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耐药结核病的诊断:检测的可靠性和即时性

国际结核病与肺部疾病杂志 2010年第3期5卷 131-140页

作者： A.Van Deun A.Martin j.c.palomino 徐彩红刘宇红 Mycobacteriology Unit Institute of Tropical MedicineAntwerpBelgium InternationalUnion Against Tuberculoslsand Lung Disease ParisFrance

随着耐多药结核病(MDR-TB)的出现,全球都迫切需要快速药敏试验方法。国家结核病防治规划(NTPs)可能发现很难从各种变化多样的快速检测方法中选择合适的方法。我们对最重要的方法进行综述,讨论他们的优点和缺点,侧重那些可以替代商品化... 详细信息

随着耐多药结核病(MDR-TB)的出现,全球都迫切需要快速药敏试验方法。国家结核病防治规划(NTPs)可能发现很难从各种变化多样的快速检测方法中选择合适的方法。我们对最重要的方法进行综述,讨论他们的优点和缺点,侧重那些可以替代商品化系统的方法,以及基因检测技术。表型和基因型药敏试验之间的关系的仍然存在问题,原因是除了对以前已研究标准化的表型的药物敏感试验外,我们关于耐药性突变的认识仍不充分。由于某些耐药菌株生长延迟,以快速生长为基础的药敏试验准确性较差。为了实现理想的耐药监测和耐多药结核病的管理,同时使实验室的工作不超负荷,需要慎重考虑检测的适应症和可疑者的界定,同时良好的显微镜依旧非常重要并且是个挑战。迄今研究较少的醋酸荧光素活性染色技术可能提供解决办法,协调早期检测和对快速药敏试验的合理的预选择。关于方法的选择,从覆盖所有人群的前景出发,应该考虑方法的适用性和敏感性。只有推广简单、低要求的方法,或者中心化的基因型药敏试验替代,但要确保标本运输程序简单才是可行的。由于不需要原代分离培养物,药敏试验结果报告时间的轻微差别相对不重要。没有任何一种检测是绝对准确的,合理的预选择可能允许使用准确度稍差但是简单的筛查方法。传统的药敏试验将依旧是用来确诊和流行病学检测必须的。

关键词：结核异烟肼利福平耐药快速药敏试验

快速培养法对结核病诊断的评价:拉丁美洲的一个多中心研究

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国际结核病与肺部疾病杂志 2006年第3期1卷 101-106页

作者： j.A.Robledo G.I.Mejía N.Morcillo L.chacón M.camacho j.Luna j.Zurita A.Bodon M.Velasco j.c.palomino A.Martin F. Portaels 张宗德 Unidad de Bacteriología y Micobacterias Corporación para investigaciones Biológicas-CIBMedellínAntioquiaDepartamento de MedicinaUniversidad Pontificia BolivarianaMedellínAntioquiaColombia Laboratorio Regional de Referencia de Micobacterias Hospital CetrángoloBuenos AiresBuenos AiresArgentina Departamento de Micobacterias Centra Nacional de Diagnóstico y ReferenciaMinisterio de SaludManaguaNicaragua Institute Nacional de Laboratories de Salud (INLASA) La PazBolivia Escuela Nacional de ciencias Biológicas Instituto Politecnico NacionalMexicoDFMexico Laboratorio de Microbiología y Tuberculosis Hospital VozandesQuitoEcuador Sección de Micobacterias Instituto de Salud Pública de ChileSantiago de ChileChile Institute of Tropical Medicine AntwerpBelgium

地点:拉丁美洲的结核病(TB)诊断实验室。目的:薄层琼脂(thin-layer agar,TLA)和罗氏培养(Lowenstein-jensen,Lj)对结核病诊断的对比评价。设计:6个实验室Ⅱ期前瞻性研究。临床诊断的TB病人样本包括痰标本和肺外结核的标本。呼吸道标本用... 详细信息

地点:拉丁美洲的结核病(TB)诊断实验室。目的:薄层琼脂(thin-layer agar,TLA)和罗氏培养(Lowenstein-jensen,Lj)对结核病诊断的对比评价。设计:6个实验室Ⅱ期前瞻性研究。临床诊断的TB病人样本包括痰标本和肺外结核的标本。呼吸道标本用NaOH／NALc去污;根据推荐的操作程序对所有标本进行离心,萋尼氏法进行抗酸菌(AFB)染色,用Lj和TLA法培养检查。计算两种培养基的敏感度和似然比、生长检测时间和污染率。结果:总共研究了1118份临床标本。所有AFB阳性标本培养后均检出结核分枝杆菌,AFB阴性标本中,Lj检出率为3．2％,TLA为4．4％。TLA和Lj的敏感性分别为92．6％(95％cI:87．9-95．9)和84．7％(95％cI:78．8-89．0)。阳性和阴性LR相似。TLA和Lj的污染率分别为5．1％和3．0％。TLA和Lj对培养阳性的检出平均时间分别为11．5天(95％cI: 9．3-15．0)和30．5天(95％cI:26．9-39．0)(Pj的总体效果,建议不同实验室使用这种方法,因它具有可靠性和可行性。

关键词：结核分枝杆菌分离结核病诊断

consumer transparency in the production chain for plant varieties produced using new genomic techniques

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aBIOTEcH 2024年第2期5卷 239-246页

作者： j.M.Lukasiewicz c.c.M.van de Wiel L.A.P.Lotz M.j.M.Smulders Wageningen University&Research P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genomic techniques(NGTs)currently fall under the Genetically Modified Organisms Directive(2001/18/Ec)in the European *** the proposal of the European commission,NGT plants are partially exempted from the regulations of this *** proposal makes a distinction between two categories of NGT plants:NGT-1 and ***-1 category plants are considered equal to plants obtained through conventional breeding *** plants will not be labelled for the consumer,although they will be labelled as ***-2 category plants may be labelled with additional information as a positive *** of seeds of varieties made with gene editing,but not the products,would mean that most steps in the production chain are transparent,but not the last step towards ***“right to know”and increasing knowledge of gene-edited food is a common theme in food labelling towards ***,we describe current labelling regimes and registers and how these may be applied to provide transparency on gene-edited products to ***,we also look into consumer studies,which indicate a greater acceptance of gene-edited food among consumers,especially when additional benefits such as sustainability are mentioned.

关键词： Labelling New genomic techniques consumer transparency Plant products

Semi-analytical investigation of heat transfer in a porous convective radiative moving longitudinal fin exposed to magnetic field in the presence of a shape-dependent trihybrid nanofluid

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 197-216页

作者： c.G.PAVITHRA B.j.GIREESHA M.L.KEERTHI Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of Mathematics and Statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presence of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is carried out. Three types of nanoparticles, each having a different shape, are considered. These shapes include spherical(Fe_3O_4), cylindrical(Au), and platelet(Zn) configurations. The combination approach is utilized to evaluate the physical and thermal characteristics of the trihybrid and hybrid nanofluids, excluding the thermal conductivity and dynamic viscosity. These two properties are inferred by means of the interpolation method based on the volume fraction of nanoparticles. The governing equation is transformed into a dimensionless form, and the Adomian decomposition Sumudu transform method(ADSTM) is adopted to solve the conundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numerical simulation results, indicating that this research is reliable. The influence of diverse factors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphical representations. Furthermore, the fluctuations in the heat transfer concerning the pertinent parameters are studied. The results show that the heat flux in the presence of the combination of spherical, cylindrical, and platelet nanoparticles is higher than that in the presence of the combination of only spherical and cylindrical nanoparticles. The temperature at the fin tip increases by 0.705 759% when the value of the Peclet number increases by 400%, while decreases by 11.825 13% when the value of the Hartman number increases by 400%.

关键词： convection radiation moving longitudinal fin Adomian decomposition Sumudu transform method(ADSTM) trihybrid nanofluid magnetic field

Integrative Analysis of Transcriptome and Phenolic compounds Profile Provides Insights into the Quality of Soursop (Annona muricata L.) Fruit

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Phyton-International journal of Experimental Botany 2024年第7期93卷 1717-1732页

作者： Yolotzin Apatzingán palomino-Hermosillo Ángel Elpidio Díaz-jasso Rosendo Balois-Morales Verónica AlhelíOchoa-jiménez Pedro Ulises Bautista-Rosales Guillermo Berumen-Varela Unidad de Tecnología de Alimentos-Secretaría de Investigación y Posgrado Universidad Autónoma de Nayarit.Ciudad de la Cultura SNTepic63000NayaritMéxico Programa Académico de Biología Unidad Académica de AgriculturaUniversidad Autónoma de NayaritKm.9.Carretera Tepic-CompostelaXalisco63780NayaritMéxico Estancias Posdoctorales-consejo Nacional de Humanidades Ciencias y TecnologíasCoordinación de Apoyos a Becarios e InvestigadoresDirección de PosgradoCiudad de México03940México

Soursop(Annona muricata L.)is a tropical fruit highly valued for its uniqueﬂavor,nutritional value,and health-promoting *** ripening process of soursop involves complex changes in gene expression and metabo-lite accumulation,which have been studied using various omics *** analysis has provided insights into the regulation of key genes involved in ripening,while metabolic compound analysis has revealed the presence of numerous bioactive compounds with potential health beneﬁ***,the integration of transcrip-tome and metabolite compound data has not been extensively explored in ***,in this paper,we present a comprehensive analysis of the transcriptome and phenolic compound proﬁles of soursop during *** integration analysis showed that the genes and phenolic compounds were mainly involved in the starch and sucrose metabolism pathways during soursop ***,the phenolic compounds Kaempferol 3-Q-galactoside,Procyanidin c1,Procyanidin trimmer c1,and m-coumaric,as well as the genes Ubiquitin-like protein 5(UBL5_ARATH),ATP-dependent zinc metalloprotease FTSH8(FTSH8_ORYSj),Zinc transporter 4(ZIP4_AR-ATH),Thioredoxin-like 3-1(TRL31_ORYSj),Mitogen-activated protein kinase YODA(YODA_ARATH),R-man-delonitrile lyase-like(MGL_ARATH),26s protease regulatory subunit 6A homolog(PRS6_SOLLc),cytochrome P45072A13(c7A13ARATH),cytochrome P45084A1(c84A1_ARATH)and Homoserine O-trans-acetylase(MET2-ORYSj)were correlated and differentially accumulated and expressed,*** study provides new insights into the molecular mechanisms underlying soursop ripening and may contribute to the development of strategies for improving the nutritional quality and shelf life of this important fruit.

关键词： Bioinformatics data integration genes metabolites postharvest storage ripening

Thermoluminescence characterization of natural and synthetic irradiated ce-monazites

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journal of Rare Earths 2024年第4期42卷 643-650页

作者： V.correcher c.Boronat j.Garcia-Guinea j.F.Benavente T.Rivera-Montalvo cIEMAT Av.Complutense 4028040MadridSpain MNcN-cSIc J.Gutierrez Abascal 228006MadridSpain Instituto Politécnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

The thermoluminescence(TL)emission of synthetic and natural ce-monazites was characterized here to determine the potential application in the identification of microscopic defects from a qualitative point of view trying to link each TL peak to a chemical-physical *** kinetic parameters that lead the luminescence processes were calculated by means of variable heating rate and computing glow curve deconvolution methods and allow identifying three groups of components at~90,130 and 290℃(for the mineral sample)and~90,170,220,270 and 320℃(for the synthetic cePO_(4):Nd_(0.20),La_(0.25)).The main differences appreciated in these complex TL curves are mainly due to(i)the content of impurities(natural sample contains lanthanides as well as U 0.60%and Th 5.22%)and(ii)the degree of crystallinity of the samples which is directly related to the type of impurities(synthetic monazite relies only on Nd and La).The behavior of the dose response in the range of 1-8 Gy is similar for both samples;the TL intensity increases linearly as the dose increases without changes in the position of the maxima,denoting first-order kinetic luminescence *** peak could be mostly associated with structural defects(i.e.,phase transitions),chemical reactions(i.e.,ce3+?ce4+redox reaction,dehydration or dehydroxylation processes)or intrinsic defects(i.e.,Frenkel defects,ODcs or NBOHcs).

关键词： Thermoluminescence Kineticparameters Phosphate ce-monazite Defects Rare earths

cO oxidation under lean and stoichiometric conditions over ceriazirconia with very low metal contents(cu,co,Ag and Pt)

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journal of Rare Earths 2024年第9期42卷 1669-1681,I0002页

作者： j.c.Martínez-Munuera M.P.Yeste A.García-García McMA Group Department of Inorganic Chemistry and Institute of MaterialsUniversity of AlicanteCarretera de San Vicente del Raspeig s/n03690San Vicente del RaspeigAlicanteSpain Solid chemistry and catalysis Group Department of Materials ScienceMetallurgic Engineering and Inorganic ChemistryInstitute of Electronic Microscopy and Materials ResearchUniversity of CádizAp.40E-11510Puerto RealCádizSpain

In this work,several ceria-zirconia based catalysts with very lo w(and equimolar) metal contents were prepared,characterised and tested for the cO oxidatio n reaction(under lean and stoichiometric conditions),trying to emulate those conditions found in a diesel oxidation catalyst(DOc) system from a diesel engine and those encountered under gasoline exhaust(λ=1).The metals chosen are cu,co,Ag and Pt(as a reliable benchmark).The results reveal enormous differences among reducibility and catalytic activity despite quite similar structural and textural properties of the catalysts,showing differences among dispersion(Ag-catalyst seems to present a low level of dispersion).This catalyst seems to be characterised,as well,by a strong electronic interaction between ce and Ag centres which is suggested to yield an improved reducibility under H_(2)-TPR ***,the order in catalytic activity(cu>Ag>co≈Pt>>support) seems not to follow the order found in reducibility and the cu-catalyst seems to be the most active independently on the reaction conditions,yielding nearly overlapped cO oxidation catalytic *** restingly,a stro ng correlation between the catalytic activity under the two conditions tested and the OSc values of the ce_(0.8)Zr_(0.2)O_(2)-supported metal catalysts is ***,OSc parameter measured at 150℃ can be used as a relevant descriptor to evaluate the cO oxidation activity at low and medium conversions for the investigated catalysts,much better than the H_(2)-TPR measurements.

关键词： cO oxidation Low metal content ceria-zirconia copper species OSc parameter Rare earths

Laser-induced graphene-coated wearable smart textile electrodes for biopotentials signal monitoring

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Frontiers of Materials Science 2024年第1期18卷 95-111页

作者： c.M.Vidhya Yogita Maithani Sakshi Kapoor j.P.Singh Department of Physics Indian Institute of Technology DelhiHauz KhasNew Delhi 110016India

This paper describes how to produce a wearable dry electrode at a reasonable cost and how to use it for the monitoring of biopotentials in *** textiles in wearable technologies have made a great advancement in the health care management and living standards of *** was manufactured using the low-cost single-step process,laser ablation of polyimide,a commercial *** dispersions were made using solvent isopropyl alcohol which has low boiling point,nontoxicity,and environmental *** successive coating of the graphene dispersion on the cotton fabric to make it conductive,the sheet resistance of the resulting fabric dropped to 3% of its initial *** laser-induced graphene(LIG)cotton dry electrodes thus manufactured are comparable to Ag/Agcl wet electrodes in terms of the skin-to-electrode impedance,measuring between 78.0 and 7.2 kΩ for the frequency between 40 Hz and 1 *** LIG cotton electrode displayed a signal-to-noise ratio of 20.17 *** to its comfort,simplicity,and good performance over a longer period of time,the textile electrode appears suited for medical applications.

关键词： biopotential electrocardiogram electromyogram flexible electrode textile porous graphene

n-Alkane bound biomarker fingerprints from asphaltenes in the bitumens of Eastern Dahomey Basin,Nigeria:Source and genetic implications

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Petroleum Research 2024年第1期9卷 85-91页

作者： Modupe A.Egbeola Olubunmi c.Adeigbe Olajide j.Adamolekun Department of Geology University of IbadanIbadanNigeria Structural Geology and Tectonics Institute of Applied GeosciencesKIT-Karlsruhe Institute of TechnologyAdenauerring 20a76131KarlsruheGermany

The asphaltene fractions of the bitumens of Eastern Dahomey Basin in Nigeria,were analyzed by flash pyrolysis-gas chromatography(Py-Gc)method in order to unravel its geochemical history and *** distributions of the initial biomarkers of the original oils from the pyrolysates are related to the assessment of organic matter source,paleo-redox conditions and source environment during ***,it effectively establishes the genetic relationship of the *** n-alkane distributions in the pyrolysates reveal nc_(9)-nc_(32)n-alkanes,maximizing at nc_(14),isoprenoids-pristane(Pr)and phytane(Ph),and some n-alkene *** peaks of low to medium-weight nc_(9)-nc20 n-alkanes and low peaks of nc_(21)+n-alkanes characterize the *** reveal that abundant algal organic matter with some terrigenous inputs contributed to the source rock of the *** high concentration of marine organic matter inputs to the source rock is further confirmed by the nc_(17)/nc27 ratios which range from 5.39 to 19.82 and shows the predominance of nc_(17)*** general unimodal n-alkane distributions in the bitumens indicate derivation from similar organic matter types showing that they are genetically *** anoxic to suboxic environmental conditions that prevailed during the deposition of the sediments is revealed by the isoprenoids,Pr/Ph ratios(0.72-1.28).Pristane/nc_(17)and Phytane/nc_(18)range from 0.16 to 0.33 and 0.22 to 0.56,revealing that the bitumens were from predominantly marine organic matter(type II kerogen)preserved in a reducing environment with no evidence of ***,the Ph/nc_(18)ratio and the cross plot of Pr+Ph/nc_(17)+nc_(18)allow the classification of the bitumens into two subfamilies/groups(A and B).The bitumen samples have low wax content as indicated by the degree of waxiness ranging from 0.21 to 0.38 which confirms low terrigenous *** on the carbon preference index(cPI:0.92 to 1.55)and odd-even predo

关键词： Genetic relationship Flash pyrolysis Biomarker Asphaltene Pyrolysates