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A peptide containing the receptor binding site of insulin-like growth factor binding protein-2 enhances bone mass in ovariectomized rats

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Bone Research 2018年第3期6卷 280-288页

作者： Gang Xi Christine Wai Clifford j.Rosen David R.Clemmons Department of Medicine University of North Carolina at Chapel HillChapel HillUSA Maine Medical Center Research Institute ScarboroughUSA

Male Igfbp2-/-mice have a significant reduction in bone mass and administration of a peptide that contains the insulin-like growth factor binding protein-2(IGFBP-2) receptor-binding domain stimulates bone formation in these animals. Female Igfbp2-/-mice do not have this phenotype but following ovariectomy(OVX) lose more bone than OVX wild-type mice. This suggests that in the absence of estrogen, IGFBP-2 is required to maintain bone mass. Therefore these studies were undertaken to determine if this peptide could stimulate bone acquisition in OVX rats. OVX rats were divided into seven treatment groups: sham animals, OVX animals, OVX animals receiving a control scrambled peptide, or one of three doses of the active peptide termed PEG-HBD-1(0.7, 2,and 6 mg·kg^(-1)) and an OVX group receiving parathyroid hormone(PTH)(50 μg·kg-1 per day). The peptides were administered for8 weeks. DXA revealed a significant reduction in femoral and tibial areal bone mineral density(aBMD) after OVX, whereas treatment with the high-dose peptide increased aBMD by 6.2% ± 2.4%(P < 0.01) compared to control peptide; similar to the increase noted with PTH(5.6% ± 3.0%, P < 0.01). Similar increases were noted with two lower doses of the peptide(3.8% ± 1.5%, P < 0.05 for low dose; 3.1% ± 1.6%, P = 0.07 for middle dose). Micro CT showed that the OVX control peptide animals had reductions of 41% and64% in femoral trabecular BV/TV and trabecular number, respectively. All three doses of the peptide increased bone volume/total volume(BV/TV) significantly, while the low and middle doses increased trabecular number. Cortical BV/TV and thickness at the midshaft increased significantly with each dose of peptide(18.9% ± 9.8%, P < 0.01 and 14.2% ± 7.9%, P < 0.01 for low dose; 23.7% ±10.7%, P < 0.001 and 15.8% ± 6.1%, P < 0.001 for middle dose; 19.0% ± 6.9%, P < 0.01 and 16.2% ± 9.7%, P < 0.001 for high dose)and with PTH(25.8% ± 9.2%, P < 0.001 and 19.4% ± 8.8%, P < 0.001). Histomorphometry showed that the low

关键词： insulin-like growth factor binding protein-2 OVX wild-type mice

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Investigation of Linear Tetra-Atomic Negative Ion by Photodetached-Electron Spectra

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Chinese Physics Letters 2011年第8期28卷 87-90页

作者： A.Rahman Iftikhar Ahmad A.Afaq M.Haneef H.j.Zhao Department of Physics Hazara UniversityMansehraPakistan Department of Physics University of MalakandChakdaraPakistan Centre of Excellence in Solid State Physics University of the PunjabQuid-e-Azam CampusLahore-54590Pakistan School of Physics and Information Science Shanxi Normal UniversityLinfen 041004

Photodetachment spectra from a linear tetra-atomic negative ion is investigated by treating the detached-electron wave function quantum mechanically.A plane polarized laser light,perpendicular to the axis of the ion,is used to detach the electron from the *** expressions for the electron flux and total photodetachment cross section are *** electron flux on screen shows strong-energy-dependent oscillations with different *** total cross section of the tetra-atomic negative ion reduces the cross section of mono-atomic,diatomic and triatomic negative ions for high energy photons,while for low energy photons it becomes four times the cross section of mono-atomic negative ions.

关键词： Electron polarized Investigation

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THE BANACH-LIE GROUP OF LIE TRIPLE AUTOMORPHISMS OF AN H^＊-ALGEBRA^＊

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Acta Mathematica Scientia 2010年第4期30卷 1219-1226页

作者： A.j.Calderón Martín C.Martín González Departamento de Matemáticas Universidad de Cádiz Departamento de Algebra Geometría y Topología Universidad de Málaga

We study the Banach-Lie group Ltaut（A） of Lie triple automorphisms of a complex associative H^＊-algebra A. Some consequences about its Lie algebra, the algebra of Lie triple derivations of A, Ltder（A）, are obtained. For a topologically simple A, in the infinite-dimensional case we have Ltaut（A）0 = Aut（A） implying Ltder（A） = Der（A）. In the finite-dimensional case Ltaut（A）0 is a direct product of Aut（A） and a certain subgroup of Lie derivations δ from A to its center, annihilating commutators.

关键词： Banach-Lie group Lie triple automorphism Lie triple derivation

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Phenotyping and other breeding approaches for a New Green Revolution

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journal of Integrative Plant Biology 2014年第5期56卷 422-424页

作者： jose Luis Araus jiansheng Li Martin A.j.Parry jiankang Wang University of Barcelona Barcelona National Maize Improvement Center Chinese Agricultural University Rothamsted Research Harpenden Herts Institute of Crop Science The Chinese Academy of Agricultural Sciences Beijing

Food security is a global concern in view of the ongoing global （social and climate） change. The challenges to food securityfrom global change, sharply increasing food and feed demands, whereas increasing the frequency and severity of stresses,coupled with degradation and scarcity of natural resources, are indeed urgent and real （Prasanna et al. 2013）. Crop productionmust double by 2050 to meet future production demands （Tilman et al. 2011）. The ability to achieve this increaserepresents a significant challenge to plant breeders. Crop yields must increase at a rate of 2.47o per year, yet the averagerate of increase is only 1.3% with yields stagnating in up to 40% of land under cereal production （Ray et al. 2012, 2013）. Therefore,crops with higher yield potential and more resistant to abiotic stress conditions are needed to address such challenges.

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Finite Element Analysis of Push-Out Test of SiC Fiber Reinforced Titanium Matrix Composites

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稀有金属材料与工程 2009年第A3期38卷 50-53页

作者： Yuan M N Yang Y Q Huang B Zhang R j School of Materials Northwestern Polytechnical University Xi＇an 710072 China

Based on the interphase layer model and the spring layer model, an improved interface model was developed to evaluate the interfacial shear strength of Titanium matrix composites(TMCs) and to analyze the effects of various parameters on the interfacial properties. The results showed that the improved interface model is more suitable for calculating the interfacial properties of SiC fiber reinforced titanium matrix composites. The interfacial shear strength of SiC/Timetal-834 predicted is 500 MPa. In addition, in order to better understand the interfacial properties of composites, some push out phenomenon were analyzed.

关键词：复合材料剪切强度碳化硅纤维物理性能

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Micro-synchrophasor based special protection scheme for distribution system automation in a smart city

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Protection and Control of Modern Power Systems 2020年第1期5卷 97-110页

作者： Deepa S.Kumar Savier j.S Biju S.S Dept of Electrical Engineering College of EngineeringTrivandrumKeralaIndia 400/220kV Substation Powergrid Corporation of India Ltd.TrivandrumKeralaIndia Power System Operations Kerala State Electricity Board Ltd.KeralaIndia

Introduction:Aspects of power system protection which contributes to mal-operations and blackouts can be improved by supervision of system behavior and response based analysis rather than condition-based or event-based analysis using wide area measurements based on synchrophasor *** paper explores the application of micro-Phasor Measurement Unit for time synchronized real-time distribution network monitoring and agile decision support schemes for system prognosis and *** description:The scheme is proposed as part of a project on“Power System Voltage Stability Analysis using synchrophasors in Distribution System of Kerala Grid”at Kerala State Electricity Board *** actual grid occurrence during the severe tropical cyclone Ockhi,is considered as the base case which motivated the *** and evaluation:A voltage stability index(VSI)based special protection scheme(SPS)for radial distribution network at a proposed smart city is presented in the present *** proposed special protection scheme on actual implementation can use data from proposed local micro-Phasor Measurement *** PMU is proposed to be placed at one of the key nodes of the distribution system network in the ***:The VSI is derived using local phasor values and is used to initiate a Special Protection Scheme for N-1 contingency at the key node,so as to ensure availability of the most essential feeder which provides supply to a hospital campus housing several health institutes of prime *** voltage stability index derived is tested and SPS is validated using real-time grid data.

关键词： Micro-phasor measurement unit Power system protection Voltage stability Power system stability Power distribution Smart grids

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A nanostructured copper telluride thin film grown at room temperature by an electrodeposition method

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journal of Semiconductors 2012年第9期33卷 22-27页

作者： S.S.Dhasade S.H.Han V.j.Fulari Holography and Material Research Laboratatory Department of PhysicsShivaji UniversityKolhapur 416004India Department of Chemistry Hanyang UniversitySouth Korea

Copper telluride onion flower like microstructures, constructed by quantum dots with various diameters, were obtained by a potentiostatic electrodeposition method at room temperature. The structural, optical, surface morphology, compositional analysis and Raman spectra properties of the deposited films have been studied using X-ray diffraction, optical absorption with scanning electron microscopy, EDAX, and Raman spectroscopy, The electrolyte concentration and deposition time can be used to control the diameter of the electrodeposited quantum dots to within a range of 50-55 nm. The films are found to be stoichiometric in composition. The optical constants such as the optical band gap energy and the optical absorption spectra show significant variation in their values with a change in deposition time. Upon deposition time the band gap energy increased from a value of 2.74 to 2.89 eV.

关键词： electrodeposition copper telluride quantum dots chemical composition optical properties

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Bioactivation of titanium dioxide scaffolds by ALP-functionalization

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Bioactive Materials 2017年第2期2卷 108-115页

作者： A.Sengottuvelan P.Balasubramanian j.Will A.R.Boccaccini Department of Materials Science and Engineering Institute of BiomaterialsUniversity of Erlangen-NurembergCauerstraße 691058 ErlangenGermany

Three dimensional TiO2 scaffolds are receiving renewed attention for bone tissue engineering (TE) due totheir biocompatibility and attractive mechanical properties. However the bioactivity of these scaffolds iscomparatively lower than that of bioactive glass or hydroxyapatite (HA) scaffolds. One strategy toimprove bioactivity is to functionalize the surface of the scaffolds using biomolecules. Alkaline phosphatase(ALP) was chosen in this study due to its important role in the bone mineralization process. Thecurrent study investigated the ALP functionalization of 3D titanium dioxide scaffolds using selfpolymerizationof dopamine. Robust titanium scaffolds (compressive strength^2.7 ± 0.3 MPa) wereproduced via foam replica method. Enzyme grafting was performed by dip-coating in polydopamine/ALPsolution. The presence of ALP was indirectly confirmed by contact angle measurements and enzymaticactivity study. The influence of the enzyme on the bioactivity, e.g. hydroxyapatite formation on thescaffold surface, was measured in simulated body fluid (SBF). After 28 days in SBF, 5 mg ALP coatedtitania scaffolds exhibited increased hydroxyapatite formation. It was thus confirmed that ALP enhancesthe bioactivity of titania scaffolds, converting an inert bioceramic in an attractive bioactive system forbone TE.

关键词： Alkaline phosphatase Titanium dioxide Scaffolds Polydopamine Surface modification Bioactivity

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H_2O_2-induced Leaf Cell Death and the Crosstalk of Reactive Nitric/Oxygen Species

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journal of Integrative Plant Biology 2013年第3期55卷 202-208页

作者： Yiqin Wang Aihong Lin Gary j. Loake Chengcai Chu State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing) Institute of Genetics and Developmental Biologythe Chinese Academy of Sciences National Agricultural Technology Park Institute of Molecular Plant Sciences School of Biological SciencesUniversity of Edinburgh

In plants, the chloroplast is the main reactive oxygen species （ROS） producing site under high light stress. Catalase （CAT）, which decomposes hydrogen peroxide （H2O2）, is one of the controlling enzymes that maintains leaf redox homeostasis. The catalase mutants with reduced leaf catalase activity from different plant species exhibit an H2O2-induced leaf cell death phenotype. This phenotype was differently affected by light intensity or photoperiod, which may be caused by plant species, leaf redox status or growth conditions. In the rice CAT mutant nitric oxide excess 1 （noe1）, higher H2O2 levels induced the generation of nitric oxide （NO） and higher S-nitrosothiol （SNO） levels, suggesting that NO acts as an important endogenous mediator in H2O2-induced leaf cell death. As a free radical, NO could also react with other intracellular and extracellular targets and form a series of related molecules, collectively called reactive nitrogen species （RNS）. Recent studies have revealed that both RNS and ROS are important partners in plant leaf cell death. Here, we summarize the recent progress on H2O2-induced leaf cell death and the crosstalk of RNS and ROS signals in the plant hypersensitive response （HR）, leaf senescence, and other forms of leaf cell death triggered by diverse environmental conditions.

关键词： H2O2 induced leaf cell death hypersensitive response leaf senescence nitric oxide reactive nitrogen species reactive oxygenspecies.

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Effects of noise on fishes: What we can learn from humans and birds

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Integrative Zoology 2015年第1期10卷 29-37页

作者： Robert j.DOOLING Marjorie R.LEEK Arthur N.POPPER Department of Psychology University of MarylandCollege ParkMarylandUSA National Center for Rehabilitative Auditory Research PortlandVA Medical CenterPortlandOregonUSA Department of Biology University of MarylandCollege ParkMarylandUSA

In this paper we describe the masking of pure tones in humans and birds by manmade noises and show that similar ideas can be applied when considering the potential effects of noise on fishes,as well as other aquatic *** from many studies on humans and birds,both in the field and in the laboratory,show that published critical ratios can be used to predict the masked thresholds for pure tones when maskers consist of complex manmade and natural *** argue from these data that a single,simple measure,the species critical ratio,can be used to estimate the effect of manmade environmental noises on the perception of communication and other biologically relevant *** also reason that if this principle holds for species as diverse as humans and birds,it probably also applies for all other vertebrates,including fishes.

关键词： behavior communication manmade noise masking sound

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