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Development ofα-synuclein as a potential molecular marker for Parkinson's Disease

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Development ofα-synuclein as a potential molecular marker f...

2011全国老年痴呆与衰老相关疾病学术会议第三届山东省神经内科医师（学术）论坛

作者： Penelope Foulds Gerwyn Green Peter Diggle David M.A.Mann j.douglas Mitchell David Allsop Division of Biomedical and Life Sciences Lancaster University Division of Medicine School of Health and Medicine Lancaster University Neurodegeneration and Mental Health Research Group University of Manchester Hope Hospital Salford M6 8HD UK

Objectives:We aim to use immunoassay methods for the measurement of total and soluble oligomeric forms of alpha-synuclein(a-syn),and phosphorylated a-syn(pS-a-syn) in;a) longitudinal blood plasma samples,and b) post-mortem cerebral spinal fluid(CSF). Background:Parkinson s disease(PD) is characterised pathologically by selective loss of dopaminergic neurones from the substantia nigra,and the presence of Lewy bodies in surviving *** major protein

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美国普利策奖金内幕

1993年

作者：（美）贝茨（Bates j.douglas）贾宗谊译

书名原文:The Pulitzer prize:the inside story of America's most Prestigious award:普利策,美国报业大王,“普利策奖金”是1917年开始颁发的美国新闻奖。本书介绍了普利策传奇般的一生和设立普利策奖金的前后经过、评选方法、组织... 详细信息

ISBN: (数字)7501118582

ISBN: (纸本)7501118582

书名原文:The Pulitzer prize:the inside story of America's most Prestigious award:普利策,美国报业大王,“普利策奖金”是1917年开始颁发的美国新闻奖。本书介绍了普利策传奇般的一生和设立普利策奖金的前后经过、评选方法、组织机构、颁奖情况等。

关键词：普利策学科:传记新闻事业史地点:美国年代:现代

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弱非线性橢圓型差分方程的交替方向迭代法

计算机研究与发展 1963年第2期 34-38页

作者： j.douglas 鮑信烱金旦华

1.引言.椭圆型微分方程的有限差分数值解法,导至求解线性或非线性高阶代数方程组的问题。最简单的这种问题是矩形域的Di-richlet问题: {（△+△）w=f,（x,y）=（i△x,j△y）∈R,w=g,（x,y）∈R,（1.1）其中△是关于x的二阶中心差商。如... 详细信息

1.引言.椭圆型微分方程的有限差分数值解法,导至求解线性或非线性高阶代数方程组的问题。最简单的这种问题是矩形域的Di-richlet问题: {（△+△）w=f,（x,y）=（i△x,j△y）∈R,w=g,（x,y）∈R,（1.1）其中△是关于x的二阶中心差商。如果在R中,

关键词：交替方向迭代法差分方程逐次超松弛法

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心理神探美国联邦调查局系列犯罪破案揭秘

心理神探美国联邦调查局系列犯罪破案揭秘

Free perforation of the small intestine in collagenous sprue

1999年

作者：（美）约翰·道格拉斯（j.douglas）（美）马克·奥尔谢克（M.Olshaker）阎卫平王春生译

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World journal of Gastroenterology 2009年第35期15卷 4446-4448页

作者： Hugh j Freeman douglas L Webber Departments of Medicine(Gastroenterology) University of British ColumbiaVancouverBC V6T 1W5Canada Departments of Pathology University of British ColumbiaVancouverBC V6T 1W5Canada

A 67-year-old man with celiac disease developed recurrent diarrhea,profound weakness and weight loss, with evidence of marked protein *** clinical course was refractory to a strict gluten-free diet and steroid *** studies led to definition of unrecognized collagenous sprue that caused ulceration and small intestinal *** PCR showed identical monoclonal T-cell populations in antemortem duodenal biopsies and postmortem jejunum,careful pathological evaluation demonstrated no frank ***,overt or even cryptic T-cell lymphoma may complicate collagenous sprue,however, small intestinal ulcers and perforation may also develop *** dramatic findings here may reflect an underlying or early molecular event in the eventual clinical appearance of overt T-cell lymphoma.

关键词： Collagenous sprue Intestinal perforation Celiac disease Refractory sprue Intestinal neoplasms Lymphoma

Potential influence of wildfire in modulating climate-induced forest redistribution in a central Rocky Mountain landscape

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Ecological Processes 2017年第1期6卷 52-68页

作者： john L.Campbell douglas j.Shinneman Department of Forest Ecosystems and Society Oregon State UniversityCorvallisORUSA U.S.Geological Survey Forest and Rangeland Ecosystem Science CenterBoiseIDUSA.

Introduction:Climate change is expected to impose significant tension on the geographic distribution of tree ***,tree species range shifts may be delayed by their long life spans,capacity to withstand long periods of physiological stress,and dispersal *** could theoretically break this biological inertia by killing forest canopies and facilitating species redistribution under changing *** investigated the capacity of wildfire to modulate climate-induced tree redistribution across a montane landscape in the central Rocky Mountains under three climate scenarios(contemporary and two warmer future climates)and three wildfire scenarios(representing historical,suppressed,and future fire regimes).Methods:Distributions of four common tree species were projected over 90 years by pairing a climate niche model with a forest landscape simulation model that simulates species dispersal,establishment,and mortality under alternative disturbance regimes and climate ***:Three species(douglas-fir,lodgepole pine,subalpine fir)declined in abundance over time,due to climate-driven contraction in area suitable for establishment,while one species(ponderosa pine)was unable to exploit climate-driven expansion of area suitable for *** fire frequency accelerated declines in area occupied by douglas-fir,lodgepole pine,and subalpine fir,and it maintained local abundance but not range expansion of ponderosa ***:Wildfire may play a larger role in eliminating these conifer species along trailing edges of their distributions than facilitating establishment along leading edges,in part due to dispersal limitations and interspecific competition,and future populations may increasingly depend on persistence in locations unfavorable for their establishment.

关键词： Forest disturbance Wildfire Climate change Central Rocky Mountains Climate niche Species migration Species distribution

Parallel boron nitride nanoribbons and etch tracks formed through catalytic etching

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Nano Research 2018年第9期11卷 4874-4882页

作者： Armin Ansary Mohsen Nasseri Mathias j. Boland douglas R. Strachan Department of Physics &Astronomy University of Kentucky Lexington KY40506 USA

One-dimensional （1D） catalytic etching was investigated in few-layer hexagonal boron nitride （hBN） films. Etching of hBN was shown to share a number of similarities with that of graphitic films. As in graphitic films, etch tracks in hBN commenced at film edges and occurred predominantly along certain crystal directions of its lattice, though it was shown that the tracks were generally narrower than those of few-layer graphene under similar processing conditions. It was also shown that catalytic hydrogenation can occur completely through a few-layer hBN film, demonstrating that this process can be used in the formation of isolated low-dimensional nanoscale structures from other layered 2D materials beyond graphene. This ability for thin hBN films to be etched completely through allowed for a crystalline substrate to guide the etching process, which was demonstrated with the successful etch track formation of few-layer hBN on single-crystalline sapphire substrates. The substrate-guided etching resulted in parallel few-layer hBN nanoribbons having an average width of 32 nm and spacing of 13 nm.

关键词： hexagonal(hBN) one-dimensional catalytic etching hydrogenation etch tracks nanoribbons

Slab and Level 2 Automation Design Guidelines for Optimum Metallurgy and Productivity for Plate and Steckel Mills

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journal of Iron and Steel Research International 2011年第S1期18卷 550-556页

作者： Stalheim douglas DGS Metallurgical Solutions Inc. 15003 NE 10th StreetVancouverWA 98684 USA

Many new steel plate processing facilities have been built in the past 10 years around the world with many more being planned for the *** is especially true in developing countries such as China,India and *** of these facilities are plate mills with either one or two stands or a Steckel mill,typically only one stand designed for the production of structural plate ***,there is a lack of understanding with both the mill builders of the world and the mill owners on the importance of properly matching up the available slab supply (either new as part of a new plate/Steckel mill complex or part of an already existing) with the desired end plate product *** mill builders and owners around the world believe that you can take any slab of any dimension and make any plate dimension you *** this is basically true with today’s Level 2 automation systems,it does not always result in optimum metallurgy/mechanical properties or *** less than optimum condition results in mechanical property failures,shape issues,productivity losses and in general a less than desirable costly processing *** is important to the overall optimization of a steel processing facility that the proper slab dimensions be used to produce the proper final plate dimensions along with achieving the required mechanical *** critical nature of this selection will be dependent on the final plate thickness and overall mechanical property *** mechanical property,shape and overall microstructure are heavily dependent on the ability to properly work the entire cross section of the slab through the rolling *** mechanical property,shape and microstructural issues are a result of improper working of the entire cross section during *** ability for a given mill to properly work the entire cross section is dependent on proper slab selection (total reduction ratio) and a proper rolling schedule either generated manual

关键词： slab dimensions optimization grain size rolling schedule automation Level 2

Metallurgical Optimization of Microalloyed Steels for Oil and Gas Transmission Pipelines

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journal of Iron and Steel Research International 2011年第S1期18卷 669-674页

作者： Stalheim douglas DGS Metallurgical Solutions Inc. 15003 NE 10th StreetVancouverWA98684 USA

The production of microalloyed steels for oil and gas transmission pipelines has increased significantly over the past *** more and more countries developing their own capabilities to produce pipeline steels to support their own internal pipeline infrastructure development,there has been an increase of steel producers working to develop their own capabilities to produce microalloyed steels for this ***,to achieve the desired mechanical property attributes for transmission pipeline applications utilizing a cost effective approach requires metallurgical optimization of the microalloyed *** achieve metallurgical optimization a basic understanding is required in the design of a cost effective alloy and then the proper processing of that alloy design to achieve the optimum microstructure/mechanical *** this sense,many producers in the world,especially those who have only recently,in the past 10 years,developed their capability to produce microalloyed transmission pipeline steels still do not achieve metallurgical optimization of their alloy and *** results in yield losses due to failures,inefficient processing causing productivity losses and additional expensive additions of alloys to compensate for failures and process *** the supplier of plate/coil has the largest percentage effect on the final cost of the pipe,the steel producer must understand proper alloy,microstructure,and process design to produce a uniform and stable plate/coil to be used in pipe *** means that strength,toughness and microstructure must be uniform down the length,across the width and through the cross *** optimization is achieved when this uniformity is achieved with a cost effective *** to that,non-uniformity results in pipe forming,welding,expansion,mechanical property and production issues resulting in downgraded pipe and cost overruns in *** paper will describe targets for p

关键词： microalloy niobium pipeline solubility grain size rolling schedule