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基于专利分析法和SWOT模型的藏药知识产权分析

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中药与临床 2024年第3期15卷 93-96页

作者：张珵李雨晴冷梦妤李沿峰秦家月饶安阳蔡俊杰梁海璇王玉鑫陈光阳陶宏迅党元野成都中医药大学药学院广州医科大学药学院江苏大学食品与生物工程学院

目的：藏医药是中华医学库中的瑰宝，然而目前我国藏药的资源开发相对滞后以及其知识产权的保护力度仍远远不够。本研究基于专利分析法和SWOT模型分析我国藏药知识产权申报过程中失权的原因，为藏药的知识产权保护提供参考依据。方法：... 详细信息

目的：藏医药是中华医学库中的瑰宝，然而目前我国藏药的资源开发相对滞后以及其知识产权的保护力度仍远远不够。本研究基于专利分析法和SWOT模型分析我国藏药知识产权申报过程中失权的原因，为藏药的知识产权保护提供参考依据。方法：本文以大为全球专利数据库为数据源，对藏药专利文献进行深入分析，从国内藏药专利法律状态进行筛选，进而分析失权专利的主要申请人、技术生命周期以及地域分布情况等多方面阐述了藏药专利发展现状。在专利分析的基础上，利用SWOT模型分析藏药发展的内部优势（S）、劣势（W）、外部机会（O）和威胁（T）并提出相关建议。结果：分析结果显示，藏药专利申请中，失权有279件，专利申请水平亟待提高；失权的藏药专利申请以个人为主，其次为企业，高校和研究机构申请占比较低；2005年前后是失权专利较多的时期，且失权藏药专利申请呈现高度区域性分布特点。其优势为国内专利数量较多，处于世界领先地位；劣势为专利授权率低，藏药专利的有效性和安全性研究有待提高，专利国际化程度低；机遇为国家积极支持民族医药产业发展，藏药的需求量与日俱增；威胁为国际市场的竞争对手具备抢占市场的潜力。结论：藏药的发展应以市场需求和国内政策支持为契机，充分发挥藏药的优势，加大高校等科研单位对苗药科技开发重视程度；针对性解决专利申请的薄弱环节。

关键词：藏药藏药知识产权专利分析法 SWOT模型

Spatiotemporal variations of benthic macrofaunal community in the Xiamen Amphioxus Nature Reserve, eastern South China Sea

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Acta Oceanologica Sinica 2020年第6期39卷 10-18页

作者： Yiyong rao Lizhe Cai Wenj.n Li Xinwei Chen Deyuan Yang College of the Environment and Ecology Xiamen UniversityXiamen 361102China Key Laboratory of the Coastal and Wetland Ecosystems(Xiamen University) Ministry of EducationXiamen 361102China

In order to realize the spatiotemporal variations of benthic macrofaunal communities at the"Amphioxus Sand"habitat,six surveys including four seasons and three consecutive summers(i.e.,2014,2015 and 2016)were conducted in two core sites,i.e.,Huangcuo(HC)and Nanxian-Shibaxian(NX),in the Xiamen Amphioxus Nature Reserve in China.A total of 155 species of macrofauna were recorded,therein,polychaetes were dominant in terms of species number and *** spatiotemporal variations of macrofaunal communities were *** density of polychaetes and the biomass of molluscs in the HC site were higher than those in the NX *** were more diverse and abundant in the cold seasons(winter and spring)than that in the warm seasons(summer and autumn).The annual variations of macrofaunal communities may be attributed to the changes in sediment texture among the three years of the *** variations in macrofaunal communities were mainly related to the proportion of polychaetes within the *** addition,the density of amphioxus(include Branchiostoma j.ponicum and ***)was negatively correlated to that of polychaetes,bivalves,and *** was less likely to be found in the sediments with higher silt and clay *** biotic indices including Margaref’s richness index(d),Peilou’s evenness index(j.),Shannon-Wiener diversity index(H′),AMBI and M-AMBI were calculated in the present *** seems suitable in assessing benthic health at the"Amphioxus Sand"habitat,and a potential risk of ecological health in Xiamen Amphioxus Nature Reserve should be aware.

关键词： spatiotemporal variation Amphioxus Sand benthic macrofaunal community Branchiostoma biotic index

Copper interactions with DNA of chromatin and its role in neurodegenerative disorders

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j.urnal of Pharmaceutical Analysis 2013年第5期3卷 354-359页

作者： M.Govindaraj. H.S.Shekar S.B.Sateesha P.Vasudeva Raj. K.R.Sambasiva rao K.S.j.rao A.j.Raj.mma Molecular Biophysics Unit Indian Institute of Science Department of Pharmacy Practice KIMS Hospital and Research CenterVIPS Department of Pharmaceutics Acharya & B.M.Reddy College of Pharmacy Department of Neuroscience Medical University of South Carolina Department of Biotechnology Acharya Nagarjuna University Centre for Neuroscience Institute for Scientifc Research and Technological services INDICASAT-AIP Department of Pharmacognosy KLEU's College of Pharmacy

In this study, we have demonstrated the conformational changes to DNA induced by abnormal interactions of copper using circular dichroism, in combination with UV-absorbance and fluorescence spectroscopy. Results confirm that binding of copper to bases of DNA in chromatin is concentration dependent. Binding efficiency of Cu2~ ions to DNA is increased in proportion to the degree of unwinding of the double helix induced by denaturation. Altered B-DNA conformation will alter the integrity of DNA which may affect the normal process of DNA replication and transcription. Copper induced DNA damage in the brain may cause neurotoxicity and the neuronal cell death and is implicated in Alzheimer＇s disease and other neurological disorders.

关键词： Human brain Chromatin DNA Copper Neurodegenerative disorders

Anti-microbial principles of selected remedial plants from Southern India

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Asian Pacific j.urnal of Tropical Biomedicine 2011年第4期1卷 298-305页

作者： Tirupathi rao G Suresh Babu K j.Uj.al Kumar Suj.na P A Veerabhadr raoa Sreedhar AS Centre for Cellular and Molecular Biology Hyderabad 500 007India Division of Organic Chemistry-I Natural Products LaboratoryIndian Institute of Chemical TechnologyHyderabad-500 607India

Obj.ctive:To examine the anti-bacterial activity of leaf extracts of Morus alba L.(Moraceae)and Piper betel L.(Piperaceae),and seed extracts of Bombax ceiba L.(Borabacaceae).Methods:We have partially purified plant extracts by solvent extraction method,and evaluated the effect of individual fractions on bacterial growth using Escherichia coli(***),Pseudomonas aeruginosa(***) and Staphylococcus aureus(***) bacterial ***:Compared with Morus and Bombax fractions,Piper fractions showed significant growth inhibition on all the three types of bacteria *** EtOAc-hexane fractions of Piper leaves exhibited significant antibacterial activity with minimum inhibitory concentrations(MIC) of 50 μg/mL culture against both gram-positive and gram-negative *** EtOAc-fractions Ⅰ,Ⅱ,and Ⅳ inhibited bacterial colony formation on soft agar in addition to growth inhibition.A combination treatment of piper fractions with ampicillin resulted in significant growth inhibition in *** and ***,and combination with anticancer drug geldanamycin(2 μg/mL) showed selective growth inhibition against *** and *** maj.r compounds,i.e.,eugenol,3-hexene-ol and stigmasterol,were primarily identified from Piper betel leaf *** the individual compounds,eugenol treatment showed improved growth inhibition compared with stigmasterol and ***:We are reporting potential anti-bacterial compounds from Piper betel against both gram-positive and gram-negative bacteria either alone or in combination with drug treatment.

关键词： Piper betel Anti-microbial activity Escherichia coli Pseudomonas aeruginosa Staphylococcus aureus Morus alba Bombax ceiba Minimum inhibitory concentration Growth inhibition

Studies on LH modulated 8 kDa peptide involved regulation of testosterone production in rat Leydig cells

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Asian j.urnal of Andrology 1999年第4期1卷 191-194页

作者： P.Ramaraj.A.j.gannadha rao Department of Diabetes Endocrinology & Metabolism The University of Hope National Medical Centre 15000 East Duarte Road Duarte CA 91007 USADepartment of Biochemistry & Department of Molecular Reproduction Development & Genetics Indian Institute of Science Bangalore-560 0112 India

Aim: To demonstrate the role of the 8 kDa peptide in regulation of testosterone production by mt Leydig cells. Meth-ods: A peptide similar to 8 kDa peptide purified from immature rat Leydig cells was isolated and purified from rat lungcytosol. Immunological and structural similarity between the peptides purified from lung and Leydig cells was estab-lished by Western blot and tryptic map comparison respectively. Results: Addition of the 8 kDa peptide 10, 50, 100;and 150 ug decreased the production of testosterone in Leydig cells dose-dependently. But the addition of the peptide150 ug along with hCG had no effect on hCG-stimulated increase in testosterone production. Conclusion: In vitro ad-dition of the peptide purified from lung cytosol to adult rat Leydig cells resulted in a concentration-dependent decrease inbasal testosterone production although it had no effect on hCG-stimulated testosterone production. (Asian j.Androl1999 Dec; 1: 191-194)

关键词： Leydig cells testosterone regulation differentiation steroidogenesis peptides LH

Heat load of a GaAs photocathode in an SRF electron gun

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Chinese Physics C 2011年第4期35卷 387-391页

作者：王尔东 j.rg Kewisch Ilan Ben-Zvi Andrew Burrill Trivini rao 吴琼 Animesh j.in Ramesh Gupta Doug Holmes 赵夔 Institute of Heavy Ion Physics Peking University Brookhave National Lab Advance Energy System

A great deal of effort has been made over the last decades to develop a better polarized electron source for high energy physics. Several laboratories operate DC guns with a gallium arsenide photocathode, which yield a highly polarized electron beam. However, the beam’s emittance might well be improved by using a superconducting radio frequency （SRF） electron gun, which delivers beams of a higher brightness than that from DC guns because the field gradient at the cathode is higher. SRF guns with metal and CsTe cathodes have been tested successfully. To produce polarized electrons, a Gallium-Arsenide photo-cathode must be used： an experiment to do so in a superconducting RF gun is under way at BNL. Since a bulk gallium arsenide （GaAs） photocathode is normal conducting, a problem arises from the heat load stemming from the cathode. We present our measurements of the electrical resistance of GaAs at cryogenic temperatures, a prediction of the heat load and verification by measuring the quality factor of the gun with and without the cathode at 2 K. We simulate heat generation and flow from the GaAs cathode using the ANSYS program. By following the findings with the heat load model, we designed and fabricated a new cathode holder （plug） to decrease the heat load from GaAs.

关键词： SRF gun GaAs photocathode heat load 2 K test

Modification of compact TiO_(2) layer by TiCl_(4)-TiCl_(3) mixture treatment and construction of high-efficiency carbon-based CsPbI_(2)Br perovskite solar cells

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j.urnal of Energy Chemistry 2021年第12期30卷 442-451,I0010页

作者： Wenran Wang Yu Lina Guizhi Zhang Cuiting Kang Zhenxiao Pan Xinhua Zhong Huashang rao Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642GuangdongChina Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642GuangdongChina

In the construction of high performance planar perovskite solar cells(PSCs),the modification of compact TiO_(2) layer and engineering of perovskite/TiO_(2) interfaces are essential for efficient electron transfer and retarded charge recombination *** this work,a facile and effective strategy is developed to modify the surface of compact TiO_(2) layer by TiCl_(4)-TiCl_(3) mixture *** with conventional sole TiCl_(4),the TiCl_(4)-TiCl_(3) treatment takes the advantage of accelerated and controlled hydrolysis of TiCl_(3),therefore TiO_(2) with dominating anatase phase and moderate roughness is obtained to facilitate the growth of CsPbI_(2) Br perovskite layer with high ***,the oxidation-driven hydrolysis of TiCl_(3) component results in surface Cl doping that facilitates interfacial electron transfer with retarded recombination *** average power conversion efficiency(PCE) of carbon-based CsPbI_(2) Br planar PSCs based on TiCl_(4)-TiCl_(3) treatment increases to 14.18% from the intial 13.04% based on conventional sole TiCl_(4) *** champion PSC exhibits a PCE of 14.46%(V_(oc)=1.28 V,j.(sc)=14.21 mA/cm^(2),and FF=0.794),which is one of the highest PCEs for carbon-based CsPbI_(2) Br PSCs.

关键词： Perovskite solar cells CsPbI_(2)Br TiO_(2) TiCl_(3) Photovoltaic

CeCl_3·7H_2O-SiO_2:Catalyst promoted microwave assisted neat synthesis,antifungal and antioxidant activities of α-diaminophosphonates

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Chinese Chemical Letters 2013年第8期24卷 759-763页

作者： Subba rao Devineni Srinivasulu Doddaga Raj.sekhar Donka Naga Raj. Chamarthi Department of Chemistry Sri Venkateswara University

CeCl_3·7H_2O supported on silica（CeCl_3·7H_2O-SiO_2） is used as a heterogeneous,efficient and recyclable catalyst for a three component one-pot reaction of an amine,aldehydes and diethyl phosphite to synthesizeα-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction ***α-diaminophosphonates（6a-j. of 4,4＇-sulfonyldianiline（Dapsone）（3） were synthesized and structural elucidation was confirmed by spectral *** and antioxidant activities were evaluated include minimum inhibitory concentrations and IC_（50） values,respectively of the titled *** 6h,6i exhibited promising antioxidant activity at lower IC_（50） values 53.7μg/mL, 53.2μg/mL,respectively as compared with standard IC_（50） value 51.6μg/mL.

关键词： α-Diaminophosphonates Green synthesis Kabachnik-Fields reaction Antifungal activity Antioxidant activity

CLEAN:Frequent Pattern-Based Traj.ctory Compression and Computation on Road Networks

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China Communications 2020年第5期17卷 119-136页

作者： Peng Zhao Qinpei Zhao Chenxi Zhang Gong Su Qi Zhang Weixiong rao Tongj. University Shanghai 201804China IBM T.j.Watson Research Center New York 10598USA

The volume of traj.ctory data has become tremendously huge in recent years. How to effectively and efficiently maintain and compute such traj.ctory data has become a challenging task. In this paper, we propose a traj.ctory spatial and temporal compression framework, namely CLEAN. The key of spatial compression is to mine meaningful traj.ctory frequent patterns on road network. By treating the mined patterns as dictionary items, the long traj.ctories have the chance to be encoded by shorter paths, thus leading to smaller space cost. And an error-bounded temporal compression is carefully designed on top of the identified spatial patterns for much low space cost. Meanwhile, the patterns are also utilized to improve the performance of two traj.ctory applications, range query and clustering, without decompression overhead. Extensive experiments on real traj.ctory datasets validate that CLEAN significantly outperforms existing state-of-art approaches in terms of spatial-temporal compression and traj.ctory applications.

关键词： traj.ctory compression pattern mining spatial-temporal compressions range query clustering