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“Autoinflammatory psoriasis”-genetics and biology of pustular psoriasis

Cellular & Molecular Immunology 2021年第2期18卷 307-317页

作者： Ranjitha Uppala Lam C.Tsoi Paul W.Harms Bo Wang Allison C.Billi Emanual Maverakis j.michelle kahlenberg Nicole L.Ward johann E.Gudjonsson Graduate Program in Immunology University of MichiganAnn ArborMIUSA Department of Dermatology University of MichiganAnn ArborMIUSA Department of Pathology University of MichiganAnn ArborMIUSA Department of Dermatology University of CaliforniaDavisSacramentoCAUSA Division of Rheumatology Department of Internal MedicineUniversity of MichiganAnn ArborMIUSA A.Alfred Taubman Medical Research Institute Ann ArborMIUSA Departments of Nutrition and Dermatology Case Western Reserve UniversityClevelandOHUSA

Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical *** psoriasis,which is the most common manifestation of psoriasis,is located on one end of the spectrum,dominated by adaptive immune responses,whereas the rarer pustular psoriasis lies on the opposite end,dominated by innate and autoinflammatory immune *** recent years,genetic studies have identified six genetic variants that predispose to pustular psoriasis,and these have highlighted the role of IL-36 cytokines as central to pustular psoriasis *** this review,we discuss the presentation and clinical subtypes of pustular psoriasis,contribution of genetic predisposing variants,critical role of the IL-36 family of cytokines in disease pathophysiology,and treatment perspectives for pustular *** further outline the application of appropriate mouse models for the study of pustular psoriasis and address the outstanding questions and issues related to our understanding of the mechanisms involved in pustular psoriasis.

关键词： Pustular psoriasis Genetics IL-36 Autoinflammation Clinical features Histology

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A vestigial pathway for sex differences in immune regulation

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Cellular & Molecular Immunology 2017年第7期14卷 578-580页

作者： Yun Liang j.michelle kahlenberg johann E Gudjonsson Department of Dermatology University of MichiganAnn ArborMI 48109USA Division of Rheumatology Department of Internal MedicineUniversity of MichiganAnn ArborMI 48109USA

Autoimmune diseases have a strikingly higher prevalence in women compared to men,with approximately 80%of individuals affected with autoimmune diseases being *** nature of this sex-bias has remained unclear,but sex hormones have previously been implicated as the leading underlying *** this research highlight,we discuss a recently identified transcription factor。

关键词： diseases autoimmune prevalence

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