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Ear.y Syphilis Pr.senting as Thickened Penile Plaques With an Embedded r.cur.ent Ulcer.(Chancr. r.dux): A Case r.por.

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Inter.ational j.ur.al of Der.atology and Vener.ology 2024年第3期7卷 160-162页

作者： Davies S.C. Hannafor. r. Cotter.j. Nor.her. Sydney Sexual Health Ser.ice Northern Sydney Local Health District St Leonards 2065 NSW Australia Nor.her. Beaches Der.atology Mona Vale 2103 NSW Australia

Intr.duction: The manifestations of syphilis ar. var.ed, and ser.logy can establish the diagnosis ear.y, especially in r.r. cases. We r.por. a case of chancr. r.dux (a r.r. r.cur.ence of pr.mar. syphilis), which was embedded within a secondar. syphilitic penile skin plaque. Ther. wer. missed oppor.unities at ear.ier.diagnosis as ser.logy for.syphilis was not or.er.d. Case pr.sentation: A 56-year.old man pr.sented with thickened penile plaques for.five months. He r.por.ed a small penile ulcer.appr.ximately one month pr.or. Ther. was no histor. of other.skin lesions or.r.sh. However. clinically ther. was an asymptomatic, indur.ted ulcer.embedded within a plaque which was swab-positive for.syphilis by PCr. A punch biopsy of a plaque was spir.chaete-positive using an immunoper.xidase stain. The patient's lesions r.solved thr.e weeks after.tr.atment with intr.muscular.benzathine penicillin. Discussion: Uncommonly r.por.ed even in the pr.antibiotic er., chancr. r.dux is now r.r.. The ulcer.usually r.cur. at or.near.the site of the or.ginal chancr., and has similar.mor.hological featur.s. The skin lesions of secondar. syphilis can exhibit r.mar.able mor.hological var.ety. The most common skin manifestation, a gener.lized macular.r.sh, was not pr.sent at any time in this case. r.ther. ther. wer. only a couple of nonspecific penile plaques. If biopsy is per.or.ed, histologic findings ar. var.able, though typically the inflammator. infiltr.te includes plasma cells. A special immunoper.xidase stain can highlight spir.chaetes in biopsy sections. Conclusion: This case highlights the impor.ance of consider.ng syphilis in the differ.ntial diagnosis of per.istent, atypical penile lesions and under.cor.s the need for.appr.pr.ate ser.logical testing in such instances. Copyr.ght © 2023 Hospital for.Skin Diseases (Institute of Der.atology),

关键词： chancr. r.dux genital r.sh immunohistochemistr. immunoper.xidase pr.mar. syphilis secondar. syphilis

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西班牙抗结核药物所致严重肝毒性反应

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结核与肺部疾病杂志 2005年第3期8卷 90-95页

作者： j. r. tost r. Vidal j. Cayla D. Diaz-Cabanela A. j.menez j. M. Br.quetas 马玙 Hospital de Ter.assa Barcelona Departamento de Medicina Universidad Autonoma de Barcelona Barcelona Hospital Valle de Hebr.n Barcelona Agenda de Salut Publica de Bar.elona Barcelona CHU j.an Canalej. La Coruna Unitat de Malalties del Tor.x Dr.ssanes Barcelona Hospital del Mar Barcelona Spain Study Gr.up for.Sever. Hepatotoxicity due to Anti-tuber.ulosis Dr.gs in Spain

目的:判定抗结核药物引起的严重肝毒性反应的发生频率及发生急性肝功能衰竭或死亡的预报指标。方法﹕西班牙肺科学会成员对1997-2001年18家医院的资料进行回顾性研究。严重肝毒性反应界定为,无临床症状者转氨酶有10倍升高或胆汁郁滞参数... 详细信息

目的:判定抗结核药物引起的严重肝毒性反应的发生频率及发生急性肝功能衰竭或死亡的预报指标。方法﹕西班牙肺科学会成员对1997-2001年18家医院的资料进行回顾性研究。严重肝毒性反应界定为,无临床症状者转氨酶有10倍升高或胆汁郁滞参数3倍增加;有肝炎症状者则为肝功能参数增加或发生肝功能衰竭。采用logistic 回归分析计算比值比(Or.及其95%可信区间(CI)研究其预报因素。结果﹕3510 例中共有166 例发生肝毒性反应,其中90 例(2.56%)为活动性结核病治疗所致。11 例(10.3%)发生急性肝功能衰竭,其中3 例进行了肝移植。总体病死率为4.7%(5 例,其中3 例与饮酒或肝毒性药物有关)。预后不良的预报指标为总胆红素>2mg/dl(Or.9.4 , 95%CI : 1.0-85.5) 及血清肌肝>1.5mg/dl(Or.32.1,95%CI:2.4-424.6)。结论﹕抗结核药物引起的严重肝毒性反应死亡率较高。必须进行经常性的临床检查及临床实验室观察以预防其发生。

关键词：结核病异烟肼利福平吡嗪酰胺重症肝炎急性肝功能衰竭抗结核药物毒性反应西班牙 logistic回归分析药物所无临床症状预报因素活动性结核病

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Fir.t-pr.nciples calculations to investigate str.ctur.l,electr.nic,magnetic,optical and ther.odynamic pr.per.ies of r._(2)r._(3)Ge(r.=Pr.Sm)

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j.ur.al of r.r. Ear.hs 2024年第7期42卷 1385-1393,I0007页

作者： A.Ezaier.r.Masr.ur.M.Hamedoun j.Khar.ach A.r.zzouk A.Hour.atallah N.Benzakour.K.Bouslykhane Labor.tor. of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In this paper.we analyzed the physical char.cter.stics of the ter.ar. alloys r._(2)r._(3)Ge(r.=Pr.and Sm)using the fir.t pr.nciples calculation based on functional density theor. integr.ted in the Wien2k *** calculated for.ation ener.ies of Pr.(2)r._(3)Ge and Sm_(2)r._(3)Ge ar.−5.3827 and−5.2782 eV/atom,r.spectively,showing that these alloys may exist *** r.sults of the band str.ctur. and density of states indicate that all of the compounds tested ar. magnetic metals,and their.magnetism is mostly r.lated to the contr.bution of Pr.and Sm *** total magnetic moments of Pr.(2)r._(3)Ge and Sm_(2)r._(3)Ge ar. 4.07245 and 11.16161μB/f.u,*** par.meter. such as heat capacity at constant pr.ssur.,entr.py,Debye temper.tur.,lattice volume,compr.ssibility coefficients,and Gr.neisen par.meter.alloys wer. calculated using the Gibbs algor.thm and studied in depth over.a lar.e temper.tur. r.nge of 0-900 *** Debye temper.tur. incr.ases with incr.asing pr.ssur. and decr.ases with decr.asing ***,the Debye temper.tur.s calculated at p=0 GPa and T=300 K ar. equal to be 342 and 322 K for.Pr.(2)r._(3)Ge and Sm_(2)r._(3)Ge,*** optical char.cter.stics such as the r.al and imaginar. por.ions of the dielectr.c function,the absor.tion coefficient,the ener.y-loss function,and the r.fr.ctive index wer. investigated and discussed in mor. depth.

关键词： Magnetic metals Functional density theor. Density of states Magnetic moment Optical and ther.odynamic pr.per.ies r.r. ear.hs

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Fetal Head Compr.ssion: Its Possible r.le in Neur.logic Inj.r.

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Open j.ur.al of Obstetr.cs and Gynecology 2024年第1期14卷 124-143页

作者： Bar.y S. Schifr.n Br.an j. Koos Wayne r. Cohen Depar.ment of Obstetr.cs and Gynecology The Western University of Health Sciences Pomona USA The David Geffen School of Medicine at UCLA Los Angeles USA The Univer.ity of Ar.zona College of Medicine Tucson USA

It is widely assumed that fetal ischemic br.in inj.r. dur.ng labor.der.ves almost exclusively fr.m sever., systemic hypoxemia with mar.ed neonatal depr.ssion and acidemia. Sever. asphyxia, however. is one of sever.l causes of per.natal neur.logical inj.r. and may not be the most common;most neonates diagnosed with hypoxic-ischemic encephalopathy do not have evidence of sever. asphyxia. Sepsis, dir.ct br.in tr.uma, and dr.g or.toxin exposur. account for.some cases, while mechanical for.es of labor.and deliver. that incr.ase fetal intr.cr.nial pr.ssur. sufficiently to impair.br.in per.usion may also contr.bute. Because of bony compliance and mobile sutur. lines, the fetal skull changes shape and r.distr.butes cer.br.spinal fluid dur.ng labor.accor.ing to constr.ints imposed by contr.ctions, and bony and soft tissue elements of the bir.h canal as the head descends. These accommodations, including the incr.ase in intr.cr.nial pr.ssur., ar. adaptive and necessar. for.efficient descent of the head while safeguar.ing cer.br.l blood flow. Autonomic r.flexes mediated thr.ugh centr.l r.ceptor. nor.ally pr.vide ample pr.tection of the br.in fr.m the consider.ble pr.ssur. exer.ed on the skull. On occasion, those for.es, which ar. tr.nsmitted intr.cr.nially, may over.ome the var.ous adaptive anatomical, car.iovascular. metabolic, and neur.logical mechanisms that maintain cer.br.l per.usion and oxygen availability, r.sulting in ischemic br.in inj.r.. Accepting the notion of a potentially adver.e impact of fetal head compr.ssion suggests that avoidance of excessive uter.ne activity and of r.lentless pushing without steady pr.gr.ss in descent may offer.pr.tection for.the fetal br.in dur.ng par.ur.tion. Excessive head compr.ssion should be consider.d in the differ.ntial diagnosis of ischemic encephalopathy.

关键词： Fetal Br.in Inj.r. Fetal Head Compr.ssion Ischemic Encephalopathy Neonatal Encephalopathy

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Heat and Mass Tr.nsfer.for.a Nanofluid Flow in Fluidized Bed Dr.er.in Pr.sence of Induced Magnetic Field

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j.ur.al of Applied Mathematics and Physics 2024年第4期12卷 1401-1425页

作者： Kiptum j. Pur.ty Mathew N. Kinyanj.i Edwar. r. Onyango Pan Afr.can Univer.ity Institute for.Basic Sciences Technology and Innovation Nairobi Kenya Depar.ment of Pur. and Applied Mathematics Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

This r.sear.h entails the study of heat and mass tr.nsfer.of nanofluid flow in a fluidized bed dr.er.used in tea dr.ing pr.cesses in pr.sence of induced magnetic field. A mathematical model descr.bing the fluid flow in a Fluidized bed dr.er.was developed using the nonlinear.par.ial differ.ntial equations. Due to their.non-linear.ty, the equations wer. solved numer.cally by use of the finite differ.nce method. The effects of physical flow par.meter. on velocity, temper.tur., concentr.tion and magnetic induction pr.files wer. studied and r.sults wer. pr.sented gr.phically. Fr.m the mathematical analysis, it was deduced that addition of silver.nanopar.icles into the fluid flow enhanced velocity and temper.tur. pr.files. This led to impr.ved heat tr.nsfer.in the fluidized bed dr.er. hence amplifying the tea dr.ing pr.cess. Fur.her.or., it was noted that induced magnetic field tends to decr.ase the fluid velocity, which r.sults in unifor. distr.bution of heat leading to efficient heat tr.nsfer.between the tea par.icles and the fluid, thus impr.ving the dr.ing pr.cess. The r.sear.h findings pr.vide infor.ation to industr.es on ways to optimize ther.al per.or.ance of fluidized bed dr.er..

关键词： Heat Tr.nsfer Induced Magnetic Field Nanofluid Fluidized Bed Dr.er

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Har.essing exosomes for.tar.eted ther.py: str.tegy and application

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Biomater.als Tr.nslational 2024年第1期5卷 46-58页

作者： r.n X. Xu r. Xu C. Su j. Or.anoid r.sear.h Center Institute of Translational Medicine Shanghai University Shanghai China National Center.for.Tr.nslational Medicine (Shanghai) SHU Br.nch Shanghai University Shanghai China Depar.ment of Micr.bial Pathogenesis Yale University School of Medicine New Haven CT United States Depar.ment of Biomedical Engineer.ng City University of Hong Kong Hong Kong Special Administrative Region China Depar.ment of Or.hopedic Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

Exosomes, nanoscopic extr.cellular.vesicles pr.duced by cells, ar. pivotal in mediating intr.cellular.communication by tr.nspor.ing nucleic acids, pr.teins, lipids, and other.bioactive molecules, ther.by influencing physiological and pathological states. Their.endogenous or.gin and inher.nt diver.ity confer.distinct advantages over.synthetic vehicles like liposomes and nanopar.icles in diagnostic and ther.peutic applications. Despite their.potential, the clinical utility of exosomes is hamper.d by challenges such as limited stor.ge stability, yield, pur.ty, and tar.eting efficiency. This r.view focuses on exosomes as tar.eted ther.peutic agents, examining their.biogenesis, classification, isolation, and char.cter.sation, while also addr.ssing the cur.ent limitations in yield, pur.ty, and tar.eting. We delve into the liter.tur. to pr.pose optimisation str.tegies that can enhance their.ther.peutic efficacy and acceler.te the tr.nslation of exosome-based ther.pies into clinical pr.ctice. © 2024, Chinese Medical Multimedia Pr.ss Co Ltd. All r.ghts r.ser.ed.

关键词： biomedical engineer.ng exosomes modification nanotechnology tar.eted ther.py

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Bivar.ate Analysis of Pollutants Monthly Maxima in Mexico City Using Extr.me Value Distr.butions and Copula

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j.ur.al of Envir.nmental Pr.tection 2024年第7期15卷 796-826页

作者： j.an A. Vazquez-Mor.les Eliane r. r.dr.gues Hor.ensia j. r.yes-Cer.antes Facultad de Ciencias Fsico-Matemticas Benemrita Universidad Autnoma de Puebla Puebla Mexico Instituto de Matemticas Universidad Nacional Autnoma de Mxico Mexico City Mexico

In the pr.sent wor., we ar. inter.sted in studying the j.int distr.butions of pair. of the monthly maxima of the pollutants used by the envir.nmental author.ties in Mexico City to classify the air.quality in the metr.politan ar.a. In or.er.to obtain the j.int distr.butions a copula will be consider.d. Since we ar. analyzing the monthly maxima, the extr.me value distr.butions of Weibull and Fr.chet ar. taken into account. Using these two distr.butions as mar.inal distr.butions in the copula a Bayesian infer.nce was made in or.er.to estimate the par.meter. of both distr.butions and also the association par.meter. appear.ng in the copula model. The pollutants taken into account ar. ozone, nitr.gen dioxide, sulphur.dioxide, car.on monoxide, and par.iculate matter.with diameter. smaller.than 10 and 2.5 micr.ns obtained fr.m the Mexico City monitor.ng networ.. The estimation was per.or.ed by taking samples of the par.meter. gener.ted thr.ugh a Mar.ov chain Monte Car.o algor.thm implemented using the softwar. OpenBugs. Once the algor.thm is implemented it is applied to the pair. of pollutants wher. one of the coor.inates of the pair.is ozone and the other.var.es on the set of the r.maining pollutants. Depending on the pollutant and the r.gion wher. they wer. collected, differ.nt r.sults wer. obtained. Hence, in some cases we have that the best model is that wher. we have a Fr.chet distr.bution as the mar.inal distr.bution for.the measur.ments of both pollutants and in other. the most suitable model is the one assuming a Fr.chet for.ozone and a Weibull for.the other.pollutant. r.sults show that, in the pr.sent case, the estimated association par.meter.is a good r.pr.sentation to the cor.elation par.meter. between the pair.of pollutants analyzed. Additionally, it is a str.ightfor.ar. task to obtain these cor.elation par.meter. fr.m the cor.esponding association par.meter..

关键词： Copula Extr.me Value Distr.bution Bayesian Infer.nce Air.Pollution Mexico City

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Genotypes and Phenotypes of Uygur.Childr.n with Xer.der.a Pigmentosum: A Case Study in Xinj.ang, China

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Inter.ational j.ur.al of Der.atology and Vener.ology 2024年第3期7卷 144-149页

作者： Qiu Y. Wang W.-j. Liang j.-Q. Yakeya B. Wang P. Zhang j.-Z. Kang X.-j. Depar.ment of Der.atology and Vener.ology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinj.ang Clinical r.sear.h Center.for.Der.atologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinj.ang Key Labor.tor. of Der.atology r.sear.h (Xj.S1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Obj.ctive: Xer.der.a pigmentosum (XP) is a r.r. autosomal r.cessive der.atosis caused by genetic defects of DNA r.pair. This study was per.or.ed to detect and analyze the genes of 2 Uygur.patients with XP and their.families and assess the patients' phenotypes, which may enr.ch the under.tanding of the genetic skin disor.er.spectr.m in Xinj.ang ar.a. Methods: We collected the clinical data fr.m 2 patients with XP and per.pher.l blood samples fr.m the patients and their.family member.. The patients' DNA was sequenced and detected by Sanger.sequencing, and gene mutations wer. scr.ened. r.sults: The pr.band in family 1 pr.sented with br.wn maculae at the exposur. site and squamous cell car.inoma secondar. to a facial r.sh. The pr.band had a homozygous nucleotide var.ation of XPC c.2251-2A> G (A change fr.m A to G in the penultimate position of the intr.n befor. the 2251 position in the coding r.gion), which was a shear.mutation. In this family, both par.nts wer. heter.zygous, and no similar.mutation detected in the sister. In family 2, the pr.band had scatter.d black br.wn spots and papules on the tr.nk and limbs. and his younger.sister.was also a patient. The pr.band and his younger.sister.had homonucleotide var.ation of XPA c.631C> T, which was nonsense mutation, r.sulting in the codon for.Ar. No.211 being changed into ter.ination codon (***211X), thus ter.inating the peptide chain synthesis pr.matur.ly. All the nor.al individuals in the two families wer. heter.zygotes, and homozygous mutations occur.ed in all the patients, which was consistent with the autosomal r.cessive inher.tance. Conclusion: XP is r.r. in Uygur.population. This study expanded the mutation spectr.m of XP and pr.vided a basis for.ear.y diagnosis, tr.atment, pr.gnostic pr.diction, and pr.natal genetic consultation. © 2022 Hospital for.Skin Diseases (Institute of Der.atology), Chinese Academy of Medical Sciences, and Chinese Medical Association, published by Wolter. Kluwer. Inc.

关键词： gene mutation xer.der.a pigmentosum XPA gene XPC gene

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Wind power.potential over.nor.her. South Amer.ca using Er.5-Land global r.analysis

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CLEAN ENEr.Y 2024年第2期8卷 104-112页

作者： Ar.egoces, Heli A. Bonivento, Guiller.o j. r.j.no, r.ber.o Univ Guaj.r. Fac Ingn Grp Invest GISA Riohacha Colombia Univ Antioquia UdeA Fac Ingn SIU Grp Proc Fisicoquim Aplicados Calle 70 52-21 Medellin Colombia

The nor.her.most r.gion of South Amer.ca has gr.at potential for.wind ener.y pr.duction and is a str.tegic ar.a for.the ener.y tr.nsition. We analysed data fr.m Er.5-Land global r.analysis fr.m 1980 to 2020 to deter.ine the wind power.potential in this ar.a. Our.aim was to identify ar.as with a high potential for.wind ener.y that could be used to supply ener.y in case of dr.ught in the r.gion or.incr.ases in fuel pr.ces. We compar.d data fr.m 19 meteor.logical stations located in Colombia with Er.5-Land r.analysis data to gener.te r.liable infor.ation for.the feasibility and oper.tion of wind far.s. Accor.ing to our.analysis, the Colombian Car.bbean and Coastal Plain have monthly aver.ge wind speeds at 90 m r.nging fr.m 4.85 to 10.34 m/s and 3.79 to 6.62 m/s, r.spectively. Based on wind power.density calculations, these r.gions have the highest wind power.density in our.study, with a monthly aver.ge of between 250 and 399 W/m2. The Car.bbean r.gion had a 69% incr.ase in wind power.density fr.m j.nuar. to j.ly compar.d with the annual aver.ge. The wind power.density in the plains incr.ased fr.m j.nuar. to Mar.h, while the Mountain r.gion had higher.anomalies fr.m May to October. The Alta Guaj.r. and Par.guana Peninsula have gr.at potential to gener.te wind ener.y due to their.pr.vileged geogr.phical location. Although Er.5 offer. valuable infor.ation about wind availability in time and space, it cannot r.pr.sent the influence of local effects on wind patter.s for.the Mountain r.gion. Data fr.m Er.5-Land global r.analysis (1980-2020) ar. used to deter.ine the wind power.potential in the nor.her.most r.gion of South Amer.ca to identify ar.as with a high potential for.wind ener.y, which could be used to supply ener.y in case of dr.ught or.incr.ases in fuel pr.ces. Gr.phical Abstr.ct

关键词： onshor. wind power wind power.potential Er.5-Land global r.analysis wind speed ENEr.Y COLOMBIA r.GION Er.5

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粉末冶金Al-5.6Zn-2Mg合金在热压缩过程中加工硬化特性及本构模型的比较

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j.ur.al of Centr.l South Univer.ity 2024年第2期31卷 346-368页

作者： KATIKA Har.kr.shna DAMODA r.K. DAVIDSON M.j. SEETHAr.M r. KASAGANI Veer. Venkata Nagar.j. Depar.ment of Mechanical Engineer.ng National Institute of TechnologyWarangal 506004India Depar.ment of Mechanical Engineer.ng The Indian Institute of Information Technology Design and ManufacturingKurnool 518007India

在300~5000℃、应变速率为0.1~0.0001 s−1的条件下,在万能试验机上对Al-5.6Zn-2Mg铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σ_(c)(ε_(c))l以及关键特征σ_(c)(ε_(c))l、σ_(p)(ε_(p))和σ_(ss)与Z系数之间的... 详细信息

在300~5000℃、应变速率为0.1~0.0001 s−1的条件下,在万能试验机上对Al-5.6Zn-2Mg铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σ_(c)(ε_(c))l以及关键特征σ_(c)(ε_(c))l、σ_(p)(ε_(p))和σ_(ss)与Z系数之间的相关性。使用了四个本构模型,Ar.henius模型、改进的j.hnson-Cook模型(Mj.)、改进的Zer.lli-Ar.str.ng模型(MZA)和开发的人工神经网络(ANN)。结果表明,ANN型模型和Ar.henius模型的相对误差的绝对平均值最低,分别为0.486%和3.36%,MZA型模型和Mj.型模型的相对误差的绝对平均值较高,分别为8.84%和3.93%。由于Ar.henius模型能够处理各种因素之间的非线性关系,因此它被认为是最合适的预测模型,但在材料性质未知或实验数据有限的情况下,Mj.模型可能是一种更简单的替代方法。MZA模型不适合估计热压缩时的流变应力。此外,训练最好的神经网络模型的预测性能最好,相对误差的绝对平均值为0.486%,r.为0.99。

关键词：加工硬化速率曲线本构建模热压缩 EBSD分析流变曲线

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