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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iboneFIT project

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journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez jose j.Gil-Cosano Esther Ubago-Guisado Francisco j.Llorente-Cantarero juan Francisco Pascual-Gázquez Kirsten K.Ness Vicente Martinez-Vizcaino jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides biomedical Research Institute of Cordoba(IMIbIC) Cordoba 14004Spain CIbERObN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(abMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with abMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific abMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure abMD(g/cm2).Associations between muscle strength and abMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low abMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower abMD Z-scores at all sites(b=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low abMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low abMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower abMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： bone health Childhood cancer DXA Lean mass Resistance training

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Life under tension: the relevance of force on biological polymers

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biophysics Reports 2024年第1期10卷 48-56页

作者： Matthew T.j.Halma Longfu Xu Department of Physics and Astronomy and Laser Lab Vrije Universiteit Amsterdam LUMICKS b.V.

Optical tweezers have elucidated numerous biological processes, particularly by enabling the precise manipulation and measurement of tension. One question concerns the biological relevance of these experiments and the generalizability of these experiments to wider biological systems. Here, we categorize the applicability of the information garnered from optical tweezers in two distinct categories: the direct relevance of tension in biological systems, and what experiments under tension can tell us about biological systems, while these systems do not reach the same tension as the experiment, still, these artificial experimental systems reveal insights into the operations of biological machines and life processes.

关键词： Tension Optical tweezers Molecular force

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State-selective charge exchange cross sections in collisions of highly-charged sulfur ions with helium and molecular hydrogen

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Chinese Physics b 2024年第2期33卷 29-33页

作者：朱小龙崔述成邢大地徐佳伟 b.Najjari 赵冬梅郭大龙高永张瑞田苏茂根张少锋马新文 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Atomic and Molecular Physics and Functional Materials of Gansu Province College of Physics and Electronic EngineeringNorthwest Normal UniversityLanzhou 730070China joint Laboratory of Atomic and Molecular Physics Northwest Normal University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730070China Advanced Energy Science and Technology Guangdong LaboratoryHuizhou 516000China

The state-selective cross section data are useful for understanding and modeling the x-ray emission in celestial *** the present work,using the cold target recoil ion momentum spectroscopy,for the first time we investigated the state-selective single electron capture processes for S^(q+)–He and H_(2)(q=11–15)collision systems at an impact energy of q×20 keV and obtained the relative state-selective cross *** results indicate that only a few principal quantum states of the projectile energy level are populated in a single electron capture *** particular,the increase of the projectile charge state leads to the population of the states with higher principal quantum *** is also shown that the experimental averaged n-shell populations are reproduced well by the over-barrier *** database is openly available in Science Data bank at 10.57760/sciencedb.j00113.00091.

关键词： highly charged sulfur ion charge exchange state-selective cross sections COLTRIMS

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A review of public health guidelines for postpartum physical activity and sedentary behavior from around the world

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journal of Sport and Health Science 2024年第4期13卷 472-483,F0003页

作者： Kelly R.Evenson Wendy j.brown Alison K.brinson Emily budzynski-Seymour Melanie Hayman Department of Epidemiology Gillings School of Global Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599-8050USA Faculty of Health Sciences and Medicine Bond UniversityGold CoastQLD 4226Australia School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Anthropology University of North Carolina at Chapel HillChapel HillNC 27599-3115USA Carolina Population Center University of North Carolina at Chapel HillChapel HillNC 27599-8120USA Faculty of Sport Health and Social SciencesSolent UniversitySouthamptonSO140YNUK Appleton Institute School of HealthMedical and Applied SciencesCentral Queensland UniversityRockhamptonQLD 4701Australia

background:The period following pregnancy is a critical time window when future habits with respect to physical activity(PA) and sedentary behavior(Sb) are established;therefore,it warrants *** purpose of this scoping review was to summarize public health-oriented country-specific postpartum PA and Sb guidelines ***:To identity guidelines published since 2010,we performed a(a) systematic search of 4 databases(CINAHL,Global Health,PubMed,and SPORTDiscus),(b) structured repeatable web-based search separately for 194 countries,and(c) separate web-based *** the most recent guideline was included for each ***:We identified 22 countries with public health-oriented postpartum guidelines for PA and 11 countries with Sb *** continents with guidelines included Europe(n=12),Asia(n=5),Oceania(n=2),Africa(n=1),North America(n=1),and South America(n=1).The most common benefits recorded for PA included weight control/management(n=10),reducing the risk of postpartum depression or depressive symptoms(n=9),and improving mood/well-being(n=8).Postpartum guidelines specified exercises to engage in,including pelvic floor exercises(n=17);muscle strengthening,weight training,or resistance exercises(n=13);aerobics/general aerobic activity(n=13);walking(n=11);cycling(n=9);and swimming(n=9).Eleven guidelines remarked on the interaction between PA and breastfeeding;several guidelines stated that PA did not impact breast milk quantity(n=7),breast milk quality(n=6),or infant growth(n=3).For Sb,suggestions included limiting long-term sitting and interrupting sitting with ***:Country-specific postpartum guidelines for PA and Sb can help promote healthy behaviors using a culturally appropriate context while providing specific guidance to public health practitioners.

关键词： breastfeeding Caesarean section Guidelines Postnatal Recommendations

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Linkage between European and East Asian Heatwaves on Synoptic Scales

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journal of Tropical Meteorology 2024年第2期30卷 97-105页

作者：蔡奋颖刘彩红杨崧邓开强 KURTHS jürgen School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)ZhuhaiGuangdong 519082 China Department of Complexity Science Potsdam Institute for Climate Impact Research(PIK)Member of the Leibniz AssociationPotsdam 14473 Germany Department of Water and Climate Risk Institute for Environmental StudiesVrije Universiteit AmsterdamAmsterdam 1087HV Netherlands Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen UniversityZhuhaiGuangdong 519082 China Department of Physics Humboldt-Universität zu BerlinBerlin 12489 Germany

Concurrent extreme weather events in geographically distant areas potentially cause high-end risks for *** using network analysis,the present study managed to identify significant nearly-simultaneous occurrences of heatwaves between the grid cells in East Asia and Eastern Europe,even though they are geographically far away from each *** further composite analysis,this study revealed that hot events first occurred in Eastern Europe,typically with a time lag of3-4 days before the East Asian heatwave *** eastward propagating atmospheric wave train,known as the circumglobal teleconnection(CGT)pattern,bridged the sequent occurrences of extreme events in these two remote *** blockings,amplified by surface warming over Eastern Europe,not only enhanced local heat extremes but also excited a CGT-like pattern characterized by alternative anomalies of high and low *** downstream anticyclones in the middle and upper troposphere reduced local cloud cover and increased downward solar radiation,thereby facilitating the formation of heatwaves over East *** half of East Asian heatwave events were preceded by Eastern European heatwave events in the 10-day time range before East Asian heatwave *** investigation of heatwave teleconnection in the two distant regions exhibits strong potential to improve the prediction accuracy of East Asian heatwaves.

关键词： concurrent heatwaves Eastern Europe East Asia circum-global teleconnection pattern

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InGaN multiple quantum well based light-emitting diodes with indium composition gradient InGaN quantum barriers

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Optoelectronics Letters 2024年第2期20卷 89-93页

作者： SANG Xien XU Yuan YIN Mengshuang WANG Fang LIOU juin j LIU Yuhuai National Center for International joint Research of Electronic Materials and Systems International Joint-Laboratory of Electronic Materials and Systems of Henan ProvinceSchool of Electrical and Information EngineeringZhengzhou UniversityZhengzhou 450001China Institute of Intelligence Sensing Zhengzhou UniversityZhengzhou 450001China Research Institute of Industrial Technology Co. Ltd.Zhengzhou UniversityZhengzhou 450001China Zhengzhou Way Do Electronics Co. Ltd.Zhengzhou 450001China School of Electrical and Information Engineering North Minzu UniversityYinchuan 750001China1

To improve the internal quantum efficiency(IQE)and light output power of In Ga N light-emitting diodes(LEDs),we proposed an In-composition gradient increase and decrease In Ga N quantum barrier *** analysis of its P-I graph,carrier concentration,and energy band diagram,the results showed that when the current was 100 m A,the In-composition gradient decrease quantum barrier(Qb)structure could effectively suppress electron leakage while improving hole injection efficiency,resulting in an increase in carrier concentration in the active region and an improvement in the effective recombination rate in the quantum well(QW).As a result,the IQE and output power of the LED were effectively improved.

关键词： diodes quantum gradient

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三轴形变核^(131)ba中的奇异集体激发模式

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物理学报 2024年第11期73卷 89-100页

作者：韦锐周厚兵王思成丁兵强赟华贾晨旭陈红星郭松 C.M.Petrache D.Mengoni A.Astier E.Dupont 吕冰锋 D.bazzacco A.boso A.Goasduff F.Recchia D.Testov F.Galtarossa G.jaworski D.R.Napoli S.Riccetto M.Siciliano j.j.Valiente-Dobon C.Andreoiu F.H.Garcia K.Ortner K.Whitmore A.Ataç-Nyberg T.bäck b.Cederwall E.A.Lawrie I.Kuti D.Sohler T.Marchlewski j.Srebrny A.Tucholski 广西师范大学物理科学与技术学院桂林541004 广西核物理与核技术重点实验室桂林541004 中国科学院近代物理研究所兰州730000 中国科学院大学北京100049 巴黎萨克雷大学 CNRS/IN2P3IJCLab奥赛91405 帕多瓦大学物理和天文学系帕多瓦I-35131 意大利国家核物理研究所帕多瓦分部帕多瓦I-35131 意大利国家核物理研究所莱尼亚罗国家实验室莱尼亚罗(帕多瓦)I-35020 费拉拉大学理学与自然科学院费拉拉西蒙菲莎大学化学系本拿比BC V5A 1S6 皇家理工学院物理系斯德哥摩尔S-10691 国家研究基金会iThemba加速器科学实验室西萨默塞特7123 西开普大学物理与天文系贝尔维尔ZA-7535 HUN-REN原子核研究所德布勒森4001 华沙巴斯德拉大学重离子实验室华沙02-093

利用意大利Legnaro实验室串列静电加速器提供的65 MeV^(13)C束流与122Sn靶的熔合蒸发反应布居了^(131)ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.... 详细信息

利用意大利Legnaro实验室串列静电加速器提供的65 MeV^(13)C束流与122Sn靶的熔合蒸发反应布居了^(131)ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.正负宇称手征带通过一系列增强的E1跃迁连接,表明它们之间存在八极关联.在低自旋区域搭建了一条新的转动带,通过一系列γ跃迁向νh1_(1/2)晕带退激.这种能级结构与摇摆带相似,但基于现有的实验证据还难以将它确认为摇摆带,不能排除其他集体激发机制,如γ振动的影响.

关键词：高自旋态手征带赝自旋八极关联摇摆运动

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由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li Ruo-Yu Liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive Ob association(Cygnus Ob2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

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Stromal cell decidualization and embryo implantation: a vulnerable step leading to successful pregnancy

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Reproductive and Developmental Medicine 2024年第2期8卷 101-110页

作者： Luhan jiang Sudini R.Fernando Suranga P.Kodithuwakku Dandan Cao William S.b.Yeung Kai-Fai Lee Department of Obstetrics and Gynaecology School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science&Export AgricultureUva Wellassa UniversityBadulla 50000Sri Lanka Department of Animal Science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka Shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-Shenzhen Hospital Shenzhen 518053China

Endometrial stromal cell decidualization is a crucial step in endometrial remodeling during *** is controlled by orchestrated ovarian hormones,followed by the activation of various downstream signaling *** evidence has shown multiple functions of decidualized endometrial stromal cells during embryo implantation,including tissue remodeling,antioxidative stress,angiogenesis,and immune *** distinct secretomes of decidualized stromal cells also reveal their intensive interactions with epithelial,endothelial,and immune ***,aberrant decidualization leads to pregnancy failures,such as recurrent pregnancy loss and repeated implantation *** review aimed to provide an overview of the molecular mechanisms underlying the divergent functions of decidualized endometrial stromal cells and their potential clinical ***,the use of single-cell RNA sequencing data further enhances our understanding of these biological *** review discusses decidualization-related signaling pathways that serve as potential therapeutic targets for treating implantation failure in in vitro fertilization and provides novel approaches to investigate the underlying causes of female infertility.

关键词： Endometrial stromal cell Decidualization Embryo implantation Recurrent pregnancy loss Repeated implantation failure

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Reduction of epinephrine in the lumbar spinal cord following repetitive blast-induced traumatic brain injury in rats

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Neural Regeneration Research 2024年第7期19卷 1548-1552页

作者： Shigeharu Tsuda Mustafa Golam jiamei Hou Kevin K.W.Wang Floyd j.Thompson Prodip bose brain Rehabilitation Research Center Malcom Randall VA Medical CenterNorth Florida/South Georgia Veterans Health SystemGainesvilleFLUSA Department of Anesthesiology College of MedicineUniversity of FloridaGainesvilleFLUSA Department of Emergency Medicine University of FloridaGainesvilleFLUSA Department of Neuroscience University of FloridaGainesvilleFLUSA Department of Neurology University of FloridaGainesvilleFLUSA

Traumatic brain inju ry-induced unfavorable outcomes in human patients have independently been associated with dysregulated levels of monoamines,especially epinephrine,although few preclinical studies have examined the epinephrine level in the central nervous system after traumatic brain *** has been shown to regulate the activities of spinal motoneurons as well as increase the heart rate,blood pressure,and blood flow to the hindlimb ***,the purpose of the present study was to determine the impact of repeated blast-induced traumatic brain injury on the epinephrine levels in seve ral function-s pecific central nervous system regions in *** three repeated blast injuries at 3-day intervals,the hippocampus,motor cortex,locus coeruleus,vestibular nuclei,and lumbar spinal cord were harvested at post-injury day eight and processed for epinephrine assays using a high-sensitive electrochemical detector cou pled with high-performance liquid *** results showed that the epinephrine levels were significantly decreased in the lumbar spinal cord tissues of blast-induced traumatic brain injury animals compared to the levels detected in age-and sex-matched sham *** other function-specific central nervous system regions,although the epinephrine levels were slightly altered following blast-induced tra u matic brain injury,they were not statistically *** results suggest that blast injury-induced significant downregulation of epinephrine in the lumbar spinal cord could negatively impact the motor and cardiovascular *** is the first repo rt to show altered epinephrine levels in the spinal cord following repetitive mild blast-induced traumatic brain injury.

关键词： balance blood flow cardiovascular system central nervous system epinephrine ischemic damage lumbar spinal cord muscle tone repeated blast spasticity traumatic brain injury

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