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Younger patients have poorer biochemical outcome after radical prostatectomy in high-risk prostate cancer

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Asian j.urnal of Andrology 2011年第5期13卷 719-723页

作者： Sung Kyu Hong j.ng Soo nam Woong na j.ng j.n Oh Cheol Yong Yoon Chang Wook j.ong Hyun j.ne Kim Seok-Soo Byun Sang eun Lee Department of Urology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea

The aim of this study was to investigate the prognostic significance of patient age with respect to tumour aggressiveness in men who underwent radical prostatectomy （RP） for prostate cancer. In this study, we reviewed the records of 743 patients who received RP without neoadj.vant or adj.vant therapy at our institution and were followed up for 〉2 years postoperatively. For our analyses, the patients were divided into two groups according to age： younger （〈60 years） and older （≥ 60 years）. Through uni- and multivariate analyses, associations of various clinicopathological parameters, including biochemical recurrence-free survival, with patient age, were evaluated among all patients, and the patients were stratified according to their D＇Amico risk classification. Among all subj.cts, younger （n= 126） and older （n=617） patients showed no significant differences regarding pathological parameters and biochemical recurrence-free survival （P=0.288）. For the high-risk group （n= 206）, younger patients had a lower rate of biochemical recurrence-free survival following surgery than older patients （P=0.017）, despite the fact that no significant differences were observed regarding various known prognostic parameters between the two age groups. In addition, multivariate analysis revealed that age was an independent predictor of biochemical recurrence-free survival among the high-risk group （P=O.O03）. Our results showed that relatively younger patients have a comparable biochemical outcome compared with their older counterparts following RP performed for prostate cancer. However, among patients with high-risk disease, younger patients have a worse biochemical outcome following RP compared with older patients.

关键词： age factors biochemical outcome prostate prostatic neoplasms prostatectomy

Numerical simulation and experimental study on dissolving characteristics of layered salt rocks

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Chinese j.urnal of Chemical Engineering 2019年第5期27卷 1030-1036页

作者： Qiqi Wanyan Yiming Xiao na Tang China University of Petroleum-Beij.ng Beijing J02249China College of Chemical Engineering and Material Science Tianjin University of Science and TechnologyTianjin 300457China Tianj.n Key Laboratory of Marine Resources and Chemistry Tianjin 300457China

Underground salt cavern reservoirs are ideal spaces for energy storage. China is rich in salt rock resources with layered lacustrine sedimentary structures. However, the dissolution mechanism of layered salt rocks remains poorly understood, resulting in significant differences between the actual measurements and the designed indices for the layered salt rock water-soluble cavity-making cycle and the cavity shape. In this work, the dissolution rates of 600 groups of layered salt rocks in China under different conditions were determined ***, the established artificial neural network prediction model was used to assess the effects of the contents of naCl, na2 SO4, and CaSO4 in the salt rocks, concentrations, dissolution angles, and flow rates on their dissolution rates by performing ANOVA and F-test. The results provide a theoretical basis for evaluating the dissolution rate of layered salt rocks under different conditions and for the numerical simulation of the layered salt rock water-soluble cavity-making process.

关键词： Salt cavern reservoirs Layered salt rock Dissolution rate ANOVA

Fabrication of Anodic Aluminum Oxide Templates with Small Interpore Distances

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Chinese Physics Letters 2010年第6期27卷 148-151页

作者： WANG na ZHANG Wen-Di XU j.-Peng MA Bin ZHANG Zong-Zhi j.N Qing-Yuan E. Bunte j. Hupkes H. P. Bochem Key Laboratory of Micro and nano Photonic Structures (Ministry of Education) Laboratory of Advanced Materials and Department of Optical Science and Engineering Fudan University Shanghai 200433 IEFS-Photovoltaik Forschungszentrum Jfilich GmbH D-52425 Julich Germany Institut fur Bio-und nanosysteme (IBN-PT) julich GmbH D52425 Julich Germany

The influence of the electropolishing and anodization voltage on surface morphology has been carefully studied for fabrication of ordered anodic aluminum oxide （AAO） templates. In accordance with that in the anodization experiment, the size of small patterns on the foil surface formed from the electropolishing treatment increases with voltage. Using a combined method of small-voltage eleetropolishing and anodization, we have fabricated well ordered templates with much smaller interpore distances compared with that under normal-voltage fabrication conditions. The Ni nanowire arrays with two small diameters are eleetrodeposited through the above templates, exhibiting different magnetic properties. This also helps us to clarify the inner structure of this kind of templates.

关键词： MICROFABRICATION ALUMINUM oxide POROUS materials ELECTROLYTIC polishing SURFACES (Technology) CHEMICAL templates naNOWIRES MAGNETIC properties

直觉模糊MABAC法在低渗碳酸盐岩气藏有利区优选中的应用

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油气藏评价与开发 2024年第4期14卷 577-585页

作者：闵超李映君李小刚华青张娜西南石油大学理学院四川成都610500 西南石油大学人工智能研究院四川成都610500 西南石油大学油气藏地质及开发工程全国重点实验室四川成都610500 中国石油西南油气田公司重庆气矿重庆400700

低渗碳酸盐岩气藏地质构造和储层特征复杂,数据获取和解释的不确定性较高,导致有利区优选的难度较大。提出了最优最劣法(BWM)赋权下的直觉模糊MABAC(多属性边界近似区域比较)法低渗碳酸盐岩有利区优选模型。首先,根据低渗碳酸盐岩地质... 详细信息

低渗碳酸盐岩气藏地质构造和储层特征复杂,数据获取和解释的不确定性较高,导致有利区优选的难度较大。提出了最优最劣法(BWM)赋权下的直觉模糊MABAC(多属性边界近似区域比较)法低渗碳酸盐岩有利区优选模型。首先,根据低渗碳酸盐岩地质特征、生烃能力和储气能力等信息,建立综合考虑低渗碳酸盐岩成藏的地质条件、施工条件的综合评价指标体系;然后利用BWM方法确定各关键评价指标权重,同时考虑多个因素对不同的油气田的影响并掌握因素之间的优先级关系;最后,利用直觉模糊信息替代精确信息,建立改进的直觉模糊多属性决策模型,对低渗碳酸盐岩气藏开发有利区进行优选。利用10个碳酸盐岩气藏区块进行实验,结果表明:剩余动态储量、有效储层厚度等因素表现良好的C区块为最优。对碳酸盐岩气藏开发有利区块按照整体距离的值进行降序排序,结果为:C区>I区>H区>A区>D区>G区>j.>E区>F区>B区。将提出的直觉模糊MABAC法与现有方法进行对比,并结合数值模拟结果分析,验证了该方法的有效性和合理性。

关键词：低渗碳酸盐岩有利区优选评价指标体系最优最劣法(BWM) 直觉模糊MABAC法

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Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways

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International j.urnal of Oral Science 2022年第2期14卷 192-200页

作者： Bongkun Choi j.-eun Kim Si-On Park eun-Young Kim Soyoon Oh Hyuksu Choi Dohee Yoon Hyo-j.n Min Hyung-Ryong Kim eun-j. Chang Department of Biomedical Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Stem Cell Immunomodulation Research Center Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Pharmacology College of DentistryJeonbuk National UniversityJeonjuKorea Department of Biochemistry and Molecular Biology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Sphingosine-1-phosphate(S1P)is an important lipid mediator that regulates a diverse range of intracellular cell signaling pathways that are relevant to tissue engineering and regenerative ***,the precise function of S1P in dental pulp stem cells(DPSCs)and its osteogenic differentiation remains *** here investigated the function of S1P/S1P receptor(S1PR)-mediated cellular signaling in the osteogenic differentiation of DPSCs and clarified the fundamental signaling *** results showed that S1P-treated DPSCs exhibited a low rate of differentiation toward the osteogenic phenotype in association with a marked reduction in osteogenesis-related gene expression and AKT *** note,both S1PR1/S1PR3 and S1PR2 agonists significantly downregulated the expression of osteogenic genes and suppressed AKT activation,resulting in an attenuated osteogenic capacity of *** importantly,an AKT activator completely abrogated the S1P-mediated downregulation of osteoblastic markers and partially prevented S1P-mediated attenuation effects during ***,the pro-inflammatory TNF-αcytokine promoted the infiltration of macrophages toward DPSCs and induced S1P production in both DPSCs and *** findings indicate that the elevation of S1P under inflammatory conditions suppresses the osteogenic capacity of the DPSCs responsible for regenerative endodontics.

关键词： pulp hinder precise

太行山复杂地形下华北暖季极端降水的时空分布特征

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大气科学学报 2024年第3期47卷 438-449页

作者：马丽武永利董春卿郝婧宇李娜山西省气象台山西太原030006

基于2012—2021年5—9月华北五省的逐日降水资料和台站地形高度数据,统计分析了华北全区及各子区域极端降水事件的降水量及其强度和频次的时空分布特征;并运用地理加权回归(GWR)模型分析得到极端降水事件的降水量、强度及频次与海拔高... 详细信息

基于2012—2021年5—9月华北五省的逐日降水资料和台站地形高度数据,统计分析了华北全区及各子区域极端降水事件的降水量及其强度和频次的时空分布特征;并运用地理加权回归(GWR)模型分析得到极端降水事件的降水量、强度及频次与海拔高度之间的关系。结果表明:1)华北区域极端降水量的时间变化均呈多波动特征且区域差异性显著,太行山以西高原和以东平原降水频次多、波动明显且强度较弱,太行山南段以南平原降水频次少、变化平缓而强度明显偏强。2)极端降水量的空间分布呈现南北少、中间多的型态分布,降水量大值区分别位于燕山东南侧和太行山南段晋冀豫三省交界处;极端降水高频站点主要聚集在晋东南地区;日最大降水量超过300 mm的站点主要集中在太行山脉和燕山山脉与华北平原的过渡地带。3)华北区域38°N以北,极端降水量、降水频次、强度和日最大降水量均随海拔高度的升高而减小;38°N以南,山西南部临运地区降水量随海拔高度的升高而显著增加。由于降水频次和强度与地形均存在正相关而导致,太行山附近降水量随海拔高度的升高而减小的贡献主要在于降水强度而非降水频次。

关键词：华北地区暖季极端降水时空特征 GWR模型地形

In vivo and in vitro study of resorbable magnesium wires for medical implants:Mg purity,surface quality,Zn alloying and polymer coating

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j.urnal of Magnesium and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar j.Luňácková M.j.x M.Žaloudková R.Vrbová M.Bartoš P.Klein L.Vištej.ová j.Dušková E.Filová Z.Sucharda M.Steinerová S.Habr K.Balík A.Singh Department of Materials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of Physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental Medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of Physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Composites and Carbon Materials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of Pathological Physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of Histology and Embryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for Structural Materials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and H_(2)generation limit the potential of Mg-based *** low-alloyed Mg-Zn wires can strongly reduce problems with large H_(2)bubbles and improve the mechanical properties considerably while maintaining excellent long-term *** pickling and a polymer coating can be effectively used to lower the rate of in vivo *** this work,microstructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires made from ultra-pure Mg,commercially pure Mg,Mg-0.15Zn,Mg-0.4Zn and Mg-1Zn was ***,Mg-0.4Zn wires together with a variant coated with a copolymer of L-lactide andε-caprolactone were tested in vivo on artificially damaged Wistar rat *** on the observed Mg-induced osteogenesis,polymer-coated Mg wires with a small addition of Zn are a perspective material for bone-support applications,such as cerclage and fixation wires.

关键词： Magnesium Resorbable Mg wire Mg-Zn implant degradation Biocompatibility study Zn grain boundary segregation

Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19

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World j.urnal of Gastroenterology 2021年第19期27卷 2341-2352页

作者： Byungchang j.n Raj.n Singh Se eun Ha Hannah Zogg Paul j.Park Seungil Ro Department of Physiology and Cell Biology University of Nevada School of MedicineRenoNV 89557United States Department of Medicine Renown HealthRenoNV 89557United States

Gastrointestinal(GI)symptoms,such as diarrhea,abdominal pain,vomiting,and anorexia,are frequently observed in patients with coronavirus disease 2019(COVID-19).However,the pathophysiological mechanisms connecting these GI symptoms to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections remain *** studies indicate that the entry of SARS-CoV-2 into intestinal cells leads to downregulation of angiotensin converting enzyme 2(ACE2)receptors resulting in impaired barrier *** intestinal ACE2 functions as a chaperone for the amino acid transporter B0AT1,the B0AT1/ACE2 complex within the intestinal epithelium acts as a regulator of gut microbiota composition and *** to the B0AT1/ACE2 complex lead to microbial dysbiosis through increased local and systemic immune *** studies have also suggested that altered serotonin metabolism may be the underlying cause of GI disorders involving *** findings of elevated plasma serotonin levels and high fecal calprotectin in COVID-19 patients with diarrhea indicate that the viral infection evokes a systemic inflammatory response that specifically involves the ***,the elevated proinflammatory cytokines correlate with elevated serotonin and fecal calprotectin levels further supporting the evidence of GI inflammation,a hallmark of functional GI ***,the finding that rectal swabs of COVID-19 patients remain positive for SARS-CoV-2 even after the nasopharynx clears the virus,suggests that viral replication and shedding from the GI tract may be more robust than that of the respiratory tract,further indicating fecal-oral transmission as another important route of viral *** review summarized the evidence for pathophysiological mechanisms(impaired barrier function,gut inflammation,altered serotonin metabolism and gut microbiota dysbiosis)underlying the GI symptoms in patients with COVID-19.

关键词： COVID-19 Gastrointestinal symptoms Gut microbiota dysbiosis Impaired barrier function Serotonin Angiotensin converting enzyme 2 receptor

基于EETs介导的细胞焦亡探讨化瘀祛痰方对ApoE^(-/-)小鼠动脉粥样硬化的影响

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中国药房 2024年第12期35卷 1437-1442页

作者：赵娜隋国媛孟嘉伟吕美君贾连群辽宁中医药大学中医脏象理论及应用教育部重点实验室沈阳110847

目的探讨化瘀祛痰方对ApoE-/-小鼠动脉粥样硬化(AS)的影响及机制。方法将30只ApoE-/-小鼠随机分为模型组、化瘀祛痰方组[20 g/(kg·d)]和瑞舒伐他汀组[1.55 mg/(kg·d)],每组10只,另取10只C57BL/6j.鼠作为正常对照组。ApoE-/-小鼠喂... 详细信息

目的探讨化瘀祛痰方对ApoE-/-小鼠动脉粥样硬化(AS)的影响及机制。方法将30只ApoE-/-小鼠随机分为模型组、化瘀祛痰方组[20 g/(kg·d)]和瑞舒伐他汀组[1.55 mg/(kg·d)],每组10只,另取10只C57BL/6j.鼠作为正常对照组。ApoE-/-小鼠喂饲高脂饲料12周复制AS模型。造模成功后,各组小鼠灌胃相应药物或生理盐水,每日1次,连续4周。末次给药后,检测各组小鼠血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、5,6-环氧二十碳三烯酸(5,6-EET)、8,9-EET、11,12-EET、14,15-EET、白细胞介素1β(IL-1β)、IL-18水平,主动脉组织中核因子κB抑制蛋白(IκB)、核因子κB(NF-κB)、NOD样受体热蛋白结构域相关蛋白3(NLRP3)、胱天蛋白酶1(Caspase-1)、IL-1β、IL-18 mRna表达水平和IκB、NF-κB、NLRP3、凋亡相关斑点样蛋白质(ASC)、Caspase-1、消皮素D(GSDMD)、IL-1β、IL-18蛋白表达水平,并观察主动脉组织形态学变化。结果与模型组比较,化瘀祛痰方组及瑞舒伐他汀组小鼠血清中TC、TG、LDL-C、IL-1β、IL-18水平,主动脉组织中IκB、NF-κB、NLRP3、Caspase-1、IL-1β、IL-18 mRna表达水平以及IκB、NF-κB、NLRP3、ASC、Caspase-1、GSDMD、IL-1β、IL-18蛋白表达水平均显著降低(P<0.05),血清中5,6-EET、8,9-EET、11,12-EET、14,15-EET水平均显著升高(P<0.05);主动脉粥样斑块明显减少。结论化瘀祛痰方可能通过EETs介导细胞焦亡发挥抗AS作用。

关键词：化瘀祛痰方动脉粥样硬化细胞焦亡环氧二十碳三烯酸