q苦恼程度评分与MMSE总分负相关(r=-0.32,ppI总分、NpI苦恼程度相关(r=0.29～0.68,ppI-Q含有精神病性、情感损害和额叶功能3个因子,总贡献率达62.23%。结论:神经精神科问卷知情者版中文译本具有较好的信度和效度,值得推广应用。

关键词：神经精神科问卷知情者版(NpI—Q) 阿尔茨海默病信度效度

维普期刊数据库

美金刚对接受多奈哌齐治疗阿尔茨海默病患者的行为效应

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(神经病学分册) 2006年第12期 12-13页

作者： cummings j.L. Schneider E. Tariot p.N. Graham S.M. 郭俊 Dr.Reed Neurological Research Center UCLABox 951769710 Westwood PlazaLos AngelesCA90095-1769United States

OBjECTIVE:To investigate the behavioral effects of memantine in moderate to severe Alzheimer disease(AD).METHODS:The authors conducted a hypothesis-generating,exploratory analysis of a 24-week,double-blind,placebo-controlled trial comparing memantine(20 mg/day)with placebo in subjects with moderate to severe AD on stable donepezil *** employed the Neuropsychiatric Inventory(NpI;12-item),administered at baseline,week 12,and week 24,to assess the effects of memantine on ***,cognitive,and functional measures were collected and relationships between these assessments and changes in behavior were *** intent-to-treat population was examined using last-observation-carried-forward and observed-cases ***:patients treated with memantine had significantly lower NpI total scores than patients treated with *** of the 12 NpI domains revealed significant effects in favor of memantine on agitation/aggression,eating/appetite,and irritability/*** patients who exhibited agitation/aggression at baseline,those treated with memantine showed significant reduction of symptoms compared with placebo-treated ***-treated patients without agitation/aggression at baseline evidenced significantly less emergence of this symptom compared with similar patients receiving *** of patients receiving memantine registered significantly less agitation-related *** were significant relationships between the NpI and the global rating scale and performance of activities of daily living,but not between changes in the NpI and ***:Treatment with memantine reduced agitation/aggression,irritability,and appetite/eating *** reduced agitation/aggression in patients who were agitated at baseline and delayed its emergence in those who were free of agitation at baseline.

关键词：多奈哌齐攻击行为侵犯行为阿尔茨海默病美金刚患者行为效应

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

北京市髋部骨折发生率流行病学研究

中华流行病学杂志 1996年第1期17卷 6-9页

作者：刘爱民徐苓赵熙和陈孝曙 Steven R cummings 北京协和医院WHO疾病分类合作中心 100730 北京协和医院妇产科中国预防医学科学院营养与食品卫生研究所美国旧金山加州大学流行病和生物统计系

为了解北京市髋部骨折发生率,调查了北京市所有能收治骨折的76所医院1988～1992年髋部骨折的出院病例。为避免遗漏非住院治疗的髋部骨折,在北京城区随机抽样2113名50岁以上妇女进行入户调查以了解过去骨折史。应答率97%。所有资料均经... 详细信息

为了解北京市髋部骨折发生率,调查了北京市所有能收治骨折的76所医院1988～1992年髋部骨折的出院病例。为避免遗漏非住院治疗的髋部骨折,在北京城区随机抽样2113名50岁以上妇女进行入户调查以了解过去骨折史。应答率97%。所有资料均经多方面、系统的有效性核实。基于1990年人口普查资料,计算出北京市年龄标化后的髓都骨折发生率女性为88/10万,男性为97/10万。用同样方法和人群标化的其它国家和地区比较,北京市的髋部骨折发生率仍属最低。

关键词：骨折髋部骨折发生率流行病学北京

维普期刊数据库

Cosmc和T-合酶在黏蛋白型O-聚糖合成中的重要作用及其与人类疾病的相关性

在线全文

学校读者我要写书评

暂无评论

生命科学 2011年第7期23卷 630-642页

作者：巨同忠 Richard D.cummings 靳嘉巍查锡良埃莫里大学医学院生物化学系复旦大学上海医学院生物化学与分子生物学系

从核心1结构(Galβ1,3GalNAcα1-O-Ser/Thr,core 1 structure,T antigen)中衍生出来的黏蛋白型O-聚糖在很多生理过程中发挥重要的生物学功能。T-合酶(core 1β3-galactosyltransferase,T-synthase)是合成核心1结构的唯一糖基转移酶,它主要的功能是将半乳糖(Galactose)添加到GalNAcα1-Ser/Thr(Tn抗原)糖链上。但是在人体和其他脊椎动物中有活性的T-合酶的形成需要一个重要的伴侣分子Cosmc;Cosmc功能丧失将直接导致T-合酶失活,其结果是机体细胞只能合成Tn抗原以及唾液酰化Tn(sialylTn,STn,Neu5Acα2,6GalNAcα1-O-Ser/Thr)。综述目前对T-合酶和Cosmc的研究以及在人类疾病(如异常O-聚糖表达相关的Tn综合征、IgA肾病和肿瘤)发生发展中的作用。

关键词： O-聚糖 T-合酶分子伴侣 Cosmc Tn抗原

维普期刊数据库