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对急性椎基底动脉阻塞实施血管内治疗的效果预测：建立一种辅助ASIAN kr登记病人选择的模型

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国际医学放射学杂志 2020年第3期 359-360页

作者： S.j.Lee j.M.Hong j.W.Choi j.H.Park B.Park D.H.Kang 张燕燕 Departments of Neurology Ajou University School of Medicine and Office of Biostatistics Ajou University Medical Center

摘要是否对与椎基底动脉闭塞(VBO)相关的脑卒中实施血管内治疗(EVT)仍存在争议。目的术前确定具有好的治疗效果的预测因素并建立模型以帮助VBO病人选择。材料

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Establishment,functional and genetic characterization of three novel patient-derived rectal cancer cell lines

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World journal of Gastroenterology 2018年第43期24卷 4880-4892页

作者： Michael Gock Christina S Mullins Carina Bergner Friedrich Prall Robert Ramer Anja Goder Oliver H kramer Falko Lange Bernd j krause Ernst Klar Michael Linnebacher Department of General Surgery University Medical CenterRostock 18055Germany Section of Molecular Oncology and Immunotherapy University MedicalCenterRostock 18055Germany Department of NuclearMedicine University Medical CenterRostock 18055Germany Institute of Pathology University MedicalCenterRostock 18055Germany Institute of Pharmacology University Medical CenterRostock 18055Germany Institute of Toxicology University Medical Center MainzMainz 55131Germany Oscar-Langendorff-Institute of Physiology University Medical CenterRostock 18055Germany

AIM To establish patient-individual tumor models of rectal cancer for analyses of novel biomarkers, individual response prediction and individual therapy *** Establishment of cell lines was conducted by direct in vitro culturing and in vivo xenografting with subsequent in vitro culturing. Cell lines were in-depth characterized concerning morphological features, invasive and migratory behavior, phenotype, molecular profile including mutational analysis, protein expression, and confirmation of origin by DNA fingerprint. Assessment of chemosensitivity towards an extensive range of current chemotherapeutic drugs and of radiosensitivity was performed including analysis of a combined radioand chemotherapeutic treatment. In addition, glucose metabolism was assessed with 18 F-fluorodeoxyglucose(FDG) and proliferation with 18 *** We describe the establishment of ultra-low passage rectal cancer cell lines of three patients suffering from rectal cancer. Two cell lines(HROC126, HROC284 Met) were established directly from tumor specimens while HROC239 T0 M1 was established subsequent to xenografting of the tumor. Molecular analysis classified all three cell lines as CIMP-0/non-MSI-H(sporadic standard) type. Mutational analysis revealed following mutational profiles: HROC126: APC^(wt), TP53^(wt), krAS^(wt), BRAF^(wt), PTEN^(wt); HROC239 T0 M1: APC^(mut), P53^(wt), krAS^(mut), BRAF^(wt), PTEN^(mut) and HROC284 Met: APC^(wt), P53^(mut), krAS^(mut), BRAF^(wt), PTEN^(mut). All cell lines could be characterized as epithelial(EpCAM+) tumor cells with equivalent morphologic features and comparable growth kinetics. The cell lines displayed a heterogeneous response toward chemotherapy, radiotherapy and their combined application. HROC126 showed a highly radio-resistant phenotype and HROC284 Met was more susceptible to a combined radiochemotherapy than HROC126 and HROC239 T0 M1. Analysis of 18 F-FDG uptake displayed a markedly reduced FDG uptake of all th

关键词： Patient-derived tumor model Rectal cancer ^(18)F-fluorodeoxyglucose ^(18)F-fluorothymidine FOLFOX FOLFIRI Personalized medicine

Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease(GCKD)cohort

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Bone Research 2023年第4期11卷 764-771页

作者： Katharina Charlotte Reimer jennifer Nadal Heike Meiselbach Matthias Schmid Ulla T.Schultheiss Fruzsina Kotsis Helena Stockmann Nele Friedrich Matthias Nauck Vera krane Kai-Uwe Eckardt Markus P.Schneider Rafael kramann jürgen Floege Turgay Saritas Department of Nephrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute of Experimental Medicine and Systems Biology RWTH Aachen UniversityAachenGermany Institute for Cell and Tumor Biology RWTH Aachen UniversityAachenGermany Institute of Medical Biometry Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany Department of Nephrology and Hypertension University of Erlangen-NürnbergErlangenGermany Institute of Genetic Epidemiology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Medicine IV-Nephrology and Primary Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Nephrology and Medical Intensive Care Charité-Universitätsmedizin BerlinBerlinGermany Department of Nephrology University Medical Center RegensburgRegensburgGermany Institute of Clinical Chemistry and Laboratory Medicine University Medicine GreifswaldGreifswaldGermany DzHK(German Centre for Cardiovascular Research) Partner Site GreifswaldUniversity MedicineGreifswaldGermany Department of Medicine I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

Mineral and bone disorder(MBD)in chronic kidney disease(CKD)is tightly linked to cardiovascular disease(CVD).In this study,we aimed to compare the prognostic value of nine MBD biomarkers to determine those associated best with adverse cardiovascular(CV)outcomes and *** 5217 participants of the German CKD(GCKD)study enrolled with an estimated glomerular filtration rate(eG FR)between 30–60 mL·min-1 per 1.73 m2 or overt proteinuria,serum osteoprotegerin(OPG),C-terminal fibroblast growth factor-23(FGF23),intact parathyroid hormone(iP TH),bone alkaline phosphatase(BAP),cross-linked C-telopeptide of type 1 collagen(CTX1),procollagen 1intact N-terminal propeptide(P1NP),phosphate,calcium,and 25-OH vitamin D were measured at *** with missing values among these parameters(n=971)were excluded,leaving a total of 4246 participants for *** a median follow-up of6.5 years,387 non-CV deaths,173 CV deaths,645 nonfatal major adverse CV events(MACEs)and 368 hospitalizations for congestive heart failure(CHF)were *** and FGF23 were associated with all outcomes,with the highest hazard ratios(HRs)for *** the final Cox regression model,adjusted for CV risk factors,including kidney function and all other investigated biomarkers,each standard deviation increase in OPG was associated with non-CV death(HR 1.76,95%CI:1.35–2.30),CV death(HR 2.18,95%CI:1.50–3.16),MACE(HR 1.38,95%CI:1.12–1.71)and hospitalization for CHF(HR 2.05,95%CI:1.56–2.69).Out of the nine biomarkers examined,stratification based on serum OPG best identified the CKD patients who were at the highest risk for any adverse CV outcome and mortality.

关键词： Kidney cardiovascular vitamin

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76kr的激发态寿命测量

Chinese Physics C 1982年第2期 255-260页

作者：赵之正孙锡军 R.B.Piercey j.H.Hamilton C.F.Maguire A.V.Ramayya R.L.Robinson H.j.Kim j.C.Wells 中国科学院近代物理研究所中国科学院近代物理研究所范德毕尔特大学物理系范德毕尔特大学物理系范德毕尔特大学物理系范德毕尔特大学物理系田纳西州橡树岭国家实验室田纳西州橡树岭国家实验室田纳西技术大学物理系

本工作用多普勒移动衰减法测量了76kr的正宇称yrast态,γ振动带和负宇称带的激发态寿命,确定了76kr的十三个激发态的寿命或合成馈送时间。上述三个带中的每一个带都具有很强的集体性,跃迁强度高达100多个单粒子单位。

关键词：能级寿命宇称单粒子粒子性质跃迁强度激发态寿命反冲核振动带 kr 多普勒移动重子核子集体性

多发伤病人CT增强扫描肾上腺高密度的临床意义

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国际医学放射学杂志 2014年第2期 203-203页

作者： j.Schek S.Macht j.Klasen-Sansone P.Heusch P.krpil R.S.Lanzman 肖雅雯 Medical Faculty Department of Diagnostic and Interventional Radiology University Dusseldorf Moorenstrasse 540225 Dusseldorf Germany

目的旨在探讨CT增强扫描肾上腺高密度在多发伤病人评估中的预测价值。方法292例病人[195例男性,97例女性,平均年龄(45.3±23.3)岁]被纳入本项回顾性研究。所

关键词：增强CT 多发伤肾上腺增强复杂低灌注

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A=60—80核中多重集体带结构的发现

Chinese Physics C 1979年第3期 355-381页

作者： j.H.Hamilton R.L.Robinson A.V.Ramayya 张敬业范德毕尔特大学物理系纳斯威尔、田纳西州橡树岭国家实验室近代物理研究所

最近对于偶偶核68,70,72Ge,70,72,74Se,74,76,78,80kr 以及65Ga,74Br 能级的研究,发现了大量不同的集体带结构.其中包括建立在近球形基态以及有较大变形（可能包括三轴形变）的激发态之上的带,建立在同样的(g9/2)2轨道上的中子对和质子... 详细信息

最近对于偶偶核68,70,72Ge,70,72,74Se,74,76,78,80kr 以及65Ga,74Br 能级的研究,发现了大量不同的集体带结构.其中包括建立在近球形基态以及有较大变形（可能包括三轴形变）的激发态之上的带,建立在同样的(g9/2)2轨道上的中子对和质子对的转动排列（RAL）带,具有奇自旋和偶自旋的 RAL 负宇称带以及偶偶核中ΔI=1的γ型振动带.直到1974年,一篇关于 Ge 和 Se 偶偶同位素的综述指出高于4+态的能级（例如见文献[1]的图1和2）,还知道得很少.除了在70,72Ge 核中有异常低的0+激发态(最初是于1948年在范德毕尔特大学在72Ge 中发现的)之外,对于这些核,理论上起先只限于按一些振动模型来处理.但是最近以来,关于这个区域的核涌现了大量的信息,表明它们具有许多引人注目的崭新的特征.对于0+激发态也获得了更为深入的认识.特别令人惊讶的是在重离子反应在束γ射线谱的研究中,我们发现了多重、独立、高集体性的带结构.本文将要介绍我们在关于68,70,72Ge[3-6],70,72,74Se[7-13]和74,76,78,80kr[14-18]诸核的研究中发现大量的集体带结构(例如在我们关于68Ge,74Se 和76kr 能级的研究中发现至少有七种不同的带,见图1—3)的证据和理论解释.这种多重结构包括:1)建立在近球形态上的基态带和以0+′态为带头的大形变态上的激发带的共存;2)以8+态为带头,被解释为建立在中子和（或者）质子的(g9/2)2准粒子组态上的 RAL 带和基态带的同时存在;3)中子和质子的 RAL 奇宇称带,来自于一个 g9/2准粒子一个 P1/2,P3/2或者 f5/2准粒子与核实的耦合;4)△I=1偶宇称带,它可很好地被认为是γ振动带;以及5)目前还不清楚其性质的其它带.

关键词：质子中子宇称核子粒子性质自旋 A 带结构能级间隔 RAL

AUTORADIOGRAPHIC STUDY OF THE ATTRITION OF MIGRATING SCHISTOSOMULA IN THE SKIN OF MICE *** CHALLENGED WITH NORMAL *** CERCARIAE AFTER IMMUNIzATION WITH HIGHLY IRRADIATED CERCARIAE

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Chinese Medical Sciences journal 1990年第1期8卷 30-36页

作者： S.Y.Li Hsu H.F.Hsu j.W.Osborne W.R.Clarke C.K.Hawk Y.Ohnishi College of Medicine University of IowaIowaUSA

The migratory pattern and attrition of75Se-labelled *** challenge cercariae in CF1mice immunized 0,1,3, or 5 times with 12kr-or 48kr-irradiated cercariae were investigatedby compressed organ *** were percutaneously inoculated with 500-1000 cer-cariae for each immunization and with a known count of approximately 90 cercariae at adifferent site for *** skin,lungs,liver,other organs,and catrcass were processedfor *** and mesenteric perfusions for worm collection were alsosampled from day 19 through *** naive tnice,25% of challenge cercariae died in *** attrition of challenge cercariae in mice immunized with 12kr-irradiated cercariaewas 43% with 1 immunization,54% with 3,and 58% with 5,whereas in mice immunized with48kr-irradiated cercariae,skin,attrition was48% with 1,63% with 3,and 76% with 5 *** all immunized mice,a high percentage of migrating sehistosomula died in the skinwithin 24 hours of a challenge *** autoradiography,it was found that thesilver foci created by single labelled worms were difficult to differentiate from those of *** study documents the induction of acquired resistance against a challenge infectionin the skin by vaccination with highly irradiated cercariae,with the degree of attemtation ofimmunizing cercariae and the number of immunizations being closely related to the *** in the ***,we discuss the contradictory views concerning the site of attritiotn ofchallenge cercariae.

关键词： autoradiography attrition—challenge cercariae immunization—highly X-irradiated cercariae Schistosoma mansoni

PHONON DENSITY OF STATES OF SOLID kr AT 2.15 GPA AND THE ROOM TEMPERATURE

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PHONON DENSITY OF STATES OF SOLID KR AT 2.15 GPA AND THE ROO...

18th International Conference on High Pressure Science and Technology

作者： j.Y.zhao E.E.Alp M.Y.Hu T.Toellner W.Sturhahn G.Y.Shen j.Shu H.K.Mao Advanced Photon Source Argonne National Laboratory9700 South Cass AvenueArgonneIL 60439USA Consortium for Advanced Radiation Source The University of ChicagoChicagoIL60637USA Geophysical laboratory and Center for High Pressure Research Carnegie Institution of Washington5251 Broad Branch RoadNWWashington DC 20015USA

A novel method, nuclear resonant inelastic X-rayscattering (NRIXS)1-3], has been used for phonondensities of states measurement in recent *** of the experiments have concentrated on Feand Sn containing materials. We have built ahigh energy-resolution monochromator (with anenergy bandwidth of 2.3 meV) for nuclearresonant scattering from the 9.4 keV nucleartransition in kr at 3ID, Advanced Photon Source.A solid kr sample that was sealed in adiamond-avil-cell at 2.15 GPa and roomtemperature has been first time studied by the

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固体气泡探测器-固体核径迹探测器的新类别

核技术 2005年第9期28卷 659-662页

作者：郭士伦 Doke T 李丽陈宝流张东海 Kikuchi j Terasawa K Komiyama M Hara K Fuse T Yasuda N Murakami T 中国原子能科学研究院北京102413 Advanced Research Institute for Science and Engineering Waseda University 山西师范大学现代物理研究所临汾041004 The Institute of Physical and Chemical Research National Institute of Radiological Sciences

利用高能重离子p、He、C、Si、Ar、Fe、kr和Xe对固体气泡探测器的性质进行了研究。结果表明,固体气泡探测器具有许多与固体核径迹探测器相似的性质,且具有显影主动性、实时记录性、体径迹显示能力等多方面普通固体核径迹探测器所不具有... 详细信息

利用高能重离子p、He、C、Si、Ar、Fe、kr和Xe对固体气泡探测器的性质进行了研究。结果表明,固体气泡探测器具有许多与固体核径迹探测器相似的性质,且具有显影主动性、实时记录性、体径迹显示能力等多方面普通固体核径迹探测器所不具有的性能。可以得出结论:固体气泡探测器是固体核径迹探测器的一种新类别。

关键词：固体气泡探测器固体核径迹探测器高能重离子探测